General Information of Drug (ID: DMHTEAO)

Drug Name
Carvedilol Drug Info
Synonyms
Artist; Carvedilolum; Coreg; Coropres; Coropress; Dibloc; Dilatrend; Eucardic; Kredex; Querto; Atlana Pharma brand of carvedilol; Carvedilolum [Latin]; Coreg CR; GlaxoSmithKline brand of carvedilol; Lakeside brand of carvedilol; Roche brand of carvedilol; BM 14190; DQ 2466; SKF 105517; Artist (TN); BM-14190; Carloc (TN); Coreg (TN); DQ-2466; Dilatrend (TN); EG-P042; Eucardic (TN); BM-14-190; BM-14.190; Carvedilol, 14C-labeled; SK&F-105517; Carvedilol (JAN/USAN/INN); Carvedilol [USAN:INN:BAN:JAN]; Carvedilol, (R)-isomer; Carvedilol, (S)-isomer; Carvedilol, (+-)-isomer; (+-)-1-(Carbazol-4-yloxy)-3-((2-(o-methoxyphenoxy)ethyl)amino)-2-propanol; (+-)-1-Carbazol-4-yloxy)-3-((2-(o-methoxyphenoxy)ethyl)amino)-2-propanol; (+/-)-1-(Carbazol-4-yloxy)-3-[[2-(o-methoxyphenoxy)ethyl]amino]-2-propanol; 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol; 1-(9H-carbazol-4-yloxy)-3-[(2-{[2-(methyloxy)phenyl]oxy}ethyl)amino]propan-2-ol; 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol; 1-(9H-carbazol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-ol
Indication
Disease Entry ICD 11 Status REF
Chronic heart failure BD1Z Approved [1]
Congestive heart failure BD10 Approved [2]
Pulmonary hypertension BB01 Approved [1]
Coronavirus Disease 2019 (COVID-19) 1D6Y Investigative [3]
Therapeutic Class
Vasodilator Agents
Cross-matching ID
PubChem CID
2585
ChEBI ID
CHEMBL723
CAS Number
CAS 72956-09-3
TTD Drug ID
DMHTEAO
VARIDT Drug ID
DR00689
INTEDE Drug ID
DR0282
ACDINA Drug ID
D00103

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Discontinued Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Labetalol DMK8U72 Hypertension BA00-BA04 Approved [4]
Prazosin DMCD9YG Benign prostatic hyperplasia GA90 Approved [21]
Ergotamine DMKR3C5 Cluster headache 8A81.0 Approved [22]
Midodrine DME2PY5 Orthostatic hypotension BA21 Approved [23]
Urapidil DMD59GI Hypertension BA00-BA04 Approved [24]
Phenylpropanolamine DMTFK3O Allergic rhinitis CA08.0 Withdrawn from market [25]
Metazosin DMAZ28C Cardiac disease BA00-BE2Z Discontinued in Phase 3 [26]
DC-015 DMCDMWJ N. A. N. A. Terminated [27]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [28]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [29]
Methotrexate DM2TEOL Anterior urethra cancer Approved [30]
Folic Acid DMEMBJC Colorectal carcinoma Approved [31]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [30]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [30]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [32]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [30]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [33]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [34]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [35]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [36]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [37]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [38]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [39]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [40]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [41]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [42]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [36]
Verapamil DMA7PEW Angina pectoris BA40 Approved [9]
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Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [43]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [44]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [45]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [46]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [47]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [48]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [41]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [49]
Verapamil DMA7PEW Angina pectoris BA40 Approved [50]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [51]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [52]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [53]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [54]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [55]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [56]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [57]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [58]
Metronidazole DMTIVEN Abscess Approved [11]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [59]
Ethanol DMDRQZU Chronic pain MG30 Approved [60]
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Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [61]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [62]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [63]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [39]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [9]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [64]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [65]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [66]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [67]
Propranolol DM79NTF Angina pectoris BA40 Approved [68]
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Drug(s) Metabolized By Cytochrome P450 2E1 (CYP2E1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Folic Acid DMEMBJC Colorectal carcinoma Approved [69]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [70]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [71]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [72]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [73]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [49]
Verapamil DMA7PEW Angina pectoris BA40 Approved [74]
Estrone DM5T6US Acne vulgaris ED80 Approved [75]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [76]
Ethanol DMDRQZU Chronic pain MG30 Approved [77]
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Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [78]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [79]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [80]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [74]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [81]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [74]
Verapamil DMA7PEW Angina pectoris BA40 Approved [82]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [83]
Estrone DM5T6US Acne vulgaris ED80 Approved [84]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [86]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [87]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [9]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [88]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [89]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [9]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [90]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [91]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [92]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [93]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [94]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [95]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [96]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [97]
Cepharanthine DM9Y5JB N. A. N. A. Approved [98]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [99]
Clozapine DMFC71L Schizophrenia 6A20 Approved [100]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [101]
Trifluoperazine DMKBYWI Anxiety Approved [102]
Olanzapine DMPFN6Y Bipolar depression Approved [100]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Dobutamine DMD1B8Z Heart failure BD10-BD13 Approved [103]
Methotrexate DM2TEOL Anterior urethra cancer Approved [104]
Vortioxetine DM6F1PU Major depressive disorder 6A70.3 Approved [105]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [107]
Labetalol DMK8U72 Hypertension BA00-BA04 Approved [108]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [109]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [110]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [111]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [112]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [113]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [114]
Paclitaxel DMLB81S Breast carcinoma Approved [115]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [116]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [117]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [20]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [118]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [119]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [120]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [121]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [122]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [123]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Folic Acid DMEMBJC Colorectal carcinoma Approved [124]
Paclitaxel DMLB81S Breast carcinoma Approved [125]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [126]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [127]
Riociguat DMXBLMP Chronic thromboembolic pulmonary hypertension Approved [128]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [129]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [130]
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Drug(s) Affected By Renin (REN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [131]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [132]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [133]
Reboxetine DM26PRD Depression 6A70-6A7Z Approved [134]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [135]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [136]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [137]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [138]
Epinephrine DM3KJBC Acute asthma CA23 Approved [139]
Chlorthalidone DM4DMBT Edema MG29 Approved [140]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [141]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [20]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [142]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [143]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [144]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [145]
Prednisone DM2HG4X Acute asthma CA23 Approved [146]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [147]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [148]
Methotrexate DM2TEOL Anterior urethra cancer Approved [149]
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Drug(s) Affected By Natriuretic peptides A (NPPA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [150]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [151]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [152]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [153]
Cilazapril DM4V6JA Congestive heart failure BD10 Approved [154]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [155]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [156]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [157]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [158]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [159]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [160]
Oxprenolol DM51OQW Anxiety Approved [161]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Luvox DMJKROX Anxiety disorder 6B00-6B0Z Approved [163]
Sodium chloride DMM3950 Skin burns ME65.0 Approved [164]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [160]
Chlorpropamide DMPHZQE Non-insulin dependent diabetes 5A11 Approved [165]
Indomethacin DMSC4A7 Bursitis Approved [166]
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Drug(s) Affected By C-reactive protein (CRP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lidocaine DML4ZOT Anaesthesia 9A78.6 Approved [20]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [167]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [168]
Quercetin DM3NC4M Obesity 5B81 Approved [169]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [170]
Acalabrutinib DM7GCVW leukaemia 2A60-2B33 Approved [171]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [172]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [173]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [174]
Testosterone DM7HUNW Hot flushes GA30 Approved [175]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Salmeterol DMIEU69 Allergic asthma CA23.0 Approved [176]
Bambuterol DMKLSHF Asthma CA23 Approved [177]
Terbutaline DMD4381 Asthma CA23 Approved [178]
Salbutamol DMN9CWF Acute asthma CA23 Approved [179]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [180]
Methotrexate DM2TEOL Anterior urethra cancer Approved [104]
Epinephrine DM3KJBC Acute asthma CA23 Approved [181]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [182]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [183]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [184]
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Drug(s) Affected By Natriuretic peptides B (NPPB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [151]
Methotrexate DM2TEOL Anterior urethra cancer Approved [104]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [185]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [186]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [187]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [188]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [189]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [190]
Ethanol DMDRQZU Chronic pain MG30 Approved [191]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [117]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [114]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [192]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [119]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [120]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [121]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [193]
Gefitinib DM15F0X Colon adenocarcinoma Approved [194]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [195]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [196]
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Drug(s) Affected By Ryanodine receptor 2 (RYR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Isoproterenol DMK7MEY Atrioventricular block Approved [197]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [198]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [199]
Atenolol DMNKG1Z Angina pectoris BA40 Approved [200]
Metoprolol DMOJ0V6 Acute coronary syndrome BA41 Approved [200]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [198]
Arsenic DMTL2Y1 N. A. N. A. Approved [201]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [198]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [202]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Bosutinib DMTI8YE Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [203]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [204]
Methotrexate DM2TEOL Anterior urethra cancer Approved [149]
Quercetin DM3NC4M Obesity 5B81 Approved [205]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [206]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [207]
Plicamycin DM7C8YV Hypercalcaemia 5B91.0 Approved [208]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [209]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [209]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Adrenergic receptor Alpha-1 (ADRA1) TTG28O6 NOUNIPROTAC Antagonist [4]
HUAMN alpha-1 adrenergic receptor (ADRA1) TTDBOI7 ADA1A_HUMAN; ADA1B_HUMAN; ADA1D_HUMAN Inhibitor [5]
HUMAN beta adrenergic receptor (BAR) TTJB8UY ADRB1_HUMAN; ADRB2_HUMAN; ADRB3_HUMAN Antagonist [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [6]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [7]
Cytochrome P450 2E1 (CYP2E1) DEVDYN7 CP2E1_HUMAN Substrate [8]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [9]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [10]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Substrate [11]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Substrate [12]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DEB3CV1 UD2B7_HUMAN Substrate [11]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Regulation of Drug Effects [13]
Beta-1 adrenergic receptor (ADRB1) OTQBWN4U ADRB1_HUMAN Gene/Protein Processing [14]
Beta-2 adrenergic receptor (ADRB2) OTSDOX4Q ADRB2_HUMAN Post-Translational Modifications [15]
C-reactive protein (CRP) OT0RFT8F CRP_HUMAN Gene/Protein Processing [16]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [15]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [15]
Natriuretic peptides A (NPPA) OTMQNTNX ANF_HUMAN Gene/Protein Processing [17]
Natriuretic peptides B (NPPB) OTSN2IPY ANFB_HUMAN Gene/Protein Processing [18]
Potassium channel subfamily K member 3 (KCNK3) OTWMAV6G KCNK3_HUMAN Gene/Protein Processing [19]
Proto-oncogene tyrosine-protein kinase Src (SRC) OTETYX40 SRC_HUMAN Drug Response [20]

References

1 Carvedilol FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 551).
3 Can beta-adrenergic blockers be used in the treatment of COVID-19 Med Hypotheses. 2020 May 5;142:109809.
4 Beta-blockers in the treatment of hypertension: are there clinically relevant differences Postgrad Med. 2009 May;121(3):90-8.
5 Carvedilol increases the production of interleukin-12 and interferon-gamma and improves the survival of mice infected with the encephalomyocarditis virus. J Am Coll Cardiol. 2003 Jan 15;41(2):340-5.
6 Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition.
7 Role of cytochrome P450 2D6 genetic polymorphism in carvedilol hydroxylation in vitro. Drug Des Devel Ther. 2016 Jun 8;10:1909-16.
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