Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJIMXH)

• Drug Name: Puerarin Drug Info
• Synonyms: NPI-031-G; Puerarin (oral formulation, alcoholism); Puerarin (oral formulation, alcoholism), Natural Pharmacia; 5-HT2creceptor antagonists/GABA receptor antagonists (oral formulation, alcoholism), Natural Pharmacia

Indication

Disease Entry	ICD 11	Status	REF
Alcohol dependence	6C40.2	Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 5281807
  ChEBI ID: CHEBI:8633
  CAS Number: CAS 3681-99-0
  TTD Drug ID: DMJIMXH

Molecule-Related Drug Atlas

Drug(s) Targeting 5-HT 2C receptor (HTR2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metergolin	DMJFP6G	Hyperprolactinaemia	5A60.1	Approved	[6]
Lorcaserin	DMG6OYJ	Obesity	5B81	Approved	[7]
Tramadol	DMRQD04	Osteoarthritis	FA00-FA05	Approved	[8]
Mirtazapine	DML53ZJ	Depression	6A70-6A7Z	Approved	[9]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[10]
Methysergide	DM1EF73	Migraine	8A80	Approved	[11]
Eltoprazine	DMW6C81	Attention deficit hyperactivity disorder	6A05.Z	Phase 3	[12]
M100907	DM7ZFBA	Sleep-wake disorder	7A00-7B2Z	Phase 3	[13]
SR46349B	DM1ODMR	Primary insomnia	7A00	Phase 3	[14]
Vabicaserin	DM9GZW6	Psychotic disorder	6A20-6A25	Phase 2	[15]

Drug(s) Affected By Telomerase reverse transcriptase (TERT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[16]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[17]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[18]
Selenium	DM25CGV	N. A.	N. A.	Approved	[19]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[20]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[23]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[24]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[25]

Drug(s) Affected By Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 (PLOD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[29]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[30]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[31]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[3]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[3]
GUAIACOL	DMN4E7T	N. A.	N. A.	Phase 3	[3]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[3]

Drug(s) Affected By Cytochrome c oxidase subunit 1 (COX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[32]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[33]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[34]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[35]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[38]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[39]
Nicotinamide	DMUPE07	Acne vulgaris	ED80	Approved	[34]

Drug(s) Affected By Pro-epidermal growth factor (EGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[40]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[42]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[44]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[45]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[46]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[47]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]

Drug(s) Affected By Interleukin-1 alpha (IL1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[49]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[50]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[50]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[50]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[50]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]

Drug(s) Affected By Heat shock protein beta-1 (HSPB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[56]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[57]
Selenium	DM25CGV	N. A.	N. A.	Approved	[58]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[61]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[62]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[35]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]

Drug(s) Affected By Insulin-like growth factor I (IGF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[65]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[66]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[69]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[70]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[35]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[71]

Drug(s) Affected By Fibroblast growth factor 1 (FGF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[49]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[75]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[68]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[76]

Drug(s) Affected By Progesterone receptor (PGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[77]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[80]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[81]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[82]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[83]
Goserelin	DMAT8CG	Breast cancer	2C60-2C65	Approved	[84]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]

Drug(s) Affected By Extracellular superoxide dismutase (SOD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[86]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[88]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[92]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[93]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[94]

Drug(s) Affected By Androgen receptor (AR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[95]
Nilutamide	DMFN07X	Prostate cancer	2C82.0	Approved	[95]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[95]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[96]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[97]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[77]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[98]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[99]
Selenium	DM25CGV	N. A.	N. A.	Approved	[100]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[101]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[102]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[103]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[104]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[105]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[106]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[20]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[108]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[109]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[44]

Drug(s) Affected By Translationally-controlled tumor protein (TPT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[113]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[114]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[115]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[110]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[116]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]

Drug(s) Affected By Nitric oxide synthase 3 (NOS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[120]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[121]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[122]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[125]
Fructose	DM43AN2	Vomiting	MD90	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]

Drug(s) Affected By Aquaporin-1 (AQP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[128]
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[129]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[130]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[132]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[133]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[134]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[135]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[31]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[136]

Drug(s) Affected By 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[137]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[138]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[92]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[139]
Dutasteride	DMQ4TJK	Benign prostatic hyperplasia	GA90	Approved	[140]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[26]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[141]
Methyltestosterone	DMWLFGO	Advanced cancer	2A00-2F9Z	Approved	[139]
Finasteride	DMWV3TZ	Baldness, male pattern		Approved	[139]

Drug(s) Affected By Desmoglein-3 (DSG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[122]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[142]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[143]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[3]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[144]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[3]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]
Chlorogenic acid	DM2Y3P4	Discovery agent	N.A.	Investigative	[3]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[146]

Drug(s) Affected By Prostaglandin E2 receptor EP1 subtype (PTGER1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[3]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[3]
GUAIACOL	DMN4E7T	N. A.	N. A.	Phase 3	[3]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[3]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]

Drug(s) Affected By Nitric oxide synthase, inducible (NOS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[31]
Indomethacin	DMSC4A7	Bursitis		Approved	[147]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[148]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[149]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[86]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[150]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[151]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[152]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[153]

Drug(s) Affected By Fibrillin-1 (FBN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[154]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[44]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[132]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[157]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[158]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[159]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[31]

Drug(s) Affected By Fibrillin-2 (FBN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[88]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[157]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[161]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[162]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[163]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[164]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[165]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[31]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[143]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[166]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[167]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[168]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[169]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[170]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[171]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[172]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[173]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[174]

Drug(s) Affected By ATP-citrate synthase (ACLY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[175]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[176]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[177]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[178]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[179]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[180]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[181]
OPC-34712	DMHG57U	Major depressive disorder	6A70.3	Approved	[182]

Drug(s) Affected By Melanocyte-stimulating hormone receptor (MC1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[69]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[34]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[183]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[184]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[130]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[185]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[3]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[3]
GUAIACOL	DMN4E7T	N. A.	N. A.	Phase 3	[3]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[3]

Drug(s) Affected By Cytoglobin (CYGB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[20]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[186]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[187]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[76]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[188]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[189]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[31]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[143]

Drug(s) Affected By Aquaporin-3 (AQP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[58]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[190]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[20]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[108]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[192]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[20]

Drug(s) Affected By Estrogen receptor beta (ESR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[193]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[194]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[195]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[196]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[197]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Mestranol	DMG3F94	Contraception	QA21	Approved	[201]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[202]

Drug(s) Affected By Hyaluronan synthase 1 (HAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[203]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[143]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[3]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[3]
GUAIACOL	DMN4E7T	N. A.	N. A.	Phase 3	[3]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[3]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[204]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[145]
Chlorogenic acid	DM2Y3P4	Discovery agent	N.A.	Investigative	[3]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[205]

Drug(s) Affected By Klotho (KL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[206]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[207]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[208]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[209]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[3]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[3]
GUAIACOL	DMN4E7T	N. A.	N. A.	Phase 3	[3]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[3]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[210]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[211]
Fructose	DM43AN2	Vomiting	MD90	Approved	[120]
Ketoprofen	DMRKXPT	Bursitis		Approved	[120]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[212]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[213]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[214]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[215]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[216]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[217]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[218]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[219]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[213]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[220]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[221]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[222]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[223]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[224]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[225]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[226]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[218]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[227]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[228]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[229]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[217]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[120]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[128]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[213]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[220]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[230]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[231]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[232]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[233]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[234]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[235]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[236]
Selenium	DM25CGV	N. A.	N. A.	Approved	[58]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[66]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[237]

Drug(s) Affected By Mitogen-activated protein kinase 9 (MAPK9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[238]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[239]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[240]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[241]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[242]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[240]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[243]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[244]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[245]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[246]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[247]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[248]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[249]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[250]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[251]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[252]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[253]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[254]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[69]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[255]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[256]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[257]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[256]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[258]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[239]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[259]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[260]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[261]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[262]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[257]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[258]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[263]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[18]
Selenium	DM25CGV	N. A.	N. A.	Approved	[264]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[237]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[265]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[266]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]

Drug(s) Affected By Retinoic acid receptor alpha (RARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[102]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[193]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[267]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[268]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[268]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[268]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[268]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[269]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[270]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[271]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[272]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[273]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[274]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[120]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[49]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[275]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[276]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[213]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[233]

Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[277]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[278]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[279]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[235]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[265]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[280]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[281]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[88]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[282]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[283]

Drug(s) Affected By Protein PML (PML)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[58]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[284]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[285]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[286]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[285]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[287]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[288]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[288]

Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[289]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[290]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[278]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[279]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[291]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[237]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[292]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[293]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[89]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[294]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[295]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[296]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[297]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[298]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[299]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[300]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[301]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[302]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[303]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[304]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[305]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[238]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[215]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[306]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[240]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[307]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[308]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[240]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[309]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[310]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[311]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[312]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[313]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[314]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Fructose	DM43AN2	Vomiting	MD90	Approved	[315]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[316]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[317]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[318]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[271]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[304]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[49]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[275]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[102]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[319]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[320]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[239]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[321]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[322]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[323]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[324]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[325]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[128]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[311]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[326]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[248]
Selenium	DM25CGV	N. A.	N. A.	Approved	[58]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[327]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]

Drug(s) Affected By G-protein coupled estrogen receptor 1 (GPER1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[328]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[329]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[108]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[330]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[328]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[177]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[184]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[331]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 2C receptor (HTR2C)	TTWJBZ5	5HT2C_HUMAN	Modulator	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2)	OTTG0NFD	S5A2_HUMAN	Gene/Protein Processing	[3]
5,6-dihydroxyindole-2-carboxylic acid oxidase	OTRK49R4	TYRP1_HUMAN	Gene/Protein Processing	[3]
Androgen receptor (AR)	OTUBKAZZ	ANDR_HUMAN	Gene/Protein Processing	[3]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[4]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[5]
Aquaporin-1 (AQP1)	OTX5MYX9	AQP1_HUMAN	Gene/Protein Processing	[3]
Aquaporin-3 (AQP3)	OT2J7JPD	AQP3_HUMAN	Gene/Protein Processing	[3]
ATP-citrate synthase (ACLY)	OTRL9ZRP	ACLY_HUMAN	Gene/Protein Processing	[3]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Gene/Protein Processing	[5]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Gene/Protein Processing	[3]

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