Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKBRDL)

Drug Name
BEZ235 Drug Info
Synonyms BEZ-235; S14-0511; NVP-BEZ-235; NVP-BEZ235, BEZ235; 2-(4-(2,3-dihydro-3-methyl-2-oxo-8-(quinolin-3-yl)imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 2 [1]
Cross-matching ID
PubChem CID
11977753
ChEBI ID
CHEBI:71952
CAS Number
CAS 915019-65-7
TTD Drug ID
DMKBRDL

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Serine/threonine-protein kinase mTOR (mTOR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sirolimus DMGW1ID Advanced cancer 2A00-2F9Z Approved [9]
Temsirolimus DMS104F Renal cell carcinoma 2C90 Approved [10]
PF-04449913 DMSB068 Chronic myelomonocytic leukaemia 2A40 Approved [11]
Everolimus DM8X2EH Advanced cancer 2A00-2F9Z Approved [12]
Novolimus DM6ZPLQ Artery stenosis BD52 Approved [13]
Zotarolimus DMRMCXW Solid tumour/cancer 2A00-2F9Z Approved [14]
Ridaforolimus DMLHEU7 Sarcoma 2A60-2C35 Phase 3 [15]
AZD2014 DMOEARH Solid tumour/cancer 2A00-2F9Z Phase 2 [16]
MM-141 DM2RJ4D Pancreatic cancer 2C10 Phase 2 [17]
PQR309 DMMCYZ8 Squamous head and neck cell carcinom 2D60.0 Phase 2 [13]
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Drug(s) Targeting PI3-kinase gamma (PIK3CG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BAY 80-6946 DMLOS5R Follicular lymphoma 2A80 Approved [18]
IPI-145 DMWA24P Follicular lymphoma 2A80 Approved [19]
Buparlisib DM1WEHC Breast cancer 2C60-2C65 Phase 3 [20]
Enzastaurin DM5H0R9 Diffuse large B-cell lymphoma 2A81 Phase 3 [17]
Rigosertib DMOSTXF Myelodysplastic syndrome 2A37 Phase 3 [21]
GDC-0032 DMT4QHD Breast cancer 2C60-2C65 Phase 3 [17]
PQR309 DMMCYZ8 Squamous head and neck cell carcinom 2D60.0 Phase 2 [22]
SAR245409 DMQM7IL Solid tumour/cancer 2A00-2F9Z Phase 2 [23]
XL147 DMML7BE Solid tumour/cancer 2A00-2F9Z Phase 2 [23]
SF1126 DML10K3 Head and neck cancer 2D42 Phase 2 [24]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [25]
Gefitinib DM15F0X Colon adenocarcinoma Approved [26]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [27]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [28]
Etretinate DM2CZFA Keratosis ED56 Approved [29]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [30]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [31]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [32]
Quercetin DM3NC4M Obesity 5B81 Approved [33]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [34]
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Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [35]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [36]
Quercetin DM3NC4M Obesity 5B81 Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [38]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [39]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [3]
Panobinostat DM58WKG Chronic graft versus host disease Approved [40]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [41]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [42]
Testosterone DM7HUNW Hot flushes GA30 Approved [43]
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Drug(s) Affected By Retinoblastoma-associated protein (RB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [44]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [45]
Gefitinib DM15F0X Colon adenocarcinoma Approved [46]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [47]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [48]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [36]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [49]
Methotrexate DM2TEOL Anterior urethra cancer Approved [50]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [52]
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Drug(s) Affected By Cathepsin B (CTSB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [53]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [54]
Selenium DM25CGV N. A. N. A. Approved [55]
Quercetin DM3NC4M Obesity 5B81 Approved [56]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [57]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [58]
Pyrimethamine DM5X7VY Malaria 1F40-1F45 Approved [59]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [60]
Propylthiouracil DM6D7N8 Hyperthyroidism 5A02 Approved [61]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [62]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [63]
Gefitinib DM15F0X Colon adenocarcinoma Approved [64]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [65]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [28]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [66]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [67]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [66]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [68]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [69]
Methotrexate DM2TEOL Anterior urethra cancer Approved [70]
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Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [71]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [72]
Gefitinib DM15F0X Colon adenocarcinoma Approved [73]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [74]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [36]
Quercetin DM3NC4M Obesity 5B81 Approved [75]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [76]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [77]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [78]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [79]
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Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [80]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [81]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [82]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [83]
Gefitinib DM15F0X Colon adenocarcinoma Approved [84]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [47]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [85]
Selenium DM25CGV N. A. N. A. Approved [55]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [86]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [87]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [88]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [89]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [90]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [82]
Gefitinib DM15F0X Colon adenocarcinoma Approved [91]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [74]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [92]
Selenium DM25CGV N. A. N. A. Approved [55]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [93]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [86]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [94]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [95]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [96]
Gefitinib DM15F0X Colon adenocarcinoma Approved [26]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [47]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [97]
Etretinate DM2CZFA Keratosis ED56 Approved [29]
Prednisone DM2HG4X Acute asthma CA23 Approved [98]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [67]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [99]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [100]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [101]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [102]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [103]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [104]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [105]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [106]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [107]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [108]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [109]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [110]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [111]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [63]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [112]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [113]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [114]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [28]
Meloxicam DM2AR7L Arthritis FA20 Approved [115]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [116]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [117]
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Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [118]
Methotrexate DM2TEOL Anterior urethra cancer Approved [119]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [120]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [78]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [121]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [122]
Testosterone DM7HUNW Hot flushes GA30 Approved [123]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [124]
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [88]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [125]
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Drug(s) Affected By Heat shock factor protein 1 (HSF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [126]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [8]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [8]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [127]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [128]
Ceftazidime DM41GRA Bacteremia 1A73 Approved [8]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [38]
Chlorpheniramine DM5URA2 Allergic rhinitis CA08.0 Approved [8]
Ethacrynic acid DM60QMR Edema MG29 Approved [8]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [8]
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Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [90]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [129]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [28]
Selenium DM25CGV N. A. N. A. Approved [55]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [130]
Methotrexate DM2TEOL Anterior urethra cancer Approved [131]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [132]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [133]
Quercetin DM3NC4M Obesity 5B81 Approved [134]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [135]
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Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [136]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [54]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [137]
Methotrexate DM2TEOL Anterior urethra cancer Approved [138]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [139]
Quercetin DM3NC4M Obesity 5B81 Approved [140]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [141]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [54]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [142]
Ethacrynic acid DM60QMR Edema MG29 Approved [143]
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Drug(s) Affected By Sequestosome-1 (SQSTM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [144]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [72]
Gefitinib DM15F0X Colon adenocarcinoma Approved [145]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [146]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [147]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [30]
Methotrexate DM2TEOL Anterior urethra cancer Approved [131]
Quercetin DM3NC4M Obesity 5B81 Approved [56]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [148]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [149]
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Drug(s) Affected By Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [150]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [86]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [151]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [153]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [154]
Testosterone DM7HUNW Hot flushes GA30 Approved [123]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [155]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [125]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [156]
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Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3A (MAP1LC3A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [157]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [158]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [159]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [160]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [161]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [162]
Capsaicin DMGMF6V Back pain ME84.Z Approved [163]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [164]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [165]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [166]
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Drug(s) Affected By UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [167]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [77]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [168]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [169]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [170]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [162]
Bortezomib DMNO38U Leukemia Approved [171]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [166]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [167]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [172]
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Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [90]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [173]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [174]
Methotrexate DM2TEOL Anterior urethra cancer Approved [175]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [176]
Quercetin DM3NC4M Obesity 5B81 Approved [177]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [178]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [179]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [180]
Testosterone DM7HUNW Hot flushes GA30 Approved [43]
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Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [181]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [167]
Quercetin DM3NC4M Obesity 5B81 Approved [56]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [38]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [182]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [183]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [184]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [185]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [186]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [161]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
PI3-kinase gamma (PIK3CG) TTHBTOP PK3CG_HUMAN Modulator [2]
Serine/threonine-protein kinase mTOR (mTOR) TTCJG29 MTOR_HUMAN Modulator [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Gene/Protein Processing [3]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [4]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Gene/Protein Processing [4]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [5]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Protein Interaction/Cellular Processes [6]
Cathepsin B (CTSB) OTP9G5QB CATB_HUMAN Protein Interaction/Cellular Processes [6]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [7]
Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1) OTHBQVD5 4EBP1_HUMAN Post-Translational Modifications [5]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Post-Translational Modifications [7]
Heat shock factor protein 1 (HSF1) OTYNJ4KP HSF1_HUMAN Gene/Protein Processing [8]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7950).
2 The dual PI3K/mTOR inhibitor NVP-BEZ235 is a potent inhibitor of ATM- and DNA-PKCs-mediated DNA damage responses. Neoplasia. 2012 Jan;14(1):34-43.
3 Antitumor action of the MET tyrosine kinase inhibitor crizotinib (PF-02341066) in gastric cancer positive for MET amplification. Mol Cancer Ther. 2012 Jul;11(7):1557-64. doi: 10.1158/1535-7163.MCT-11-0934. Epub 2012 Jun 22.
4 Synergistic induction of cell death in haematological malignancies by combined phosphoinositide-3-kinase and BET bromodomain inhibition. Br J Haematol. 2015 Jul;170(2):275-8. doi: 10.1111/bjh.13283. Epub 2015 Jan 12.
5 Dual targeting of phosphoinositide 3-kinase and mammalian target of rapamycin using NVP-BEZ235 as a novel therapeutic approach in human ovarian carcinoma. Clin Cancer Res. 2011 Apr 15;17(8):2373-84. doi: 10.1158/1078-0432.CCR-10-2289. Epub 2011 Mar 3.
6 The dual PI3K/mTOR inhibitor NVP-BEZ235 and chloroquine synergize to trigger apoptosis via mitochondrial-lysosomal cross-talk. Int J Cancer. 2013 Jun 1;132(11):2682-93. doi: 10.1002/ijc.27935. Epub 2012 Dec 4.
7 Dual inhibitor of phosphoinositide 3-kinase/mammalian target of rapamycin NVP-BEZ235 effectively inhibits cisplatin-resistant urothelial cancer cell growth through autophagic flux. Toxicol Lett. 2013 Jul 18;220(3):267-76. doi: 10.1016/j.toxlet.2013.04.021. Epub 2013 May 4.
8 A Gene Expression Biomarker Predicts Heat Shock Factor 1 Activation in a Gene Expression Compendium. Chem Res Toxicol. 2021 Jul 19;34(7):1721-1737. doi: 10.1021/acs.chemrestox.0c00510. Epub 2021 Jun 25.
9 Knockouts model the 100 best-selling drugs--will they model the next 100 Nat Rev Drug Discov. 2003 Jan;2(1):38-51.
10 Advances in kinase targeting: current clinical use and clinical trials. Trends Pharmacol Sci. 2014 Nov;35(11):604-20.
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