Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKER83)

Drug Name
Hesperetin Drug Info
Synonyms
Hesperin; Hesperitin; TNP00238; YSO2; Cyanidanon 4'-methyl ether 1626; Flavanone, 3',5,7-trihydroxy-4'-methoxy-(VAN); Flavanone, 3',5,7-trihydroxy-4'-methoxy-(VAN) (8CI); (-)-hesperetin; (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydro-4H-chromen-4-one; (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydrochromen-4-one; (S)-2,3-Dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone; (S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one; 3',5,7-Trihydroxy-4'-methoxyflavanone; 3',5,7-Trihydroxy-4-methoxyflavanone; 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (S)-(9CI); 5,7,3'-Trihydroxy-4'-methoxyflavanone
Indication
Disease Entry ICD 11 Status REF
High blood cholesterol level 5C80.00 Approved [1]
Therapeutic Class
Anticholesteremic Agents
Cross-matching ID
PubChem CID
72281
ChEBI ID
CHEMBL399121
CAS Number
CAS 520-33-2
TTD Drug ID
DMKER83
VARIDT Drug ID
DR00557
INTEDE Drug ID
DR0808

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Approved Drug(s)
Investigative Drug(s)
Preclinical Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Diacylglycerol acyltransferase 1 (DGAT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
LCQ908 DMFLJHQ Familial chylomicronemia syndrome 5C80 Phase 3 [10]
AZD7687 DMS9I6A Diabetic complication 5A2Y Phase 1 [11]
P-7435 DMNZQU5 Diabetic complication 5A2Y Phase 1 [12]
PMID25470667-Compound-Figure4-1A DMMVQW8 N. A. N. A. Patented [13]
Azole derivative 7 DMVUJGI N. A. N. A. Patented [13]
Carbamide derivative 3 DM4ISCQ N. A. N. A. Patented [13]
T863 DMX41ZF Discovery agent N.A. Patented [13]
Benzamide derivative 19 DM5YNTM N. A. N. A. Patented [13]
Lactam derivative 5 DMX5FYZ N. A. N. A. Patented [13]
Pyridine-carboximide derivative 2 DMHXWZB N. A. N. A. Patented [13]
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Drug(s) Transported By Breast cancer resistance protein (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [14]
Methotrexate DM2TEOL Anterior urethra cancer Approved [15]
Folic Acid DMEMBJC Colorectal carcinoma Approved [16]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [17]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [18]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [19]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [20]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [19]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [21]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [22]
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Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [23]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [24]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [25]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [26]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [27]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [28]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [29]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [30]
Verapamil DMA7PEW Angina pectoris BA40 Approved [31]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [32]
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Drug(s) Affected By Cytochrome c (CYCS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [33]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [34]
Gefitinib DM15F0X Colon adenocarcinoma Approved [35]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [36]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [37]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [38]
Methotrexate DM2TEOL Anterior urethra cancer Approved [39]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
Pefloxacin DM49IGF Gonococcal urethritis 1A70.0Y Approved [42]
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Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [43]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [44]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [45]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [46]
Capsaicin DMGMF6V Back pain ME84.Z Approved [47]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [48]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [49]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [48]
Desipramine DMT2FDC Attention deficit hyperactivity disorder 6A05.Z Approved [44]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [50]
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Drug(s) Affected By NAD-dependent protein deacylase sirtuin-6 (SIRT6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Testosterone DM7HUNW Hot flushes GA30 Approved [52]
Paclitaxel DMLB81S Breast carcinoma Approved [53]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [54]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [55]
SEN-196 DMLDBQ5 Huntington disease 8A01.10 Phase 2 [56]
TAK-715 DMZKPI8 Rheumatoid arthritis FA20 Phase 2 [57]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [58]
NORCANTHARIDIN DM9B6Y1 Discovery agent N.A. Investigative [53]
paraquat DMR8O3X Discovery agent N.A. Investigative [59]
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Drug(s) Affected By Copper chaperone for superoxide dismutase (CCS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [60]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [61]
Testosterone enanthate DMB6871 N. A. N. A. Approved [62]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [64]
Ethanol DMDRQZU Chronic pain MG30 Approved [65]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [66]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [54]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [67]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [68]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [69]
Vidarabine DM0N85H Hepatosplenic T-cell lymphoma Approved [69]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [70]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [71]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [72]
Etidronic acid DM1XHYJ Bone Paget disease Approved [69]
Tiaprofenic acid DM23D7J Osteoarthritis FA00-FA05 Approved [69]
Bromperidol DM24XYQ Schizophrenia 6A20 Approved [69]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [73]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [74]
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Drug(s) Affected By Sex hormone-binding globulin (SHBG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [75]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Fructose DM43AN2 Vomiting MD90 Approved [76]
Oxcarbazepine DM5PU6O Epilepsy 8A60-8A68 Approved [77]
Estrone DM5T6US Acne vulgaris ED80 Approved [78]
Testosterone DM7HUNW Hot flushes GA30 Approved [79]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [80]
Dienestrol DMBSXI0 Atrophic vaginitis GA30.2 Approved [78]
Masoprocol DMMVNZ0 Prostate cancer 2C82.0 Approved [78]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [78]
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Drug(s) Affected By Fatty acid-binding protein, adipocyte (FABP4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [81]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [82]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [84]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [81]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [85]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [86]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [87]
Capsaicin DMGMF6V Back pain ME84.Z Approved [88]
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Drug(s) Affected By DNA repair nuclease/redox regulator APEX1 (APEX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [89]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [90]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [64]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [91]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [54]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [92]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [93]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [94]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [95]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [96]
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Drug(s) Affected By Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (ALDH4A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [97]
Selenium DM25CGV N. A. N. A. Approved [98]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [99]
Testosterone DM7HUNW Hot flushes GA30 Approved [100]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [100]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [85]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [64]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [101]
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Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [102]
Triacetin DM0AEPG Onychomycosis EE12.1 Approved [103]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [104]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [105]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [106]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [107]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [108]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [109]
Methotrexate DM2TEOL Anterior urethra cancer Approved [110]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
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Drug(s) Affected By Phospholipid hydroperoxide glutathione peroxidase GPX4 (GPX4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [111]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [112]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [113]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [114]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [115]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [64]
Gallium nitrate DMF9O6B Hypercalcaemia 5B91.0 Approved [116]
Trabectedin DMG3Y89 Leiomyosarcoma 2B58 Approved [117]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [118]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [119]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [120]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [121]
Gefitinib DM15F0X Colon adenocarcinoma Approved [122]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [123]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [107]
Etretinate DM2CZFA Keratosis ED56 Approved [124]
Prednisone DM2HG4X Acute asthma CA23 Approved [125]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [126]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [127]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [128]
Gefitinib DM15F0X Colon adenocarcinoma Approved [129]
Prednisone DM2HG4X Acute asthma CA23 Approved [125]
Methotrexate DM2TEOL Anterior urethra cancer Approved [130]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [131]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [132]
Quercetin DM3NC4M Obesity 5B81 Approved [133]
Fluoxetine DM3PD2C Bipolar depression Approved [134]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [135]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [136]
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Drug(s) Affected By CCAAT/enhancer-binding protein alpha (CEBPA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [137]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [138]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [139]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [140]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [141]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [142]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [85]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [141]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [143]
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Drug(s) Affected By Kelch-like ECH-associated protein 1 (KEAP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [144]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [137]
Selenium DM25CGV N. A. N. A. Approved [98]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [145]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [146]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [147]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [147]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [147]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [148]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [149]
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Drug(s) Affected By Programmed cell death 6-interacting protein (PDCD6IP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [113]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [64]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [54]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [68]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [151]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [152]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [153]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [154]
MG-132 DMKA2YS N. A. N. A. Preclinical [154]
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Drug(s) Affected By Resistin (RETN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [155]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [156]
Amlodipine DMBDAZV Angina pectoris BA40 Approved [157]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [158]
Vitamin B3 DMQVRZH Chronic renal failure GB61.Z Approved [159]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [160]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [161]
isobutylmethylxanthine DM46F5X Discovery agent N.A. Investigative [162]
Icosapentum DMF1CM7 N. A. N. A. Investigative [163]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [164]
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Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [165]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [166]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [167]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [166]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [167]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [54]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [95]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [168]
Urethane DM7NSI0 N. A. N. A. Phase 4 [169]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Diacylglycerol acyltransferase 1 (DGAT1) TTF8P9I DGAT1_HUMAN Inhibitor [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 1A2 (CYP1A2) Main DME DEJGDUW CP1A2_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
CCAAT/enhancer-binding protein alpha (CEBPA) OTOM9OE4 CEBPA_HUMAN Gene/Protein Processing [5]
Copper chaperone for superoxide dismutase (CCS) OTXHT3QO CCS_HUMAN Protein Interaction/Cellular Processes [6]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [5]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Gene/Protein Processing [7]
Cytochrome b-c1 complex subunit Rieske, mitochondrial OTA2AXFN UCRI_HUMAN Protein Interaction/Cellular Processes [6]
Cytochrome c (CYCS) OTBFALJD CYC_HUMAN Gene/Protein Processing [8]
Cytochrome P450 2C19 (CYP2C19) OTFMJYYE CP2CJ_HUMAN Gene/Protein Processing [9]
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (ALDH4A1) OT25Z6XH AL4A1_HUMAN Protein Interaction/Cellular Processes [6]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Gene/Protein Processing [6]
DNA repair nuclease/redox regulator APEX1 (APEX1) OT53OI14 APEX1_HUMAN Protein Interaction/Cellular Processes [6]

References

1 Drug information of Hesperetin, 2008. eduDrugs.
2 In vitro inhibition of diacylglycerol acyltransferase by prenylflavonoids from Sophora flavescens. Planta Med. 2004 Mar;70(3):258-60.
3 Interaction of the breast cancer resistance protein with plant polyphenols. Biochem Biophys Res Commun. 2004 Apr 23;317(1):269-75.
4 In vitro investigation of cytochrome P450-mediated metabolism of dietary flavonoids. Food Chem Toxicol. 2002 May;40(5):609-16.
5 Hesperetin inhibit adipocyte differentiation and enhance Bax- and p21-mediated adipolysis in human mesenchymal stem cell adipogenesis. J Biochem Mol Toxicol. 2015 Mar;29(3):99-108. doi: 10.1002/jbt.21672. Epub 2014 Oct 26.
6 Various concentrations of hesperetin induce different types of programmed cell death in human breast cancerous and normal cell lines in a ROS-dependent manner. Chem Biol Interact. 2023 Sep 1;382:110642. doi: 10.1016/j.cbi.2023.110642. Epub 2023 Jul 23.
7 Hesperetin induced G1-phase cell cycle arrest in human breast cancer MCF-7 cells: involvement of CDK4 and p21. Nutr Cancer. 2007;59(1):115-9. doi: 10.1080/01635580701419030.
8 Role of hesperetin (a natural flavonoid) and its analogue on apoptosis in HT-29 human colon adenocarcinoma cell line--a comparative study. Food Chem Toxicol. 2012 Mar;50(3-4):660-71.
9 Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. Toxicol Lett. 2018 Sep 15;294:27-36.
10 DGAT1 inhibitors as anti-obesity and anti-diabetic agents. Curr Opin Drug Discov Devel. 2010 Jul;13(4):489-96.
11 Clinical pipeline report, company report or official report of AstraZeneca (2011).
12 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033014)
13 Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58.
14 Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer. Int J Oncol. 2007 Mar;30(3):717-25.
15 Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter. Cancer Res. 2003 Sep 1;63(17):5538-43.
16 The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models. Mol Pharmacol. 2007 Jan;71(1):240-9.
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