Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMN7S4L)

Drug Name
OXYRESVERATROL Drug Info
Synonyms
Oxyresveratrol; 29700-22-9; Tetrahydroxystilbene; (E)-4-(3,5-Dihydroxystyryl)benzene-1,3-diol; UNII-6V071CP5CR; trans-oxyresveratrol; 4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,3-diol; OXYLRESVERATROL; 4721-07-7; 4-[2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,3-diol; CHEMBL43065; CHEBI:7870; 6V071CP5CR; 2,3',4,5'-Tetrahydroxystilbene; AK158555; 4-(3,5-Dihydroxystyryl)benzene-1,3-diol; J-501984; 4-[(E)-2-(3,5-dihydroxyphenyl)vinyl]benzene-1,3-diol; 1,3-Benzenediol, 4-[(1E)-2-(3,5-dihydroxyphenyl)ethenyl]-; Puag-haad
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5281717
ChEBI ID
CHEMBL43065
CAS Number
CAS 29700-22-9
TTD Drug ID
DMN7S4L

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Preclinical Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Tyrosinase (TYR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [5]
Monobenzone DMVJS2K Vitiligo ED63.0 Approved [5]
Multi-epitope peptide melanoma vaccine DMZPEHY Melanoma 2C30 Phase 3 [6]
Melanoma vaccine DMQEC6Z Melanoma 2C30 Phase 3 [7]
Polynoma-1 DM3QDA6 Melanoma 2C30 Phase 2 [8]
MKC-1106-MT DMXKOW6 Melanoma 2C30 Phase 2 [9]
Multi-epitope tyrosinase/gp100 vaccine DMN68ZL Melanoma 2C30 Phase 2 [10]
PMID29130358-Compound-Figure11(3) DMSME2B N. A. N. A. Patented [11]
Benzothiazole analog 1 DMHXFCQ Albinism EC23.2 Patented [12]
Monoamine derivative 2 DMAZ6DI Albinism EC23.2 Patented [12]
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Drug(s) Affected By Mucin-2 (MUC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [13]
Quercetin DM3NC4M Obesity 5B81 Approved [14]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [15]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [16]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [17]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [18]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [19]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [20]
Arsenic DMTL2Y1 N. A. N. A. Approved [21]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [22]
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Drug(s) Affected By Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [23]
Quercetin DM3NC4M Obesity 5B81 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [24]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [25]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [26]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [25]
Topotecan DMP6G8T Central nervous system neoplasm Approved [27]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [23]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [28]
Nicotinamide mononucleotide DMW1LKP N. A. N. A. Preclinical [4]
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Drug(s) Affected By Nicotinate-nucleotide pyrophosphorylase (QPRT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [24]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [31]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [32]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [33]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [34]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [35]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [36]
Arsenic DMTL2Y1 N. A. N. A. Approved [37]
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Drug(s) Affected By Nicotinate phosphoribosyltransferase (NAPRT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [24]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [18]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [31]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [38]
Daporinad DMCU74R leukaemia 2A60-2B33 Phase 2 [39]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [40]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [41]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [42]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [43]
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Drug(s) Affected By Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 (NMNAT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [17]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [44]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [31]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [33]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [41]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [45]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [46]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [47]
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Drug(s) Affected By Claudin-1 (CLDN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [48]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [49]
Methotrexate DM2TEOL Anterior urethra cancer Approved [50]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [52]
Panobinostat DM58WKG Chronic graft versus host disease Approved [53]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [54]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [55]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [56]
Leflunomide DMR8ONJ Arthritis FA20 Approved [57]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [58]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [59]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [60]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [61]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [62]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [63]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [64]
Gefitinib DM15F0X Colon adenocarcinoma Approved [65]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [66]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [67]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [68]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [59]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [69]
Paclitaxel DMLB81S Breast carcinoma Approved [70]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [71]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [58]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [72]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [73]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [61]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [62]
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Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [74]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [75]
Gefitinib DM15F0X Colon adenocarcinoma Approved [76]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [77]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [78]
Quercetin DM3NC4M Obesity 5B81 Approved [79]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [80]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [81]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [78]
Ethacrynic acid DM60QMR Edema MG29 Approved [82]
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Drug(s) Affected By Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [83]
Methotrexate DM2TEOL Anterior urethra cancer Approved [84]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [85]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [86]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [87]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [88]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [89]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [90]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [91]
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Drug(s) Affected By Tight junction protein ZO-1 (TJP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [48]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [92]
Methotrexate DM2TEOL Anterior urethra cancer Approved [50]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [93]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [24]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [25]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [31]
Ethanol DMDRQZU Chronic pain MG30 Approved [94]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [95]
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Drug(s) Affected By Acetyl-CoA carboxylase 1 (ACACA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [96]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [97]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [98]
Quercetin DM3NC4M Obesity 5B81 Approved [99]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [85]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [100]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [101]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [102]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [103]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [104]
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Drug(s) Affected By Serine/threonine-protein kinase STK11 (STK11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [96]
Selenium DM25CGV N. A. N. A. Approved [23]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [105]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [18]
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [106]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [107]
Arsenic DMTL2Y1 N. A. N. A. Approved [108]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [109]
APR-246 DMNFADH Ovarian cancer 2C73 Phase 2 [110]
GDC-0980/RG7422 DMF3MV1 Non-hodgkin lymphoma 2B33.5 Phase 2 [111]
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Drug(s) Affected By Mitogen-activated protein kinase 14 (MAPK14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [112]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [113]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [77]
Methotrexate DM2TEOL Anterior urethra cancer Approved [114]
Quercetin DM3NC4M Obesity 5B81 Approved [115]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [116]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [117]
Ethacrynic acid DM60QMR Edema MG29 Approved [82]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [118]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [119]
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Drug(s) Affected By Occludin (OCLN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [120]
Methotrexate DM2TEOL Anterior urethra cancer Approved [121]
Quercetin DM3NC4M Obesity 5B81 Approved [122]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [87]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [123]
Testosterone DM7HUNW Hot flushes GA30 Approved [124]
Thioguanine DM7NKEV Acute lymphocytic leukaemia 2B33.3 Approved [125]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [126]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [44]
Ethanol DMDRQZU Chronic pain MG30 Approved [94]
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Drug(s) Affected By Homeobox protein CDX-2 (CDX2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [127]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [128]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [18]
Chenodiol DMQ8JIK Cholelithiasis DC11 Approved [129]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [130]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [131]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [132]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [41]
SB-431542 DM0YOXQ Pulmonary fibrosis CB03.4 Preclinical [133]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Tyrosinase (TYR) TTULVH8 TYRO_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Acetyl-CoA carboxylase 1 (ACACA) OT5CQPZY ACACA_HUMAN Post-Translational Modifications [2]
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) OTI862QH CPT1A_HUMAN Gene/Protein Processing [2]
Claudin-1 (CLDN1) OT27KV99 CLD1_HUMAN Gene/Protein Processing [3]
Homeobox protein CDX-2 (CDX2) OTCG4TSY CDX2_HUMAN Gene/Protein Processing [3]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Gene/Protein Processing [3]
Mitogen-activated protein kinase 14 (MAPK14) OT5TCO3O MK14_HUMAN Gene/Protein Processing [3]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Gene/Protein Processing [3]
Mitogen-activated protein kinase 8 (MAPK8) OTEREYS5 MK08_HUMAN Gene/Protein Processing [3]
Mucin-2 (MUC2) OT3X4QVX MUC2_HUMAN Gene/Protein Processing [4]
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 (NMNAT1) OTGJH9XH NMNA1_HUMAN Gene/Protein Processing [4]

References

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2 Oxyresveratrol ameliorates nonalcoholic fatty liver disease by regulating hepatic lipogenesis and fatty acid oxidation through liver kinase B1 and AMP-activated protein kinase. Chem Biol Interact. 2018 Jun 1;289:68-74. doi: 10.1016/j.cbi.2018.04.023. Epub 2018 Apr 24.
3 Oxyresveratrol improves tight junction integrity through the PKC and MAPK signaling pathways in Caco-2?cells. Food Chem Toxicol. 2017 Oct;108(Pt A):203-213. doi: 10.1016/j.fct.2017.08.002. Epub 2017 Aug 2.
4 Oxyresveratrol stimulates mucin production in an NAD+-dependent manner in human intestinal goblet cells. Food Chem Toxicol. 2018 Aug;118:880-888.
5 Identification of an Alkylhydroquinone from Rhus succedanea as an Inhibitor of Tyrosinase and Melanogenesis. J Agric Food Chem. 2009 Mar 25;57(6):2200-5.
6 Safety and immunogenicity of vaccination with MART-1 (26-35, 27L), gp100 (209-217, 210M), and tyrosinase (368-376, 370D) in-adjuvant with PF-3512676 and GM-CSF in metastatic melanoma. Correction in: volume 35 on page 650.
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19 Time dependent impact of copper oxide nanomaterials on the expression of genes associated with oxidative stress, metal binding, inflammation and mucus secretion in single and co-culture intestinal in vitro models. Toxicol In Vitro. 2021 Aug;74:105161. doi: 10.1016/j.tiv.2021.105161. Epub 2021 Apr 9.
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21 Inorganic arsenic exposure promotes malignant progression by HDAC6-mediated down-regulation of HTRA1. J Appl Toxicol. 2023 Aug;43(8):1214-1224. doi: 10.1002/jat.4457. Epub 2023 Mar 11.
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42 Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
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