Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMO14SG)

• Drug Name: Mebendazole Drug Info
• Synonyms: Bantenol; Banworm; Besantin; Lomper; MBDZ; Madicure; Mebendan; Mebendazol; Mebendazolum; Mebenoazole; Mebenvet; Mebex; Mebutar; Noverme; Ovitelmin; Pantelmin; Sqworm; Sufil; Surfont; Telmin; Vermicidin; Vermicol; Vermidil; Vermin; Vermirax; Vermox; Verpanyl; Versid; Wormkuur; Abello Farmacia Brand of Mebendazole; Anti Worm; Ardeypharm Brand of Mebendazole; Boots Brand of Mebendazole; Boots Threadworm Treatment; Diba Brand of Mebendazole; Elfar Brand of Mebendazole; Equivurm Plus; Esteve Brand of Mebendazole; Healthypharm Brand of Mebendazole; Janssen Brand of Mebendazole; Leidapharm Brand of Mebendazole; Norgine Brand of Mebendazole; Pfizer Brand of Mebendazole; Pripsen Mebendazole; SSL Brand of Mebendazole; Streger Brand of Mebendazole; Taxandria Brand of Mebendazole; Tedec Meiji Brand of Mebendazole; R 17635; R17635; Anti-Worm; Antiox (TN); Degort's Brand of Mebendazole; Mebendazol [INN-Spanish]; Mebendazole(USAN); Mebendazolum [INN-Latin]; Ovex (TN); Pripsen (TN); R 17,635; R-17635; Vermox (TN); MEBENDAZOLE, 99%; Mebendazole (JAN/USP); Mebendazole (JAN/USP/INN); Mebendazole [USAN:INN:BAN:JAN]; Methyl5-benzoyl benzimidazole-2-carbamate; Methyl 5-benzoyl-2-benzimidazolecarbamate; Methyl 5-benzoyl-2-benzimidazolylcarbamate; N-2 (5-Benzoyl-benzimidazole) carbamate de methyle; N-2 (5-Benzoyl-benzimidazole) carbamate de methyle [French]; Methyl N-(5-benzoyl-2-benzimidazolyl)carbamate; Methyl (5-benzoyl-1H-benzimidazol-2-yl)carbamate; Methyl [5-(phenylcarbonyl)-1H-benzimidazol-2-yl]carbamate; N-(Benzoyl-5, benzimidazolyl)-2, carbamate de methyle; N-(Benzoyl-5, benzimidazolyl)-2, carbamate de methyle [French]; Methyl N-(5-benzoyl-1H-benzimidazol-2-yl)carbamate; Methyl N-(6-benzoyl-1H-benzimidazol-2-yl)carbamate; Carbamic acid, N-(5-benzoylbenzimidazol-2-yl)-, methyl ester; Carbamic acid, (5-benzoyl-1H-benzimidazol-2-yl)-, methyl ester; Methyl N-(6-benzoyl-1H-1,3-benzodiazol-2-yl)carbamate; Carbamic acid, (5-benzoyl-1H-benzimidazol-2-yl)-, methyl ester (9CI); (5-Benzoyl-1H-benzimidazol-2-yl)-carbamic acid methyl ester; (5-Benzoyl-1H-benzimidazol-2-yl)carbamic acid methyl ester; (5-Benzoyl-1H-benzoimidazol-2-yl)-carbamic acid methyl ester; 2-Benzimidazolecarbamic acid, 5-benzoyl-, methyl ester; 2-Benzimidazolecarbamic acid, 5-benzoyl-, methyl ester (8CI); 5-Benzoyl-2-benzimidazolecarbamic acid methyl ester; 5-Benzoyl-2-benzimidazolecarbamic acid, methyl ester

Indication

Disease Entry	ICD 11	Status	REF
Ascariasis	1F62	Approved	[1]
Enterobiasis	1F65	Approved	[1]
Helminth infection	1F90.0	Approved	[1]
Trichuris trichiura infection	1F6G	Approved	[1]
Worm infection	1F90.Z	Approved	[2]

• Therapeutic Class: Antinematodal Agents
• Cross-matching ID:
  PubChem CID: 4030
  ChEBI ID: CHEBI:6704
  CAS Number: CAS 31431-39-7
  TTD Drug ID: DMO14SG
  VARIDT Drug ID: DR00633
  INTEDE Drug ID: DR1005
  ACDINA Drug ID: D00385

Molecule-Related Drug Atlas

Drug(s) Targeting Tubulin beta (TUBB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vincristine	DMINOX3	Acute lymphoblastic leukaemia	2A85	Approved	[12]
Albendazole	DMYZ57N	Echinococcus granulosus infectious disease		Approved	[3]
Vindesine	DMVR628	Acute lymphoblastic leukaemia	2A85	Approved	[13]
Taxol	DMUOT9V	Breast cancer	2C60-2C65	Approved	[14]
Plinabulin	DMD7L48	Non-small-cell lung cancer	2C25.Y	Phase 3	[15]
Batabulin	DMHWE5R	Solid tumour/cancer	2A00-2F9Z	Phase 2/3	[16]
ABT-751	DMNG35S	Solid tumour/cancer	2A00-2F9Z	Phase 2	[17]
DOLASTATIN-10	DMDUV1S	Solid tumour/cancer	2A00-2F9Z	Phase 2	[18]
BNC-105	DMJC8DR	Mesothelioma	2C51.2	Phase 2	[19]
Lexibulin	DMLEX1D	Glioblastoma multiforme	2A00.0	Phase 2	[20]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[21]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[22]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[23]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[24]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[25]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[26]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[27]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[28]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[22]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[29]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[30]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[31]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[32]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[33]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[34]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[35]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[36]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[37]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[38]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[39]

Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[40]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[40]
Etoricoxib	DM6A4NW	Rheumatoid arthritis	FA20	Approved	[40]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[41]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[42]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[43]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[44]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[45]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[46]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[47]

Drug(s) Affected By Proepiregulin (EREG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[48]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[6]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[6]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[6]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[50]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[6]

Drug(s) Affected By L-lactate dehydrogenase A chain (LDHA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[54]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[47]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[55]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[59]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[62]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[63]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[64]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[65]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[64]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[66]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[68]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[69]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[70]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[65]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[66]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[72]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Selenium	DM25CGV	N. A.	N. A.	Approved	[74]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[75]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[76]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[77]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[79]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[80]
Fructose	DM43AN2	Vomiting	MD90	Approved	[47]
Ketoprofen	DMRKXPT	Bursitis		Approved	[47]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[81]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[82]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[83]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[84]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[85]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[86]

Drug(s) Affected By Interleukin-1 alpha (IL1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[87]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[6]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[6]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[86]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[6]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[88]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[6]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[90]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[91]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[92]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[6]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[93]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[6]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[94]
Selenium	DM25CGV	N. A.	N. A.	Approved	[95]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[96]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[97]

Drug(s) Affected By Antileukoproteinase (SLPI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[6]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[6]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[6]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[6]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[6]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[6]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[6]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[6]

Drug(s) Affected By Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Selenium	DM25CGV	N. A.	N. A.	Approved	[98]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[99]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[102]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[104]

Drug(s) Affected By Protein S100-A8 (S100A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[105]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[106]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[105]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[108]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[59]
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[105]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[105]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[109]

Drug(s) Affected By Protein S100-A9 (S100A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[105]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[106]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[73]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[110]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[59]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[112]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[113]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[114]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[115]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[116]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[117]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[118]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[119]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[120]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[121]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[119]

Drug(s) Affected By Hepatocyte growth factor receptor (MET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cabozantinib	DMIYDT4	Medullary thyroid gland carcinoma		Approved	[122]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[123]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[6]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[6]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[6]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[6]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[125]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[124]

Drug(s) Affected By Interleukin-6 receptor subunit alpha (IL6R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[126]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[112]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[128]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[129]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[9]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[130]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[131]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[132]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[133]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[134]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[135]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[136]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[91]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[6]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[93]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[137]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[6]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[138]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[139]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[141]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[47]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[87]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[142]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[143]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[82]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[144]

Drug(s) Affected By Microtubule-associated protein tau (MAPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[146]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[147]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[148]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[149]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[150]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[112]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[128]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[152]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[153]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[154]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[104]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[155]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[156]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[157]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[158]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[159]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[160]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[86]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[161]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[162]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[163]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[165]

Drug(s) Affected By Hexokinase-1 (HK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[166]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[167]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[168]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[170]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[172]

Drug(s) Affected By Bone morphogenetic protein 6 (BMP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[6]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[6]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[6]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[6]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[6]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[6]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[174]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[6]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[109]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[175]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[176]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[177]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[82]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[178]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[179]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[180]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[181]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[182]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[183]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[184]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[176]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[185]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[186]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[187]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[175]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[47]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[90]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[82]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[178]

Drug(s) Affected By Multidrug resistance-associated protein 1 (ABCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[188]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[189]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[190]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[191]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[192]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[193]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[194]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[195]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[196]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[196]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[197]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[198]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[199]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[200]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[201]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[202]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[203]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[159]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[6]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[204]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[205]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[206]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[207]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[208]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[209]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[210]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[212]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[213]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[214]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[215]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[216]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[84]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[147]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[217]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[88]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[218]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[219]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[217]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[220]

Drug(s) Affected By Mitogen-activated protein kinase 9 (MAPK9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[216]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[217]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[221]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[222]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[217]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[223]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[224]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[112]

Drug(s) Affected By Neurogenic locus notch homolog protein 1 (NOTCH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[225]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[226]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[228]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[229]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[168]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[230]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[231]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[232]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[233]

Drug(s) Affected By Caspase-7 (CASP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[234]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[65]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[235]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[236]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[237]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[237]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[50]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[99]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[238]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[239]

Drug(s) Affected By Transforming protein RhoA (RHOA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[240]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[50]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[241]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[242]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[243]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[244]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[245]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[246]

Drug(s) Affected By Ras-related C3 botulinum toxin substrate 1 (RAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[247]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[248]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[250]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[248]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[251]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[252]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[253]

Drug(s) Affected By Focal adhesion kinase 1 (PTK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[179]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[254]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[106]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[242]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[255]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[256]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[257]
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[258]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[259]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[260]

Drug(s) Affected By Interleukin-24 (IL24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[87]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[6]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[91]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[6]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[6]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[261]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[6]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[107]

Drug(s) Affected By Transcription factor HES-1 (HES1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[262]
Selenium	DM25CGV	N. A.	N. A.	Approved	[98]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[229]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[263]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[259]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[168]

Drug(s) Affected By Advanced glycosylation end product-specific receptor (AGER)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[264]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[229]
TRIENTINE	DMD2WPG	Inborn error of metabolism	5C50-5C59	Approved	[265]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[105]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[266]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[266]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[105]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[267]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[268]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[266]

Drug(s) Affected By PTB-containing, cubilin and LRP1-interacting protein (PID1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[6]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[6]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[6]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[6]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[6]
Amikacin	DM5PDRB	Bacteremia	1A73	Approved	[6]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[6]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[6]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[6]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[112]

Drug(s) Affected By Rho guanine nucleotide exchange factor 2 (ARHGEF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[241]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[269]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[270]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[112]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[260]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[103]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[271]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[272]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[267]

Drug(s) Affected By Multidrug and toxin extrusion protein 1 (SLC47A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pyrimethamine	DM5X7VY	Malaria	1F40-1F45	Approved	[273]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[274]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[275]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[274]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[276]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[112]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[277]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[278]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[274]

Drug(s) Affected By NACHT, LRR and PYD domains-containing protein 3 (NLRP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[90]
Selenium	DM25CGV	N. A.	N. A.	Approved	[95]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[279]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[280]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[229]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[281]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[282]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[283]
Atropine	DMEN6X7	Organophosphate poisoning	NE6Z	Approved	[105]

Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[284]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[6]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[285]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[6]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[6]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[124]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[286]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[287]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[6]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tubulin beta (TUBB)	TTYFKSZ	NOUNIPROTAC	Binder	[3]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4) Main DME	DE4LYSA	CP3A4_HUMAN	Substrate	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Advanced glycosylation end product-specific receptor (AGER)	OTPY0IH7	RAGE_HUMAN	Gene/Protein Processing	[5]
Antileukoproteinase (SLPI)	OTUNFUU8	SLPI_HUMAN	Gene/Protein Processing	[6]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Post-Translational Modifications	[7]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Gene/Protein Processing	[8]
Bone morphogenetic protein 6 (BMP6)	OT9WN536	BMP6_HUMAN	Gene/Protein Processing	[6]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Gene/Protein Processing	[9]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Gene/Protein Processing	[10]
Caspase-7 (CASP7)	OTAPJ040	CASP7_HUMAN	Gene/Protein Processing	[10]
Cystine/glutamate transporter (SLC7A11)	OTKJ6PXW	XCT_HUMAN	Gene/Protein Processing	[6]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Gene/Protein Processing	[11]

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