General Information of Drug (ID: DMPA5WD)

Drug Name
Harmine Drug Info
Synonyms
Harmine; 442-51-3; 7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole; Banisterine; Leucoharmine; Telepathine; Yageine; Yajeine; 7-Methoxy-1-methyl-9H-beta-carboline; 9H-Pyrido[3,4-b]indole, 7-methoxy-1-methyl-; Telepathin; Banisterin; Yagein; Harmin; 1-Methyl-7-methoxy-beta-carboline; UNII-4FHH5G48T7; 7-Methoxy-1-methyl-9H-pyrido(3,4-b)indole; Harmin hydrochloride; Harmine, 98%; Banisterine monohydrate; EINECS 207-131-4; 9H-Pyrido(3,4-b)indole, 7-methoxy-1-methyl-; BRN 0178813; 4FHH5G48T7; C13H12N2O; CHEBI:28121; 7-METHOXY-1-METHYL-9H-BETA-CARBOLINE
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5280953
ChEBI ID
CHEBI:28121
CAS Number
CAS 442-51-3
TTD Drug ID
DMPA5WD

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Patented Agent(s)
Investigative Drug(s)
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID28766366-Compound-Scheme21Left DMWTRUK N. A. N. A. Patented [2]
PMID28766366-Compound-Scheme21Right DMF3X40 N. A. N. A. Patented [2]
PMID28766366-Compound-Scheme14BINDY DMBQ0RN N. A. N. A. Patented [2]
PMID28766366-Compound-Scheme16DMAT DMQ5UEA N. A. N. A. Patented [2]
leucettine L41 DMBYND6 Discovery agent N.A. Investigative [6]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Moclobemide DMNZWL7 Depression 6A70-6A7Z Approved [7]
Tranylcypromine DMGB5RE Major depressive disorder 6A70.3 Approved [8]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [9]
Isocarboxazid DMAF1NB Depression 6A70-6A7Z Approved [10]
TRYPTAMINE DMAFPHB N. A. N. A. Phase 3 [11]
Psoralen DMIZJ8M N. A. N. A. Phase 3 [12]
CHF-3381 DMQ2O8V Neuropathic pain 8E43.0 Phase 2 [13]
Ladostigil DMJSY3Q Alzheimer disease 8A20 Phase 2 [14]
CX157 DMS2WB5 Mood disorder 6A60-6E23 Phase 2 [15]
PIPERINE DMYEAB1 Vitiligo ED63.0 Phase 1/2 [16]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID28766366-Compound-Scheme21Left DMWTRUK N. A. N. A. Patented [2]
PMID28766366-Compound-Scheme21Right DMF3X40 N. A. N. A. Patented [2]
PMID28766366-Compound-Scheme14BINDY DMBQ0RN N. A. N. A. Patented [2]
TG003 DMP4HR2 Discovery agent N.A. Patented [2]
PMID28766366-Compound-Scheme2WO2012/098065bottom DMO4Q95 N. A. N. A. Patented [2]
PMID28766366-Compound-Scheme16DMAT DMQ5UEA N. A. N. A. Patented [2]
PMID28766366-Compound-Scheme7WO2012/098070upper DMGAQR5 N. A. N. A. Patented [2]
PMID28766366-Compound-Scheme9EHT1610 DMMZGC8 N. A. N. A. Patented [2]
PMID28766366-Compound-Scheme9EHT5372 DM0O18N N. A. N. A. Patented [2]
PMID28766366-Compound-Scheme25-2 DM7OGWH N. A. N. A. Patented [2]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID28766366-Compound-Scheme21Left DMWTRUK N. A. N. A. Patented [2]
PMID28766366-Compound-Scheme21Right DMF3X40 N. A. N. A. Patented [2]
PMID24900749C1a DMZPUSO Discovery agent N.A. Investigative [17]
Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [18]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [19]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [20]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [21]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [22]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [23]
Ethacrynic acid DM60QMR Edema MG29 Approved [24]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [25]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [26]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [27]
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Drug(s) Affected By Amine oxidase A (MAOA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [28]
Quercetin DM3NC4M Obesity 5B81 Approved [29]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [30]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [31]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [32]
Selegiline DM6034S Major depressive disorder 6A70.3 Approved [33]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [34]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [35]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [36]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [37]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [38]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [31]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [39]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [40]
Testosterone DM7HUNW Hot flushes GA30 Approved [41]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [41]
Leflunomide DMR8ONJ Arthritis FA20 Approved [42]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [35]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [43]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [44]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
Menthol DMG2KW7 Back pain ME84.Z Approved [47]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [48]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [49]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [50]
Hydroxychloroquine DMSIVND Chronic renal failure GB61.Z Approved [51]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [52]
Arsenic DMTL2Y1 N. A. N. A. Approved [53]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [54]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [55]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [56]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [57]
Methotrexate DM2TEOL Anterior urethra cancer Approved [58]
Quercetin DM3NC4M Obesity 5B81 Approved [59]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [60]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [61]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [62]
Testosterone DM7HUNW Hot flushes GA30 Approved [41]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [63]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [64]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [65]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [66]
Gefitinib DM15F0X Colon adenocarcinoma Approved [67]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [34]
Selenium DM25CGV N. A. N. A. Approved [68]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [69]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [70]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [71]
Methotrexate DM2TEOL Anterior urethra cancer Approved [72]
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Drug(s) Affected By Insulin (INS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [73]
Methotrexate DM2TEOL Anterior urethra cancer Approved [72]
Epinephrine DM3KJBC Acute asthma CA23 Approved [74]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [75]
Fructose DM43AN2 Vomiting MD90 Approved [76]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [77]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [78]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [79]
Propranolol DM79NTF Angina pectoris BA40 Approved [80]
Testosterone DM7HUNW Hot flushes GA30 Approved [81]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [55]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [82]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [56]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [83]
Selenium DM25CGV N. A. N. A. Approved [68]
Etretinate DM2CZFA Keratosis ED56 Approved [84]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [85]
Methotrexate DM2TEOL Anterior urethra cancer Approved [28]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [86]
Quercetin DM3NC4M Obesity 5B81 Approved [59]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [55]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [87]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [57]
Methotrexate DM2TEOL Anterior urethra cancer Approved [88]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [89]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [30]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [90]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [91]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [92]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [93]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [55]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [87]
Methotrexate DM2TEOL Anterior urethra cancer Approved [28]
Quercetin DM3NC4M Obesity 5B81 Approved [29]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [30]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [90]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [94]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [95]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [96]
Testosterone DM7HUNW Hot flushes GA30 Approved [41]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [55]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [97]
Prednisone DM2HG4X Acute asthma CA23 Approved [98]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [89]
Quercetin DM3NC4M Obesity 5B81 Approved [99]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [100]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [101]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [102]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [103]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [104]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [55]
Gefitinib DM15F0X Colon adenocarcinoma Approved [67]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [87]
Prednisone DM2HG4X Acute asthma CA23 Approved [98]
Quercetin DM3NC4M Obesity 5B81 Approved [29]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [105]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [106]
Testosterone DM7HUNW Hot flushes GA30 Approved [41]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [41]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [29]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [83]
Selenium DM25CGV N. A. N. A. Approved [107]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [86]
Quercetin DM3NC4M Obesity 5B81 Approved [59]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [108]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [108]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [109]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [110]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [37]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [111]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amiloride DMRTSGP Congestive heart failure BD10 Approved [112]
Arsenic DMTL2Y1 N. A. N. A. Approved [113]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [114]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [115]
D-glucose DMMG2TO Discovery agent N.A. Investigative [116]
Hexadecanoic acid DMWUXDZ Discovery agent N.A. Investigative [117]
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Drug(s) Affected By Cyclin-A1 (CCNA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [34]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [118]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [34]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [109]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [119]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [118]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [120]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [37]
Folic Acid DMEMBJC Colorectal carcinoma Approved [121]
Atropine DMEN6X7 Organophosphate poisoning NE6Z Approved [122]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [123]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [124]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [125]
Gefitinib DM15F0X Colon adenocarcinoma Approved [126]
Selenium DM25CGV N. A. N. A. Approved [107]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [57]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [127]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [86]
Quercetin DM3NC4M Obesity 5B81 Approved [29]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [30]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [56]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [128]
Methotrexate DM2TEOL Anterior urethra cancer Approved [38]
Quercetin DM3NC4M Obesity 5B81 Approved [29]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [30]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [90]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [40]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [129]
Testosterone DM7HUNW Hot flushes GA30 Approved [41]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [130]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [72]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [131]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [132]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [133]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [37]
Ethanol DMDRQZU Chronic pain MG30 Approved [134]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [48]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [50]
Arsenic DMTL2Y1 N. A. N. A. Approved [133]
Diphenylpyraline DMW4X37 Allergic rhinitis CA08.0 Approved [135]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [136]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [90]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [109]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [37]
Menthol DMG2KW7 Back pain ME84.Z Approved [47]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [50]
Hydroxychloroquine DMSIVND Chronic renal failure GB61.Z Approved [51]
Arsenic DMTL2Y1 N. A. N. A. Approved [138]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [139]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [124]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [83]
Quercetin DM3NC4M Obesity 5B81 Approved [59]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [30]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [31]
Panobinostat DM58WKG Chronic graft versus host disease Approved [140]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [141]
Testosterone DM7HUNW Hot flushes GA30 Approved [41]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [41]
Leflunomide DMR8ONJ Arthritis FA20 Approved [42]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [142]
Panobinostat DM58WKG Chronic graft versus host disease Approved [140]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [142]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [37]
Ethanol DMDRQZU Chronic pain MG30 Approved [143]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [144]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [145]
Phenylephrine DMZHUO5 Allergic rhinitis CA08.0 Approved [146]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [140]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [147]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [37]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [50]
Urethane DM7NSI0 N. A. N. A. Phase 4 [148]
OTX-015 DMI8RG1 Acute myeloid leukaemia 2A60 Phase 1/2 [149]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [147]
Mivebresib DMCPF90 Acute myeloid leukaemia 2A60 Phase 1 [149]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [150]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [151]
Tributylstannanyl DMHN7CB Discovery agent N.A. Investigative [152]
⏷ Show the Full List of 9 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [55]
Quercetin DM3NC4M Obesity 5B81 Approved [29]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [153]
Testosterone DM7HUNW Hot flushes GA30 Approved [41]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [41]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [29]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [154]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [155]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [156]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [157]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) TTSBVFO DYR1A_HUMAN Inhibitor [2]
Dual-specificity tyrosine-phosphorylation regulated kinase 2 (DYRK2) TT84OS6 DYRK2_HUMAN Inhibitor [2]
Dual-specificity tyrosine-phosphorylation regulated kinase 3 (DYRK3) TTV4EX0 DYRK3_HUMAN Inhibitor [2]
Monoamine oxidase type A (MAO-A) TT3WG5C AOFA_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Amine oxidase A (MAOA) OT8NIWMQ AOFA_HUMAN Gene/Protein Processing [3]
Cyclin-A1 (CCNA1) OTX4HD45 CCNA1_HUMAN Gene/Protein Processing [4]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Gene/Protein Processing [4]
Cyclin-dependent kinase 4 inhibitor B (CDKN2B) OTAG24N1 CDN2B_HUMAN Gene/Protein Processing [4]
Cyclin-dependent kinase inhibitor 1C (CDKN1C) OTASTJ3Q CDN1C_HUMAN Gene/Protein Processing [4]
Cyclin-dependent kinase inhibitor 2A (CDKN2A) OTN0ZWAE CDN2A_HUMAN Gene/Protein Processing [4]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Gene/Protein Processing [5]
Forkhead box protein M1 (FOXM1) OT5887KR FOXM1_HUMAN Gene/Protein Processing [4]
G1/S-specific cyclin-E2 (CCNE2) OTBBUKQQ CCNE2_HUMAN Gene/Protein Processing [4]
Insulin (INS) OTZ85PDU INS_HUMAN Gene/Protein Processing [4]

References

1 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
2 Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199.
3 In vitro monoamine oxidase inhibition potential of alpha-methyltryptamine analog new psychoactive substances for assessing possible toxic risks. Toxicol Lett. 2017 Apr 15;272:84-93.
4 A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication. Nat Med. 2015 Apr;21(4):383-8. doi: 10.1038/nm.3820. Epub 2015 Mar 9.
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