Details of Disease

General Information of Disease (ID: DISC2UN8)

Disease Name	Adrenal adenoma
Synonyms	adrenal incidentaloma; cortical cell adenoma; benign adrenal gland adenoma; benign adrenal adenoma; benign adenoma of the adrenal gland; benign adenoma of adrenal gland; adrenocortical adenoma; adrenal gland adenoma; adrenal cortical adenoma; adrenal cortex adenoma; adrenal adenoma; adenoma, adrenocortical, benign; adenoma of the adrenal gland; adenoma of the adrenal cortex; adenoma of adrenal gland; adenoma of adrenal cortex
Disease Class	2F37: Endocrine gland neoplasm
Definition	A benign neoplasm that can arise from any of the adrenal cortical layers. It can be associated with the overproduction of glucocorticoids (Cushing's syndrome), androgenic or estrogenic steroids (adrenogenital syndrome), or mineralocorticoids (Conn's syndrome). (Sternberg Diagnostic Surgical Pathology, 3rd ed.)
Disease Hierarchy	DIS78ZEV: Adenoma DISEG3D2: Benign neoplasm of adrenal gland DISO17X1: Adrenal cortex neoplasm DISYCU8Q: Benign epithelial neoplasm DISC2UN8: Adrenal adenoma
ICD Code	ICD-11 ICD-11: 2F37.Y Expand ICD-11 '2F37.Y
Disease Identifiers	MONDO ID MONDO_0003924 MESH ID D018246 UMLS CUI C0206667 MedGen ID 61654 HPO ID HP:0008256 Orphanet ID 99888 SNOMED CT ID 1156661006

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Generalized glucocorticoid	DMWRUA3	Investigative	NA	[1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 17 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
COASY	TT4YO0Z	Limited	Biomarker	[2]
CYP11B1	TTIQUX7	Limited	Posttranslational Modification	[3]
GPR182	TTT23CG	Limited	Biomarker	[4]
PDE2A	TTJGW1Z	Limited	Altered Expression	[5]
PROKR2	TTM67AX	Limited	Altered Expression	[6]
USP8	TT1J07C	Limited	Genetic Variation	[7]
CDKN1A	TT9GUW0	Strong	Genetic Variation	[8]
CDKN1B	TTLGFVW	Strong	Biomarker	[9]
CYP11A1	TTSYVO6	Strong	Altered Expression	[10]
CYP11B2	TT9MNE2	Strong	Altered Expression	[11]
DHCR24	TTTK0NH	Strong	Altered Expression	[12]
GIP	TT40HS5	Strong	Biomarker	[13]
GIPR	TTYMKBE	Strong	Altered Expression	[14]
KCNJ5	TTEO25X	Strong	Genetic Variation	[15]
MC2R	TTPWFDX	Strong	Altered Expression	[10]
PDE11A	TTTWC79	Strong	Genetic Variation	[9]
ATP1A1	TTWK8D0	Definitive	Genetic Variation	[3]
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⏷ Show the Full List of 17 DTT(s)

This Disease Is Related to 5 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
CYP4B1	DEMF740	Limited	Altered Expression	[16]
HSD3B2	DEN0GVQ	Limited	Altered Expression	[10]
CYB5A	DE9A2LB	Strong	Altered Expression	[17]
CYP4F3	DEFCMPI	Strong	Altered Expression	[18]
SULT2A1	DE0P6LK	Strong	Biomarker	[19]
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This Disease Is Related to 18 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ABLIM1	OTHXEK3E	Limited	Biomarker	[20]
ACADVL	OT50L4XB	Limited	Genetic Variation	[21]
ALOX15B	OTWQQ08W	Limited	Genetic Variation	[21]
ATP2B3	OT9DIEOP	Limited	Genetic Variation	[22]
DCUN1D1	OT8UJLZU	Limited	Altered Expression	[23]
ENC1	OTJEUB6U	Limited	Altered Expression	[5]
GEMIN2	OT4L6TLL	Limited	Altered Expression	[24]
MCM3	OTOOHQPM	Limited	Biomarker	[25]
PHYHIP	OTPC9JBM	Limited	Altered Expression	[5]
PMPCA	OT5X1G9Q	Limited	Altered Expression	[26]
PRKAR1B	OT777OHS	Limited	Genetic Variation	[27]
PROK1	OT8S7RUG	Limited	Altered Expression	[6]
AIP	OTDJ3OSV	Strong	Genetic Variation	[9]
BMS1	OTEGQ8ZO	Strong	Biomarker	[28]
MEN1	OTN6U6V0	Strong	Biomarker	[9]
PDE8B	OT4217NK	Strong	Genetic Variation	[9]
PRKACB	OT6RMDCE	Strong	Biomarker	[29]
SDHC	OTC8G2MX	Strong	Biomarker	[9]
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⏷ Show the Full List of 18 DOT(s)

References

1	The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
2	Steroidogenic Acute Regulatory Protein Overexpression Correlates with Protein Kinase A Activation in Adrenocortical Adenoma.PLoS One. 2016 Sep 8;11(9):e0162606. doi: 10.1371/journal.pone.0162606. eCollection 2016.
3	Hypomethylation of CYP11B2 in Aldosterone-Producing Adenoma.Hypertension. 2016 Dec;68(6):1432-1437. doi: 10.1161/HYPERTENSIONAHA.116.08313. Epub 2016 Oct 17.
4	Expression and function of adrenomedullin and its receptors in Conn's adenoma cells.Int J Mol Med. 2001 Dec;8(6):675-9. doi: 10.3892/ijmm.8.6.675.
5	Characterization of differential gene expression in adrenocortical tumors harboring beta-catenin (CTNNB1) mutations.J Clin Endocrinol Metab. 2011 Jul;96(7):E1206-11. doi: 10.1210/jc.2010-2143. Epub 2011 May 11.
6	Role of Endocrine Gland-Derived Vascular Endothelial Growth Factor (EG-VEGF) and Its Receptors in Adrenocortical Tumors.Horm Cancer. 2015 Dec;6(5-6):225-36. doi: 10.1007/s12672-015-0236-z.
7	Landscape of somatic mutations in sporadic GH-secreting pituitary adenomas.Eur J Endocrinol. 2016 Mar;174(3):363-72. doi: 10.1530/EJE-15-1064. Epub 2015 Dec 23.
8	A somatic mutation of the p21(Waf1/Cip1) gene in a human adrenocortical adenoma.Anticancer Res. 1997 Jan-Feb;17(1B):633-6.
9	Multiple endocrine neoplasias: advances and challenges for the future.J Intern Med. 2009 Jul;266(1):1-4. doi: 10.1111/j.1365-2796.2009.02108.x.
10	Analysis of mRNA expression for steroidogenic enzymes in the remaining adrenal cortices attached to adrenocortical adenomas.Eur J Endocrinol. 2008 Jun;158(6):867-78. doi: 10.1530/EJE-07-0626.
11	Targeting CXCR4 (CXC Chemokine Receptor Type 4) for Molecular Imaging of Aldosterone-Producing Adenoma.Hypertension. 2018 Feb;71(2):317-325. doi: 10.1161/HYPERTENSIONAHA.117.09975. Epub 2017 Dec 26.
12	Seladin-1/DHCR24 expression in normal ovary, ovarian epithelial and granulosa tumours.Clin Endocrinol (Oxf). 2005 Jul;63(1):111-5. doi: 10.1111/j.1365-2265.2005.02308.x.
13	Adrenal GIPR expression and chromosome 19q13 microduplications in GIP-dependent Cushing's syndrome.JCI Insight. 2017 Sep 21;2(18):e92184. doi: 10.1172/jci.insight.92184. eCollection 2017 Sep 21.
14	The ectopic expression of the gastric inhibitory polypeptide receptor is frequent in adrenocorticotropin-independent bilateral macronodular adrenal hyperplasia, but rare in unilateral tumors.J Clin Endocrinol Metab. 2002 May;87(5):1980-5. doi: 10.1210/jcem.87.5.8458.
15	18-Oxocortisol Synthesis in Aldosterone-Producing Adrenocortical Adenoma and Significance of KCNJ5 Mutation Status.Hypertension. 2019 Jun;73(6):1283-1290. doi: 10.1161/HYPERTENSIONAHA.118.12064.
16	Suppression of cytochrome P450 4B1: An early event in adrenocortical tumorigenesis.Surgery. 2017 Jan;161(1):257-263. doi: 10.1016/j.surg.2016.04.056. Epub 2016 Nov 16.
17	High expression of cytochrome b5 in adrenocortical adenomas from patients with Cushing's syndrome associated with high secretion of adrenal androgens.J Clin Endocrinol Metab. 1993 May;76(5):1286-90. doi: 10.1210/jcem.76.5.8496319.
18	Expression of cytochrome P-450 mRNAs in steroidogenesis of adrenocortical adenomas from patients with primary aldosteronism.Mol Cell Endocrinol. 1991 Apr;76(1-3):7-12. doi: 10.1016/0303-7207(91)90254-p.
19	Plasma steroid metabolome profiling for the diagnosis of adrenocortical carcinoma.Eur J Endocrinol. 2019 Feb 1;180(2):117-125. doi: 10.1530/EJE-18-0782.
20	Microarray gene expression and immunohistochemistry analyses of adrenocortical tumors identify IGF2 and Ki-67 as useful in differentiating carcinomas from adenomas.Endocr Relat Cancer. 2009 Jun;16(2):573-83. doi: 10.1677/ERC-08-0237. Epub 2009 Feb 13.
21	Loss of heterozygosity of 17p13, with possible involvement of ACADVL and ALOX15B, in the pathogenesis of adrenocortical tumors.Ann Surg. 2008 Jan;247(1):157-64. doi: 10.1097/SLA.0b013e318153ff55.
22	Molecular Heterogeneity in Aldosterone-Producing Adenomas.J Clin Endocrinol Metab. 2016 Mar;101(3):999-1007. doi: 10.1210/jc.2015-3239. Epub 2016 Jan 14.
23	Squamous cell carcinoma-related oncogene is highly expressed in developing, normal, and adenomatous adrenal tissue but not in aggressive adrenocortical carcinomas.Surgery. 2004 Dec;136(6):1122-8. doi: 10.1016/j.surg.2004.06.041.
24	Is there a role for epithelial-mesenchymal transition in adrenocortical tumors?.Endocrine. 2017 Nov;58(2):276-288. doi: 10.1007/s12020-017-1409-z. Epub 2017 Sep 8.
25	Minichromosome Maintenance Proteins MCM-3, MCM-5, MCM-7, and Ki-67 as Proliferative Markers in Adrenocortical Tumors.Anticancer Res. 2019 Mar;39(3):1151-1159. doi: 10.21873/anticanres.13224.
26	Ribonucleic acid expression of the CLA-1 gene, a human homolog to mouse high density lipoprotein receptor SR-BI, in human adrenal tumors and cultured adrenal cells.J Clin Endocrinol Metab. 1997 Aug;82(8):2522-7. doi: 10.1210/jcem.82.8.4123.
27	cAMP pathway alterations from the cell surface to the nucleus in adrenocortical tumors.Endocr Res. 2002 Nov;28(4):765-75. doi: 10.1081/erc-120017071.
28	PURE ANDROGEN-PRODUCING ADRENAL TUMOR: CLINICAL FEATURES AND PATHOGENESIS.Endocr Pract. 2017 Apr 2;23(4):399-407. doi: 10.4158/EP161580.OR. Epub 2017 Jan 17.
29	Activating PRKACB somatic mutation in cortisol-producing adenomas. JCI Insight. 2018 Apr 19;3(8):e98296. doi: 10.1172/jci.insight.98296. eCollection 2018 Apr 19.