General Information of Disease (ID: DIS78ZEV)

Disease Name Adenoma
Synonyms acinar cell adenoma; adenoma, benign; acinar cell adenoma (morphologic abnormality); acinic cell adenoma; adenomas; adenoma
Definition
A neoplasm arising from the epithelium. It may be encapsulated or non-encapsulated but non-invasive. The neoplastic epithelial cells may or may not display cellular atypia or dysplasia. In the gastrointestinal tract, when dysplasia becomes severe it is sometimes called carcinoma in situ. Representative examples are pituitary gland adenoma, follicular adenoma of the thyroid gland, and adenomas (or adenomatous polyps) of the gastrointestinal tract.|Editor note: check status re benign
Disease Hierarchy
DIS0T594: Epithelial neoplasm
DIS78ZEV: Adenoma
Disease Identifiers
MONDO ID
MONDO_0004972
MESH ID
D000236
UMLS CUI
C0001430
MedGen ID
125
SNOMED CT ID
1187227004

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 221 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ABCG2 TTIMJ02 Limited Biomarker [1]
ADORA2B TTNE7KG Limited Biomarker [2]
ATP1A1 TTWK8D0 Limited Genetic Variation [3]
CLDN6 TTKSV48 Limited Altered Expression [4]
CYP2A6 TTAQ6ZW Limited Altered Expression [5]
F9 TTFEZ5Q Limited Biomarker [6]
GCLM TTNFESW Limited Altered Expression [7]
GJA1 TT4F7SL Limited Biomarker [8]
GJB1 TTSJIRP Limited Biomarker [8]
HSD11B2 TT9H85R Limited Biomarker [9]
JAG2 TTOJY1B Limited Altered Expression [10]
NME1 TTDY8JH Limited Biomarker [11]
STOML2 TTOI329 Limited Altered Expression [12]
CR1 TTEA8OW moderate Altered Expression [13]
GSTA1 TT4P8DE moderate Altered Expression [14]
IMP3 TTEJA2R moderate Altered Expression [15]
LAMP1 TTC214J moderate Biomarker [16]
PIM3 TTCGOIN moderate Biomarker [17]
TDGF1 TTN7HMG moderate Altered Expression [13]
UBE2E2 TTXJEOF moderate Biomarker [18]
AGR2 TT9K86S Strong Biomarker [19]
AKR1B1 TTFBNVI Strong Biomarker [20]
ALAS1 TTG1FXO Strong Biomarker [21]
ALCAM TT2AFT6 Strong Biomarker [22]
ALOX12 TT12ABZ Strong Biomarker [23]
ALOX15 TTN9T81 Strong Altered Expression [24]
ALOX5 TTSJ6Q4 Strong Altered Expression [25]
ALOX5AP TTDMBF5 Strong Genetic Variation [26]
AMACR TTLN1AP Strong Altered Expression [27]
ANXA10 TT0NL6U Strong Biomarker [28]
APEX1 TTHGL48 Strong Altered Expression [29]
BACE2 TT69DB8 Strong Biomarker [30]
BACH1 TT2ME4S Strong Altered Expression [31]
BAGE TTS5GLJ Strong Altered Expression [32]
BAK1 TTFM7V0 Strong Biomarker [33]
BCL2L1 TTRE6AX Strong Altered Expression [34]
BDKRB1 TTG5QIA Strong Altered Expression [35]
BUB1 TT78309 Strong Altered Expression [36]
CA1 TTHQPL7 Strong Biomarker [37]
CACNA1D TT7RGTM Strong Genetic Variation [38]
CACNA1G TT729IR Strong Biomarker [39]
CACNA1H TTZPWGN Strong Genetic Variation [40]
CASP10 TTX5HEK Strong Altered Expression [41]
CBX7 TTBN3HC Strong Altered Expression [42]
CCKBR TTVFO0U Strong Altered Expression [43]
CD24 TTCTYNP Strong Altered Expression [44]
CDC25A TTLZS4Q Strong Biomarker [45]
CDH3 TTARMD9 Strong Altered Expression [46]
CDKN2C TTBRUGA Strong Genetic Variation [47]
CEACAM6 TTIGH2W Strong Altered Expression [48]
CGB3 TTUH273 Strong Altered Expression [49]
CHRM3 TTQ13Z5 Strong Biomarker [50]
CHUK TT1F8OQ Strong Biomarker [51]
CNTF TTGEM5Q Strong Altered Expression [52]
CPA1 TT3LJ6G Strong Genetic Variation [53]
CRHR1 TT7EFHR Strong Altered Expression [54]
CRHR2 TTIY658 Strong Altered Expression [54]
CSE1L TTTRULD Strong Biomarker [55]
CSNK1D TTH30UI Strong Genetic Variation [56]
CSNK1E TTA8PLI Strong Biomarker [57]
CTSE TTLXC4Q Strong Altered Expression [58]
CYP11A1 TTSYVO6 Strong Altered Expression [59]
CYP17A1 TTRA5BZ Strong Biomarker [60]
CYP1B1 TTI84H7 Strong Genetic Variation [61]
CYP21A2 TTP4GLG Strong Altered Expression [62]
CYP26A1 TTD7Q0R Strong Altered Expression [63]
CYP2C9 TTR40YJ Strong Genetic Variation [64]
DKK2 TTST5KX Strong Posttranslational Modification [65]
DKK3 TTY2ZV6 Strong Posttranslational Modification [66]
DLK1 TTF4AVB Strong Altered Expression [67]
ELAVL1 TTPC9D0 Strong Altered Expression [68]
EPHB3 TT5LM7U Strong Altered Expression [69]
EPHB6 TTZEMUY Strong Altered Expression [70]
EREG TTYSB89 Strong Altered Expression [71]
ETS1 TTTGPSD Strong Altered Expression [72]
FABP3 TT3TGLR Strong Altered Expression [73]
FAP TTGPQ0F Strong Biomarker [74]
FBXO11 TT6G10V Strong Biomarker [75]
FDXR TT3W4IX Strong Biomarker [20]
FFAR2 TT0FYAN Strong Altered Expression [76]
FGF19 TTGCH11 Strong Altered Expression [77]
FOLR1 TTVC37M Strong Biomarker [78]
FST TTDNM9W Strong Altered Expression [79]
FYN TT2B9KF Strong Biomarker [80]
G6PC TTBQMJ8 Strong Genetic Variation [81]
GAPDH TTUGSWA Strong Biomarker [21]
GAST TT4LRVO Strong Biomarker [82]
GHRHR TTG4R8V Strong Genetic Variation [83]
GHRL TT1OCL0 Strong Altered Expression [84]
GIP TT40HS5 Strong Biomarker [85]
GIPR TTYMKBE Strong Altered Expression [86]
GJC1 TTEP7OC Strong Posttranslational Modification [87]
GLUL TTURQ2G Strong Biomarker [88]
GPA33 TT96HUR Strong Altered Expression [89]
GPC3 TTJTSX4 Strong Biomarker [90]
GPNMB TT7315J Strong Genetic Variation [91]
GPR182 TTT23CG Strong Biomarker [92]
GREM1 TTOUZN5 Strong Biomarker [93]
HCAR2 TTWNV8U Strong Altered Expression [76]
HCRTR1 TT60Q8D Strong Altered Expression [94]
HCRTR2 TT9N02I Strong Altered Expression [94]
HDAC2 TTSHTOI Strong Altered Expression [95]
HMBS TTT0HW3 Strong Biomarker [96]
HNF1A TT01M3K Strong Genetic Variation [97]
HSD11B1 TTN7BL9 Strong Altered Expression [98]
HSD17B1 TTIWB6L Strong Altered Expression [99]
HTR4 TT07C3Y Strong Altered Expression [100]
IGF2 TTE8WGO Strong Altered Expression [101]
IGF2R TTPNE41 Strong Genetic Variation [102]
IGFBP3 TTZHNQA Strong Biomarker [102]
ITGA4 TTJMF9P Strong Biomarker [103]
KCNH1 TT9XKUC Strong Altered Expression [104]
KCNJ1 TTJ13ST Strong Genetic Variation [105]
KCNJ5 TTEO25X Strong Genetic Variation [106]
KCNK3 TTGR91N Strong Altered Expression [107]
KLF4 TTTI53X Strong Biomarker [108]
KLK14 TTDA81R Strong Altered Expression [109]
KLK6 TTLPF4X Strong Biomarker [110]
KLK7 TTE6GTB Strong Altered Expression [111]
KRT17 TTKV0EC Strong Biomarker [112]
LANCL1 TTZW8NS Strong Altered Expression [113]
LHCGR TT2O4W9 Strong Altered Expression [114]
LIFR TTID542 Strong Altered Expression [115]
LILRB1 TTC0QRJ Strong Biomarker [116]
LILRB2 TTHC6XU Strong Biomarker [117]
LYZ TTAOZBW Strong Altered Expression [118]
MC2R TTPWFDX Strong Altered Expression [119]
MCHR1 TTX4RTB Strong Altered Expression [120]
MCHR2 TTS17MG Strong Altered Expression [120]
MCM7 TT1RM3F Strong Altered Expression [121]
MGMT TTJ8DV7 Strong Genetic Variation [122]
MKI67 TTB4UNG Strong Biomarker [123]
MMP1 TTMX39J Strong Genetic Variation [124]
MMP7 TTMTWOS Strong Altered Expression [89]
MRC1 TTKV8W5 Strong Genetic Variation [125]
MSI1 TTSM4BA Strong Altered Expression [126]
MUC1 TTBHFYQ Strong Biomarker [127]
MUC17 TTVO0JU Strong Altered Expression [128]
MUC5AC TTEL90S Strong Biomarker [129]
MUTYH TTNB0ZK Strong Genetic Variation [130]
MYB TT8V13P Strong Biomarker [131]
NAGLU TTDM6HZ Strong Biomarker [132]
ODC1 TTUMGNO Strong Genetic Variation [133]
OLFM4 TTK1CX7 Strong Altered Expression [134]
OPRD1 TT27RFC Strong Biomarker [135]
PCNA TTLG1PD Strong Altered Expression [136]
PCSK1 TTED9LZ Strong Altered Expression [137]
PDE11A TTTWC79 Strong Altered Expression [138]
PDE4B TTVIAT9 Strong Biomarker [139]
PDE4C TT6A59G Strong Altered Expression [140]
PGC TT7K6AD Strong Biomarker [82]
PLK2 TT976FS Strong Biomarker [141]
POR TTOQ9GZ Strong Altered Expression [142]
PPARD TT2JWF6 Strong Biomarker [143]
PRKAR2B TTW4Y2M Strong Altered Expression [144]
PRKCZ TTBSN0L Strong Altered Expression [145]
PRLR TTBPXMA Strong Altered Expression [146]
PSMD10 TT2H4LN Strong Biomarker [147]
PTGDR TTNVEIR Strong Altered Expression [148]
PTGIS TTLXKZR Strong Biomarker [149]
PTGS1 TT8NGED Strong Genetic Variation [150]
PTPRJ TTWMKXP Strong Genetic Variation [151]
REG4 TTVZEHU Strong Genetic Variation [128]
REN TTB2MXP Strong Biomarker [152]
RNF43 TTD91BL Strong Altered Expression [153]
ROR2 TTUDPCI Strong Posttranslational Modification [154]
RPS6KA6 TT3KYWB Strong Altered Expression [155]
RSPO1 TTI9HL4 Strong Biomarker [156]
RUNX3 TTKCVO7 Strong Altered Expression [157]
SCARB1 TTRE324 Strong Biomarker [158]
SCG3 TTY5R9H Strong Altered Expression [159]
SCGB1A1 TTONPVW Strong Biomarker [160]
SDC2 TT5H2F0 Strong Posttranslational Modification [161]
SDHD TTVH9W8 Strong Genetic Variation [162]
SERPINB5 TT1KW50 Strong Altered Expression [163]
SFRP4 TTX8I1Y Strong Posttranslational Modification [164]
SGK1 TTTV8EJ Strong Biomarker [165]
SHH TTIENCJ Strong Altered Expression [166]
SLC12A1 TTS087L Strong Genetic Variation [105]
SLC19A1 TT09I7D Strong Genetic Variation [167]
SLC23A2 TTOP832 Strong Genetic Variation [168]
SLC33A1 TTL69WB Strong Genetic Variation [169]
SLC38A1 TT1YE9Z Strong Altered Expression [170]
SLC5A5 TTW7HI9 Strong Altered Expression [171]
SLC9A3 TTFZVPO Strong Altered Expression [172]
SLCO1B1 TTFGXEB Strong Biomarker [173]
SMAD9 TTX8EBV Strong Biomarker [174]
SNAP25 TTYQWA0 Strong Altered Expression [175]
SORD TTLSRBZ Strong Altered Expression [176]
SORT1 TTRX9AV Strong Biomarker [177]
SPDEF TT2ZUPY Strong Biomarker [178]
SPN TTOZAX0 Strong Altered Expression [179]
SRPK1 TTU3WV6 Strong Altered Expression [180]
SSTR1 TTIND6G Strong Altered Expression [181]
SSTR3 TTJX3UE Strong Altered Expression [182]
SSTR5 TT2BC4G Strong Altered Expression [183]
STRAP TT165DP Strong Altered Expression [184]
TFF1 TTNOJIZ Strong Altered Expression [129]
TGM1 TT7A949 Strong Genetic Variation [185]
THRA TTTSEPU Strong Posttranslational Modification [186]
TIE1 TTT4236 Strong Biomarker [187]
TPO TT52XDZ Strong Biomarker [188]
TRH TT2Z39D Strong Biomarker [189]
TRIP10 TTKHTGE Strong Genetic Variation [190]
TRPM7 TTFPVZO Strong Genetic Variation [191]
TXNRD1 TTR7UJ3 Strong Genetic Variation [190]
TYMP TTO0IB8 Strong Altered Expression [192]
USP10 TT5IH09 Strong Biomarker [193]
USP44 TTJLTNM Strong Altered Expression [194]
USP8 TT1J07C Strong Genetic Variation [195]
UTS2 TTERU0T Strong Altered Expression [196]
VHL TTEMWSD Strong Biomarker [197]
XRCC5 TTCB9KW Strong Biomarker [198]
ZNF217 TTY3BRA Strong Biomarker [199]
CALR TTUZ7OA Definitive Biomarker [200]
CASR TTBUYHA Definitive Genetic Variation [201]
CHPF TTAZB7S Definitive Altered Expression [202]
CRH TTA7YIZ Definitive Biomarker [203]
CYP11B1 TTIQUX7 Definitive Biomarker [60]
GNRHR TT8R70G Definitive Altered Expression [114]
HMGA2 TTSTVM0 Definitive Altered Expression [204]
------------------------------------------------------------------------------------
⏷ Show the Full List of 221 DTT(s)
This Disease Is Related to 9 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
KCNH7 DT3WXPI Strong Altered Expression [205]
SLC20A1 DTMULXV Strong Altered Expression [206]
SLC26A1 DTJ785O Strong Altered Expression [170]
SLC26A2 DTFSLX5 Strong Altered Expression [207]
SLC26A3 DTN1FMD Strong Biomarker [208]
SLC26A6 DTVGOLN Strong Altered Expression [170]
SLC26A7 DTOTME4 Strong Altered Expression [170]
SLC9A2 DTV8JXE Strong Altered Expression [172]
SLCO6A1 DTIFXNS Strong Biomarker [18]
------------------------------------------------------------------------------------
⏷ Show the Full List of 9 DTP(s)
This Disease Is Related to 13 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
MTRR DE6NIY9 Limited Biomarker [209]
ADH1C DEM1HNL Strong Altered Expression [210]
ADHFE1 DE8RJ3F Strong Altered Expression [211]
BAAT DERA3OF Strong Biomarker [212]
CHST3 DEQIZP2 Strong Altered Expression [142]
CYB5A DE9A2LB Strong Altered Expression [142]
FMO3 DEP76YL Strong Altered Expression [213]
GGCT DEKW6PB Strong Biomarker [214]
GSTA4 DEH7XYP Strong Biomarker [215]
HSD17B7 DEDMWFX Strong Biomarker [216]
HSD3B1 DERDQWN Strong Altered Expression [217]
NAT1 DE7OAB3 Strong Genetic Variation [218]
PER1 DE9HF0I Strong Biomarker [219]
------------------------------------------------------------------------------------
⏷ Show the Full List of 13 DME(s)
This Disease Is Related to 320 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
APOBEC1 OTY8QX2R Limited Altered Expression [220]
CCDC6 OTXRQDYG Limited Biomarker [6]
CLDN7 OTNE0XHQ Limited Biomarker [221]
DEFA5 OT95CBQ9 Limited Altered Expression [222]
FHL2 OT0OAYWT Limited Biomarker [223]
KLK11 OT5PKX7Y Limited Altered Expression [224]
LAMP3 OTN0XL3W Limited Altered Expression [225]
LRG1 OTLD0KWA Limited Biomarker [16]
LSAMP OTYXVQX2 Limited Altered Expression [225]
NDRG4 OTJBOTD8 Limited Biomarker [226]
PITX1 OTA0UN4C Limited Biomarker [227]
PTMA OT2W4T1M Limited Therapeutic [228]
RAD50 OTYMU9G1 Limited Altered Expression [136]
RAP1GAP OTC31ONQ Limited Altered Expression [229]
S100A11 OTI57KDN Limited Altered Expression [230]
SYTL2 OTUIOWKL Limited Altered Expression [12]
TAS2R38 OTX5MM36 Limited Biomarker [6]
TCN2 OT41D0L3 Limited Biomarker [209]
THBS4 OTA1T9KK Limited Biomarker [231]
CDH20 OTJQVC1V Disputed Genetic Variation [232]
COL4A6 OTUREU5Z Disputed Genetic Variation [232]
LAMA3 OTFME7HT Disputed Genetic Variation [232]
NF1 OTC29NHH Disputed Biomarker [233]
NRXN3 OTJ0I7HJ Disputed Genetic Variation [232]
SUZ12 OT655XF8 Disputed Biomarker [233]
CHST4 OTESMIW5 moderate Altered Expression [234]
MPPED2 OT7XLMJ6 moderate Posttranslational Modification [235]
NOXO1 OTW29FB4 moderate Biomarker [236]
POLE OTFM3MMU moderate Genetic Variation [237]
RPL10A OTDLCJ53 moderate Biomarker [238]
TMEM70 OTLTKYXG moderate Altered Expression [18]
TPD52 OTPKSK43 moderate Altered Expression [239]
ACAD8 OT3JI5GB Strong Biomarker [240]
ACIN1 OTK81F92 Strong Genetic Variation [241]
ACSL4 OTI71MUJ Strong Altered Expression [242]
ADCY3 OTGOQM6B Strong Biomarker [243]
AIP OTDJ3OSV Strong Genetic Variation [244]
AKAP10 OTPNFTOU Strong Altered Expression [245]
ANXA3 OTDD8OI7 Strong Genetic Variation [246]
APBA1 OTUH9JPD Strong Genetic Variation [247]
APBA2 OTXD8ID1 Strong Biomarker [248]
APOD OTT77XW8 Strong Biomarker [249]
ARC OTN2QQPG Strong Biomarker [250]
ARHGAP24 OTCQCEZS Strong Genetic Variation [251]
ARHGDIB OT9PD6CS Strong Altered Expression [252]
ARHGEF4 OTR2VG0W Strong Biomarker [253]
ARMH1 OTTJC0D6 Strong Altered Expression [113]
ASCL1 OTI4X44G Strong Biomarker [254]
ASCL2 OT3D62WB Strong Biomarker [255]
ATP2A3 OTFYDEES Strong Altered Expression [256]
ATP2B3 OT9DIEOP Strong Biomarker [257]
ATP5F1B OTLFZUQK Strong Altered Expression [258]
AXIN2 OTRMGQNU Strong Posttranslational Modification [259]
BAG4 OTUPX3M2 Strong Altered Expression [260]
BCL2L11 OTNQQWFJ Strong Biomarker [261]
BCL9L OTTWI90E Strong Biomarker [262]
BID OTOSHSHU Strong Altered Expression [263]
BLM OTEJOAJX Strong Biomarker [264]
BUB1B OT8KME51 Strong Altered Expression [36]
C1QL1 OTNQ0G3E Strong Biomarker [265]
CA8 OT9Y8GA8 Strong Biomarker [266]
CABLES1 OTMN4XSX Strong Altered Expression [267]
CCL4L2 OTDBSXOU Strong Biomarker [268]
CDC73 OT6JASZ1 Strong Genetic Variation [269]
CDH13 OTD2CYM5 Strong Altered Expression [270]
CDH17 OT9EV2XK Strong Biomarker [219]
CDO1 OTLG1P77 Strong Posttranslational Modification [271]
CDX2 OTCG4TSY Strong Altered Expression [272]
CEMIP OTK80FYN Strong Altered Expression [273]
CHD5 OTS5EVHH Strong Biomarker [274]
CIB1 OT4BVCRU Strong Altered Expression [267]
CIB2 OT9ZJX1I Strong Genetic Variation [275]
CILK1 OTWOYEYP Strong Altered Expression [276]
CIRBP OTXWTPBL Strong Altered Expression [277]
CITED1 OTUJQ3VL Strong Altered Expression [278]
CKAP2 OTCLTC0J Strong Altered Expression [279]
CLDN2 OTRF3D6Y Strong Altered Expression [280]
CLOCK OTNEOJY7 Strong Genetic Variation [247]
COX5A OTP0961M Strong Biomarker [281]
CPOX OTIAY121 Strong Biomarker [281]
CRABP1 OTISDG5X Strong Biomarker [39]
CRACD OTII2U6L Strong Genetic Variation [282]
CREB3L3 OTDMU3GP Strong Altered Expression [283]
CREBZF OTO3TOEU Strong Biomarker [75]
CRISP2 OT8HLTV5 Strong Biomarker [284]
CTBP1 OTVYH2DH Strong Biomarker [285]
CTBP2 OTGZGT87 Strong Biomarker [286]
CTSZ OTSCX2LL Strong Altered Expression [287]
DCC OT2C1SHW Strong Genetic Variation [288]
DCTN6 OTI8PIN9 Strong Biomarker [289]
DEFA1 OT5N1B9B Strong Altered Expression [290]
DEFA3 OTO3N8E1 Strong Altered Expression [290]
DIS3 OT7UPHJS Strong Altered Expression [291]
DKK4 OTWCCVF6 Strong Biomarker [292]
DLC1 OTP8LMCR Strong Genetic Variation [293]
DLEC1 OTMKKBUW Strong Genetic Variation [293]
DMBT1 OTVNU9D9 Strong Altered Expression [294]
DROSHA OTCE68KZ Strong Biomarker [295]
DTD1 OT63V2KK Strong Altered Expression [170]
DVL2 OTMNYNCM Strong Genetic Variation [296]
DYNLL1 OTR69LHT Strong Genetic Variation [293]
E2F4 OTB3JFH4 Strong Biomarker [297]
EBNA1BP2 OTBRVMZH Strong Altered Expression [113]
EEF1G OTW7DH2F Strong Altered Expression [298]
EGR3 OTGPJIRA Strong Genetic Variation [299]
EIF2S1 OTM0GDTP Strong Altered Expression [300]
EIF6 OTEXMUED Strong Biomarker [301]
ENC1 OTJEUB6U Strong Biomarker [302]
ENPP7 OTWOBMQ9 Strong Biomarker [303]
ERGIC2 OT3MEGIU Strong Biomarker [304]
ERV3-1 OT4CW64T Strong Altered Expression [305]
ESD OTUSIBPS Strong Biomarker [306]
ESRP1 OTNCS4SL Strong Biomarker [307]
FABP6 OTIRQWLW Strong Altered Expression [308]
FGF13 OTHNNVSG Strong Biomarker [309]
FGF3 OT9PK2SI Strong Altered Expression [310]
FHL5 OT6C00Z1 Strong Altered Expression [283]
FLVCR1 OT9XCFOC Strong Biomarker [311]
FOXL2 OTFRQUYL Strong Altered Expression [312]
FUBP1 OT77SC9N Strong Biomarker [313]
FUT8 OTJJCVG1 Strong Altered Expression [314]
FZD1 OTZATHVS Strong Biomarker [315]
FZD5 OTXFFY56 Strong Biomarker [315]
FZD6 OTBCPII8 Strong Altered Expression [316]
GADD45G OT8V1J4M Strong Genetic Variation [317]
GALNT12 OTVIBUST Strong Biomarker [318]
GATA2 OTBP2QQ2 Strong Altered Expression [319]
GATA5 OTO81B63 Strong Biomarker [103]
GCM1 OT5CPAUT Strong Biomarker [320]
GCM2 OTSKNPTI Strong Altered Expression [320]
GDF1 OTZ1VRBH Strong Genetic Variation [321]
GFRA2 OT34CXNN Strong Altered Expression [322]
GH2 OT32TR4C Strong Genetic Variation [323]
GKN1 OT7ZYFQ9 Strong Altered Expression [324]
GLS2 OT08MSHL Strong Genetic Variation [325]
GNAS OTMH8BKJ Strong Genetic Variation [326]
GNB3 OTA6HYBA Strong Genetic Variation [327]
GPHN OTAKK1SV Strong Altered Expression [328]
GPX2 OTXI2NTI Strong Altered Expression [329]
GUCA2A OTUSF75G Strong Altered Expression [330]
GUK1 OTLI0HRU Strong Altered Expression [331]
H2AZ1 OT3KJJNQ Strong Biomarker [297]
HEY2 OTU4J3ZI Strong Altered Expression [332]
HGD OTTKLQOO Strong Biomarker [333]
HGS OTCYYCAC Strong Altered Expression [331]
HHIPL1 OT3GMU2X Strong Biomarker [334]
HLTF OTRX2OSF Strong Biomarker [335]
IFI27 OTI2XGIT Strong Biomarker [289]
IFITM3 OT2QP8D3 Strong Biomarker [336]
IFNA17 OTHXRYG3 Strong Biomarker [337]
IGF2BP2 OT4ZSEEE Strong Biomarker [338]
IHH OT1DWGXC Strong Altered Expression [339]
IMMP2L OT9WGAFD Strong Biomarker [338]
INHA OT7HWCO3 Strong Altered Expression [340]
INHBB OT2QLD11 Strong Posttranslational Modification [341]
INHBC OT8SUTZR Strong Altered Expression [342]
INSL3 OT7KUNTE Strong Altered Expression [343]
INTS2 OT2N5TCK Strong Altered Expression [310]
KCNE2 OTUO214Y Strong Biomarker [344]
KCNH6 OTQ52G7V Strong Altered Expression [205]
KLF9 OTBFEJRQ Strong Biomarker [345]
KPNA2 OTU7FOE6 Strong Altered Expression [346]
KRT15 OTS6WLF7 Strong Biomarker [347]
KRT20 OT4RB40L Strong Biomarker [348]
KRT7 OTLT3JFN Strong Biomarker [112]
LAMA1 OTQZMP86 Strong Biomarker [243]
LAT OTZC1XZ1 Strong Biomarker [349]
LECT2 OTSFZ9JD Strong Biomarker [350]
LGALS4 OTKQCG0H Strong Altered Expression [351]
LMAN1 OTYHKDEO Strong Altered Expression [352]
LRATD1 OT65IL83 Strong Altered Expression [353]
LRCH1 OT0RCL85 Strong Altered Expression [291]
LRIG1 OTY5HZN5 Strong Biomarker [354]
MACC1 OTV3DLX0 Strong Biomarker [355]
MAGI1 OTMV4ASV Strong Altered Expression [356]
MAL OTBM30SW Strong Genetic Variation [357]
MALL OTKGZ89D Strong Altered Expression [358]
MAPK15 OT8SW0L7 Strong Altered Expression [359]
MBD4 OTWR9YXE Strong Genetic Variation [360]
MCC OTQVI1EM Strong Biomarker [164]
MCM2 OTGGORIQ Strong Biomarker [361]
MED7 OTGF64SM Strong Altered Expression [85]
MIB1 OT5C404P Strong Biomarker [123]
MOK OTQK7M9V Strong Altered Expression [276]
MPC1 OT6DYFUO Strong Biomarker [362]
MPG OTAHW80B Strong Biomarker [363]
MRGBP OTXBPDMS Strong Biomarker [364]
MSH6 OT46FP09 Strong Genetic Variation [365]
MSX1 OT5U41ZP Strong Altered Expression [366]
MT3 OTVCZ7HI Strong Biomarker [53]
MUC2 OT3X4QVX Strong Biomarker [127]
MUC3A OTI4XUDY Strong Altered Expression [367]
MUC6 OTPVL723 Strong Altered Expression [368]
MYH11 OTVNVWY3 Strong Genetic Variation [369]
MYOD1 OTV2S79X Strong Posttranslational Modification [370]
NAA16 OTWMA7LK Strong Genetic Variation [371]
NBAS OTW9IBRI Strong Biomarker [132]
NCOA6 OTOMIGTV Strong Altered Expression [372]
NDRG2 OT5L6KD7 Strong Posttranslational Modification [373]
NEFM OT8VCBNF Strong Biomarker [374]
NEUROD1 OTZQ7QJ2 Strong Altered Expression [375]
NEUROG1 OTMJZP9G Strong Biomarker [39]
NEUROG2 OTAEMIGT Strong Biomarker [376]
NFIB OTX94PD0 Strong Genetic Variation [377]
NKD1 OTY3MO97 Strong Biomarker [378]
NKX2-1 OTCMEJTA Strong Altered Expression [379]
NLK OT2LETFS Strong Altered Expression [380]
NOC2L OTNT7R33 Strong Biomarker [381]
NPRL2 OTOB10MO Strong Altered Expression [382]
NR2F1 OTGWZWYL Strong Altered Expression [383]
NR5A1 OTOULYR4 Strong Altered Expression [384]
NRCAM OT80HHQ2 Strong Altered Expression [385]
NTHL1 OTPQXPT1 Strong Genetic Variation [386]
NUDT1 OTZSES3W Strong Genetic Variation [387]
OGN OTKP5S4L Strong Altered Expression [388]
PAX8 OTRPD9MI Strong Genetic Variation [389]
PCDHGC3 OTDXTUMI Strong Posttranslational Modification [390]
PCGF2 OTIY1J5L Strong Biomarker [391]
PCP4 OTM1XXYX Strong Biomarker [392]
PDCD4 OTZ6NXUX Strong Biomarker [393]
PDCD6IP OTS8T6A7 Strong Altered Expression [394]
PDE8B OT4217NK Strong Biomarker [140]
PDZK1IP1 OTWA6M5K Strong Biomarker [395]
PER3 OTVKYVJA Strong Genetic Variation [247]
PKHD1 OTAH8SMF Strong Biomarker [396]
PLAG1 OTT9AJQY Strong Biomarker [397]
PLEC OTU4XDEG Strong Altered Expression [398]
PMEPA1 OTY8Z9UF Strong Biomarker [399]
PMPCA OT5X1G9Q Strong Biomarker [158]
PMS2 OTNLWTMI Strong Biomarker [400]
POU1F1 OTXT8A5C Strong Altered Expression [206]
PPP1R13L OTNCPLWE Strong Genetic Variation [321]
PPP2R1B OTFIHQGD Strong Biomarker [401]
PRDM5 OTU1GB68 Strong Genetic Variation [402]
PRKACB OT6RMDCE Strong Genetic Variation [403]
PROP1 OT8GF6N8 Strong Altered Expression [404]
PROX1 OT68R6IO Strong Altered Expression [405]
PRSS55 OTXXWI5Y Strong Biomarker [284]
PSG9 OT0UWPND Strong Altered Expression [406]
PSMC4 OTS3XN41 Strong Biomarker [21]
PSMD7 OT7PZZ4K Strong Altered Expression [113]
PSMD9 OT6Y5CC3 Strong Biomarker [289]
PTPRF OTH5KF2D Strong Altered Expression [206]
PTPRG OT9N2WOF Strong Posttranslational Modification [407]
PTPRM OTCEL6PN Strong Altered Expression [408]
PTTG1 OTIMYS4W Strong Altered Expression [409]
PVALB OTZW1WVQ Strong Biomarker [410]
RAB20 OTP9OOVS Strong Biomarker [411]
RAB8A OTPB54Y3 Strong Altered Expression [412]
RABEPK OTCZSREH Strong Altered Expression [113]
RAP1B OTHEIIMM Strong Biomarker [297]
RASAL1 OTAHUNN7 Strong Altered Expression [413]
RBL1 OTDEBFYC Strong Altered Expression [414]
RERG OTF6MMLV Strong Altered Expression [415]
RETREG1 OTYOSLZX Strong Posttranslational Modification [416]
RGCC OTYJMLWM Strong Altered Expression [417]
RIOX2 OT2YFPI2 Strong Altered Expression [418]
RIT2 OTSNYG0D Strong Biomarker [419]
RMC1 OT7K8MTJ Strong Biomarker [420]
RND3 OTXMXPIH Strong Biomarker [421]
RNH1 OT6EC79B Strong Genetic Variation [321]
RRAS OTBBF28C Strong Biomarker [422]
SAT2 OT28QL7H Strong Posttranslational Modification [423]
SCG2 OTXWUQQL Strong Biomarker [424]
SCIN OT6U09OL Strong Biomarker [425]
SCN7A OTK05PXY Strong Biomarker [132]
SCO2 OTJQQDRS Strong Altered Expression [192]
SCTR OTC80IMR Strong Posttranslational Modification [341]
SDHC OTC8G2MX Strong Posttranslational Modification [426]
SELENOP OT02B8IR Strong Biomarker [190]
SEPTIN9 OT1VMRFQ Strong Biomarker [427]
SERPINE2 OTYF5340 Strong Altered Expression [428]
SETDB1 OTWVUA1B Strong Altered Expression [429]
SF1 OTLEDM2S Strong Altered Expression [430]
SFRP2 OT8GZ0CA Strong Biomarker [431]
SH3BP4 OTVIRKW7 Strong Biomarker [432]
SHC3 OT305NPA Strong Genetic Variation [321]
SKI OT4KJ8F6 Strong Altered Expression [433]
SKIL OTNBXH32 Strong Altered Expression [433]
SMC1A OT9ZMRK9 Strong Altered Expression [434]
SNAP23 OTY2MYBX Strong Altered Expression [175]
SNED1 OTBQVXY5 Strong Altered Expression [435]
SOX17 OT9H4WWE Strong Biomarker [65]
SPART OTIVOS2I Strong Posttranslational Modification [436]
SPATA13 OTQ8NPAW Strong Altered Expression [437]
SPEN OT37A2MD Strong Altered Expression [438]
SPPL3 OT2HLJF6 Strong Biomarker [338]
SPZ1 OTQH8HJ5 Strong Biomarker [284]
STX1A OTSBUZB4 Strong Altered Expression [175]
SYNM OTOI8TRJ Strong Biomarker [80]
SYP OTFJKMO4 Strong Posttranslational Modification [439]
TARBP2 OT1QQ8H3 Strong Altered Expression [372]
TBP OT6C0S52 Strong Biomarker [96]
TBRG1 OTMV5L8H Strong Biomarker [440]
TBX19 OTXEMR2U Strong Biomarker [404]
TCF7 OT1ID822 Strong Genetic Variation [441]
TCFL5 OTJL4348 Strong Genetic Variation [364]
TEX30 OT87WEPQ Strong Biomarker [399]
TFAP2E OTA4B1SG Strong Genetic Variation [334]
TFF3 OTJJDRTU Strong Biomarker [442]
TG OT3ELHIJ Strong Altered Expression [443]
THADA OTYZQX0F Strong Genetic Variation [444]
TICAM2 OTK7GIJ5 Strong Biomarker [289]
TLE4 OT4QEH6T Strong Altered Expression [254]
TMED7 OTONO8E6 Strong Biomarker [289]
TNMD OTHLVA9G Strong Biomarker [445]
TOX OTE8BL5Z Strong Altered Expression [446]
TP53INP2 OT0GTBXO Strong Biomarker [135]
TP73 OT0LUO47 Strong Genetic Variation [251]
TRAPPC4 OT3THRCA Strong Altered Expression [447]
TRAPPC9 OTF0CVMC Strong Posttranslational Modification [448]
TRIM21 OTA4UJCF Strong Biomarker [200]
TSHZ3 OTAN7RY5 Strong Biomarker [449]
TSPYL2 OTGGW2EF Strong Altered Expression [450]
TTF1 OT4K90WD Strong Altered Expression [451]
EPS8 OTZ6ES6V Definitive Altered Expression [452]
GHRH OT94U6MO Definitive Biomarker [83]
ING3 OTDIJXFP Definitive Altered Expression [453]
NAV3 OT97M1TR Definitive Genetic Variation [454]
SFRP1 OT0U9G41 Definitive Biomarker [431]
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⏷ Show the Full List of 320 DOT(s)

References

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71 Integrated genomic analysis of colorectal cancer progression reveals activation of EGFR through demethylation of the EREG promoter.Oncogene. 2016 Dec 15;35(50):6403-6415. doi: 10.1038/onc.2016.170. Epub 2016 Jun 6.
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73 Expression of heart-type fatty acid-binding protein in human gastric carcinoma and its association with tumor aggressiveness, metastasis and poor prognosis.Pathobiology. 2004;71(5):267-73. doi: 10.1159/000080061.
74 Syndromic Gastric Polyps: At the Crossroads of Genetic and Environmental Cancer Predisposition.Adv Exp Med Biol. 2016;908:347-69. doi: 10.1007/978-3-319-41388-4_17.
75 Potential miRNA-target interactions for the screening of gastric carcinoma development in gastric adenoma/dysplasia.Int J Med Sci. 2018 Mar 14;15(6):610-616. doi: 10.7150/ijms.24061. eCollection 2018.
76 Clostridium butyricum, a butyrate-producing probiotic, inhibits intestinal tumor development through modulating Wnt signaling and gut microbiota.Cancer Lett. 2020 Jan 28;469:456-467. doi: 10.1016/j.canlet.2019.11.019. Epub 2019 Nov 14.
77 Upregulation of Fibroblast Growth Factor 19 Is Associated with the Initiation of Colorectal Adenoma.Dig Dis. 2019;37(3):214-225. doi: 10.1159/000494454. Epub 2018 Dec 5.
78 Folate Receptor Near-Infrared Optical Imaging Provides Sensitive and Specific Intraoperative Visualization of Nonfunctional Pituitary Adenomas.Oper Neurosurg (Hagerstown). 2019 Jan 1;16(1):59-70. doi: 10.1093/ons/opy034.
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80 Differential expression of the neural cell adhesion molecule NCAM 140 in human pituitary tumors.FEBS Lett. 1990 Oct 15;272(1-2):45-9. doi: 10.1016/0014-5793(90)80445-o.
81 Targeted deletion of liver glucose-6 phosphatase mimics glycogen storage disease type 1a including development of multiple adenomas.J Hepatol. 2011 Mar;54(3):529-37. doi: 10.1016/j.jhep.2010.08.014. Epub 2010 Oct 1.
82 Atrophic and Metaplastic Progression in the Background Mucosa of Patients with Gastric Adenoma.PLoS One. 2017 Jan 10;12(1):e0169456. doi: 10.1371/journal.pone.0169456. eCollection 2017.
83 Use of the metallothionein promoter-human growth hormone-releasing hormone (GHRH) mouse to identify regulatory pathways that suppress pituitary somatotrope hyperplasia and adenoma formation due to GHRH-receptor hyperactivation.Endocrinology. 2009 Jul;150(7):3177-85. doi: 10.1210/en.2008-1482. Epub 2009 Apr 2.
84 Differential expression of ghrelin and its receptor (GHS-R1a) in various adrenal tumors and normal adrenal gland.Horm Metab Res. 2008 Mar;40(3):181-8. doi: 10.1055/s-2007-1004574. Epub 2008 Feb 4.
85 The Sp transcription factors are involved in the cellular expression of the human glucose-dependent insulinotropic polypeptide receptor gene and overexpressed in adrenals of patients with Cushing's syndrome.J Mol Endocrinol. 2005 Aug;35(1):61-71. doi: 10.1677/jme.1.01765.
86 Adrenal GIPR expression and chromosome 19q13 microduplications in GIP-dependent Cushing's syndrome.JCI Insight. 2017 Sep 21;2(18):e92184. doi: 10.1172/jci.insight.92184. eCollection 2017 Sep 21.
87 Quantitative validation of GJC1 promoter hypermethylation in benign and malignant colorectal tumors.Endocr Relat Cancer. 2011 Oct 27;18(6):C31-4. doi: 10.1530/ERC-11-0204. Print 2011 Oct.
88 Genomic profiling of well-differentiated hepatocellular neoplasms with diffuse glutamine synthetase staining reveals similar genetics across the adenoma to carcinoma spectrum.Mod Pathol. 2019 Nov;32(11):1627-1636. doi: 10.1038/s41379-019-0282-0. Epub 2019 Jun 12.
89 A hypermorphic epithelial -catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations.Dis Model Mech. 2015 Nov;8(11):1361-73. doi: 10.1242/dmm.019844. Epub 2015 Aug 6.
90 Utility of an immunohistochemical panel consisting of glypican-3, heat-shock protein-70, and glutamine synthetase in the distinction of low-grade hepatocellular carcinoma from hepatocellular adenoma.Appl Immunohistochem Mol Morphol. 2013 Mar;21(2):170-6. doi: 10.1097/PAI.0b013e31825d527f.
91 GPNMB methylation: a new marker of potentially carcinogenic colon lesions.BMC Cancer. 2018 Nov 6;18(1):1068. doi: 10.1186/s12885-018-4903-7.
92 Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation. J Clin Invest. 2017 Feb 1;127(2):593-607.
93 Clinicopathological features of a kindred with SCG5-GREM1-associated hereditary mixed polyposis syndrome.Hum Pathol. 2017 Feb;60:75-81. doi: 10.1016/j.humpath.2016.10.002. Epub 2016 Oct 28.
94 Preproorexin and orexin receptors are expressed in cortisol-secreting adrenocortical adenomas, and orexins stimulate in vitro cortisol secretion and growth of tumor cells.J Clin Endocrinol Metab. 2005 Jun;90(6):3544-9. doi: 10.1210/jc.2004-2385. Epub 2005 Mar 29.
95 Regulation of VDR Expression in Apc-Mutant Mice, Human Colon Cancers and Adenomas.Cancer Prev Res (Phila). 2015 May;8(5):387-99. doi: 10.1158/1940-6207.CAPR-14-0371. Epub 2015 Apr 14.
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97 Somatic HNF1A mutations in the malignant transformation of hepatocellular adenomas: a retrospective analysis of data from MSK-IMPACT and TCGA.Hum Pathol. 2019 Jan;83:1-6. doi: 10.1016/j.humpath.2018.08.004. Epub 2018 Aug 17.
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