General Information of Disease (ID: DISV809X)

Disease Name Mixed anxiety and depressive disorder
Synonyms anxiety depression; mixed anxiety and depressive disorder
Disease Hierarchy
DISBI2BT: Anxiety disorder
DIS3XJ69: Depression
DISV809X: Mixed anxiety and depressive disorder
Disease Identifiers
MONDO ID
MONDO_0041086
UMLS CUI
C0338908
MedGen ID
572834
SNOMED CT ID
231504006

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 5 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Alprazolam DMC7XDN Approved Small molecular drug [1]
Amitriptyline DMK7F9S Approved Small molecular drug [2]
Chlordiazepoxide DMTN5XI Approved Small molecular drug [3]
Maprotiline DMPWB7T Approved Small molecular drug [4]
Perphenazine DMA4MRX Approved Small molecular drug [5]
------------------------------------------------------------------------------------

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 15 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
OPRK1 TTQW87Y Limited Biomarker [6]
PKD2L1 TTAHD89 Limited Genetic Variation [7]
TPH2 TT3KLDP Limited Altered Expression [8]
CFP TTLA0VS Strong Biomarker [9]
CRH TTA7YIZ Strong Biomarker [10]
CRHR1 TT7EFHR Strong Biomarker [10]
FGF14 TTKJX1V Strong Biomarker [11]
GRIK4 TTQV6BO Strong Biomarker [12]
GRM2 TTXJ47W Strong Biomarker [13]
HTR1B TTK8CXU Strong Genetic Variation [14]
HTR2C TTWJBZ5 Strong Altered Expression [15]
HTR6 TTJS8PY Strong Biomarker [16]
OPRL1 TTNT7K8 Strong Biomarker [17]
SMC2 TTS8D17 Strong Genetic Variation [18]
DRD3 TT4C8EA Definitive Genetic Variation [19]
------------------------------------------------------------------------------------
⏷ Show the Full List of 15 DTT(s)
This Disease Is Related to 1 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
SLC45A2 DTNCJAT Strong Biomarker [20]
------------------------------------------------------------------------------------
This Disease Is Related to 1 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
SCLY DEH4TD6 Strong Genetic Variation [21]
------------------------------------------------------------------------------------
This Disease Is Related to 27 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
NOS1AP OTDFOBRU Limited Genetic Variation [22]
ALLC OTZE4XV7 Strong Biomarker [14]
BATF2 OT4XBZC9 Strong Biomarker [23]
CAPS OTC9GZ2M Strong Genetic Variation [7]
CNTN3 OTC1274J Strong Genetic Variation [24]
CORT OTX3GUHB Strong Biomarker [25]
CRYBG1 OTIPDI15 Strong Biomarker [20]
DMTN OTDTKPBW Strong Biomarker [26]
DNASE1L3 OTEUIMC2 Strong Biomarker [27]
DTNBP1 OT9UQT2S Strong Genetic Variation [28]
FMR1 OTWEV0T5 Strong Genetic Variation [29]
FOXD3 OTXYV6GO Strong Genetic Variation [30]
HARS1 OTHOEOTS Strong Biomarker [31]
HNRNPU OTLQN1E2 Strong Biomarker [32]
KRT7 OTLT3JFN Strong Genetic Variation [21]
LAMA1 OTQZMP86 Strong Biomarker [33]
LRWD1 OTHRVJQC Strong Genetic Variation [34]
MCIDAS OTK1JVAH Strong Genetic Variation [35]
MOCOS OT0TL3Q5 Strong Genetic Variation [24]
PLXNA2 OTNNBJMQ Strong Genetic Variation [36]
PNOC OTJEAADN Strong Biomarker [17]
PTPN5 OT2H1KDK Strong Biomarker [37]
PTS OTTYWQXR Strong Biomarker [38]
SMCP OTXKY794 Strong Genetic Variation [24]
TAL1 OTX4K6QZ Strong Genetic Variation [21]
TMEM59L OTSN3KG4 Strong Biomarker [39]
COPE OTBKHBT7 Definitive Biomarker [40]
------------------------------------------------------------------------------------
⏷ Show the Full List of 27 DOT(s)

References

1 Alprazolam FDA Label
2 Amitriptyline FDA Label
3 Chlordiazepoxide FDA Label
4 Maprotiline FDA Label
5 Perphenazine FDA Label
6 Design and Synthesis of a Novel and Selective Kappa Opioid Receptor (KOR) Antagonist (BTRX-335140).J Med Chem. 2019 Feb 28;62(4):1761-1780. doi: 10.1021/acs.jmedchem.8b01679. Epub 2019 Feb 13.
7 Screening for trauma-related symptoms via a smartphone app: The validity of Smart Assessment on your Mobile in referred police officers.Int J Methods Psychiatr Res. 2017 Sep;26(3):e1579. doi: 10.1002/mpr.1579.
8 Tryptophan hydroxylase 2 as a therapeutic target for psychiatric disorders: focus on animal models.Expert Opin Ther Targets. 2019 Aug;23(8):655-667. doi: 10.1080/14728222.2019.1634691. Epub 2019 Jul 2.
9 Regional Brain Volumes Moderate, but Do Not Mediate, the Effects of Group-Based Exercise Training on Reductions in Loneliness in Older Adults.Front Aging Neurosci. 2017 Apr 25;9:110. doi: 10.3389/fnagi.2017.00110. eCollection 2017.
10 Computational investigation of binding mechanism of substituted pyrazinones targeting corticotropin releasing factor-1 receptor deliberated for anti-depressant drug design.J Biomol Struct Dyn. 2019 Aug;37(12):3226-3244. doi: 10.1080/07391102.2018.1513379. Epub 2018 Dec 24.
11 Intracellular Fibroblast Growth Factor 14: Emerging Risk Factor for Brain Disorders.Front Cell Neurosci. 2017 Apr 19;11:103. doi: 10.3389/fncel.2017.00103. eCollection 2017.
12 Increased Dosage of High-Affinity Kainate Receptor Gene grik4 Alters Synaptic Transmission and Reproduces Autism Spectrum Disorders Features.J Neurosci. 2015 Oct 7;35(40):13619-28. doi: 10.1523/JNEUROSCI.2217-15.2015.
13 Metabotropic Glutamate Receptors 2 and 3 as Targets for Treating Nicotine Addiction.Biol Psychiatry. 2018 Jun 1;83(11):947-954. doi: 10.1016/j.biopsych.2017.11.021. Epub 2017 Nov 21.
14 The relationship between serotonin receptor 1B polymorphisms A-161T and alcohol dependence.Alcohol Clin Exp Res. 2009 Sep;33(9):1589-95. doi: 10.1111/j.1530-0277.2009.00990.x. Epub 2009 Jun 10.
15 Targeting the 5-HT2C Receptor in Biological Context and the Current State of 5-HT2C Receptor Ligand Development.Curr Top Med Chem. 2019;19(16):1381-1398. doi: 10.2174/1568026619666190709101449.
16 Age-Related Change in 5-HT(6) Receptor Availability in Healthy Male Volunteers Measured with (11)C-GSK215083 PET.J Nucl Med. 2018 Sep;59(9):1445-1450. doi: 10.2967/jnumed.117.206516. Epub 2018 Apr 6.
17 Nociceptin/orphanin FQ receptor agonists increase aggressiveness in the mouse resident-intruder test.Behav Brain Res. 2019 Jan 1;356:120-126. doi: 10.1016/j.bbr.2018.08.019. Epub 2018 Aug 22.
18 Childhood theory of mind does not predict psychotic experiences and social functioning in a general population sample of adolescents.PLoS One. 2019 Feb 28;14(2):e0213165. doi: 10.1371/journal.pone.0213165. eCollection 2019.
19 COMT and DRD3 polymorphisms, environmental exposures, and personality traits related to common mental disorders.Am J Med Genet. 2000 Feb 7;96(1):102-7. doi: 10.1002/(sici)1096-8628(20000207)96:1<102::aid-ajmg20>3.0.co;2-3.
20 Multimorbidity of overweight and obesity alongside anxiety and depressive disorders in individuals with spinal cord injury.J Spinal Cord Med. 2021 Nov;44(6):992-1000. doi: 10.1080/10790268.2018.1507801. Epub 2018 Sep 5.
21 An overview of which health domains to consider and when to apply them in measurement-based care for depression and anxiety disorders.Nord J Psychiatry. 2018 Jul;72(5):367-373. doi: 10.1080/08039488.2018.1465592. Epub 2018 May 1.
22 Nitric oxide pathway genes (NOS1AP and NOS1) are involved in PTSD severity, depression, anxiety, stress and resilience.Gene. 2017 Aug 20;625:42-48. doi: 10.1016/j.gene.2017.04.048. Epub 2017 Apr 29.
23 Family contributions to sport performance and their utility in predicting appropriate referrals to mental health optimization programmes.Eur J Sport Sci. 2019 Aug;19(7):972-982. doi: 10.1080/17461391.2019.1574906. Epub 2019 Feb 8.
24 The influence of selected psychological variables on quality of life of chronically dialysed patients.Scand J Caring Sci. 2019 Dec;33(4):840-847. doi: 10.1111/scs.12680. Epub 2019 May 9.
25 Differential Peripheral Proteomic Biosignature of Fluoxetine Response in a Mouse Model of Anxiety/Depression.Front Cell Neurosci. 2017 Aug 16;11:237. doi: 10.3389/fncel.2017.00237. eCollection 2017.
26 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) used in a naturalistic group setting is associated with unintended improvements in depression and anxiety.Am J Drug Alcohol Abuse. 2019;45(2):161-169. doi: 10.1080/00952990.2018.1545024. Epub 2019 Mar 1.
27 Therapeutic use of classic psychedelics to treat cancer-related psychiatric distress.Int Rev Psychiatry. 2018 Aug;30(4):317-330. doi: 10.1080/09540261.2018.1482261. Epub 2018 Aug 13.
28 Association study of candidate variants from brain-derived neurotrophic factor and dystrobrevin-binding protein 1 with neuroticism, anxiety, and depression.Psychiatr Genet. 2008 Oct;18(5):219-25. doi: 10.1097/YPG.0b013e3283050aee.
29 Prevalence and risk of migraine headaches in adult fragile X premutation carriers.Clin Genet. 2013 Dec;84(6):546-51. doi: 10.1111/cge.12109. Epub 2013 Feb 21.
30 Life events and depression in a community sample of siblings.Psychol Med. 2001 Apr;31(3):401-10. doi: 10.1017/s0033291701003361.
31 The symptomatology of climacteric syndrome: whether associated with the physical factors or psychological disorder in perimenopausal/postmenopausal patients with anxiety-depression disorder.Arch Gynecol Obstet. 2012 May;285(5):1345-52. doi: 10.1007/s00404-011-2151-z. Epub 2011 Nov 29.
32 Role of the Attachment Style in Determining the Association Between Headache Features and Psychological Symptoms in Migraine Children and Adolescents. An Analytical Observational Case-Control Study.Headache. 2017 Feb;57(2):266-275. doi: 10.1111/head.13007. Epub 2017 Jan 6.
33 Adherence To Respiratory And Nonrespiratory Medication In Patients With COPD: Results Of The German COSYCONET Cohort.Patient Prefer Adherence. 2019 Oct 10;13:1711-1721. doi: 10.2147/PPA.S223438. eCollection 2019.
34 A unique database for gathering data from a mobile app and medical prescription software: a useful data source to collect and analyse patient-reported outcomes of depression and anxiety symptoms.Int J Psychiatry Clin Pract. 2017 Nov;21(4):318-321. doi: 10.1080/13651501.2017.1315139. Epub 2017 Apr 21.
35 Mild cognitive impairment in Parkinson's disease: a distinct clinical entity?.Transl Neurodegener. 2017 Sep 13;6:24. doi: 10.1186/s40035-017-0094-4. eCollection 2017.
36 Anxiety and comorbid measures associated with PLXNA2.Arch Gen Psychiatry. 2007 Mar;64(3):318-26. doi: 10.1001/archpsyc.64.3.318.
37 Child STEPs in California: A cluster randomized effectiveness trial comparing modular treatment with community implemented treatment for youth with anxiety, depression, conduct problems, or traumatic stress.J Consult Clin Psychol. 2017 Jan;85(1):13-25. doi: 10.1037/ccp0000133. Epub 2016 Aug 22.
38 Risk Factors Associated with Alcohol Use in Early Adolescence among American Inner-City Youth: A Longitudinal Study.Subst Use Misuse. 2020;55(3):358-366. doi: 10.1080/10826084.2019.1671867. Epub 2019 Nov 5.
39 The Neuron-Specific Protein TMEM59L Mediates Oxidative Stress-Induced Cell Death.Mol Neurobiol. 2017 Aug;54(6):4189-4200. doi: 10.1007/s12035-016-9997-9. Epub 2016 Jun 21.
40 COPE for Adolescent Syrian Refugees in Lebanon: A Brief Cognitive-Behavioral Skill-Building Intervention to Improve Quality of Life and Promote Positive Mental Health.Clin Nurs Res. 2020 May;29(4):226-234. doi: 10.1177/1054773818808114. Epub 2018 Nov 26.