Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM04SWY)

Drug Name
1-Phenyl-propane-1,2-dione Drug Info
Synonyms
1-PHENYL-1,2-PROPANEDIONE; 1-Phenylpropane-1,2-dione; 579-07-7; Acetylbenzoyl; Acetyl benzoyl; Benzoylacetyl; 1,2-Propanedione, 1-phenyl-; Methylphenylglyoxal; Pyruvophenone; Phenylmethyldiketone; Benzoyl methyl ketone; Methyl phenyl diketone; 3-Phenyl-2,3-propanedione; Methyl phenyl glyoxal; Phenyl methyl diketone; UNII-ZB5XA3GD0I; 1-phenyl-1,2-propandione; 1-Phenyl-propane-1,2-dione; FEMA No. 3226; CCRIS 6297; NSC 7643; EINECS 209-435-2; ZB5XA3GD0I; AI3-23868; CHEBI:63552; BVQVLAIMHVDZEL-UHFFFAOYSA-N; 1-Phenyl-1,2-propanedione, 98
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
11363
ChEBI ID
CHEBI:63552
CAS Number
CAS 579-07-7
TTD Drug ID
DM04SWY
INTEDE Drug ID
DR2715

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Liver carboxylesterase (CES1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [4]
PACTIMIBE DM0NZDT Arteriosclerosis BD40 Phase 2/3 [5]
K-604 DMQVN6P Arteriosclerosis BD40 Phase 2 [6]
Eldacimibe DML7WP0 Hyperlipidaemia 5C80 Phase 2 [7]
GR148672X DM7W6YN Acute lymphoblastic leukaemia 2A85 Clinical trial [8]
Avasimibe DMFG4OM Peripheral vascular disease BD4Z Discontinued in Phase 3 [9]
E-5324 DM562BM Hyperlipidaemia 5C80 Discontinued in Phase 2 [10]
RP-64477 DMTQ3BS Hyperlipidaemia 5C80 Discontinued in Phase 2 [11]
CI-976 DMBO28J Hyperlipidaemia 5C80 Discontinued in Phase 2 [12]
CL-283796 DM7LIDT Hyperlipidaemia 5C80 Discontinued in Phase 2 [13]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [14]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [15]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [16]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [17]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [18]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [19]
Ethacrynic acid DM60QMR Edema MG29 Approved [20]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [21]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [22]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [23]
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Drug(s) Affected By Heme oxygenase 1 (HMOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [24]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [25]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [26]
Verapamil DMA7PEW Angina pectoris BA40 Approved [27]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [28]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [29]
Selenium DM25CGV N. A. N. A. Approved [30]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [31]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [32]
Methotrexate DM2TEOL Anterior urethra cancer Approved [33]
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Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [34]
Diazepam DM08E9O Alcohol withdrawal Approved [35]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [36]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [2]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [34]
Quercetin DM3NC4M Obesity 5B81 Approved [37]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [38]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [34]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [39]
Testosterone DM7HUNW Hot flushes GA30 Approved [40]
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Drug(s) Affected By Transcription factor MafF (MAFF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [41]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [42]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [43]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [2]
Quercetin DM3NC4M Obesity 5B81 Approved [37]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [44]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [45]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [46]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [47]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [48]
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Drug(s) Affected By Dehydrogenase/reductase SDR family member 11 (DHRS11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [3]
Quercetin DM3NC4M Obesity 5B81 Approved [3]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [47]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Flufenamic Acid DMC8VNH Dysmenorrhea GA34.3 Approved [3]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [51]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [52]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [53]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [54]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Liver carboxylesterase (CES1) TTMF541 EST1_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Aldo-keto reductase family 1 member C2 (AKR1C2) OTQ2XMO3 AK1C2_HUMAN Gene/Protein Processing [2]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Gene/Protein Processing [2]
Dehydrogenase/reductase SDR family member 11 (DHRS11) OTU3J0ZL DHR11_HUMAN Biotransformations [3]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Gene/Protein Processing [2]
Transcription factor MafF (MAFF) OT9B7MX0 MAFF_HUMAN Gene/Protein Processing [2]

References

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