Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM23HCX)

Drug Name
Dextropropoxyphene Drug Info
Synonyms
Algafan; Antalvic; Destropropossifene; Dextropropoxifeno; Dextropropoxyphen; Dextropropoxyphenum; Dextroproxifeno; Femadol; Levopropoxyphene; Propoxyphene; Proxagesic; Proxyphen; Destropropossifene [DCIT]; Dextroproxifeno [Spanish]; SK 65; D-Propoxyphene; Dextropropoxifeno [INN-Spanish]; Dextropropoxyphene[INN:BAN]; Dextropropoxyphenum [INN-Latin]; Bulk dextropropoxyphene (non-dosage forms); Alpha-4-Dimethylamino-1,2-diphenyl-3-methyl-2-butanol propionate; Alpha-D-4-Dimethylamino-3-methyl-1,2-diphenyl-2-butanol propionate; Alpha-D-4-Dimethylamino-3-methyl-1,2-diphenyl-2-butanol-propionat; Alpha-D-4-Dimethylamino-3-methyl-1,2-diphenyl-2-butanol-propionat [German]; Alpha-(+)-4-Dimethylamino-1,2-diphenyl-3-methyl-2-butanol propionate ester; Alpha-(+)-4-Dimethylamino-1,2-diphenyl-3-methyl-2-propionoxybutane; [(2S,3R)-4-(dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl] propanoate; (+)-1,2-Diphenyl-2-propionoxy-3-methyl-4-dimethylaminobutane; (+)-4-Dimethylamino-1,2-diphenyl-3-methyl-2-propionyloxybutane; (1S,2R)-1-benzyl-3-(dimethylamino)-2-methyl-1-phenylpropyl propanoate; (D)-PROPOXYPHENE; (S)-alpha-(2-(Dimethylamino)-1-methylethyl)-alpha-phenylbenzeneethanol propanoate; 4-Dimethylamino-3-methyl-1,2-diphenyl-2-propoxybutane
Indication
Disease Entry ICD 11 Status REF
Pain MG30-MG3Z Approved [1]
Therapeutic Class
Analgesics
Cross-matching ID
PubChem CID
10100
ChEBI ID
CHEBI:51173
CAS Number
CAS 469-62-5
TTD Drug ID
DM23HCX
INTEDE Drug ID
DR0478
ACDINA Drug ID
D00564

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Opioid receptor (OPR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methadone DMTW6IU Advanced cancer 2A00-2F9Z Approved [6]
Ketobemidone DMM3L6Z Pain MG30-MG3Z Approved [7]
Oxymorphone DM65AGJ Pain MG30-MG3Z Approved [8]
Sufentanil DMU7YEL Analgesia MB40.8 Approved [9]
Naltrexone DMUL45H Alcohol dependence 6C40.2 Approved [10]
Levorphanol DMGS80V Pain MG30-MG3Z Approved [11]
Pentazocine DM1XBHS Pain MG30-MG3Z Approved [12]
Nalmefene DM4YWCZ Opioid dependence 6C43.2Z Approved [13]
Tilidine DMJW0VS Pain MG30-MG3Z Approved [14]
Dihydrocodeine DMB0FWL Allergic rhinitis CA08.0 Phase 4 [15]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [16]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [17]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [18]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [19]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [20]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [21]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [22]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [23]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [17]
Verapamil DMA7PEW Angina pectoris BA40 Approved [24]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [25]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [26]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [27]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [20]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [24]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [28]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [29]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [30]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [31]
Propranolol DM79NTF Angina pectoris BA40 Approved [32]
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Drug(s) Affected By Cocaine esterase (CES2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [33]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [34]
Methotrexate DM2TEOL Anterior urethra cancer Approved [35]
Quercetin DM3NC4M Obesity 5B81 Approved [36]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [37]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [38]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [39]
Testosterone enanthate DMB6871 N. A. N. A. Approved [40]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [41]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
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Drug(s) Affected By Liver carboxylesterase 1 (CES1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [43]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [44]
Selenium DM25CGV N. A. N. A. Approved [45]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [46]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [47]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [48]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [33]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [49]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [41]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Opioid receptor (OPR) TTN4QDT NOUNIPROTAC Agonist [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [3]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cocaine esterase (CES2) OTC647SQ EST2_HUMAN Protein Interaction/Cellular Processes [5]
Liver carboxylesterase 1 (CES1) OT9L0LR8 EST1_HUMAN Protein Interaction/Cellular Processes [5]

References

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