Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7VTQO)

Drug Name
Entecavir Drug Info
Synonyms
Baraclude; ETV; Entecavir hydrate; Entecavir monohydrate; BMS-200475; Baraclude (TN); Entecavir (INN); Entecavir (USAN); Entecavir hydrate (JAN); SQ-34676; 2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one; 2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-1,9-dihydro-6H-purin-6-one; 2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-1,9-dihydro-6H-purin-6-one-water (1/1); 2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-3H-purin-6-one; 6-H-Purin-6-one-,2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]; 9-((1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl)guanine monohydrate
Indication
Disease Entry ICD 11 Status REF
Hepatitis B virus infection 1E51.0 Approved [1]
Therapeutic Class
Antiviral Agents
Cross-matching ID
PubChem CID
135398508
ChEBI ID
CHEBI:473990
CAS Number
CAS 142217-69-4
TTD Drug ID
DM7VTQO
VARIDT Drug ID
DR01277
ACDINA Drug ID
D00232

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
Drug Status:
Clinical Trial Drug(s)
Approved Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Hepatitis B virus Reverse transcriptase (HBV RT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clevudine DMR21Q3 Hepatitis B 1E51 Phase 3 [6]
LB80380 DMJM9LZ Hepatitis B virus infection 1E51.0 Phase 2b [7]
Pradefovir DM1O0DV Hepatitis virus infection 1E50-1E51 Phase 2 [8]
MIV-210 DM2NF6X Hepatitis B virus infection 1E51.0 Phase 2 [9]
Drug(s) Transported By Breast cancer resistance protein (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [10]
Methotrexate DM2TEOL Anterior urethra cancer Approved [11]
Folic Acid DMEMBJC Colorectal carcinoma Approved [12]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [13]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [14]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [15]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [16]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [15]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [17]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [18]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Organic anion transporter 2 (SLC22A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [19]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [20]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [21]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [22]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [23]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [24]
Aciclovir DMYLOVR Genital herpes 1A94 Approved [25]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [26]
Theophylline DMRJFN9 Bronchitis CA20 Approved [23]
Tetracycline DMZA017 Acne vulgaris ED80 Approved [27]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Organic cation transporter 3 (SLC22A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Propranolol DM79NTF Angina pectoris BA40 Approved [28]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [29]
Metformin DM89QE1 Colorectal carcinoma Approved [30]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [28]
Epinephrine DM3KJBC Acute asthma CA23 Approved [29]
Norepinephrine DMOUC09 Alopecia ED70 Approved [29]
Amphetamine DMSZQAK Attention deficit hyperactivity disorder 6A05.Z Approved [31]
Acetylcholine DMDF79Z Cataract 9B10 Approved [32]
Sodium chloride DMM3950 Skin burns ME65.0 Approved [33]
Etilefrine DM67PWD Cardiovascular disease BA00-BE2Z Withdrawn from market [34]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Peptide transporter 2 (SLC15A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [35]
Ampicillin DMHWE7P Acute epiglottitis Approved [36]
Enalapril DMNFUZR Congestive heart failure BD10 Approved [37]
Cefadroxil DMMC345 Bacterial infection 1A00-1C4Z Approved [38]
Cephalexin DMD5JU8 Acute otitis media AB00 Approved [36]
Valaciclovir DMHKS94 Genital herpes 1A94 Approved [39]
Cefaclor DMJXDGC Bacterial infection 1A00-1C4Z Approved [35]
Aminolevulinic acid hci DMS4BLQ Acne vulgaris ED80 Approved [40]
Spirapril DM5XLTY Hypertension BA00-BA04 Approved [41]
Cefixime DMY60I8 Acute gonococcal cervicitis Approved [36]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Organic cation/carnitine transporter 2 (SLC22A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [42]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [43]
Levacecarnine hci DMJBOCR Cognitive impairment 6D71 Approved [44]
Amphetamine DMSZQAK Attention deficit hyperactivity disorder 6A05.Z Approved [45]
Potassium Chloride DMMTAJC Hypokalemia 5C77 Approved [46]
Tiotropium DMFDC0Q Chronic obstructive pulmonary disease CA22 Approved [47]
Ipratropium DMFQ320 Obstructive lung disease CA22.Z Approved [47]
Mepyramine DMB4SFH Allergic rhinitis CA08.0 Approved [48]
Acetylcarnitine DM4UE3K Chronic fatigue syndrome 8E49 Phase 4 [49]
acetyl-L-carnitine DM74HGJ Discovery agent N.A. Investigative [43]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Concentrative nucleoside transporter 2 (SLC28A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [50]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [51]
Uridine DMQTREB Depression 6A70-6A7Z Approved [52]
Didanosine DMI2QPE Human immunodeficiency virus infection 1C62 Approved [53]
Drug(s) Transported By Concentrative Na(+)-nucleoside cotransporter 3 (SLC28A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [54]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [55]
Clofarabine DMCVJ86 Acute lymphoblastic leukaemia 2A85 Approved [56]
Thioguanine DM7NKEV Acute lymphocytic leukaemia 2B33.3 Approved [54]
Drug(s) Transported By Equilibrative nucleoside transporter 1 (SLC29A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [57]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [50]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [58]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [59]
Clofarabine DMCVJ86 Acute lymphoblastic leukaemia 2A85 Approved [56]
Trifluridine DMG2YBD Herpetic keratitis 1F00.10 Approved [60]
Adenosine DMM2NSK Paroxysmal supraventricular tachycardia BC81.Z Approved [61]
Tecadenoson DM9T6MS Atrial fibrillation BC81.3 Discontinued in Phase 3 [62]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Transported By Equilibrative nucleoside transporter 2 (SLC29A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [50]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [58]
Clofarabine DMCVJ86 Acute lymphoblastic leukaemia 2A85 Approved [56]
Trifluridine DMG2YBD Herpetic keratitis 1F00.10 Approved [60]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Hepatitis B virus Reverse transcriptase (HBV RT) TTS5K1M DPOL_HBVA3 Modulator [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Equilibrative nucleoside transporter 2 (SLC29A2) DTW78DQ S29A2_HUMAN Substrate [3]
Equilibrative nucleoside transporter 1 (SLC29A1) DTXD1TQ S29A1_HUMAN Substrate [3]
Concentrative nucleoside transporter 2 (SLC28A2) DT82KPY S28A2_HUMAN Substrate [3]
Concentrative Na(+)-nucleoside cotransporter 3 (SLC28A3) DT4YL5R S28A3_HUMAN Substrate [3]
Peptide transporter 2 (SLC15A2) DT8QKNP S15A2_HUMAN Substrate [4]
Organic cation/carnitine transporter 2 (SLC22A5) DT3HUVD S22A5_HUMAN Substrate [3]
Organic anion transporter 2 (SLC22A7) DT0OC1Q S22A7_HUMAN Substrate [5]
Organic cation transporter 3 (SLC22A3) DT6201N S22A3_HUMAN Substrate [3]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [3]

References

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28 Influx Transport of Cationic Drug at the Blood-Retinal Barrier: Impact on the Retinal Delivery of Neuroprotectants. Biol Pharm Bull. 2017;40(8):1139-1145.
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