Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMC4IUQ)

Drug Name
5-(N,N-hexamethylene)-amiloride Drug Info
Synonyms
5-(N,N-Hexamethylene)amiloride; Hexamethyleneamiloride; 1428-95-1; Hexamethylene amiloride; HMA-5; HMA; C12H18ClN7O; 3-Amino-6-chloro-5-(1-homopiperidyl)-N-(diaminomethylene)pyrazinecarboxamide; N,N-HEXAMETHYLENEAMILORIDE; CHEBI:76400; 3-amino-5-(azepan-1-yl)-6-chloro-N-(diaminomethylene)pyrazine-2-carboxamide; 3-Amino-N-(aminoiminomethyl)-6-chloro-5-(hexahydro-1H-azepin-1-yl)pyrazinecarboxamide; Pyrazinecarboxamide, 3-amino-N-(aminoiminomethyl)-6-chloro-5-(hexahydro-1H-azepin-1-yl)-; 5-HMA; Spectrum_001596
Indication
Disease Entry ICD 11 Status REF
Coronavirus infection 1D92 Preclinical [1]
Cross-matching ID
PubChem CID
1794
ChEBI ID
CHEBI:76400
CAS Number
CAS 1428-95-1
TTD Drug ID
DMC4IUQ
VARIDT Drug ID
DR00899

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Adrenergic receptor alpha-2C (ADRA2C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
MOXONIDINE DMGFB0E Alcohol dependence 6C40.2 Approved [5]
Dihydroergocristine DM5SQ1G Alcohol dependence 6C40.2 Approved [6]
Brimonidine DMQLT4N Ocular hypertension 9C61.01 Approved [7]
Amosulalol DML8QSZ Hypertension BA00-BA04 Approved [8]
Amezinium DM6I2WQ Hypotension BA20-BA21 Approved [9]
Propylhexedrine DMTBW2O Obesity 5B81 Approved [10]
Tetrahydrozoline DMT57WC Ocular disease 1F00.1Z Approved [11]
Rilmenidine DM13PQW Hypertension BA00-BA04 Approved [12]
Xylometazoline DMKV32D Allergic rhinitis CA08.0 Phase 4 [13]
TNX-102 DMO1234 Fibromyalgia MG30.01 Phase 3 [14]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Gonadotropin-releasing hormone receptor (GNRHR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gonadorelin DMAQ469 Amenorrhea GA20.0 Approved [15]
Relugolix DMK7IWL Prostate cancer 2C82.0 Approved [16]
Ganirelix DMGMB30 Ovulation dysfunction 5A80 Approved [17]
Abarelix DM5WFNP Prostate cancer 2C82.0 Approved [18]
Triptorelin DMTK4LS Infertility GB04 Approved [19]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [20]
Nafarelin DMAHEFY Endometriosis GA10 Approved [21]
Cetrorelix DMFD9Q6 Ovarian stimulation LB45.1 Approved [22]
Elagolix sodium DMRDUC0 Endometriosis GA10 Approved [23]
Degarelix DM3O8QY Prostate cancer 2C82.0 Approved [24]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [25]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [26]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [27]
Methotrexate DM2TEOL Anterior urethra cancer Approved [28]
Quercetin DM3NC4M Obesity 5B81 Approved [29]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [30]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [31]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [32]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [33]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [34]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [35]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [36]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [37]
Etretinate DM2CZFA Keratosis ED56 Approved [38]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [39]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [40]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [41]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [42]
Quercetin DM3NC4M Obesity 5B81 Approved [29]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [43]
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Drug(s) Affected By Endoplasmin (HSP90B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [35]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [44]
Selenium DM25CGV N. A. N. A. Approved [45]
Quercetin DM3NC4M Obesity 5B81 Approved [46]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [47]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [48]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [49]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [50]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [51]
Testosterone enanthate DMB6871 N. A. N. A. Approved [52]
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Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [53]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [54]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [55]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [56]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [57]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [58]
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [59]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [60]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [61]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [62]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [25]
Triacetin DM0AEPG Onychomycosis EE12.1 Approved [63]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [26]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [64]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [36]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [65]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [39]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [66]
Methotrexate DM2TEOL Anterior urethra cancer Approved [28]
Quercetin DM3NC4M Obesity 5B81 Approved [29]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Adrenergic receptor alpha-2C (ADRA2C) TT2NUT5 ADA2C_HUMAN Modulator (allosteric modulator) [2]
Gonadotropin-releasing hormone receptor (GNRHR) TT8R70G GNRHR_HUMAN Modulator (allosteric modulator) [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Gene/Protein Processing [4]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Gene/Protein Processing [4]
Endoplasmin (HSP90B1) OT02XLBR ENPL_HUMAN Gene/Protein Processing [4]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Gene/Protein Processing [4]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) OTYG179K PR15A_HUMAN Gene/Protein Processing [4]

References

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