Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGO2D7)

Drug Name
3-acetyl-11-keto-beta-boswellic acid Drug Info
Synonyms
AKBA; 67416-61-9; 3-O-Acetyl-11-keto-beta-Boswellic Acid; AKbetaBA; UNII-BS16QT99Q1; Acetyl-11-keto-beta-boswellic acid; CHEMBL237111; BS16QT99Q1; Acetyl-11-keto--boswellic acid; AKBA cpd; Acetyl-11-keto-b-boswellic acid; acetyl-11-ketoboswellic acid; Acetyl-11-keto-beta-Boswellic Acid, Boswellia serrata; 3-Acetyl-11-keto-; 3alpha-acetoxy-11-keto-beta-boswellic acid; Curator_000001; MolPort-020-005-785; HMMGKOVEOFBCAU-BCDBGHSCSA-N
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
11168203
ChEBI ID
CHEBI:166842
CAS Number
CAS 67416-61-9
TTD Drug ID
DMGO2D7

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
RG-7234 DM5RAB9 Type-2 diabetes 5A11 Phase 2 [4]
[(125)I] RB129 DMX0G7E Discovery agent N.A. Investigative [5]
11-keto-beta-boswellicacid DMM6CJI Discovery agent N.A. Investigative [1]
Ganoderic acid A DM42EVG Discovery agent N.A. Investigative [1]
Drug(s) Targeting Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
GLYCYRRHIZIN DM8M2N3 Influenza virus infection 1E30-1E32 Phase 3 [6]
BVT.2733 DM6RUKX Lupus 4A40 Phase 3 [7]
INCB13739 DMLQ3PO Type-2 diabetes 5A11 Phase 2a [8]
URSOLIC ACID DM4SOAW Metabolic syndrome x 5C50-5D2Z Phase 2 [1]
JTT-654 DM50M2R Type-2 diabetes 5A11 Phase 2 [4]
RG-4929 DMT4QRD Metabolic disorder 5C50-5D2Z Phase 2 [4]
BMS-770767 DMTVGY7 Hypercholesterolaemia 5C80.0 Phase 2 [4]
UE-2343 DMIERPK Alzheimer disease 8A20 Phase 2 [9]
AZD-4017 DML9M5S Ocular hypertension 9C61.01 Phase 2 [4]
Xanamem DM580GT Alzheimer disease 8A20 Phase 1/2 [10]
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Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [11]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [12]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [13]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [14]
Selenium DM25CGV N. A. N. A. Approved [15]
Etretinate DM2CZFA Keratosis ED56 Approved [16]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [17]
Methotrexate DM2TEOL Anterior urethra cancer Approved [18]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [19]
Quercetin DM3NC4M Obesity 5B81 Approved [20]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [21]
Gefitinib DM15F0X Colon adenocarcinoma Approved [22]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [23]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [24]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [25]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [26]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [25]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [27]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [28]
Methotrexate DM2TEOL Anterior urethra cancer Approved [29]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [30]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [31]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [32]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [33]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [34]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [21]
Verapamil DMA7PEW Angina pectoris BA40 Approved [35]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [36]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [37]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [38]
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Drug(s) Affected By DNA topoisomerase 1 (TOP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Teniposide DMLW57T Acute lymphoblastic leukaemia 2A85 Approved [34]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [39]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [14]
Selenium DM25CGV N. A. N. A. Approved [40]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [44]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
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Drug(s) Affected By DNA topoisomerase 2-alpha (TOP2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [47]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [48]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [49]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [50]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [42]
Quercetin DM3NC4M Obesity 5B81 Approved [52]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [53]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [54]
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Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [55]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [56]
Selenium DM25CGV N. A. N. A. Approved [15]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [57]
Methotrexate DM2TEOL Anterior urethra cancer Approved [18]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [58]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [59]
Quercetin DM3NC4M Obesity 5B81 Approved [20]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [53]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [60]
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Drug(s) Affected By Cyclin-A2 (CCNA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [61]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [12]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [62]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [64]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [65]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [19]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [66]
Quercetin DM3NC4M Obesity 5B81 Approved [52]
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Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [21]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [67]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [64]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [26]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [65]
Quercetin DM3NC4M Obesity 5B81 Approved [52]
Fluoxetine DM3PD2C Bipolar depression Approved [68]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [69]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [71]
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Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [11]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [12]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [67]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [72]
Selenium DM25CGV N. A. N. A. Approved [15]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [26]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [73]
Methotrexate DM2TEOL Anterior urethra cancer Approved [74]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [58]
Quercetin DM3NC4M Obesity 5B81 Approved [20]
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Drug(s) Affected By G1/S-specific cyclin-D2 (CCND2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [75]
Selenium DM25CGV N. A. N. A. Approved [15]
Methotrexate DM2TEOL Anterior urethra cancer Approved [18]
Quercetin DM3NC4M Obesity 5B81 Approved [20]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [76]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [77]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [78]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [79]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [80]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [81]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [78]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [82]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [49]
Gefitinib DM15F0X Colon adenocarcinoma Approved [83]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [84]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Etretinate DM2CZFA Keratosis ED56 Approved [16]
Prednisone DM2HG4X Acute asthma CA23 Approved [85]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [26]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [86]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [87]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [88]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [89]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [90]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [91]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [92]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [93]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [94]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [95]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [96]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [97]
Gefitinib DM15F0X Colon adenocarcinoma Approved [98]
Prednisone DM2HG4X Acute asthma CA23 Approved [85]
Methotrexate DM2TEOL Anterior urethra cancer Approved [99]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [100]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [101]
Quercetin DM3NC4M Obesity 5B81 Approved [102]
Fluoxetine DM3PD2C Bipolar depression Approved [68]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [103]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [104]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [30]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [96]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [21]
Verapamil DMA7PEW Angina pectoris BA40 Approved [35]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [105]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [106]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [84]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [107]
Meloxicam DM2AR7L Arthritis FA20 Approved [108]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [26]
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Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [109]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [110]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [24]
Selenium DM25CGV N. A. N. A. Approved [40]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [111]
Methotrexate DM2TEOL Anterior urethra cancer Approved [18]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [112]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [113]
Quercetin DM3NC4M Obesity 5B81 Approved [114]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [115]
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Drug(s) Affected By Beclin-1 (BECN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcipotriol DM03CP7 Psoriasis EA90 Approved [116]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [21]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [117]
Methotrexate DM2TEOL Anterior urethra cancer Approved [18]
Quercetin DM3NC4M Obesity 5B81 Approved [118]
Fluoxetine DM3PD2C Bipolar depression Approved [119]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [120]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [121]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [122]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [123]
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Drug(s) Affected By Autophagy protein 5 (ATG5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [124]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [125]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [126]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [127]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [122]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [128]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [129]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [130]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) TTN7BL9 DHI1_HUMAN Inhibitor [1]
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) TT9H85R DHI2_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [2]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [2]
Autophagy protein 5 (ATG5) OT4T5SMS ATG5_HUMAN Gene/Protein Processing [3]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [3]
Beclin-1 (BECN1) OT4X293M BECN1_HUMAN Gene/Protein Processing [3]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [2]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Gene/Protein Processing [3]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Post-Translational Modifications [3]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Gene/Protein Processing [3]
Cyclin-dependent kinase 4 (CDK4) OT7EP05T CDK4_HUMAN Gene/Protein Processing [3]

References

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3 Acetyl-11-keto--boswellic acid enhances the cisplatin sensitivity of non-small cell lung cancer cells through cell cycle arrest, apoptosis induction, and autophagy suppression via p21-dependent signaling pathway. Cell Biol Toxicol. 2021 Apr;37(2):209-228. doi: 10.1007/s10565-020-09541-5. Epub 2020 Jun 20.
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19 Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
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