General Information of Drug (ID: DMGXENV)

Drug Name
Saxagliptin Drug Info
Synonyms
Onglyza; BMS 477118-11; BMS-477118; Kombiglyze XR (TN); OPC-262; Onglyza (TN); BMS-477118-11; (1S,5S)-2-[2-amino-2-(3-hydroxy-1-adamantyl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile; 2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2S)-amino(3-hydroxytricyclo[3.3
Indication
Disease Entry ICD 11 Status REF
Type-2 diabetes 5A11 Approved [1]
Cross-matching ID
PubChem CID
11243969
ChEBI ID
CHEBI:71272
CAS Number
CAS 361442-04-8
TTD Drug ID
DMGXENV
VARIDT Drug ID
DR00226
INTEDE Drug ID
DR1465
ACDINA Drug ID
D00616

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sitagliptin DMGDKXN Cystic fibrosis CA25 Approved [8]
Alogliptin DM8WI3R Type-2 diabetes 5A11 Approved [9]
Linagliptin DMWFJTR Non-insulin dependent diabetes 5A11 Approved [10]
Vildagliptin DMYN59P Type-2 diabetes 5A11 Approved [11]
Dapagliflozin Propanediol; Saxagliptin Hydrochloride DM34TXO Type-2 diabetes 5A11 Approved [12]
Anagliptin DMJXIC9 Type-2 diabetes 5A11 Approved [13]
SaxaDapa FDC DMAPRWV Diabetic complication 5A2Y Phase 3 [14]
LC-150444 DM09RKB Type-2 diabetes 5A11 Phase 3 [15]
Dutogliptin DMM5VTA Type-2 diabetes 5A11 Phase 3 [16]
MK-3102 DM3PSUF Type-2 diabetes 5A11 Phase 3 [17]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [18]
Methotrexate DM2TEOL Anterior urethra cancer Approved [19]
Folic Acid DMEMBJC Colorectal carcinoma Approved [20]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [21]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [22]
Verapamil DMA7PEW Angina pectoris BA40 Approved [23]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [24]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [25]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [26]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [27]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [23]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [28]
Methotrexate DM2TEOL Anterior urethra cancer Approved [29]
Folic Acid DMEMBJC Colorectal carcinoma Approved [30]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [29]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [29]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [31]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [29]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [32]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [33]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [34]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [35]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [36]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [37]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [38]
L-Tryptophan DMIBH7M Depression 6A70-6A7Z Approved [39]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [40]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [41]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [42]
Cilostazol DMZMSCT Intermittent claudication BD40.00 Approved [43]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Digoxin DMQCTIH Arrhythmia BC9Z Approved [44]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [44]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [44]
Estrone sulfate DMVBIZL Atrophic vaginitis GA30.2 Approved [45]
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [46]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [47]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [48]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [49]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [50]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [51]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [52]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [53]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [47]
Verapamil DMA7PEW Angina pectoris BA40 Approved [54]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [55]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [56]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [57]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [58]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [59]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [60]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [61]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [62]
Verapamil DMA7PEW Angina pectoris BA40 Approved [63]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [58]
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Drug(s) Affected By Dipeptidyl peptidase 4 (DPP4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [64]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [65]
Testosterone DM7HUNW Hot flushes GA30 Approved [66]
Alogliptin DM8WI3R Type-2 diabetes 5A11 Approved [67]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [68]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [69]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [70]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [71]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [72]
Anagliptin DMJXIC9 Type-2 diabetes 5A11 Approved [73]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Dipeptidyl peptidase 4 (DPP-4) TTDIGC1 DPP4_HUMAN Inhibitor [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Organic anion transporting polypeptide 4C1 (SLCO4C1) DTY0QMU SO4C1_HUMAN Substrate [3]
Multidrug resistance-associated protein 1 (ABCC1) DTSYQGK MRP1_HUMAN Substrate [4]
Organic anion transporter 3 (SLC22A8) DTVP67E S22A8_HUMAN Substrate [3]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [5]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [6]
Cytochrome P450 3A5 (CYP3A5) Main DME DEIBDNY CP3A5_HUMAN Substrate [6]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Dipeptidyl peptidase 4 (DPP4) OT16MVL9 DPP4_HUMAN Gene/Protein Processing [7]

References

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