Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMM0HR1)

• Drug Name: Pargyline Drug Info
• Synonyms: Benzylmethylpropargylamine; Benzylmethylpropynylamine; Eudatin; Eutron; Methylbenzylpropynylamine; Paragyline; Pargilina; Pargylamine; Pargylin; Pargylinum; Supirdyl; A 19120; MO 911; Pargilina [INN-Spanish]; Pargyline (INN); Pargyline [INN:BAN]; Pargylinum [INN-Latin]; Benzyl-methyl-2-propinylamin; Benzyl-methyl-2-propinylamin [Czech]; N-Methyl-N-benzylpropynylamine; N-Methyl-N-propargylbenzylamine; N-Methyl-N-2-propynylbenzylamine; N-Benzyl-N-methyl-2-propynylamine; N-Benzyl-N-methyl-2-propyn-1; N-Benzyl-N-methyl-2-propyn-1-amine; N-benzyl-N-methylprop-2-yn-1-amine; N-methyl-N-(phenylmethyl)prop-2-yn-1-amine

Indication

Disease Entry	ICD 11	Status	REF
Hypertension	BA00-BA04	Approved	[1]
Muscular dystrophy	8C70	Patented	[2]
Skin imperfections	EK71	Patented	[2]

• Therapeutic Class: Antihypertensive Agents
• Cross-matching ID:
  PubChem CID: 4688
  ChEBI ID: CHEBI:7930
  CAS Number: CAS 555-57-7
  TTD Drug ID: DMM0HR1

Molecule-Related Drug Atlas

Drug(s) Targeting Monoamine oxidase (MAO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Moclobemide	DMNZWL7	Depression	6A70-6A7Z	Approved	[2]
Phenelzine	DMHIDUE	Depression	6A70-6A7Z	Approved	[2]
Tranylcypromine	DMGB5RE	Major depressive disorder	6A70.3	Approved	[2]
Selegiline	DM6034S	Major depressive disorder	6A70.3	Approved	[2]
Methylene blue	DMJAPE7	Acquired methemoglobinemia	3A93	Approved	[6]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[2]
Ergoloid mesylate	DMORPBA	Alzheimer disease	8A20	Approved	[7]
Cyclopropylamine derivative 11	DMMJ0YN	N. A.	N. A.	Patented	[8]
PMID27019002-Compound-20a	DMRX748	N. A.	N. A.	Patented	[8]
Cyclopropylamine derivative 9	DMX7YAL	N. A.	N. A.	Patented	[8]

Drug(s) Targeting Monoamine oxidase type B (MAO-B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selegiline Hydrochloride	DM3VR1L	Parkinson disease	8A00.0	Approved	[9]
Phenelzine	DMHIDUE	Depression	6A70-6A7Z	Approved	[10]
Tranylcypromine	DMGB5RE	Major depressive disorder	6A70.3	Approved	[11]
Selegiline	DM6034S	Major depressive disorder	6A70.3	Approved	[12]
Safinamide mesylate	DM0J2ZT	Parkinson disease	8A00.0	Approved	[13]
Rasagiline	DM3WKQ4	Parkinson disease	8A00.0	Approved	[14]
Sulphadoxine	DMZI2UF	Malaria	1F40-1F45	Approved	[15]
Indeloxazine	DMWO3N6	Dementia	6D80-6D86	Approved	[1]
Budipine	DMODHQI	Migraine	8A80	Approved	[16]
Safinamide	DM0YWJC	Parkinson disease	8A00.0	Approved	[17]

Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[18]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[19]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[20]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[21]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[22]
Clopidogrel	DMOL54H	Acute coronary syndrome	BA41	Approved	[23]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[24]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[25]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[26]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[27]

Drug(s) Affected By Amine oxidase B (MAOB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[28]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[29]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[30]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Selegiline	DM6034S	Major depressive disorder	6A70.3	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
BENZYL BENZOATE	DMDPYI5	Infestations of lice and scabies	1G00.Z	Approved	[4]
Linezolid	DMGFPU2	Bacteremia	1A73	Approved	[36]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Monoamine oxidase (MAO)	TT32XQJ	NOUNIPROTAC	Inhibitor	[2]
Monoamine oxidase type B (MAO-B)	TTGP7BY	AOFB_HUMAN	Inhibitor	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Amine oxidase B (MAOB)	OTTDFM1O	AOFB_HUMAN	Gene/Protein Processing	[4]
Cytochrome P450 2B6 (CYP2B6)	OTOYO4S7	CP2B6_HUMAN	Gene/Protein Processing	[5]

References

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