Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMW4M97)

Drug Name

Clevidipine butyrate Drug Info

Synonyms

Clevidipine; Cleviprex; 167221-71-8; Clevelox; rac-Clevidipine; H 324/38; Methyl (1-oxobutoxy)methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dime thyl-3,5-pyridinedicarboxylate; Methyl (1-oxobutoxy)methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate; Cleviprex (TN); 3-((butyryloxy)methyl) 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; METHYL 5-{[(BUTANOYLOXY)METHOXY]CARBONYL}-4-(2,3-DICHLOROPHENYL)-2,6-DIMETHYL-1,4-DIHYDROPYRIDINE-3

Indication

Disease Entry	ICD 11	Status	REF
Hypertension	BA00-BA04	Approved	[1]

Cross-matching ID

PubChem CID: 153994
ChEBI ID: CHEBI:135738
CAS Number: CAS 167221-71-8
TTD Drug ID: DMW4M97
INTEDE Drug ID: DR0339
ACDINA Drug ID: D00953

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Calcium channel unspecific (CaC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicardipine	DMCDYW7	High blood pressure	BA00	Approved	[6]
Nisoldipine	DM7ISKJ	Hypertension	BA00-BA04	Approved	[7]
Felodipine	DMOSW35	Hypertension	BA00-BA04	Approved	[8]
Nimodipine	DMQ0RKZ	Cerebral vasospasm	BA85.Z	Approved	[9]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[10]
Isradipine	DMA5XGH	Hypertension	BA00-BA04	Approved	[10]
DIPROTEVERINE HYDROCHLORIDE	DMG8U6M	Angina pectoris	BA40	Phase 3	[11]
ATI-2042	DMWP59B	Atrial fibrillation	BC81.3	Phase 2	[12]
HBI-3000	DM74ZKN	Heart arrhythmia	BC65	Phase 2	[13]
Nexopamil	DML5S71	Hypertension	BA00-BA04	Phase 2	[14]
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Drug(s) Targeting Voltage-gated L-type calcium channel (L-CaC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[10]
Epalrestat	DM5OGK0	Diabetic neuropathy	8C0Z	Approved	[15]
Otilonium bromide	DM05968	Gastric motility disorder	DA21	Approved	[16]
Levamlodipine	DM92S6N	Hypertension	BA00-BA04	Phase 4	[17]
Cilnidipine	DM1975O	High blood pressure	BA00	Phase 3	[18]
Pinaverium bromide	DM7OSHC	Irritable bowel syndrome	DD91.0	Phase 3	[16]
MEM-1003	DMYZU6G	Bipolar disorder	6A60	Phase 2a	[19]
Gallopamil	DMXBR27	Asthma	CA23	Phase 2	[20]
BAY-Y-5959	DMLO18H	Cardiovascular disease	BA00-BE2Z	Phase 2	[21]
Furnidipine	DME94QF	Nerve injury	ND56.4	Discontinued in Phase 3	[22]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[23]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[24]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[25]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[26]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[27]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[29]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[30]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[24]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[31]
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Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[32]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[33]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[34]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[27]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[35]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[36]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[37]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[38]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[39]
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Drug(s) Metabolized By Cytochrome P450 2E1 (CYP2E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[40]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[41]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[44]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[45]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[46]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[47]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[48]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[49]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[50]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[5]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[51]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[52]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[53]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[55]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[56]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[57]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[58]
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Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[5]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[60]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[61]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[62]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[63]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[64]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[65]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[66]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[67]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Calcium channel unspecific (CaC)	TT5HONZ	NOUNIPROTAC	Modulator	[1]
Voltage-gated L-type calcium channel (L-CaC)	TTXHYV6	NOUNIPROTAC	Inhibitor	[2]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[3]
Cytochrome P450 2E1 (CYP2E1)	DEVDYN7	CP2E1_HUMAN	Substrate	[4]
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Substrate	[4]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Gene/Protein Processing	[5]
Cytochrome P450 1B1 (CYP1B1)	OTYXFLSD	CP1B1_HUMAN	Gene/Protein Processing	[5]

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