Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWCQP4)

Drug Name
Interferon Alfa-2b Drug Info
Synonyms Intron A; Viraferon
Indication
Disease Entry ICD 11 Status REF
Melanoma 2C30 Approved [1]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
71306834
CAS Number
CAS 98530-12-2
TTD Drug ID
DMWCQP4
ACDINA Drug ID
D01166

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Interferon-alpha 2 (IFNA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Peginterferon alfa-2b DMAP58Y Hepatitis C virus infection 1E51.1 Approved [2]
Peginterferon alfa-2a DMJI3BA Chronic hepatitis B virus infection Approved [2]
Albinterferon alfa-2b DMK0QW6 Hepatitis C virus infection 1E51.1 Phase 3 [4]
Interferon alpha 2a DMOTH6V Hepatitis C virus infection 1E51.1 Phase 3 [5]
Hebergel DMQTLVB Virus infection 1A24-1D9Z Phase 3 [6]
P-1101 DM7WYXJ Essential thrombocythemia 3B63.1Z Phase 3 [7]
Interferon alpha-2b DMVACTU Hepatitis C virus infection 1E51.1 Phase 2 [8]
Novaferon DMEHOI1 Colorectal cancer 2B91.Z Phase 2 [9]
Instiladrin DMNKAFQ Bladder cancer 2C94 Phase 2 [10]
CIGB-128 DMB2MKU Basal cell carcinoma 2C32 Phase 1 [11]
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Drug(s) Affected By 2'-5'-oligoadenylate synthase 1 (OAS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [12]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [14]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [12]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [15]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [16]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [17]
Testosterone DM7HUNW Hot flushes GA30 Approved [18]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [19]
Leflunomide DMR8ONJ Arthritis FA20 Approved [20]
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Drug(s) Affected By Interferon-induced, double-stranded RNA-activated protein kinase (EIF2AK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [21]
Quercetin DM3NC4M Obesity 5B81 Approved [22]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [23]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [24]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Testosterone enanthate DMB6871 N. A. N. A. Approved [26]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [27]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [28]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [29]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [30]
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Drug(s) Affected By Tyrosine-protein kinase JAK1 (JAK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [31]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [15]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [33]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Tofacitinib DMBS370 Rheumatoid arthritis FA20 Approved [34]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [35]
Clozapine DMFC71L Schizophrenia 6A20 Approved [36]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [37]
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Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [38]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [39]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [40]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [41]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [42]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [43]
Methotrexate DM2TEOL Anterior urethra cancer Approved [44]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [45]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [46]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
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Drug(s) Affected By Signal transducer and activator of transcription 1-alpha/beta (STAT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [48]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [49]
Methotrexate DM2TEOL Anterior urethra cancer Approved [12]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [50]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [52]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [53]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [12]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [17]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [54]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Signal transducer and activator of transcription 2 (STAT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [23]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [54]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [35]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [28]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [29]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [55]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [56]
Arsenic DMTL2Y1 N. A. N. A. Approved [57]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [58]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [59]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Interferon-alpha 2 (IFNA2) TTSIUJ9 IFNA2_HUMAN Modulator [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
2'-5'-oligoadenylate synthase 1 (OAS1) OT8ZLOCY OAS1_HUMAN Gene/Protein Processing [3]
Interferon-induced, double-stranded RNA-activated protein kinase (EIF2AK2) OT8DXMS3 E2AK2_HUMAN Gene/Protein Processing [3]
Non-receptor tyrosine-protein kinase TYK2 OTHEOTA8 TYK2_HUMAN Gene/Protein Processing [3]
Signal transducer and activator of transcription 1-alpha/beta (STAT1) OTLMBUZ6 STAT1_HUMAN Gene/Protein Processing [3]
Signal transducer and activator of transcription 2 (STAT2) OTO9G2RZ STAT2_HUMAN Post-Translational Modifications [3]
Signal transducer and activator of transcription 3 (STAT3) OTAAGKYZ STAT3_HUMAN Post-Translational Modifications [3]
Tyrosine-protein kinase JAK1 (JAK1) OT0X3D17 JAK1_HUMAN Gene/Protein Processing [3]

References

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23 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
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