Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMY29Q8)

Drug Name
Calyculin-A Drug Info
Synonyms
calyculin A; C05370; 101932-71-2; [(3R,5R,7R,8S,9S)-2-[(1S,3S,4S,5R,6R,7E,9E,11E,13Z)-14-cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyl-tetradeca-7,9,11,13-tetraenyl]-9-[(E)-3-[2-[(1S)-3-[[(2S,3S,4S)-4-(dimethylamino)-2,3-dihydroxy-5-methoxy-pentanoyl]amino]-1-methyl-propyl]oxazol-4-yl]allyl]-7-hydroxy-4,4,8-trimethyl-1,10-dioxaspiro[4.5]decan-3-yl] dihydrogen phosphate
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5311365
CAS Number
CAS 101932-71-2
TTD Drug ID
DMY29Q8

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Solute carrier family 12 member 1 (SLC12A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [6]
Potassium Chloride DMMTAJC Hypokalemia 5C77 Approved [7]
Furosemide DMMQ8ZG Congestive heart failure BD10 Approved [8]
Bumetanide DMRV7H0 Congestive heart failure BD10 Approved [9]
Ethacrynic acid DM60QMR Edema MG29 Approved [10]
Torasemide DMXKJ6C Congestive heart failure BD10 Approved [11]
Bendroflumethiazide DM7EVLC High blood pressure BA00 Approved [12]
Trichlormethiazide DMHAQCO Hypertension BA00-BA04 Approved [13]
Hydroflumethiazide DMVPUQI Congestive heart failure BD10 Approved [12]
Methyclothiazide DMN7SDE Edema MG29 Approved [12]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein c-Fos (FOS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [14]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [15]
Verapamil DMA7PEW Angina pectoris BA40 Approved [16]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [17]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [16]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [18]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [19]
Methotrexate DM2TEOL Anterior urethra cancer Approved [20]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [21]
Quercetin DM3NC4M Obesity 5B81 Approved [22]
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Drug(s) Affected By Plastin-2 (LCP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [23]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [24]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [26]
Hydroxyflutamide DMGIZF5 Prostate cancer 2C82.0 Approved [27]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [28]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [29]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [30]
Arsenic DMTL2Y1 N. A. N. A. Approved [31]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [32]
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Drug(s) Affected By Leukemia inhibitory factor (LIF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [33]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [34]
Methotrexate DM2TEOL Anterior urethra cancer Approved [35]
Quercetin DM3NC4M Obesity 5B81 Approved [36]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [38]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [39]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [40]
Leflunomide DMR8ONJ Arthritis FA20 Approved [41]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [42]
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Drug(s) Affected By Catenin beta-1 (CTNNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [43]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [19]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [44]
Quercetin DM3NC4M Obesity 5B81 Approved [45]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [46]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [47]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [48]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [49]
Testosterone DM7HUNW Hot flushes GA30 Approved [50]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [51]
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Drug(s) Affected By CREB-binding protein (CREBBP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [52]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [54]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [55]
Testosterone DM7HUNW Hot flushes GA30 Approved [56]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [57]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [58]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [59]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [30]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [60]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Solute carrier family 12 member 1 (SLC12A1) TTS087L S12A1_HUMAN Blocker [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Post-Translational Modifications [2]
CREB-binding protein (CREBBP) OTPA4QGM CBP_HUMAN Post-Translational Modifications [3]
Leukemia inhibitory factor (LIF) OTO46S5S LIF_HUMAN Gene/Protein Processing [3]
Plastin-2 (LCP1) OTK61F2A PLSL_HUMAN Post-Translational Modifications [4]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Gene/Protein Processing [5]

References

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35 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
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41 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
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60 CXCL14 downregulation in human keratinocytes is a potential biomarker for a novel in vitro skin sensitization test. Toxicol Appl Pharmacol. 2020 Jan 1;386:114828. doi: 10.1016/j.taap.2019.114828. Epub 2019 Nov 14.