Details of the Drug Reposition

General Information of This Drug (ID: DMZEPFJ)

Drug Name
Demeclocycline   DMZEPFJ
Synonyms
Bioterciclin; Clortetrin; DMCT; DMCTC; Declomycin; Deganol; Demeclociclina; Demeclocyclinum; Demeclor; Demethylchlorotetracycline; Demethylchlortetracyclin; Demethylchlortetracycline; Demethylchlortetracyclinum; Demetraclin; Diuciclin; Ledermycin; Methylchlorotetracycline; Mexocine; Novotriclina; Perciclina; Sumaclina; Demeclocycline Monohydrochloride; Demethylchlortetracycline base; Ledermycin hydrochloride; RP 10192; DMCT (antibiotic); Declomycin (TN); Declostatin (TN); Demeclociclina [INN-Spanish]; Demeclocycline (USP); Demeclocycline [USAN:BAN]; Demeclocyclinum [INN-Latin]; Demethylchlortetracycline (JAN); Ledermycin (TN); Tri-demethylchlortetracycline; [4S-(4alpha,4aalpha,5aalpha,6beta,12aalpha)]-7-chloro-4-(dimethylamino)1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide; (2E)-2-[amino(hydroxy)methylidene]-7-chloro-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione; (2E,4S,4aS,5aS,6R,12aR)-2-[amino(hydroxy)methylidene]-7-chloro-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione; (2E,4S,4aS,5aS,6S,12aS)-2-[amino(hydroxy)methylidene]-7-chloro-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione; (2Z,4S,4aS,5aS,6S,12aS)-2-[amino(hydroxy)methylidene]-7-chloro-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione; (4S,4aS,5aS,6S,12aS)-7-chloro-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide; 2-[amino(hydroxy)methylidene]-7-chloro-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione; 6-Demethyl-7-chlorotetracycline; 6-Demethyl-7-chlortetracycline; 6-Demethylchlorotetracycline; 6-Demethylchlortetracycline; 6-Demetil-7-clorotetraciclina; 6-Demetil-7-clorotetraciclina [Italian]; 7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide; 7-Chloro-4-dimethylamino-3,6,10,12,12a-pentahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide; 7-Chloro-6-demethyltetracycline
Therapeutic Class
Antibiotics
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

Information on Drug Reposition of This Drug

Molecular Interaction Atlas (MIA)
20 Approved Indication(s)
Indication Name Indication ID ICD-11 Status REF
Yaws DISLTH3X N.A. Approved [1]
Typhus DISJ5JX1 N.A. Approved [1]
Trachoma DIS2WZUR N.A. Approved [1]
Syphilis DISJ73BS N.A. Approved [1]
Staphylococcus aureus infection DISK6PTH N.A. Approved [1]
Rocky mountain spotted fever DISFN72S N.A. Approved [1]
Rickettsialpox DISEMENW N.A. Approved [1]
Relapsing fever DISEA4L7 N.A. Approved [1]
Q fever DISK1S90 N.A. Approved [1]
Ornithosis DIS4YMZ8 N.A. Approved [1]
Lymphogranuloma venereum DIS0MMFT N.A. Approved [1]
Chancroid DISMVLOF N.A. Approved [1]
Brucellosis DISEAYGH N.A. Approved [1]
Acute gonococcal cervicitis DIS4LKDT N.A. Approved [1]
Actinomycosis DIS7YFRP N.A. Approved [1]
Lyme disease DISO70G5 1C1G Approved [2]
Bronchitis DISBM6EQ CA20 Approved [2]
Pneumonia DIS8EF3M CA40 Approved [1]
Acne vulgaris DISKW8PI ED80 Approved [2]
Urinary tract infection DISMT6UV GC08 Approved [1]
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⏷ Show the Full List of 20 Indications(s)
1 Withdrawn Indication(s)
Indication Name Indication ID ICD-11 Status REF
Acute gonococcal endometritis DISZ8BW7 N.A. Withdrawn [3]
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1 Discontinued in Phase 3 Indication(s)
Indication Name Indication ID ICD-11 Status REF
Granuloma inguinale DISRKXBH N.A. Discontinued in Phase 3 [4]
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2 Discontinued in Phase 2 Indication(s)
Indication Name Indication ID ICD-11 Status REF
Gonorrhea DISQ5AO6 1A7Z Discontinued in Phase 2 [5]
Pharyngitis DISSN548 CA02.Z Discontinued in Phase 2 [6]
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1 Investigative Indication(s)
Indication Name Indication ID ICD-11 Status REF
Sinusitis DISX5NCF CA0A.Z Investigative [1]
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References

1 Demeclocycline FDA Label
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3 ClinicalTrials.gov (NCT01843179) Sulindac for Patients With AML
4 Atorvastatin Therapy for the Prevention of Atrial Fibrillation (SToP-AF)
5 Radiolabeled Monoclonal Antibody Plus Rituximab With and Without Filgrastim and Interleukin-11 in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma
6 Metformin Plus Paclitaxel for Metastatic or Recurrent Head and Neck Cancer