Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTP (ID: DTVP67E)

• DTP Name: Organic anion transporter 3 (SLC22A8) DTP Info
• Gene Name: OAT3

Molecule-Related Drug & Molecule List

38 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aciclovir	DMYLOVR	Genital herpes	1A94	Approved	[1]
Adefovir	DMM278X	N. A.	N. A.	Approved	[2]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[3]
Bumetanide	DMRV7H0	Congestive heart failure	BD10	Approved	[4]
Cefaclor	DMJXDGC	Bacterial infection	1A00-1C4Z	Approved	[5]
Cefazolin	DMPDYFR	Bacteremia	1A73	Approved	[6]
Cefdinir	DMJ7A0H	Bacterial infection	1A00-1C4Z	Approved	[5]
Cefotiam	DMF5HU6	Respiratory tract infection	CA45	Approved	[7]
Ceftizoxime	DM3VOGS	Acute gonococcal cervicitis		Approved	[5]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[8]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[9]
Cilostazol	DMZMSCT	Intermittent claudication	BD40.00	Approved	[10]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[11]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[12]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[13]
Estrone sulfate	DMVBIZL	Atrophic vaginitis	GA30.2	Approved	[14]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[15]
Furosemide	DMMQ8ZG	Congestive heart failure	BD10	Approved	[4]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[2]
L-Tryptophan	DMIBH7M	Depression	6A70-6A7Z	Approved	[16]
MCI-186	DM8ZHP1	Amyotrophic lateral sclerosis	8B60.0	Approved	[17]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[18]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Olmesartan medoxomil	DMWBHRY	High blood pressure	BA00	Approved	[20]
Oseltamivir	DMGO72P	Influenza	1E30-1E32	Approved	[2]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[21]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[22]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[23]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[15]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[24]
Saxagliptin	DMGXENV	Type-2 diabetes	5A11	Approved	[25]
Sitagliptin	DMGDKXN	Cystic fibrosis	CA25	Approved	[11]
Tenofovir	DM1IS6U	Chronic hepatitis B virus infection		Approved	[26]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[27]
Trichlormethiazide	DMHAQCO	Hypertension	BA00-BA04	Approved	[23]
Valaciclovir	DMHKS94	Genital herpes	1A94	Approved	[28]
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[23]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[28]

3 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzylpenicillin	DMS9503	Actinomycosis		Phase 3	[23]
Dimesna	DMU4T9Y	Diabetic nephropathy	GB61.Z	Phase 3	[29]
PGF2alpha	DM4XAU7	Solid tumour/cancer	2A00-2F9Z	Clinical trial	[13]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cephaloridine	DM4Y95F	Gram-positive bacterial infection	1B74-1G40	Withdrawn from market	[5]

4 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[30]
AMINOHIPPURIC ACID	DMUN54G	Discovery agent	N.A.	Investigative	[22]
Phenolsulfonphthalein	DMCTUAD	N. A.	N. A.	Investigative	[6]
uric acid	DMA1MKT	Discovery agent	N.A.	Investigative	[31]

References

• [1] Expression of organic anion transporter 2 in the human kidney and its potential role in the tubular secretion of guanine-containing antiviral drugs. Drug Metab Dispos. 2012 Mar;40(3):617-24.
• [2] FDA Drug Development and Drug Interactions
• [3] Renal transport of organic compounds mediated by mouse organic anion transporter 3 (mOat3): further substrate specificity of mOat3. Drug Metab Dispos. 2004 May;32(5):479-83.
• [4] Interactions of human organic anion transporters with diuretics. J Pharmacol Exp Ther. 2004 Mar;308(3):1021-9.
• [5] Human organic anion transporter hOAT3 is a potent transporter of cephalosporin antibiotics, in comparison with hOAT1. Biochem Pharmacol. 2005 Oct 1;70(7):1104-13.
• [6] Expression levels of renal organic anion transporters (OATs) and their correlation with anionic drug excretion in patients with renal diseases. Pharm Res. 2004 Jan;21(1):61-7.
• [7] Adaptive responses of renal organic anion transporter 3 (OAT3) during cholestasis. Am J Physiol Renal Physiol. 2008 Jul;295(1):F247-52.
• [8] Overlapping in vitro and in vivo specificities of the organic anion transporters OAT1 and OAT3 for loop and thiazide diuretics. Am J Physiol Renal Physiol. 2008 Apr;294(4):F867-73.
• [9] Renal transport of adefovir, cidofovir, and tenofovir by SLC22A family members (hOAT1, hOAT3, and hOCT2). Pharm Res. 2007 Apr;24(4):811-5.
• [10] Aspirin and probenecid inhibit organic anion transporter 3-mediated renal uptake of cilostazol and probenecid induces metabolism of cilostazol in the rat. Drug Metab Dispos. 2014 Jun;42(6):996-1007.
• [11] Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4C1, and multidrug resistance P-glycoprotein. J Pharmacol Exp Ther. 2007 May;321(2):673-83.
• [12] Organic anion transporter 3 (oat3/slc22a8) interacts with carboxyfluoroquinolones, and deletion increases systemic exposure to ciprofloxacin. Mol Pharmacol. 2008 Jul;74(1):122-31.
• [13] Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J Pharmacol Exp Ther. 2002 Apr;301(1):293-8.
• [14] Involvement of tyrosine kinase and PI3K in the regulation of OAT3-mediated estrone sulfate transport in isolated rabbit renal proximal tubules. Am J Physiol Renal Physiol. 2005 Nov;289(5):F1057-64.
• [15] A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters. J Pharmacol Exp Ther. 2005 Oct;315(1):337-45.
• [16] Murine renal organic anion transporters mOAT1 and mOAT3 facilitate the transport of neuroactive tryptophan metabolites. Am J Physiol Cell Physiol. 2005 Nov;289(5):C1075-84.
• [17] Human organic anion transporters 1 (hOAT1/SLC22A6) and 3 (hOAT3/SLC22A8) transport edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5-one) and its sulfate conjugate. Drug Metab Dispos. 2007 Aug;35(8):1429-34.
• [18] Organic anion transporter 3 is involved in the brain-to-blood efflux transport of thiopurine nucleobase analogs. J Neurochem. 2004 Aug;90(4):931-41.
• [19] Methotrexate-loxoprofen interaction: involvement of human organic anion transporters hOAT1 and hOAT3. Drug Metab Pharmacokinet. 2004 Oct;19(5):369-74.
• [20] Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor. Drug Metab Dispos. 2007 Dec;35(12):2166-76.
• [21] Transporter-mediated influx and efflux mechanisms of pitavastatin, a new inhibitor of HMG-CoA reductase. J Pharm Pharmacol. 2005 Oct;57(10):1305-11.
• [22] Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol. 2001 May;59(5):1277-86.
• [23] Prediction of the overall renal tubular secretion and hepatic clearance of anionic drugs and a renal drug-drug interaction involving organic anion transporter 3 in humans by in vitro uptake experiments. Drug Metab Dispos. 2011 Jun;39(6):1031-8.
• [24] The contribution of organic anion transporters OAT1 and OAT3 to the renal uptake of rosuvastatin. J Pharmacol Exp Ther. 2007 Sep;322(3):1221-7.
• [25] Comparative clinical pharmacokinetics of dipeptidyl peptidase-4 inhibitors. Clin Pharmacokinet. 2012 Aug 1;51(8):501-14.
• [26] Tenofovir alafenamide is not a substrate for renal organic anion transporters (OATs) and does not exhibit OAT-dependent cytotoxicity. Antivir Ther. 2014;19(7):687-92.
• [27] Human organic anion transporters mediate the transport of tetracycline. Jpn J Pharmacol. 2002 Jan;88(1):69-76.
• [28] Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24.
• [29] In vitro and in vivo assessment of renal drug transporters in the disposition of mesna and dimesna. J Clin Pharmacol. 2012 Apr;52(4):530-42.
• [30] Characterization of ochratoxin A transport by human organic anion transporters. Life Sci. 2001 Sep 21;69(18):2123-35.
• [31] Involvement of uric acid transporters in alteration of serum uric acid level by angiotensin II receptor blockers. Pharm Res. 2008 Mar;25(3):639-46.