Details of the Drug Combination

General Information of Drug Combination (ID: DCWTM2A)

• Drug Combination Name: Bortezomib + Azacitidine
• Indication: Leukemia; Status: Phase 1 [1]
• Component Drugs:
  Bortezomib (DMNO38U): Small molecular drug
  Azacitidine (DMTA5OE): Small molecular drug

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Bortezomib

Disease Entry	ICD 11	Status	REF
Leukemia	N.A.	Approved	[2]
Lung cancer	2C25.0	Approved	[2]
Lymphoproliferative syndrome	N.A.	Approved	[2]
MALT lymphoma	N.A.	Approved	[2]
Mantle cell lymphoma	2A85.5	Approved	[3]
Minimally invasive lung adenocarcinoma	N.A.	Approved	[2]
Multiple myeloma	2A83	Approved	[4]
Nodal marginal zone lymphoma	2A85.0	Approved	[2]
Plasma cell myeloma	2A83.1	Approved	[2]
Recurrent adult burkitt lymphoma	2A85.6	Approved	[2]
Non-hodgkin lymphoma	2B33.5	Phase 3	[4]
B-cell neoplasm	N.A.	Investigative	[2]
Colon cancer	2B90.Z	Investigative	[2]
Gastric cancer	2B72	Investigative	[2]

Bortezomib Interacts with 3 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Cationic trypsinogen (PRSS1)	TT2WR1T	TRY1_HUMAN	Inhibitor	[13]
Kallikrein-related peptidase (KLK)	TT5L2VC	NOUNIPROTAC	Inhibitor	[13]
Proteasome (PS)	TTU7ZMG	NOUNIPROTAC	Modulator	[14]

Bortezomib Interacts with 1 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[15]

Bortezomib Interacts with 5 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[16]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Metabolism	[17]
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Metabolism	[18]
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Metabolism	[19]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Metabolism	[18]

Bortezomib Interacts with 549 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Decreases Expression	[20]
Extended synaptotagmin-2 (ESYT2)	OTWCXTX3	ESYT2_HUMAN	Decreases Expression	[7]
Alternative prion protein (PRNP)	OTE85L1Q	APRIO_HUMAN	Increases Expression	[7]
Cytosolic acyl coenzyme A thioester hydrolase (ACOT7)	OT7C68YV	BACH_HUMAN	Decreases Expression	[7]
GTP-binding protein 1 (GTPBP1)	OTA9KV6C	GTPB1_HUMAN	Decreases Expression	[7]
Galectin-8 (LGALS8)	OT71LJ8T	LEG8_HUMAN	Increases Expression	[7]
26S proteasome non-ATPase regulatory subunit 12 (PSMD12)	OTWICA51	PSD12_HUMAN	Increases Expression	[7]
Leukocyte-specific transcript 1 protein (LST1)	OTUVG424	LST1_HUMAN	Decreases Expression	[7]
Agrin (AGRN)	OTWJENAZ	AGRIN_HUMAN	Decreases Expression	[7]
Krev interaction trapped protein 1 (KRIT1)	OT58AP1I	KRIT1_HUMAN	Increases Expression	[7]
Beta-1,3-N-acetylglucosaminyltransferase manic fringe (MFNG)	OTUX45ZF	MFNG_HUMAN	Decreases Expression	[7]
Pirin (PIR)	OT8ALXHU	PIR_HUMAN	Increases Expression	[7]
Stearoyl-CoA desaturase (SCD)	OTB1073G	SCD_HUMAN	Decreases Expression	[7]
TRAF-type zinc finger domain-containing protein 1 (TRAFD1)	OT7AU2R3	TRAD1_HUMAN	Increases Expression	[7]
Cytoplasmic dynein 1 intermediate chain 1 (DYNC1I1)	OTFX1KCG	DC1I1_HUMAN	Increases Expression	[7]
Chromodomain-helicase-DNA-binding protein 2 (CHD2)	OTRKL6YC	CHD2_HUMAN	Increases Expression	[7]
Golgi SNAP receptor complex member 2 (GOSR2)	OTYHIYN2	GOSR2_HUMAN	Increases Expression	[7]
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10)	OTOKUXUH	ADA10_HUMAN	Decreases Expression	[7]
Apolipoprotein L1 (APOL1)	OT8QBVTY	APOL1_HUMAN	Increases Expression	[7]
Interferon-inducible protein AIM2 (AIM2)	OT86QUI8	AIM2_HUMAN	Increases Expression	[7]
Myosin regulatory light chain 12B (MYL12B)	OTXMLQOT	ML12B_HUMAN	Increases Expression	[7]
Centrosomal protein of 290 kDa (CEP290)	OTVN52VH	CE290_HUMAN	Increases Expression	[7]
Small ribosomal subunit protein uS12m (MRPS12)	OTGY4GIX	RT12_HUMAN	Decreases Expression	[7]
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT)	OT1Z1ZXE	OGT1_HUMAN	Decreases Expression	[7]
V-type proton ATPase subunit e 1 (ATP6V0E1)	OTZZIUYY	VA0E1_HUMAN	Increases Expression	[7]
ATP-binding cassette sub-family C member 4 (ABCC4)	OTO27PAL	MRP4_HUMAN	Decreases Expression	[7]
Transcription factor MafG (MAFG)	OTBQFUZH	MAFG_HUMAN	Increases Expression	[7]
Interleukin-1 receptor-associated kinase-like 2 (IRAK2)	OT6Y1QZN	IRAK2_HUMAN	Increases Expression	[7]
PHD finger protein 1 (PHF1)	OTW2PSIR	PHF1_HUMAN	Increases Expression	[7]
Synaptogyrin-2 (SYNGR2)	OTJX84RI	SNG2_HUMAN	Decreases Expression	[7]
Cytohesin-interacting protein (CYTIP)	OTRJ3ZC5	CYTIP_HUMAN	Increases Expression	[7]
Growth arrest-specific protein 7 (GAS7)	OT0M5TNY	GAS7_HUMAN	Decreases Expression	[7]
Glycosaminoglycan xylosylkinase (FAM20B)	OTOA0UYT	XYLK_HUMAN	Decreases Expression	[7]
Suppressor of cytokine signaling 5 (SOCS5)	OTN1ABYR	SOCS5_HUMAN	Increases Expression	[7]
Protein tyrosine phosphatase type IVA 3 (PTP4A3)	OTXMMWUN	TP4A3_HUMAN	Decreases Expression	[7]
Deformed epidermal autoregulatory factor 1 homolog (DEAF1)	OTCLX3ZW	DEAF1_HUMAN	Decreases Expression	[7]
Calpain-15 (CAPN15)	OT0WE161	CAN15_HUMAN	Decreases Expression	[7]
Carbonyl reductase 3 (CBR3)	OT9G6SF0	CBR3_HUMAN	Increases Expression	[7]
Triple functional domain protein (TRIO)	OT71X1AK	TRIO_HUMAN	Decreases Expression	[7]
Cystatin-F (CST7)	OTQWZUVQ	CYTF_HUMAN	Increases Expression	[7]
ATP-dependent DNA helicase Q4 (RECQL4)	OT59LSW7	RECQ4_HUMAN	Increases Expression	[7]
Erlin-2 (ERLIN2)	OT551BVG	ERLN2_HUMAN	Decreases Expression	[7]
Pre-mRNA-processing factor 6 (PRPF6)	OT3U0ABN	PRP6_HUMAN	Decreases Expression	[7]
Lysine-specific demethylase 4B (KDM4B)	OT5P1UPY	KDM4B_HUMAN	Decreases Expression	[7]
Methyl-CpG-binding domain protein 4 (MBD4)	OTWR9YXE	MBD4_HUMAN	Increases Expression	[7]
Arginyl-tRNA--protein transferase 1 (ATE1)	OT3QNM39	ATE1_HUMAN	Increases Expression	[7]
GDH/6PGL endoplasmic bifunctional protein (H6PD)	OTO7TNDD	G6PE_HUMAN	Decreases Expression	[7]
NAD kinase (NADK)	OTYN9GX0	NADK_HUMAN	Decreases Expression	[7]
AP-2 complex subunit alpha-1 (AP2A1)	OTEFZB21	AP2A1_HUMAN	Decreases Expression	[7]
Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4)	OTBMJUOC	M4K4_HUMAN	Increases Expression	[7]
Phosphatidylserine lipase ABHD16A (ABHD16A)	OTDS9K1Z	ABHGA_HUMAN	Increases Expression	[7]
G patch domain and ankyrin repeat-containing protein 1 (GPANK1)	OT1TN2KT	GPAN1_HUMAN	Increases Expression	[7]
Putative lipid scramblase CLPTM1 (CLPTM1)	OT14QP7N	CLPT1_HUMAN	Decreases Expression	[7]
HLA class II histocompatibility antigen, DR alpha chain (HLA-DRA)	OT7KZMP2	DRA_HUMAN	Decreases Expression	[7]
Thy-1 membrane glycoprotein (THY1)	OTVONVTB	THY1_HUMAN	Decreases Expression	[7]
HLA class II histocompatibility antigen, DP beta 1 chain (HLA-DPB1)	OTW8JHU2	DPB1_HUMAN	Decreases Expression	[7]
HLA class II histocompatibility antigen, DO alpha chain (HLA-DOA)	OTZE5Q7R	DOA_HUMAN	Decreases Expression	[7]
Trypsin-2 (PRSS2)	OTOMVUWL	TRY2_HUMAN	Decreases Expression	[7]
Prosaposin (PSAP)	OTUOEKY7	SAP_HUMAN	Increases Expression	[7]
Guanine nucleotide-binding protein G(i) subunit alpha-3 (GNAI3)	OT89UWAR	GNAI3_HUMAN	Increases Expression	[7]
Monoacylglycerol lipase ABHD2 (ABHD2)	OTCRUOCS	ABHD2_HUMAN	Increases Expression	[7]
Gamma-enolase (ENO2)	OTRODL0T	ENOG_HUMAN	Increases Expression	[7]
Tropomyosin alpha-1 chain (TPM1)	OTD73X6R	TPM1_HUMAN	Increases Expression	[7]
Cancer/testis antigen family 45 member A6 (CT45A5)	OTIFETOM	CT456_HUMAN	Increases Expression	[7]
Schwannomin-interacting protein 1 (SCHIP1)	OTF3FR4A	SCHI1_HUMAN	Decreases Expression	[7]
Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3)	OT2HZK5M	GTR3_HUMAN	Increases Expression	[7]
Ras-related protein Ral-A (RALA)	OT734R7X	RALA_HUMAN	Increases Expression	[7]
B-cell antigen receptor complex-associated protein alpha chain (CD79A)	OTOJC8DV	CD79A_HUMAN	Decreases Expression	[7]
Granzyme A (GZMA)	OT43R33L	GRAA_HUMAN	Decreases Expression	[7]
Cytochrome b-245 light chain (CYBA)	OT16N9ZO	CY24A_HUMAN	Decreases Expression	[7]
Sodium/potassium-transporting ATPase subunit alpha-3 (ATP1A3)	OTM8EG6H	AT1A3_HUMAN	Decreases Expression	[7]
Perforin-1 (PRF1)	OTFVXD7H	PERF_HUMAN	Decreases Expression	[7]
Ras-related C3 botulinum toxin substrate 2 (RAC2)	OTAOHFNH	RAC2_HUMAN	Decreases Expression	[7]
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)	OT18H1B0	ERF3A_HUMAN	Decreases Expression	[7]
Cyclic AMP-dependent transcription factor ATF-2 (ATF2)	OTNIZPEA	ATF2_HUMAN	Increases Expression	[7]
Immunoglobulin lambda-like polypeptide 1 (IGLL1)	OTRTNVOG	IGLL1_HUMAN	Decreases Expression	[7]
Transcription factor JunD (JUND)	OTNKACJD	JUND_HUMAN	Decreases Expression	[7]
Ras-related protein Rab-5A (RAB5A)	OTFR2KM4	RAB5A_HUMAN	Decreases Expression	[7]
B-cell lymphoma 3 protein (BCL3)	OT1M5B95	BCL3_HUMAN	Decreases Expression	[7]
5'-nucleotidase (NT5E)	OT7J5LT6	5NTD_HUMAN	Decreases Expression	[7]
CD9 antigen (CD9)	OT2184XU	CD9_HUMAN	Increases Expression	[7]
Tyrosine-protein kinase JAK1 (JAK1)	OT0X3D17	JAK1_HUMAN	Decreases Expression	[7]
ER lumen protein-retaining receptor 1 (KDELR1)	OT8YBS5G	ERD21_HUMAN	Decreases Expression	[7]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)	OTDRV63V	GA45A_HUMAN	Increases Expression	[7]
NKG2-D type II integral membrane protein (KLRK1)	OTQWXK71	NKG2D_HUMAN	Decreases Expression	[7]
CD82 antigen (CD82)	OTH8MC64	CD82_HUMAN	Decreases Expression	[7]
HLA class II histocompatibility antigen, DM beta chain (HLA-DMB)	OT17HGXJ	DMB_HUMAN	Decreases Expression	[7]
Flavin reductase (BLVRB)	OTHCFN2C	BLVRB_HUMAN	Increases Expression	[7]
G1/S-specific cyclin-D2 (CCND2)	OTDULQF9	CCND2_HUMAN	Decreases Expression	[7]
14-3-3 protein sigma (SFN)	OTLJCZ1U	1433S_HUMAN	Increases Expression	[7]
Stress-induced-phosphoprotein 1 (STIP1)	OT7TXLOX	STIP1_HUMAN	Decreases Expression	[7]
Guanylate-binding protein 2 (GBP2)	OTVU4G07	GBP2_HUMAN	Increases Expression	[7]
Transcription factor 7 (TCF7)	OT1ID822	TCF7_HUMAN	Decreases Expression	[7]
Pre-B-cell leukemia transcription factor 3 (PBX3)	OT8WMVM4	PBX3_HUMAN	Decreases Expression	[7]
Trifunctional enzyme subunit alpha, mitochondrial (HADHA)	OTO557N2	ECHA_HUMAN	Increases Expression	[7]
Eukaryotic translation initiation factor 2 subunit 3 (EIF2S3)	OTARRES9	IF2G_HUMAN	Decreases Expression	[7]
Eukaryotic translation initiation factor 1 (EIF1)	OTB4GZ0V	EIF1_HUMAN	Increases Expression	[7]
5-hydroxytryptamine receptor 2B (HTR2B)	OTM1AD9J	5HT2B_HUMAN	Decreases Expression	[7]
Lamina-associated polypeptide 2, isoform alpha (TMPO)	OTL68EL4	LAP2A_HUMAN	Decreases Expression	[7]
ETS translocation variant 4 (ETV4)	OT8C98UZ	ETV4_HUMAN	Decreases Expression	[7]
Killer cell immunoglobulin-like receptor 2DS4 (KIR2DS4)	OT00N6UJ	KI2S4_HUMAN	Decreases Expression	[7]
26S proteasome regulatory subunit 6B (PSMC4)	OTS3XN41	PRS6B_HUMAN	Increases Expression	[7]
Lys-63-specific deubiquitinase BRCC36 (BRCC3)	OTK0ZN7Y	BRCC3_HUMAN	Decreases Expression	[7]
LIM and senescent cell antigen-like-containing domain protein 1 (LIMS1)	OT729S0T	LIMS1_HUMAN	Increases Expression	[7]
Large ribosomal subunit protein bL19m (MRPL19)	OTRBKF6R	RM19_HUMAN	Increases Expression	[7]
Ubiquitin-conjugating enzyme E2 R1 (CDC34)	OTNBK390	UB2R1_HUMAN	Increases Expression	[7]
Choline-phosphate cytidylyltransferase A (PCYT1A)	OTMH0YLN	PCY1A_HUMAN	Increases Expression	[7]
Protein phosphatase 1F (PPM1F)	OTU0MVR7	PPM1F_HUMAN	Increases Expression	[7]
Protein numb homolog (NUMB)	OTMB586Q	NUMB_HUMAN	Increases Expression	[7]
Cytosolic purine 5'-nucleotidase (NT5C2)	OTJMF66Z	5NTC_HUMAN	Increases Expression	[7]
DNA ligase 4 (LIG4)	OT40DNXU	DNLI4_HUMAN	Increases Expression	[7]
Dynamin-2 (DNM2)	OTUYU2U3	DYN2_HUMAN	Decreases Expression	[7]
Poly(A) polymerase alpha (PAPOLA)	OTPHD65D	PAPOA_HUMAN	Decreases Expression	[7]
Tyrosine-protein kinase Blk (BLK)	OT1EB8MT	BLK_HUMAN	Decreases Expression	[7]
26S proteasome non-ATPase regulatory subunit 7 (PSMD7)	OT7PZZ4K	PSMD7_HUMAN	Increases Expression	[7]
AF4/FMR2 family member 1 (AFF1)	OTT2C78E	AFF1_HUMAN	Increases Expression	[7]
Importin subunit alpha-1 (KPNA2)	OTU7FOE6	IMA1_HUMAN	Increases Expression	[7]
Diacylglycerol kinase epsilon (DGKE)	OTWS86AS	DGKE_HUMAN	Decreases Expression	[7]
Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6)	OTK13JKC	MP2K6_HUMAN	Decreases Expression	[7]
Rho GDP-dissociation inhibitor 1 (ARHGDIA)	OTEXWJDO	GDIR1_HUMAN	Decreases Expression	[7]
Cysteine-rich protein 2 (CRIP2)	OTVVJSYX	CRIP2_HUMAN	Decreases Expression	[7]
Delta-1-pyrroline-5-carboxylate synthase (ALDH18A1)	OT6W40XU	P5CS_HUMAN	Decreases Expression	[7]
Myc-associated zinc finger protein (MAZ)	OTEHKN1M	MAZ_HUMAN	Decreases Expression	[7]
ADP-ribosylation factor-like protein 4C (ARL4C)	OTQ3QNNU	ARL4C_HUMAN	Decreases Expression	[7]
Small integral membrane protein 11 (SMIM11)	OTZPLVUC	SIM11_HUMAN	Decreases Expression	[7]
Triosephosphate isomerase (TPI1)	OT14KP4B	TPIS_HUMAN	Increases Expression	[7]
Cell division control protein 42 homolog (CDC42)	OT5QBC5M	CDC42_HUMAN	Decreases Expression	[7]
Large ribosomal subunit protein uL24 (RPL26)	OTFNRC27	RL26_HUMAN	Increases Expression	[7]
cAMP-dependent protein kinase inhibitor alpha (PKIA)	OT8M5GVO	IPKA_HUMAN	Increases Expression	[7]
AP-1 complex subunit sigma-1A (AP1S1)	OTQ2H8DN	AP1S1_HUMAN	Decreases Expression	[7]
Small ribosomal subunit protein uS17 (RPS11)	OTILZE44	RS11_HUMAN	Increases Expression	[7]
ADP-ribosylation factor 6 (ARF6)	OTVV7KJO	ARF6_HUMAN	Increases Expression	[7]
Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A)	OT6285L4	FKB1A_HUMAN	Decreases Expression	[7]
Calcineurin subunit B type 1 (PPP3R1)	OTGQNFJQ	CANB1_HUMAN	Decreases Expression	[7]
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PPP2R2A)	OT9297OG	2ABA_HUMAN	Increases Expression	[7]
Small ribosomal subunit protein uS5m (MRPS5)	OTZZR208	RT05_HUMAN	Decreases Expression	[7]
Spectrin beta chain, non-erythrocytic 1 (SPTBN1)	OTOVM4D4	SPTB2_HUMAN	Increases Expression	[7]
Large neutral amino acids transporter small subunit 1 (SLC7A5)	OT2WPVXD	LAT1_HUMAN	Decreases Expression	[7]
2-oxoglutarate dehydrogenase complex component E1 (OGDH)	OTHGTQWF	ODO1_HUMAN	Decreases Expression	[7]
Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase , mitochondrial (ALDH6A1)	OT8LCZCT	MMSA_HUMAN	Decreases Expression	[7]
Mitochondrial 2-oxoglutarate/malate carrier protein (SLC25A11)	OT7EVFBK	M2OM_HUMAN	Decreases Expression	[7]
cAMP-responsive element modulator (CREM)	OTJIJ5AL	CREM_HUMAN	Increases Expression	[7]
Centromere protein C (CENPC)	OTVJ6VE9	CENPC_HUMAN	Increases Expression	[7]
Transcription factor p65 (RELA)	OTUJP9CN	TF65_HUMAN	Decreases Expression	[7]
Neurogenic locus notch homolog protein 2 (NOTCH2)	OTQ3Y9PA	NOTC2_HUMAN	Decreases Expression	[7]
CTD small phosphatase-like protein 2 (CTDSPL2)	OTPF8W4P	CTSL2_HUMAN	Decreases Expression	[7]
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)	OTFH9M73	PTN11_HUMAN	Decreases Expression	[7]
Serine/arginine-rich splicing factor 1 (SRSF1)	OTF61HOV	SRSF1_HUMAN	Decreases Expression	[7]
Rho GTPase-activating protein 1 (ARHGAP1)	OT0H2ZBZ	RHG01_HUMAN	Decreases Expression	[7]
FACT complex subunit SSRP1 (SSRP1)	OT5TYJK9	SSRP1_HUMAN	Decreases Expression	[7]
Sodium/bile acid cotransporter 7 (SLC10A7)	OTYLAWNV	NTCP7_HUMAN	Increases Expression	[7]
Apolipoprotein B receptor (APOBR)	OT9EUZX3	APOBR_HUMAN	Decreases Expression	[7]
Nuclear factor 1 A-type (NFIA)	OTDHQ9CG	NFIA_HUMAN	Decreases Expression	[7]
Interferon-related developmental regulator 2 (IFRD2)	OT2URF18	IFRD2_HUMAN	Decreases Expression	[7]
Protein AF1q (MLLT11)	OTG5RVHC	AF1Q_HUMAN	Increases Expression	[7]
PR domain zinc finger protein 2 (PRDM2)	OT8L7CGX	PRDM2_HUMAN	Decreases Expression	[7]
Dual specificity protein phosphatase 4 (DUSP4)	OT6WAO12	DUS4_HUMAN	Decreases Expression	[7]
Chromobox protein homolog 3 (CBX3)	OTOP9RLD	CBX3_HUMAN	Increases Expression	[7]
Phosducin-like protein (PDCL)	OTDNHIXG	PHLP_HUMAN	Increases Expression	[7]
DNA-binding protein Ikaros (IKZF1)	OTCW1FKL	IKZF1_HUMAN	Decreases Expression	[7]
Protein OS-9 (OS9)	OTB5B2TY	OS9_HUMAN	Increases Expression	[7]
Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5)	OT404F9K	FKBP5_HUMAN	Decreases Expression	[7]
Transformer-2 protein homolog alpha (TRA2A)	OT5NHOO3	TRA2A_HUMAN	Decreases Expression	[7]
Rap guanine nucleotide exchange factor 1 (RAPGEF1)	OTZ0TBN1	RPGF1_HUMAN	Decreases Expression	[7]
Nuclear transcription factor Y subunit gamma (NFYC)	OTZVVEV7	NFYC_HUMAN	Decreases Expression	[7]
Transcription factor Dp-1 (TFDP1)	OT6RZ7VT	TFDP1_HUMAN	Decreases Expression	[7]
Fas-activated serine/threonine kinase (FASTK)	OTTHFZMP	FASTK_HUMAN	Decreases Expression	[7]
Mediator of DNA damage checkpoint protein 1 (MDC1)	OTEUQH4J	MDC1_HUMAN	Decreases Expression	[7]
Structural maintenance of chromosomes protein 1A (SMC1A)	OT9ZMRK9	SMC1A_HUMAN	Decreases Expression	[7]
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D)	OT43TTX0	2A5D_HUMAN	Decreases Expression	[7]
Kinesin-like protein KIF22 (KIF22)	OTY6X6BL	KIF22_HUMAN	Decreases Expression	[7]
Killer cell immunoglobulin-like receptor 3DS1 (KIR3DS1)	OTJWIO4T	KI3S1_HUMAN	Decreases Expression	[7]
Killer cell immunoglobulin-like receptor 2DS3 (KIR2DS3)	OT3PSLDL	KI2S3_HUMAN	Decreases Expression	[7]
DAZ-associated protein 2 (DAZAP2)	OTNURO9F	DAZP2_HUMAN	Decreases Expression	[7]
Neutrophil cytosol factor 4 (NCF4)	OTX007YL	NCF4_HUMAN	Decreases Expression	[7]
kinase isozyme 2, mitochondrial (PDK2)	OTM436F9	PDK2_HUMAN	Decreases Expression	[7]
Leucine-rich repeat-containing protein 41 (LRRC41)	OT4YSBV5	LRC41_HUMAN	Decreases Expression	[7]
Ras suppressor protein 1 (RSU1)	OTO5GHT1	RSU1_HUMAN	Increases Expression	[7]
Scaffold attachment factor B1 (SAFB)	OTGRV2LW	SAFB1_HUMAN	Decreases Expression	[7]
NF-kappa-B inhibitor beta (NFKBIB)	OTY1ZJXH	IKBB_HUMAN	Increases Expression	[7]
NGFI-A-binding protein 2 (NAB2)	OTG4BDF3	NAB2_HUMAN	Decreases Expression	[7]
Neuronal pentraxin-1 (NPTX1)	OTKVHCV0	NPTX1_HUMAN	Decreases Expression	[7]
Coiled-coil domain-containing protein 6 (CCDC6)	OTXRQDYG	CCDC6_HUMAN	Decreases Expression	[7]
Drebrin (DBN1)	OTZVKG8A	DREB_HUMAN	Increases Expression	[7]
Solute carrier family 35 member G1 (SLC35G1)	OTKZUA8O	S35G1_HUMAN	Decreases Expression	[7]
Protein mono-ADP-ribosyltransferase PARP6 (PARP6)	OTWSXW4O	PARP6_HUMAN	Decreases Expression	[7]
Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1)	OTN7XAUD	LRRF1_HUMAN	Increases Expression	[7]
Polycomb group RING finger protein 3 (PCGF3)	OTY7TPPZ	PCGF3_HUMAN	Increases Expression	[7]
NAD kinase 2, mitochondrial (NADK2)	OT1I8GDE	NAKD2_HUMAN	Increases Expression	[7]
B-cell CLL/lymphoma 7 protein family member A (BCL7A)	OTYFUJTP	BCL7A_HUMAN	Decreases Expression	[7]
Glycerol-3-phosphate acyltransferase 3 (GPAT3)	OTJUGPK0	GPAT3_HUMAN	Increases Expression	[7]
Acylglycerol kinase, mitochondrial (AGK)	OTJGWBYT	AGK_HUMAN	Decreases Expression	[7]
Vesicle transport protein SFT2C (SFT2D3)	OT0IEAAR	SFT2C_HUMAN	Decreases Expression	[7]
Transmembrane protein 41B (TMEM41B)	OTW0B0KS	TM41B_HUMAN	Increases Expression	[7]
Torsin-1A-interacting protein 1 (TOR1AIP1)	OTTG8MAK	TOIP1_HUMAN	Decreases Expression	[7]
Tetratricopeptide repeat protein 39A (TTC39A)	OT80PQWX	TT39A_HUMAN	Increases Expression	[7]
Protein furry homolog (FRY)	OT74IAG2	FRY_HUMAN	Increases Expression	[7]
Probable E3 ubiquitin-protein ligase HECTD2 (HECTD2)	OTDIBGQV	HECD2_HUMAN	Increases Expression	[7]
G-protein coupled receptor 157 (GPR157)	OTE7K9D7	GP157_HUMAN	Decreases Expression	[7]
Obscurin (OBSCN)	OTT14OVX	OBSCN_HUMAN	Decreases Expression	[7]
G kinase-anchoring protein 1 (GKAP1)	OTHZRJ56	GKAP1_HUMAN	Increases Expression	[7]
Protein TASOR 2 (TASOR2)	OTN4VE8H	TASO2_HUMAN	Decreases Expression	[7]
Sushi domain-containing protein 4 (SUSD4)	OTWCJTT3	SUSD4_HUMAN	Decreases Expression	[7]
Proteasome adapter and scaffold protein ECM29 (ECPAS)	OT1C0KOI	ECM29_HUMAN	Increases Expression	[7]
DENN domain-containing protein 4C (DENND4C)	OT8SYN47	DEN4C_HUMAN	Increases Expression	[7]
Pecanex-like protein 4 (PCNX4)	OTV474RQ	PCX4_HUMAN	Increases Expression	[7]
Protein SPT2 homolog (SPTY2D1)	OT1RY99Z	SPT2_HUMAN	Increases Expression	[7]
CWF19-like protein 1 (CWF19L1)	OTAMYTOW	C19L1_HUMAN	Decreases Expression	[7]
U11/U12 small nuclear ribonucleoprotein 48 kDa protein (SNRNP48)	OTSR6DEJ	SNR48_HUMAN	Increases Expression	[7]
SPRY domain-containing SOCS box protein 3 (SPSB3)	OTHGEE2K	SPSB3_HUMAN	Increases Expression	[7]
E3 ubiquitin-protein ligase TRIM65 (TRIM65)	OTSQTK3A	TRI65_HUMAN	Decreases Expression	[7]
Leucine-rich repeat and fibronectin type-III domain-containing protein 4 (LRFN4)	OT7RWBKE	LRFN4_HUMAN	Decreases Expression	[7]
Type-1 angiotensin II receptor-associated protein (AGTRAP)	OT02N7LD	ATRAP_HUMAN	Decreases Expression	[7]
Transmembrane protein 92 (TMEM92)	OTTKJ2C0	TMM92_HUMAN	Decreases Expression	[7]
MICOS complex subunit MIC27 (APOOL)	OTC1WT8O	MIC27_HUMAN	Increases Expression	[7]
DnaJ homolog subfamily C member 14 (DNAJC14)	OT7DPIVN	DJC14_HUMAN	Decreases Expression	[7]
TBC1 domain family member 9 (TBC1D9)	OTSSCTB5	TBCD9_HUMAN	Increases Expression	[7]
Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1)	OTMQXW7S	RAPH1_HUMAN	Increases Expression	[7]
Serine/threonine-protein kinase MARK2 (MARK2)	OTJWGLUZ	MARK2_HUMAN	Decreases Expression	[7]
Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B)	OTE8GBUR	RIR2B_HUMAN	Increases Expression	[7]
Probable C-mannosyltransferase DPY19L4 (DPY19L4)	OTQ89TXA	D19L4_HUMAN	Increases Expression	[7]
Coiled-coil domain-containing protein 186 (CCDC186)	OTONSQAD	CC186_HUMAN	Increases Expression	[7]
C-myc promoter-binding protein (DENND4A)	OT8FFZ29	MYCPP_HUMAN	Increases Expression	[7]
Cytochrome P450 2U1 (CYP2U1)	OT6RXLXS	CP2U1_HUMAN	Increases Expression	[7]
HAUS augmin-like complex subunit 6 (HAUS6)	OT7ZVR57	HAUS6_HUMAN	Increases Expression	[7]
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (PIP4P1)	OT991XS0	PP4P1_HUMAN	Decreases Expression	[7]
Kinectin (KTN1)	OTQAV541	KTN1_HUMAN	Increases Expression	[7]
Phosphatidylcholine:ceramide cholinephosphotransferase 1 (SGMS1)	OTZQE7PW	SMS1_HUMAN	Increases Expression	[7]
Sodium-independent sulfate anion transporter (SLC26A11)	OTWBV9CR	S2611_HUMAN	Increases Expression	[7]
RNA-binding protein MEX3D (MEX3D)	OTAUWRK7	MEX3D_HUMAN	Decreases Expression	[7]
Dynein axonemal assembly factor 5 (DNAAF5)	OTN0CT52	DAAF5_HUMAN	Decreases Expression	[7]
Syntaxin-12 (STX12)	OT5IBQ62	STX12_HUMAN	Increases Expression	[7]
Mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3)	OTNJX38T	M4K3_HUMAN	Increases Expression	[7]
Protein FAM219A (FAM219A)	OTAFZHY9	F219A_HUMAN	Increases Expression	[7]
Mitofusin-1 (MFN1)	OTCBXQZF	MFN1_HUMAN	Decreases Expression	[7]
Pleckstrin homology domain-containing family M member 2 (PLEKHM2)	OT4ZYV73	PKHM2_HUMAN	Decreases Expression	[7]
Mitochondrial Rho GTPase 2 (RHOT2)	OTV8WT2L	MIRO2_HUMAN	Decreases Expression	[7]
Xaa-Arg dipeptidase (PM20D2)	OTD2Y7LU	P20D2_HUMAN	Increases Expression	[7]
Solute carrier family 38 member 6 (SLC38A6)	OTIC8SHQ	S38A6_HUMAN	Increases Expression	[7]
Abl interactor 1 (ABI1)	OT5H4M62	ABI1_HUMAN	Increases Expression	[7]
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase (GCNT2)	OTRUIMC4	GNT2A_HUMAN	Increases Expression	[7]
Protein FAM43A (FAM43A)	OT5RPQRE	FA43A_HUMAN	Decreases Expression	[7]
CAP-Gly domain-containing linker protein 4 (CLIP4)	OT75KVQK	CLIP4_HUMAN	Increases Expression	[7]
Putative transporter SVOPL (SVOPL)	OTJ4G2ND	SVOPL_HUMAN	Decreases Expression	[7]
Polypeptide N-acetylgalactosaminyltransferase 4 (GALNT4)	OT6WKC13	GALT4_HUMAN	Increases Expression	[7]
Coiled-coil domain-containing protein 82 (CCDC82)	OT16EAZ7	CCD82_HUMAN	Increases Expression	[7]
SH2 domain-containing protein 3C (SH2D3C)	OTAGXO0N	SH2D3_HUMAN	Decreases Expression	[7]
Methyltransferase-like protein 27 (METTL27)	OTOF0GTU	MET27_HUMAN	Decreases Expression	[7]
ADP-ribosylation factor GTPase-activating protein 1 (ARFGAP1)	OTM3KHIE	ARFG1_HUMAN	Decreases Expression	[7]
Protein KRI1 homolog (KRI1)	OT1IGOK7	KRI1_HUMAN	Increases Expression	[7]
ATPase family gene 2 protein homolog A (AFG2A)	OTPZKWN7	AFG2A_HUMAN	Increases Expression	[7]
Equilibrative nucleobase transporter 1 (SLC43A3)	OTR60ZLA	S43A3_HUMAN	Decreases Expression	[7]
Neuropilin and tolloid-like protein 2 (NETO2)	OT0YAMC0	NETO2_HUMAN	Decreases Expression	[7]
Polyhomeotic-like protein 3 (PHC3)	OTTTLIAP	PHC3_HUMAN	Increases Expression	[7]
Glutathione S-transferase C-terminal domain-containing protein (GSTCD)	OTIIINMT	GSTCD_HUMAN	Decreases Expression	[7]
Folliculin (FLCN)	OTVM78XM	FLCN_HUMAN	Increases Expression	[7]
Tubulin--tyrosine ligase (TTL)	OTSS1CK4	TTL_HUMAN	Decreases Expression	[7]
Protein NEDD1 (NEDD1)	OTBD6X77	NEDD1_HUMAN	Increases Expression	[7]
Protein FAM76A (FAM76A)	OT28WHO4	FA76A_HUMAN	Increases Expression	[7]
Proline-rich protein 7 (PRR7)	OT56XAQK	PRR7_HUMAN	Decreases Expression	[7]
Transmembrane protein 254 (TMEM254)	OTGDPU8S	TM254_HUMAN	Decreases Expression	[7]
Retinol dehydrogenase 11 (RDH11)	OTIND43N	RDH11_HUMAN	Increases Expression	[7]
POC1 centriolar protein homolog B (POC1B)	OTDIMIRZ	POC1B_HUMAN	Increases Expression	[7]
Interferon-induced protein 44 (IFI44)	OTOKSZVA	IFI44_HUMAN	Increases Expression	[7]
Large ribosomal subunit protein uL30m (MRPL30)	OT26OPYV	RM30_HUMAN	Decreases Expression	[7]
RB1-inducible coiled-coil protein 1 (RB1CC1)	OTZK8PFX	RBCC1_HUMAN	Increases Expression	[7]
Elongator complex protein 5 (ELP5)	OTW5R7YD	ELP5_HUMAN	Decreases Expression	[7]
DDB1- and CUL4-associated factor 11 (DCAF11)	OTNSGYK1	DCA11_HUMAN	Decreases Expression	[7]
Arginine/serine-rich protein PNISR (PNISR)	OTUM02FW	PNISR_HUMAN	Increases Expression	[7]
General transcription factor 3C polypeptide 2 (GTF3C2)	OTWDANLJ	TF3C2_HUMAN	Decreases Expression	[7]
Transmembrane protein 263 (TMEM263)	OTO1RSTS	TM263_HUMAN	Increases Expression	[7]
Protein THEM6 (THEM6)	OT51SVLH	THEM6_HUMAN	Decreases Expression	[7]
Pleckstrin homology-like domain family A member 1 (PHLDA1)	OTFTWMIQ	PHLA1_HUMAN	Increases Expression	[7]
Hexosaminidase D (HEXD)	OTTMQKLM	HEXD_HUMAN	Decreases Expression	[7]
E3 ubiquitin-protein ligase RNF138 (RNF138)	OTPU0CO4	RN138_HUMAN	Increases Expression	[7]
Heterogeneous nuclear ribonucleoprotein L-like (HNRNPLL)	OTA6Q5E0	HNRLL_HUMAN	Increases Expression	[7]
Uncharacterized protein C4orf3 (C4ORF3)	OT6TFN1O	CD003_HUMAN	Decreases Expression	[7]
tRNA-splicing endonuclease subunit Sen15 (TSEN15)	OT14UW31	SEN15_HUMAN	Decreases Expression	[7]
Palladin (PALLD)	OTZ2MUJZ	PALLD_HUMAN	Increases Expression	[7]
Protein N-lysine methyltransferase METTL21A (METTL21A)	OTXJTNXY	MT21A_HUMAN	Increases Expression	[7]
E3 ubiquitin-protein ligase rififylin (RFFL)	OT85MGDH	RFFL_HUMAN	Increases Expression	[7]
Proteasome inhibitor PI31 subunit (PSMF1)	OTX84WLQ	PSMF1_HUMAN	Decreases Expression	[7]
Protein FAM168A (FAM168A)	OTDXQCS5	F168A_HUMAN	Increases Expression	[7]
Protein NDRG1 (NDRG1)	OTVO66BO	NDRG1_HUMAN	Increases Expression	[7]
TRAF family member-associated NF-kappa-B activator (TANK)	OTZSGFIK	TANK_HUMAN	Increases Expression	[7]
Ras-related protein Rab-8B (RAB8B)	OTBPUHV9	RAB8B_HUMAN	Decreases Expression	[7]
GTP-binding protein Rit1 (RIT1)	OTVNOGOH	RIT1_HUMAN	Increases Expression	[7]
Phosphorylase b kinase regulatory subunit beta (PHKB)	OTKXZZIU	KPBB_HUMAN	Increases Expression	[7]
BLOC-2 complex member HPS3 (HPS3)	OTAKROK7	HPS3_HUMAN	Decreases Expression	[7]
F-box/WD repeat-containing protein 7 (FBXW7)	OTJXE4OT	FBXW7_HUMAN	Decreases Expression	[7]
Polyamine deacetylase HDAC10 (HDAC10)	OTHCKKUQ	HDA10_HUMAN	Decreases Expression	[7]
NXPE family member 3 (NXPE3)	OTLVZ8W2	NXPE3_HUMAN	Increases Expression	[7]
Transmembrane protein 230 (TMEM230)	OTAFALFV	TM230_HUMAN	Decreases Expression	[7]
SOSS complex subunit B2 (NABP1)	OTFTNFHW	SOSB2_HUMAN	Increases Expression	[7]
Ankyrin repeat domain-containing protein 9 (ANKRD9)	OT7VGO6G	ANKR9_HUMAN	Increases Expression	[7]
ADP-ribosylation factor-like protein 8A (ARL8A)	OTEYM6FA	ARL8A_HUMAN	Increases Expression	[7]
m7GpppX diphosphatase (DCPS)	OT1FZVC9	DCPS_HUMAN	Decreases Expression	[7]
Protein FAM241B (FAM241B)	OTLISLRC	F241B_HUMAN	Increases Expression	[7]
R3H domain-containing protein 4 (R3HDM4)	OTE0Q78Q	R3HD4_HUMAN	Decreases Expression	[7]
E3 ubiquitin-protein ligase CHFR (CHFR)	OTRAD2TT	CHFR_HUMAN	Decreases Expression	[7]
ATP-dependent DNA helicase DDX11 (DDX11)	OT1WR3MD	DDX11_HUMAN	Decreases Expression	[7]
Kelch domain-containing protein 7B (KLHDC7B)	OT2H5BNX	KLD7B_HUMAN	Increases Expression	[7]
H/ACA ribonucleoprotein complex non-core subunit NAF1 (NAF1)	OTMJKJAK	NAF1_HUMAN	Increases Expression	[7]
Uncharacterized protein C9orf85 (C9ORF85)	OTJWBPL3	CI085_HUMAN	Increases Expression	[7]
Pannexin-2 (PANX2)	OTAQ2S8R	PANX2_HUMAN	Increases Expression	[7]
Ribosomal protein S6 kinase delta-1 (RPS6KC1)	OT2LRTG4	KS6C1_HUMAN	Increases Expression	[7]
Structural maintenance of chromosomes protein 6 (SMC6)	OT3IBHQD	SMC6_HUMAN	Increases Expression	[7]
Protein orai-2 (ORAI2)	OTYISRYH	ORAI2_HUMAN	Decreases Expression	[7]
E3 ubiquitin-protein ligase RING2 (RNF2)	OTFPLOIN	RING2_HUMAN	Increases Expression	[7]
Krueppel-like factor 6 (KLF6)	OTQY9S7F	KLF6_HUMAN	Increases Expression	[7]
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial (SDHC)	OTC8G2MX	C560_HUMAN	Decreases Expression	[7]
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1A)	OTVTB5R5	PI51A_HUMAN	Decreases Expression	[7]
Apolipoprotein L4 (APOL4)	OTTOH86V	APOL4_HUMAN	Decreases Expression	[7]
Protein NipSnap homolog 1 (NIPSNAP1)	OTKXKUT8	NIPS1_HUMAN	Decreases Expression	[7]
Protein FAM118B (FAM118B)	OTRLY4B0	F118B_HUMAN	Increases Expression	[7]
Target of rapamycin complex 2 subunit MAPKAP1 (MAPKAP1)	OTYKB9G3	SIN1_HUMAN	Decreases Expression	[7]
TM2 domain-containing protein 3 (TM2D3)	OT6MS96W	TM2D3_HUMAN	Increases Expression	[7]
Ferroptosis suppressor protein 1 (AIFM2)	OT57XWXO	FSP1_HUMAN	Increases Expression	[7]
Tubulin-specific chaperone D (TBCD)	OTS4JKNQ	TBCD_HUMAN	Decreases Expression	[7]
Iron-sulfur cluster assembly 1 homolog, mitochondrial (ISCA1)	OTU230MC	ISCA1_HUMAN	Increases Expression	[7]
Bublin coiled-coil protein (BBLN)	OTUMVEWE	BBLN_HUMAN	Decreases Expression	[7]
Coiled-coil domain-containing protein 32 (CCDC32)	OTPPUFIF	CCD32_HUMAN	Increases Expression	[7]
Kinesin-like protein KIFC1 (KIFC1)	OTNQDS00	KIFC1_HUMAN	Decreases Expression	[7]
Katanin p60 ATPase-containing subunit A-like 1 (KATNAL1)	OTBUZ7KA	KATL1_HUMAN	Increases Expression	[7]
Protein C1orf43 (C1ORF43)	OTT9CVZR	CA043_HUMAN	Decreases Expression	[7]
TM2 domain-containing protein 2 (TM2D2)	OTB51WEY	TM2D2_HUMAN	Increases Expression	[7]
FSD1-like protein (FSD1L)	OTBQ48RF	FSD1L_HUMAN	Increases Expression	[7]
C-type lectin domain family 7 member A (CLEC7A)	OTRTBH27	CLC7A_HUMAN	Increases Expression	[7]
Serrate RNA effector molecule homolog (SRRT)	OTMYPSWV	SRRT_HUMAN	Decreases Expression	[7]
Protein kinase C and casein kinase substrate in neurons protein 1 (PACSIN1)	OT07Z2RQ	PACN1_HUMAN	Increases Expression	[7]
Sterile alpha motif domain-containing protein 10 (SAMD10)	OTBKWB5C	SAM10_HUMAN	Decreases Expression	[7]
INO80 complex subunit B (INO80B)	OTSHV8JF	IN80B_HUMAN	Decreases Expression	[7]
Uncharacterized protein C6orf62 (C6ORF62)	OTGK4G35	CF062_HUMAN	Increases Expression	[7]
Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1)	OT4U7SBG	GBRL1_HUMAN	Increases Expression	[7]
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (NUCKS1)	OTL4VJC5	NUCKS_HUMAN	Decreases Expression	[7]
Oxysterol-binding protein-related protein 2 (OSBPL2)	OTCK671N	OSBL2_HUMAN	Increases Expression	[7]
Dual specificity protein phosphatase 15 (DUSP15)	OTS6PQYL	DUS15_HUMAN	Decreases Expression	[7]
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 (KCTD10)	OT5HFZXU	BACD3_HUMAN	Increases Expression	[7]
UPF0696 protein C11orf68 (C11ORF68)	OTOKOGZ6	CK068_HUMAN	Decreases Expression	[7]
Differentially expressed in FDCP 6 homolog (DEF6)	OTIRBYVK	DEFI6_HUMAN	Decreases Expression	[7]
Sentrin-specific protease 3 (SENP3)	OTFQDOMC	SENP3_HUMAN	Decreases Expression	[7]
ESF1 homolog (ESF1)	OTHEDM0A	ESF1_HUMAN	Increases Expression	[7]
RNA polymerase II-associated protein 3 (RPAP3)	OTCW17LF	RPAP3_HUMAN	Increases Expression	[7]
Sin3 histone deacetylase corepressor complex component SDS3 (SUDS3)	OTZ1AARI	SDS3_HUMAN	Increases Expression	[7]
Caspase activity and apoptosis inhibitor 1 (CAAP1)	OTD2DN1Z	CAAP1_HUMAN	Increases Expression	[7]
Kinesin-like protein KIF9 (KIF9)	OT7W6VI1	KIF9_HUMAN	Decreases Expression	[7]
E3 ubiquitin-protein ligase SMURF2 (SMURF2)	OT3TRVL7	SMUF2_HUMAN	Increases Expression	[7]
Transcription factor IIIB 50 kDa subunit (BRF2)	OT2C6TH2	BRF2_HUMAN	Increases Expression	[7]
Retinoid-inducible serine carboxypeptidase (SCPEP1)	OT43LYEZ	RISC_HUMAN	Increases Expression	[7]
POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1)	OT0X9WGR	PATZ1_HUMAN	Decreases Expression	[7]
DNA dC->dU-editing enzyme APOBEC-3G (APOBEC3G)	OT410VP5	ABC3G_HUMAN	Increases Expression	[7]
DnaJ homolog subfamily C member 4 (DNAJC4)	OT4BUBQU	DNJC4_HUMAN	Decreases Expression	[7]
DNA-directed DNA/RNA polymerase mu (POLM)	OT0SRIP4	DPOLM_HUMAN	Decreases Expression	[7]
Carbohydrate sulfotransferase 11 (CHST11)	OTNJJ5Q1	CHSTB_HUMAN	Decreases Expression	[7]
Uncharacterized protein C14orf132 (C14ORF132)	OTBVC3AO	CN132_HUMAN	Decreases Expression	[7]
Putative RNA-binding protein Luc7-like 1 (LUC7L)	OT77JDB7	LUC7L_HUMAN	Increases Expression	[7]
Prefoldin subunit 4 (PFDN4)	OT5NRHER	PFD4_HUMAN	Increases Expression	[7]
Solute carrier family 35 member C2 (SLC35C2)	OT9H15XZ	S35C2_HUMAN	Decreases Expression	[7]
Gephyrin (GPHN)	OTAKK1SV	GEPH_HUMAN	Decreases Expression	[7]
Endophilin-B2 (SH3GLB2)	OTF7BB9S	SHLB2_HUMAN	Decreases Expression	[7]
Muscleblind-like protein 1 (MBNL1)	OTOV7J85	MBNL1_HUMAN	Decreases Expression	[7]
CDC42 small effector protein 2 (CDC42SE2)	OT8SG9I1	C42S2_HUMAN	Decreases Expression	[7]
RNA-binding protein PNO1 (PNO1)	OT010GIS	PNO1_HUMAN	Increases Expression	[7]
DDB1- and CUL4-associated factor 13 (DCAF13)	OTQQ0QXT	DCA13_HUMAN	Increases Expression	[7]
FGFR1 oncogene partner 2 (FGFR1OP2)	OTAHO1ZC	FGOP2_HUMAN	Increases Expression	[7]
DNA-directed RNA polymerase III subunit RPC5 (POLR3E)	OT69PWBM	RPC5_HUMAN	Increases Expression	[7]
Anoctamin-10 (ANO10)	OTG3BNOU	ANO10_HUMAN	Increases Expression	[7]
BSD domain-containing protein 1 (BSDC1)	OT853CP9	BSDC1_HUMAN	Increases Expression	[7]
G patch domain-containing protein 2-like (GPATCH2L)	OTETUZ64	GPT2L_HUMAN	Increases Expression	[7]
AFG2-interacting ribosome maturation factor (AIRIM)	OTGG814L	AIRIM_HUMAN	Increases Expression	[7]
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 (B3GNT2)	OTE69HV8	B3GN2_HUMAN	Decreases Expression	[7]
Opioid growth factor receptor (OGFR)	OTROS6RJ	OGFR_HUMAN	Decreases Expression	[7]
E3 ubiquitin-protein ligase KCMF1 (KCMF1)	OTVTKFAU	KCMF1_HUMAN	Increases Expression	[7]
Stromal interaction molecule 2 (STIM2)	OTYNXAW0	STIM2_HUMAN	Decreases Expression	[7]
Inhibitor of Bruton tyrosine kinase (IBTK)	OTB2GM4G	IBTK_HUMAN	Increases Expression	[7]
E3 ubiquitin-protein ligase RNF14 (RNF14)	OTWX0D0H	RNF14_HUMAN	Increases Expression	[7]
Fibulin-5 (FBLN5)	OTLVNZ8U	FBLN5_HUMAN	Decreases Expression	[7]
Beta-1,4-galactosyltransferase 6 (B4GALT6)	OTBM8F2U	B4GT6_HUMAN	Increases Expression	[7]
LIM domain-containing protein 1 (LIMD1)	OTN1CG6R	LIMD1_HUMAN	Increases Expression	[7]
Protein NDRG3 (NDRG3)	OTJTJCHD	NDRG3_HUMAN	Decreases Expression	[7]
LIM domain and actin-binding protein 1 (LIMA1)	OTONPC9R	LIMA1_HUMAN	Increases Expression	[7]
AF4/FMR2 family member 4 (AFF4)	OTTL5Y8R	AFF4_HUMAN	Increases Expression	[7]
NADH-cytochrome b5 reductase 1 (CYB5R1)	OTMDHMLA	NB5R1_HUMAN	Increases Expression	[7]
Methyl-CpG-binding domain protein 1 (MBD1)	OTD19VO6	MBD1_HUMAN	Decreases Expression	[7]
Oxidative stress-induced growth inhibitor 1 (OSGIN1)	OT9KIVZW	OSGI1_HUMAN	Increases Expression	[7]
Cell division cycle protein 23 homolog (CDC23)	OTC4O83E	CDC23_HUMAN	Increases Expression	[7]
Anaphase-promoting complex subunit 5 (ANAPC5)	OTGTJNNR	APC5_HUMAN	Decreases Expression	[7]
Calcipressin-3 (RCAN3)	OTTS3CQA	RCAN3_HUMAN	Decreases Expression	[7]
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (ASAP1)	OT4DLRYY	ASAP1_HUMAN	Decreases Expression	[7]
Tetratricopeptide repeat protein 7A (TTC7A)	OTDHLPQM	TTC7A_HUMAN	Decreases Expression	[7]
Nucleosome assembly protein 1-like 2 (NAP1L2)	OT8QI4GF	NP1L2_HUMAN	Increases Expression	[7]
Protein PHTF1 (PHTF1)	OTYCZ84A	PHTF1_HUMAN	Increases Expression	[7]
26S proteasome non-ATPase regulatory subunit 13 (PSMD13)	OTNQ351N	PSD13_HUMAN	Increases Expression	[7]
Cytosolic carboxypeptidase 1 (AGTPBP1)	OTR92JFR	CBPC1_HUMAN	Increases Expression	[7]
Serine/threonine-protein kinase ICK (CILK1)	OTWOYEYP	CILK1_HUMAN	Increases Expression	[7]
Structural maintenance of chromosomes protein 3 (SMC3)	OTWGFRHD	SMC3_HUMAN	Increases Expression	[7]
Myotubularin-related protein 6 (MTMR6)	OTQPAWI3	MTMR6_HUMAN	Increases Expression	[7]
Phospholipase A-2-activating protein (PLAA)	OTZ7NJGA	PLAP_HUMAN	Increases Expression	[7]
Phenylalanine--tRNA ligase alpha subunit (FARSA)	OT3U1P20	SYFA_HUMAN	Decreases Expression	[7]
Nck-associated protein 1 (NCKAP1)	OTEZQXXJ	NCKP1_HUMAN	Increases Expression	[7]
Kelch-like protein 20 (KLHL20)	OTC0SFS9	KLH20_HUMAN	Increases Expression	[7]
ARF GTPase-activating protein GIT1 (GIT1)	OTHO92S5	GIT1_HUMAN	Decreases Expression	[7]
RING finger protein 11 (RNF11)	OTFBJSKQ	RNF11_HUMAN	Increases Expression	[7]
Transformation/transcription domain-associated protein (TRRAP)	OT68OI2Y	TRRAP_HUMAN	Decreases Expression	[7]
Carbohydrate sulfotransferase 2 (CHST2)	OTV11IZF	CHST2_HUMAN	Decreases Expression	[7]
G-protein-signaling modulator 3 (GPSM3)	OT2MO458	GPSM3_HUMAN	Decreases Expression	[7]
U6 snRNA-associated Sm-like protein LSm4 (LSM4)	OTLKJB3A	LSM4_HUMAN	Decreases Expression	[7]
DNA-directed RNA polymerase III subunit RPC8 (POLR3H)	OT7GM7MX	RPC8_HUMAN	Decreases Expression	[7]
NEDD8 ultimate buster 1 (NUB1)	OTWA6RTX	NUB1_HUMAN	Increases Expression	[7]
Selenoprotein K (SELENOK)	OTKM7N7P	SELK_HUMAN	Increases Expression	[7]
Numb-like protein (NUMBL)	OTWMTMMH	NUMBL_HUMAN	Increases Expression	[7]
ATPase MORC2 (MORC2)	OT52A8BJ	MORC2_HUMAN	Increases Expression	[7]
Aldo-keto reductase family 1 member B10 (AKR1B10)	OTOA4HTH	AK1BA_HUMAN	Increases Expression	[21]
Aldo-keto reductase family 1 member B1 (AKR1B1)	OTRX72TH	ALDR_HUMAN	Increases Expression	[21]
Aldo-keto reductase family 1 member C3 (AKR1C3)	OTU2SXBA	AK1C3_HUMAN	Increases Expression	[21]
Aldo-keto reductase family 1 member C2 (AKR1C2)	OTQ2XMO3	AK1C2_HUMAN	Affects Expression	[21]
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Increases Expression	[21]
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A)	OTBPCU2O	TR10A_HUMAN	Decreases Expression	[22]
NF-kappa-B inhibitor epsilon (NFKBIE)	OTLAYEL9	IKBE_HUMAN	Increases Stability	[23]
Myc box-dependent-interacting protein 1 (BIN1)	OTK8O0X8	BIN1_HUMAN	Increases Expression	[12]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)	OTA1CPBV	TR10B_HUMAN	Increases Expression	[24]
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK)	OTLF4ZB1	IKKA_HUMAN	Increases Expression	[10]
Apoptosis regulatory protein Siva (SIVA1)	OTDT0XZK	SIVA_HUMAN	Decreases Expression	[12]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Decreases Expression	[25]
High affinity copper uptake protein 1 (SLC31A1)	OTXLRTUB	COPT1_HUMAN	Decreases Degradation	[26]
CASP8 and FADD-like apoptosis regulator (CFLAR)	OTX14BAS	CFLAR_HUMAN	Decreases Expression	[12]
Histone-lysine N-methyltransferase SUV39H1 (SUV39H1)	OTDTF5BU	SUV91_HUMAN	Decreases Expression	[12]
Serine protease HTRA2, mitochondrial (HTRA2)	OTC7616F	HTRA2_HUMAN	Affects Localization	[27]
Bcl-2-like protein 11 (BCL2L11)	OTNQQWFJ	B2L11_HUMAN	Increases Activity	[28]
Nuclear protein 1 (NUPR1)	OT4FU8C0	NUPR1_HUMAN	Increases Expression	[29]
DENN domain-containing protein 4B (DENND4B)	OTFEO8KG	DEN4B_HUMAN	Increases Expression	[30]
Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B)	OTL9I7LO	GA45B_HUMAN	Increases Expression	[30]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)	OTYG179K	PR15A_HUMAN	Increases Expression	[30]
Growth arrest and DNA damage-inducible protein GADD45 gamma (GADD45G)	OT8V1J4M	GA45G_HUMAN	Increases Expression	[25]
BAG family molecular chaperone regulator 3 (BAG3)	OTVXYUDQ	BAG3_HUMAN	Increases Expression	[30]
Apoptosis-inducing factor 1, mitochondrial (AIFM1)	OTKPWB7Q	AIFM1_HUMAN	Affects Localization	[27]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Decreases Expression	[31]
Prelamin-A/C (LMNA)	OT3SG7ZR	LMNA_HUMAN	Increases Cleavage	[32]
RAF proto-oncogene serine/threonine-protein kinase (RAF1)	OT51LSFO	RAF1_HUMAN	Decreases Expression	[33]
Receptor tyrosine-protein kinase erbB-2 (ERBB2)	OTOAUNCK	ERBB2_HUMAN	Decreases Phosphorylation	[34]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)	OTM0GDTP	IF2A_HUMAN	Increases Phosphorylation	[35]
Transcription factor Jun (JUN)	OTCYBO6X	JUN_HUMAN	Decreases Expression	[10]
Heat shock protein HSP 90-alpha (HSP90AA1)	OTLG1WPK	HS90A_HUMAN	Decreases Expression	[10]
Heat shock protein HSP 90-beta (HSP90AB1)	OTR69EG7	HS90B_HUMAN	Increases Expression	[36]
Growth-regulated alpha protein (CXCL1)	OT3WCTZV	GROA_HUMAN	Increases Expression	[30]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Increases Cleavage	[37]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Increases Expression	[30]
C-C motif chemokine 3 (CCL3)	OTW2H3ND	CCL3_HUMAN	Decreases Expression	[38]
Cytochrome c oxidase subunit 8A, mitochondrial (COX8A)	OTU0NR39	COX8A_HUMAN	Decreases Expression	[39]
Parathyroid hormone-related protein (PTHLH)	OTI1JF13	PTHR_HUMAN	Decreases Expression	[38]
Interferon-induced transmembrane protein 1 (IFITM1)	OTECO1G8	IFM1_HUMAN	Decreases Expression	[12]
Protein Cripto (CRIPTO)	OT46DZXJ	TDGF1_HUMAN	Increases Expression	[36]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Decreases Expression	[10]
Transcription factor 4 (TCF4)	OTB9ASTK	ITF2_HUMAN	Increases Expression	[36]
Histone H2AX (H2AX)	OT18UX57	H2AX_HUMAN	Decreases Phosphorylation	[40]
Interleukin-7 receptor subunit alpha (IL7R)	OTBMFLQQ	IL7RA_HUMAN	Increases Expression	[10]
Heat shock 70 kDa protein 6 (HSPA6)	OTH4S7WB	HSP76_HUMAN	Increases Expression	[30]
Transcription factor JunB (JUNB)	OTG2JXV5	JUNB_HUMAN	Decreases Expression	[41]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4)	OTRFV19J	ATF4_HUMAN	Increases Expression	[30]
Nuclear factor NF-kappa-B p105 subunit (NFKB1)	OTNRRD8I	NFKB1_HUMAN	Decreases Expression	[42]
Tumor necrosis factor receptor superfamily member 6 (FAS)	OTP9XG86	TNR6_HUMAN	Decreases Expression	[10]
DnaJ homolog subfamily B member 1 (DNAJB1)	OTCOSEVH	DNJB1_HUMAN	Increases Expression	[30]
Pentraxin-related protein PTX3 (PTX3)	OTPXHRKU	PTX3_HUMAN	Decreases Expression	[10]
CD27 antigen (CD27)	OTH7NA58	CD27_HUMAN	Increases Expression	[36]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Decreases Activity	[33]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Decreases Activity	[33]
Tyrosine-protein phosphatase non-receptor type 6 (PTPN6)	OT33XNZM	PTN6_HUMAN	Decreases Expression	[12]
SHC-transforming protein 1 (SHC1)	OT1J5IRN	SHC1_HUMAN	Decreases Expression	[10]
Catenin beta-1 (CTNNB1)	OTZ932A3	CTNB1_HUMAN	Increases Expression	[43]
Replication protein A 14 kDa subunit (RPA3)	OT8JAQGL	RFA3_HUMAN	Decreases Expression	[12]
Pro-adrenomedullin (ADM)	OT7T0TA4	ADML_HUMAN	Decreases Expression	[10]
DNA damage-inducible transcript 3 protein (DDIT3)	OTI8YKKE	DDIT3_HUMAN	Increases Expression	[12]
Alpha-synuclein (SNCA)	OTPWC1MR	SYUA_HUMAN	Increases Expression	[36]
Breast cancer type 1 susceptibility protein (BRCA1)	OT5BN6VH	BRCA1_HUMAN	Decreases Expression	[44]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Increases Expression	[25]
Small ribosomal subunit protein eS19 (RPS19)	OTBKGP48	RS19_HUMAN	Increases Expression	[30]
Mitogen-activated protein kinase 8 (MAPK8)	OTEREYS5	MK08_HUMAN	Increases Phosphorylation	[45]
Mitogen-activated protein kinase 9 (MAPK9)	OTCEVJ9E	MK09_HUMAN	Increases Phosphorylation	[45]
Cyclin-dependent kinase inhibitor 1B (CDKN1B)	OTNY5LLZ	CDN1B_HUMAN	Increases Expression	[8]
Tumor necrosis factor ligand superfamily member 6 (FASLG)	OTZARCHH	TNFL6_HUMAN	Increases Expression	[46]
Isocitrate dehydrogenase subunit alpha, mitochondrial (IDH3A)	OT5QQB5L	IDH3A_HUMAN	Decreases Expression	[39]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10)	OT4PXBTA	TNF10_HUMAN	Decreases Expression	[47]
Small ribosomal subunit protein mS29 (DAP3)	OTNPEZYM	RT29_HUMAN	Increases Expression	[12]
DNA mismatch repair protein Msh6 (MSH6)	OT46FP09	MSH6_HUMAN	Decreases Expression	[12]
Hepatocyte nuclear factor 3-alpha (FOXA1)	OTEBY0TD	FOXA1_HUMAN	Decreases Expression	[10]
BH3-interacting domain death agonist (BID)	OTOSHSHU	BID_HUMAN	Increases Cleavage	[25]
NACHT, LRR and PYD domains-containing protein 12 (NLRP12)	OTGR132Z	NAL12_HUMAN	Increases Expression	[10]
C-C motif chemokine 8 (CCL8)	OTCTWYN8	CCL8_HUMAN	Affects Expression	[22]
Cytochrome c (CYCS)	OTBFALJD	CYC_HUMAN	Affects Localization	[27]
Heat shock factor protein 1 (HSF1)	OTYNJ4KP	HSF1_HUMAN	Increases Expression	[36]
Nuclear factor NF-kappa-B p100 subunit (NFKB2)	OTS231V7	NFKB2_HUMAN	Decreases Expression	[42]
Dystonin (DST)	OTHZBM4X	DYST_HUMAN	Increases Expression	[12]
Heat shock factor protein 2 (HSF2)	OTXNJIJ9	HSF2_HUMAN	Increases Expression	[48]
Fragile X messenger ribonucleoprotein 1 (FMR1)	OTWEV0T5	FMR1_HUMAN	Decreases Expression	[12]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Decreases Expression	[28]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)	OT4SO7J4	BNIP3_HUMAN	Increases Expression	[32]
Baculoviral IAP repeat-containing protein 1 (NAIP)	OTLA925F	BIRC1_HUMAN	Affects Expression	[42]
Chromatin assembly factor 1 subunit A (CHAF1A)	OTXSSY4H	CAF1A_HUMAN	Decreases Expression	[12]
Serine-protein kinase ATM (ATM)	OTQVOHLT	ATM_HUMAN	Increases Cleavage	[49]
Bcl-2-interacting killer (BIK)	OTTH1T3D	BIK_HUMAN	Increases Activity	[28]
Interleukin-18 receptor 1 (IL18R1)	OT83XMPQ	IL18R_HUMAN	Increases Expression	[36]
Baculoviral IAP repeat-containing protein 3 (BIRC3)	OT3E95KB	BIRC3_HUMAN	Increases Expression	[50]
Baculoviral IAP repeat-containing protein 2 (BIRC2)	OTFXFREP	BIRC2_HUMAN	Decreases Expression	[23]
Cullin-1 (CUL1)	OTXPE1UZ	CUL1_HUMAN	Increases Expression	[36]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)	OTXEE550	APR_HUMAN	Decreases Expression	[42]
Transcription elongation factor A protein-like 1 (TCEAL1)	OTAPG2L5	TCAL1_HUMAN	Increases Expression	[36]
Interferon regulatory factor 4 (IRF4)	OT1DHQ1P	IRF4_HUMAN	Decreases Expression	[41]
Bcl-2 homologous antagonist/killer (BAK1)	OTDP6ILW	BAK_HUMAN	Increases Expression	[51]
Carbonic anhydrase 9 (CA9)	OTNA51XT	CAH9_HUMAN	Decreases Expression	[52]
TIR domain-containing adapter molecule 2 (TICAM2)	OTK7GIJ5	TCAM2_HUMAN	Increases Expression	[10]
Cell division cycle and apoptosis regulator protein 1 (CCAR1)	OTUXLQZZ	CCAR1_HUMAN	Increases Expression	[53]
Ectodysplasin-A receptor-associated adapter protein (EDARADD)	OT0G52MC	EDAD_HUMAN	Increases Expression	[36]
DNA-binding death effector domain-containing protein 2 (DEDD2)	OT0WXRWT	DEDD2_HUMAN	Increases Expression	[12]
Heat shock protein 105 kDa (HSPH1)	OTVRR73T	HS105_HUMAN	Increases Expression	[25]
Bcl-2-like protein 2 (BCL2L2)	OTMKVO0J	B2CL2_HUMAN	Increases Expression	[54]
N-alpha-acetyltransferase 80 (NAA80)	OTLWR71Z	NAA80_HUMAN	Decreases Expression	[12]
MOB kinase activator 3A (MOB3A)	OTILIOXF	MOB3A_HUMAN	Decreases Expression	[12]
Baculoviral IAP repeat-containing protein 7 (BIRC7)	OTITCGHB	BIRC7_HUMAN	Decreases Expression	[55]
NACHT, LRR and PYD domains-containing protein 3 (NLRP3)	OTZM6MHU	NLRP3_HUMAN	Decreases Expression	[12]
Bcl-2-binding component 3, isoforms 3/4 (BBC3)	OTUAXDAY	BBC3B_HUMAN	Increases Expression	[56]
Tribbles homolog 3 (TRIB3)	OTG5OS7X	TRIB3_HUMAN	Increases Expression	[20]
Cell growth regulator with EF hand domain protein 1 (CGREF1)	OTBZQX97	CGRE1_HUMAN	Increases Expression	[36]
Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1)	OTJGE772	CHAC1_HUMAN	Increases Expression	[30]
Fanconi anemia group D2 protein (FANCD2)	OTVEB5LF	FACD2_HUMAN	Decreases Expression	[57]
Eukaryotic translation initiation factor 2A (EIF2A)	OTWXELQP	EIF2A_HUMAN	Decreases Phosphorylation	[58]
DNA replication factor Cdt1 (CDT1)	OTVY53VG	CDT1_HUMAN	Decreases Expression	[12]
Interleukin-23 subunit alpha (IL23A)	OTYO99HC	IL23A_HUMAN	Increases Expression	[36]
Diablo IAP-binding mitochondrial protein (DIABLO)	OTHJ9MCZ	DBLOH_HUMAN	Increases Expression	[42]
Anaphase-promoting complex subunit 11 (ANAPC11)	OTK2SJXR	APC11_HUMAN	Decreases Expression	[12]
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)	OT0DZGY4	E2AK3_HUMAN	Increases Phosphorylation	[30]
Lipid transferase CIDEB (CIDEB)	OT873IYM	CIDEB_HUMAN	Decreases Expression	[12]
Cell cycle progression protein 1 (CCPG1)	OT0IHDKL	CCPG1_HUMAN	Increases Expression	[10]
Transcription factor 19 (TCF19)	OT7NKLF9	TCF19_HUMAN	Decreases Expression	[12]
Cyclic AMP-dependent transcription factor ATF-5 (ATF5)	OT03QCLM	ATF5_HUMAN	Increases Expression	[25]
Rho-related BTB domain-containing protein 2 (RHOBTB2)	OT2DATFX	RHBT2_HUMAN	Increases Response To Substance	[59]
Palmitoyl thioesterase CPT1C (CPT1C)	OT8F1MBF	CPT1C_HUMAN	Increases Response To Substance	[59]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (ATP2A1)	OT959A3A	AT2A1_HUMAN	Affects Response To Substance	[60]
Serine/threonine-protein kinase 4 (STK4)	OTBRYNNH	STK4_HUMAN	Increases Response To Substance	[61]
Transcription factor SOX-8 (SOX8)	OTEJXYZM	SOX8_HUMAN	Increases Response To Substance	[59]
DNA repair endonuclease XPF (ERCC4)	OTFIOPG1	XPF_HUMAN	Increases Response To Substance	[59]
Polyunsaturated fatty acid lipoxygenase ALOX12 (ALOX12)	OTFL5KR5	LOX12_HUMAN	Increases Response To Substance	[59]
Heat shock protein beta-1 (HSPB1)	OTHFZ8ED	HSPB1_HUMAN	Decreases Response To Substance	[62]
Superoxide dismutase , mitochondrial (SOD2)	OTIWXGZ9	SODM_HUMAN	Increases Response To Substance	[59]
Unconventional myosin-Va (MYO5A)	OTMWLP3E	MYO5A_HUMAN	Increases Response To Substance	[59]
Proteasome subunit beta type-5 (PSMB5)	OTOZXAS6	PSB5_HUMAN	Decreases Response To Substance	[63]
Retinoblastoma-associated protein (RB1)	OTQJUJMZ	RB_HUMAN	Increases Response To Substance	[64]
BRCA1-associated RING domain protein 1 (BARD1)	OTTC0Z9Y	BARD1_HUMAN	Increases Response To Substance	[64]
General transcription and DNA repair factor IIH helicase subunit XPB (ERCC3)	OTVAW3P1	ERCC3_HUMAN	Increases Response To Substance	[59]
Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)	OTY9R6FZ	ERN1_HUMAN	Decreases Response To Substance	[35]

Indication(s) of Azacitidine

Disease Entry	ICD 11	Status	REF
Acute myelogenous leukaemia	2A41	Approved	[5]
Chronic myelomonocytic leukemia	N.A.	Approved	[5]
Leukemia	N.A.	Approved	[5]
Myelodysplastic syndrome	2A37	Approved	[6]
Myeloproliferative neoplasm	2A20	Approved	[5]
Plasma cell myeloma	2A83.1	Approved	[5]

Azacitidine Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
DNA [cytosine-5]-methyltransferase (DNMT)	TTHVCUP	NOUNIPROTAC	Inhibitor	[69]

Azacitidine Interacts with 2 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytidine aminohydrolase (CDA)	DEKEDRC	CDD_HUMAN	Metabolism	[70]
Cytidine deaminase (cdd)	DEYILK4	E0TLJ6_MYCHH	Metabolism	[71]

Azacitidine Interacts with 202 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Affects Expression	[72]
Tectonin beta-propeller repeat-containing protein 2 (TECPR2)	OT1UFECZ	TCPR2_HUMAN	Increases Expression	[65]
TBC1 domain family member 4 (TBC1D4)	OTK66C40	TBCD4_HUMAN	Decreases Expression	[65]
Multiple epidermal growth factor-like domains protein 6 (MEGF6)	OTEUYTP1	MEGF6_HUMAN	Decreases Expression	[65]
Protein S100-A9 (S100A9)	OTOARHCS	S10A9_HUMAN	Increases Expression	[65]
Receptor-type tyrosine-protein phosphatase C (PTPRC)	OT6KOR77	PTPRC_HUMAN	Increases Expression	[65]
Heat shock 70 kDa protein 6 (HSPA6)	OTH4S7WB	HSP76_HUMAN	Increases Expression	[65]
Gamma-aminobutyric acid receptor subunit beta-1 (GABRB1)	OT4L2SSB	GBRB1_HUMAN	Increases Expression	[65]
Transcription factor E3 (TFE3)	OTM99ZWH	TFE3_HUMAN	Increases Expression	[65]
Protein S100-P (S100P)	OTJCXNJG	S100P_HUMAN	Increases Expression	[65]
Protein PML (PML)	OT6SM2GD	PML_HUMAN	Increases Expression	[65]
DNA-binding protein inhibitor ID-1 (ID1)	OTKGNZN5	ID1_HUMAN	Increases Expression	[65]
Cyclin-dependent kinase 4 inhibitor B (CDKN2B)	OTAG24N1	CDN2B_HUMAN	Decreases Methylation	[65]
LIM and senescent cell antigen-like-containing domain protein 1 (LIMS1)	OT729S0T	LIMS1_HUMAN	Increases Expression	[65]
E3 SUMO-protein ligase RanBP2 (RANBP2)	OTFG5CVF	RBP2_HUMAN	Increases Expression	[65]
Cyclin-dependent kinase inhibitor 1C (CDKN1C)	OTASTJ3Q	CDN1C_HUMAN	Increases Expression	[65]
Ras-related protein Rab-13 (RAB13)	OTIQ484I	RAB13_HUMAN	Decreases Methylation	[65]
Claudin-10 (CLDN10)	OT2CVAKY	CLD10_HUMAN	Decreases Expression	[65]
Sushi repeat-containing protein SRPX (SRPX)	OT5B9LXS	SRPX_HUMAN	Decreases Expression	[65]
DNA-binding protein inhibitor ID-3 (ID3)	OTUULW5Z	ID3_HUMAN	Increases Expression	[65]
Collagen alpha-1(XIV) chain (COL14A1)	OTLNJ13O	COEA1_HUMAN	Increases Expression	[65]
Equilibrative nucleoside transporter 2 (SLC29A2)	OTUAOB8T	S29A2_HUMAN	Decreases Expression	[65]
Cytohesin-1 (CYTH1)	OTYH9NRJ	CYH1_HUMAN	Increases Expression	[65]
DNA dC->dU-editing enzyme APOBEC-3F (APOBEC3F)	OT750IJM	ABC3F_HUMAN	Increases Expression	[65]
Angiogenic factor with G patch and FHA domains 1 (AGGF1)	OTA7U2T8	AGGF1_HUMAN	Increases Expression	[65]
E3 ubiquitin-protein ligase Praja-1 (PJA1)	OTFKTMEI	PJA1_HUMAN	Increases Expression	[65]
Tetraspanin-32 (TSPAN32)	OTSXW7EW	TSN32_HUMAN	Decreases Expression	[65]
Tribbles homolog 1 (TRIB1)	OTPEO17G	TRIB1_HUMAN	Decreases Expression	[65]
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF)	OTT5JX1F	LITAF_HUMAN	Decreases Expression	[65]
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1A)	OTVTB5R5	PI51A_HUMAN	Decreases Expression	[65]
Centromere protein O (CENPO)	OTXAH83Y	CENPO_HUMAN	Increases Expression	[65]
Iron-sulfur cluster assembly 1 homolog, mitochondrial (ISCA1)	OTU230MC	ISCA1_HUMAN	Increases Expression	[65]
E3 ubiquitin-protein ligase TRIM8 (TRIM8)	OTS6JFR0	TRIM8_HUMAN	Increases Expression	[65]
Uncharacterized protein C6orf62 (C6ORF62)	OTGK4G35	CF062_HUMAN	Increases Expression	[65]
Metal transporter CNNM2 (CNNM2)	OTZHO8WU	CNNM2_HUMAN	Decreases Expression	[65]
DNA dC->dU-editing enzyme APOBEC-3G (APOBEC3G)	OT410VP5	ABC3G_HUMAN	Increases Expression	[65]
NTF2-related export protein 2 (NXT2)	OTK82YVT	NXT2_HUMAN	Increases Expression	[65]
THUMP domain-containing protein 1 (THUMPD1)	OTKU8KWH	THUM1_HUMAN	Increases Expression	[65]
Protein FAM8A1 (FAM8A1)	OT1QVTGS	FA8A1_HUMAN	Increases Expression	[65]
Type 2 lactosamine alpha-2,3-sialyltransferase (ST3GAL6)	OTB17Q43	SIA10_HUMAN	Increases Expression	[65]
Methionine-R-sulfoxide reductase B2, mitochondrial (MSRB2)	OTURGRA8	MSRB2_HUMAN	Increases Expression	[65]
Mitotic spindle assembly checkpoint protein MAD1 (MAD1L1)	OTJCX8K9	MD1L1_HUMAN	Decreases Expression	[65]
Signal-regulatory protein beta-1 (SIRPB1)	OTGHALWJ	SIRB1_HUMAN	Decreases Expression	[66]
Syntenin-1 (SDCBP)	OTS3NCC5	SDCB1_HUMAN	Decreases Expression	[66]
Complexin-1 (CPLX1)	OT7UIGTP	CPLX1_HUMAN	Increases Expression	[66]
Nephrocystin-1 (NPHP1)	OTZHCFFQ	NPHP1_HUMAN	Increases Expression	[66]
Phosphatase and actin regulator 2 (PHACTR2)	OTWMX2A8	PHAR2_HUMAN	Increases Expression	[66]
Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1)	OT4TMERS	NFAC1_HUMAN	Increases Expression	[66]
Metalloproteinase inhibitor 1 (TIMP1)	OTOXC51H	TIMP1_HUMAN	Increases Expression	[66]
Cystatin-C (CST3)	OTNZ6AO4	CYTC_HUMAN	Increases Expression	[66]
Cystatin-S (CST4)	OTXXM8EH	CYTS_HUMAN	Increases Expression	[66]
Interstitial collagenase (MMP1)	OTI4I2V1	MMP1_HUMAN	Increases Expression	[66]
Keratin, type II cytoskeletal 8 (KRT8)	OTTM4X11	K2C8_HUMAN	Increases Expression	[66]
Neurofilament light polypeptide (NEFL)	OTQESJV4	NFL_HUMAN	Increases Expression	[66]
Protein disulfide-isomerase (P4HB)	OTTYNYPF	PDIA1_HUMAN	Increases Expression	[66]
Profilin-1 (PFN1)	OTHTGA1H	PROF1_HUMAN	Increases Expression	[66]
Tropomyosin beta chain (TPM2)	OTA1L0P8	TPM2_HUMAN	Increases Expression	[66]
Small ribosomal subunit protein uS2 (RPSA)	OTJZHEGT	RSSA_HUMAN	Decreases Expression	[66]
Glycodelin (PAEP)	OTQA0NV4	PAEP_HUMAN	Decreases Expression	[66]
E3 SUMO-protein ligase EGR2 (EGR2)	OTAVQ78J	EGR2_HUMAN	Increases Expression	[66]
Pregnancy-specific beta-1-glycoprotein 1 (PSG1)	OT1U4ZZW	PSG1_HUMAN	Increases Expression	[66]
Collagen alpha-3(VI) chain (COL6A3)	OTAS6R6I	CO6A3_HUMAN	Decreases Expression	[66]
Parathyroid hormone-related protein (PTHLH)	OTI1JF13	PTHR_HUMAN	Decreases Expression	[66]
Plastin-3 (PLS3)	OTYBM4PK	PLST_HUMAN	Decreases Expression	[66]
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (MTHFD2)	OT1LQSGX	MTDC_HUMAN	Decreases Expression	[66]
Desmin (DES)	OTI09KBW	DESM_HUMAN	Increases Expression	[66]
5'-nucleotidase (NT5E)	OT7J5LT6	5NTD_HUMAN	Increases Expression	[66]
Fibroblast growth factor 7 (FGF7)	OTGK6ANL	FGF7_HUMAN	Decreases Expression	[66]
Insulin-like growth factor-binding protein 4 (IGFBP4)	OT2HZRBD	IBP4_HUMAN	Increases Expression	[66]
Transcription elongation factor A protein 1 (TCEA1)	OTBFO594	TCEA1_HUMAN	Decreases Expression	[66]
V-type proton ATPase 16 kDa proteolipid subunit c (ATP6V0C)	OTKPL09B	VATL_HUMAN	Increases Expression	[66]
Protein ITPRID2 (ITPRID2)	OTO3JDX5	ITPI2_HUMAN	Increases Expression	[66]
Interleukin-12 subunit beta (IL12B)	OT0JF8A3	IL12B_HUMAN	Increases Expression	[66]
Neurotensin/neuromedin N (NTS)	OTPGDNQS	NEUT_HUMAN	Decreases Expression	[66]
Guanylate-binding protein 2 (GBP2)	OTVU4G07	GBP2_HUMAN	Decreases Expression	[66]
MHC class II transactivator (CIITA)	OTRJNZFO	C2TA_HUMAN	Increases Expression	[66]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Increases Expression	[66]
Exosome RNA helicase MTR4 (MTREX)	OTSQY30V	MTREX_HUMAN	Increases Expression	[66]
Alpha-S1-casein (CSN1S1)	OTXOW6XJ	CASA1_HUMAN	Increases Expression	[66]
Nuclear receptor-interacting protein 1 (NRIP1)	OTIZOJQV	NRIP1_HUMAN	Decreases Expression	[66]
Homeobox protein Hox-A1 (HOXA1)	OTMSOJ7D	HXA1_HUMAN	Increases Expression	[66]
Ephrin-A3 (EFNA3)	OTJGOUMZ	EFNA3_HUMAN	Increases Expression	[66]
GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 (ART1)	OT7FBG5W	NAR1_HUMAN	Increases Expression	[66]
Branched-chain-amino-acid aminotransferase, cytosolic (BCAT1)	OTYHXLWZ	BCAT1_HUMAN	Decreases Expression	[66]
Microfibrillar-associated protein 2 (MFAP2)	OTMHVBTV	MFAP2_HUMAN	Decreases Expression	[66]
Laminin subunit beta-2 (LAMB2)	OT71OI2Y	LAMB2_HUMAN	Increases Expression	[66]
NHP2-like protein 1 (SNU13)	OTH56TIH	NH2L1_HUMAN	Increases Expression	[66]
Homeobox protein DLX-6 (DLX6)	OT0FIJHY	DLX6_HUMAN	Increases Expression	[66]
Elongation factor 1-alpha 1 (EEF1A1)	OT00THXS	EF1A1_HUMAN	Decreases Expression	[66]
Cytochrome c oxidase subunit 6A2, mitochondrial (COX6A2)	OTQR5SXD	CX6A2_HUMAN	Increases Expression	[66]
cAMP-responsive element modulator (CREM)	OTJIJ5AL	CREM_HUMAN	Decreases Expression	[66]
Caldesmon (CALD1)	OTNJKJ6Q	CALD1_HUMAN	Increases Expression	[66]
ATP-dependent RNA helicase A (DHX9)	OT5AAOQI	DHX9_HUMAN	Decreases Expression	[66]
Serine/threonine-protein kinase PAK 1 (PAK1)	OT17LZNZ	PAK1_HUMAN	Increases Expression	[66]
Dual specificity mitogen-activated protein kinase kinase 5 (MAP2K5)	OT6T408U	MP2K5_HUMAN	Decreases Expression	[66]
Chitotriosidase-1 (CHIT1)	OTPQR0A6	CHIT1_HUMAN	Increases Expression	[66]
Ras and Rab interactor 1 (RIN1)	OTPBROUD	RIN1_HUMAN	Increases Expression	[66]
Keratin, type I cuticular Ha2 (KRT32)	OTZCGZYT	K1H2_HUMAN	Increases Expression	[66]
Ras GTPase-activating protein 3 (RASA3)	OT9C54MN	RASA3_HUMAN	Increases Expression	[66]
Mediator of DNA damage checkpoint protein 1 (MDC1)	OTEUQH4J	MDC1_HUMAN	Increases Expression	[66]
Mortality factor 4-like protein 2 (MORF4L2)	OT8OI3EC	MO4L2_HUMAN	Decreases Expression	[66]
kinase isozyme 1, mitochondrial (PDK1)	OTMABK9Z	PDK1_HUMAN	Increases Expression	[66]
Serine/threonine-protein kinase 38 (STK38)	OTKMYCYR	STK38_HUMAN	Decreases Expression	[66]
Serine/threonine-protein phosphatase 2A activator (PTPA)	OTRGFOI7	PTPA_HUMAN	Increases Expression	[66]
Reticulocalbin-1 (RCN1)	OT3JBGAG	RCN1_HUMAN	Decreases Expression	[66]
Olfactory receptor 8B8 (OR8B8)	OTCISNYV	OR8B8_HUMAN	Increases Expression	[66]
Serine/arginine-rich splicing factor 7 (SRSF7)	OTRS4W4S	SRSF7_HUMAN	Decreases Expression	[66]
Guanylate kinase (GUK1)	OTLI0HRU	KGUA_HUMAN	Increases Expression	[66]
Filamin A-interacting protein 1-like (FILIP1L)	OTPY8IMS	FIL1L_HUMAN	Decreases Expression	[66]
Nucleolar MIF4G domain-containing protein 1 (NOM1)	OTWZSJJC	NOM1_HUMAN	Decreases Expression	[66]
Opioid growth factor receptor-like protein 1 (OGFRL1)	OT6QGBYE	OGRL1_HUMAN	Increases Expression	[66]
Serine/threonine-protein kinase MRCK alpha (CDC42BPA)	OTCPFOSA	MRCKA_HUMAN	Decreases Expression	[66]
Extracellular sulfatase Sulf-1 (SULF1)	OTJCNCO0	SULF1_HUMAN	Decreases Expression	[66]
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase (GCNT2)	OTRUIMC4	GNT2A_HUMAN	Decreases Expression	[66]
Oxidation resistance protein 1 (OXR1)	OTPIDMT3	OXR1_HUMAN	Increases Expression	[66]
Alpha-2,8-sialyltransferase 8B (ST8SIA2)	OTRBBBD8	SIA8B_HUMAN	Decreases Expression	[66]
Type II iodothyronine deiodinase (DIO2)	OTGPNSLH	IOD2_HUMAN	Decreases Expression	[66]
G-patch domain and KOW motifs-containing protein (GPKOW)	OTGS3H0M	GPKOW_HUMAN	Increases Expression	[66]
Rho guanine nucleotide exchange factor 2 (ARHGEF2)	OTBQTFRT	ARHG2_HUMAN	Decreases Expression	[66]
Homogentisate 1,2-dioxygenase (HGD)	OTTKLQOO	HGD_HUMAN	Increases Expression	[66]
Secretory carrier-associated membrane protein 4 (SCAMP4)	OTSCZTJ5	SCAM4_HUMAN	Increases Expression	[66]
Protein bicaudal D homolog 1 (BICD1)	OT78IYPF	BICD1_HUMAN	Decreases Expression	[66]
Ankyrin repeat and SOCS box protein 2 (ASB2)	OTF9LV7L	ASB2_HUMAN	Increases Expression	[66]
Eyes absent homolog 1 (EYA1)	OTHU807A	EYA1_HUMAN	Decreases Expression	[66]
Bcl-2-like protein 13 (BCL2L13)	OT2VRFTM	B2L13_HUMAN	Increases Expression	[66]
RNA helicase Mov10l1 (MOV10L1)	OTP978LK	M10L1_HUMAN	Increases Expression	[66]
Rac GTPase-activating protein 1 (RACGAP1)	OTQE8IEH	RGAP1_HUMAN	Increases Expression	[66]
Ras-related protein Rab-1B (RAB1B)	OTAFCUAS	RAB1B_HUMAN	Increases Expression	[66]
Semaphorin-6C (SEMA6C)	OT1N59T5	SEM6C_HUMAN	Increases Expression	[66]
Sentrin-specific protease 3 (SENP3)	OTFQDOMC	SENP3_HUMAN	Increases Expression	[66]
Ribonuclease P protein subunit p21 (RPP21)	OT53MDNE	RPP21_HUMAN	Increases Expression	[66]
Protocadherin-18 (PCDH18)	OTTLQWRN	PCD18_HUMAN	Decreases Expression	[66]
Protein S100-A14 (S100A14)	OTVFJJ91	S10AE_HUMAN	Decreases Expression	[66]
Tryptase gamma (TPSG1)	OTDESHKT	TRYG1_HUMAN	Decreases Expression	[66]
Rho GTPase-activating protein 35 (ARHGAP35)	OTJ8POG0	RHG35_HUMAN	Increases Expression	[66]
Neuroligin-3 (NLGN3)	OTKDEC1Q	NLGN3_HUMAN	Increases Expression	[66]
Polycystin-2-like protein 1 (PKD2L1)	OT1KJDAT	PK2L1_HUMAN	Increases Expression	[66]
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1)	OTTLJH8W	ATS1_HUMAN	Decreases Expression	[66]
Cytoplasmic phosphatidylinositol transfer protein 1 (PITPNC1)	OT64TTGC	PITC1_HUMAN	Decreases Expression	[66]
Transcription factor SOX-13 (SOX13)	OTCIF6KC	SOX13_HUMAN	Decreases Expression	[66]
Afadin- and alpha-actinin-binding protein (SSX2IP)	OTEIZ7N1	ADIP_HUMAN	Increases Expression	[66]
Transmembrane emp24 domain-containing protein 3 (TMED3)	OTNOPHHC	TMED3_HUMAN	Increases Expression	[66]
Protocadherin beta-4 (PCDHB4)	OTF665E0	PCDB4_HUMAN	Decreases Expression	[66]
Protocadherin beta-14 (PCDHB14)	OTFZF1ST	PCDBE_HUMAN	Decreases Expression	[66]
Adenylate kinase isoenzyme 5 (AK5)	OTTGXLOT	KAD5_HUMAN	Increases Expression	[66]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Increases Expression	[73]
Tyrosine aminotransferase (TAT)	OT2CJ91O	ATTY_HUMAN	Increases Expression	[73]
CCAAT/enhancer-binding protein alpha (CEBPA)	OTOM9OE4	CEBPA_HUMAN	Increases Expression	[73]
Hematopoietically-expressed homeobox protein HHEX (HHEX)	OTLIUVYX	HHEX_HUMAN	Increases Expression	[73]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 (GNG7)	OTHS1L0E	GBG7_HUMAN	Affects Methylation	[74]
Claudin-7 (CLDN7)	OTNE0XHQ	CLD7_HUMAN	Decreases Expression	[75]
Claudin-9 (CLDN9)	OTCKI2IZ	CLD9_HUMAN	Increases Expression	[76]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Decreases Expression	[77]
Calcitonin (CALCA)	OTZ11LHB	CALC_HUMAN	Decreases Methylation	[78]
Tyrosine-protein kinase Fyn (FYN)	OTLSLVZS	FYN_HUMAN	Increases Expression	[79]
L-lactate dehydrogenase B chain (LDHB)	OT9B1CT3	LDHB_HUMAN	Increases Expression	[80]
Histone H1.0 (H1-0)	OTRLJK4Z	H10_HUMAN	Increases Expression	[81]
Interleukin-6 receptor subunit alpha (IL6R)	OTCQL07Z	IL6RA_HUMAN	Affects Expression	[72]
Gamma-enolase (ENO2)	OTRODL0T	ENOG_HUMAN	Decreases Expression	[82]
Chromogranin-A (CHGA)	OTXYX5JH	CMGA_HUMAN	Decreases Expression	[82]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Increases Expression	[83]
15-hydroxyprostaglandin dehydrogenase (HPGD)	OTYZI6JB	PGDH_HUMAN	Decreases Methylation	[84]
Histone H2AX (H2AX)	OT18UX57	H2AX_HUMAN	Increases Expression	[85]
Methylated-DNA--protein-cysteine methyltransferase (MGMT)	OT40A9WH	MGMT_HUMAN	Increases Expression	[86]
Fibulin-1 (FBLN1)	OT5MHHOP	FBLN1_HUMAN	Increases Expression	[79]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)	OTDRV63V	GA45A_HUMAN	Increases Expression	[87]
G1/S-specific cyclin-D2 (CCND2)	OTDULQF9	CCND2_HUMAN	Affects Methylation	[88]
Cyclin-dependent kinase inhibitor 2A (CDKN2A)	OTN0ZWAE	CDN2A_HUMAN	Decreases Methylation	[89]
Killer cell immunoglobulin-like receptor 2DL1 (KIR2DL1)	OTL1LBQJ	KI2L1_HUMAN	Increases Expression	[90]
Killer cell immunoglobulin-like receptor 2DL2 (KIR2DL2)	OTOVUTJD	KI2L2_HUMAN	Increases Expression	[90]
Killer cell immunoglobulin-like receptor 2DL3 (KIR2DL3)	OTFCN53B	KI2L3_HUMAN	Increases Expression	[90]
Killer cell immunoglobulin-like receptor 3DL1 (KIR3DL1)	OTPOSXFX	KI3L1_HUMAN	Increases Expression	[90]
Killer cell immunoglobulin-like receptor 2DS4 (KIR2DS4)	OT00N6UJ	KI2S4_HUMAN	Increases Expression	[90]
Tumor necrosis factor ligand superfamily member 6 (FASLG)	OTZARCHH	TNFL6_HUMAN	Increases Response To Substance	[91]
Tuberin (TSC2)	OT47LWI9	TSC2_HUMAN	Increases Expression	[92]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10)	OT4PXBTA	TNF10_HUMAN	Increases Response To Substance	[91]
Homeobox protein Nkx-2.5 (NKX2-5)	OTS1SAWM	NKX25_HUMAN	Increases Expression	[93]
Death-associated protein kinase 1 (DAPK1)	OTNCNUCO	DAPK1_HUMAN	Affects Methylation	[94]
Claudin-8 (CLDN8)	OT7IIWXG	CLD8_HUMAN	Increases Expression	[76]
Small ribosomal subunit protein eS6 (RPS6)	OTT4D1LN	RS6_HUMAN	Decreases Phosphorylation	[79]
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA)	OT83PT85	PP2AA_HUMAN	Increases Expression	[95]
Cyclin-A1 (CCNA1)	OTX4HD45	CCNA1_HUMAN	Decreases Expression	[96]
Heat shock factor protein 1 (HSF1)	OTYNJ4KP	HSF1_HUMAN	Decreases Activity	[97]
Transcription factor p65 (RELA)	OTUJP9CN	TF65_HUMAN	Affects Localization	[72]
Tight junction protein ZO-1 (TJP1)	OTBDCUPK	ZO1_HUMAN	Increases Expression	[76]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)	OT4SO7J4	BNIP3_HUMAN	Increases Expression	[98]
N-myc-interactor (NMI)	OTYVG3NM	NMI_HUMAN	Increases Expression	[79]
NAD(P) transhydrogenase, mitochondrial (NNT)	OTAIOGZK	NNTM_HUMAN	Increases Expression	[75]
Cyclin-G2 (CCNG2)	OTII38K2	CCNG2_HUMAN	Decreases Expression	[79]
Occludin (OCLN)	OTSUTVWL	OCLN_HUMAN	Increases Expression	[76]
kinase isozyme 4, mitochondrial (PDK4)	OTCMHMBZ	PDK4_HUMAN	Decreases Methylation	[99]
Dual specificity protein phosphatase 6 (DUSP6)	OT4H6RKW	DUS6_HUMAN	Increases Expression	[79]
Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B)	OTE8GBUR	RIR2B_HUMAN	Increases Expression	[100]
Krueppel-like factor 6 (KLF6)	OTQY9S7F	KLF6_HUMAN	Increases Expression	[79]
Killer cell immunoglobulin-like receptor 2DL4 (KIR2DL4)	OTXN18OA	KI2L4_HUMAN	Increases Expression	[90]
Protein Niban 1 (NIBAN1)	OTYOLI12	NIBA1_HUMAN	Increases Expression	[79]
Calcium homeostasis modulator protein 2 (CALHM2)	OTWWM6HI	CAHM2_HUMAN	Increases Expression	[75]
Homeobox protein SIX2 (SIX2)	OTYOVGSC	SIX2_HUMAN	Decreases Expression	[75]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1)	OT9HYT7A	PLCB1_HUMAN	Increases Expression	[101]
Sal-like protein 4 (SALL4)	OTC08PR5	SALL4_HUMAN	Affects Methylation	[68]
Transcription factor MafB (MAFB)	OTH2N3T8	MAFB_HUMAN	Increases Expression	[75]
Sodium/nucleoside cotransporter 1 (SLC28A1)	OTXWVV9O	S28A1_HUMAN	Increases Response To Substance	[102]

Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Adult Nasal Type Extranodal NK/T-cell Lymphoma	DCVI4CO	N. A.	Phase 1	[103]

References

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• [2] Bortezomib FDA Label
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• [4] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6391).
• [5] Azacitidine FDA Label
• [6] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6796).
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