Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3GYAL)

• Drug Name: Deoxycholic acid Drug Info
• Synonyms: (3alpha,5beta,12alpha)-3,12-Dihydroxycholan-24-oic acid; 3,12-Dihydroxycholanic acid; 3alpha,12alpha-Dihydroxy-5beta-cholan-24-oic acid; 3alpha,12alpha-Dihydroxy-5beta-cholanic acid; 5-beta-Deoxycholic acid; 7-Deoxycholic acid; 7alpha-Deoxycholic acid; ATX-101; Choleic acid; Cholerebic; Cholic acid, deoxy-; Cholorebic; DEOXYCHOLIC ACID; Degalol; Deoxy cholic acid; Deoxycholatic acid; Desoxycholic acid; Desoxycholsaeure; Dihydroxycholanoic acid; Droxolan; Pyrochol; Septochol; Sodium deoxycholate; deoxycholate

Indication

Disease Entry	ICD 11	Status	REF
Subcutaneous fat disorder	EF02	Approved	[1]

• Cross-matching ID:
  PubChem CID: 222528
  ChEBI ID: CHEBI:28834
  CAS Number: CAS 83-44-3
  TTD Drug ID: DM3GYAL
  VARIDT Drug ID: DR01301

Molecule-Related Drug Atlas

Drug(s) Transported By Breast cancer resistance protein (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[8]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[10]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[11]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[12]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[13]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[14]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[13]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[15]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[16]

Drug(s) Transported By Apical sodium-dependent bile acid transporter (SLC10A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[17]
Taurocholic Acid	DM2LZ8F	Type-2 diabetes	5A11	Phase 1/2	[18]
Sodium taurocholate	DM3GO0J	Type-2 diabetes	5A11	Phase 1/2	[18]
glycodeoxycholic acid	DM1XEJV	Discovery agent	N.A.	Investigative	[17]

Drug(s) Affected By GTPase HRas (HRAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Selenium	DM25CGV	N. A.	N. A.	Approved	[20]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[22]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[23]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[24]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[25]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]

Drug(s) Affected By CCAAT/enhancer-binding protein beta (CEBPB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[30]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[36]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[39]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[40]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[41]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[42]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[43]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[44]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[45]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[46]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[47]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[49]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[49]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[50]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[51]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[52]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[49]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[49]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[49]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[54]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[55]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[56]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[57]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[58]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[59]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[60]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[61]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[62]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[63]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[61]

Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[64]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[65]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[66]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[67]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[68]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[68]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[69]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[70]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[71]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[72]

Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[73]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[74]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[75]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[76]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[77]
Clopidogrel	DMOL54H	Acute coronary syndrome	BA41	Approved	[78]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[79]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[80]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[81]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[82]

Drug(s) Affected By ATP-binding cassette sub-family C member 3 (ABCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[83]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[84]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[85]
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[86]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[87]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[88]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[30]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[89]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[90]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[91]

Drug(s) Affected By Bile salt export pump (ABCB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[92]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[93]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[93]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[94]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[92]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[93]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[95]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[92]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[96]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[92]

Drug(s) Affected By Fibroblast growth factor 19 (FGF19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[97]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[98]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[37]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[100]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[5]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[5]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[102]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[103]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[104]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[105]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[106]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[107]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[108]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[109]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Selenium	DM25CGV	N. A.	N. A.	Approved	[111]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[113]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[114]
Fructose	DM43AN2	Vomiting	MD90	Approved	[115]
Ketoprofen	DMRKXPT	Bursitis		Approved	[115]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[116]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[117]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[118]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[119]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[120]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[121]

Drug(s) Affected By Prelamin-A/C (LMNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[20]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[122]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[123]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[124]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[127]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[128]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[129]

Drug(s) Affected By Metallothionein-2 (MT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[131]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[132]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[133]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[135]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[136]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[137]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]

Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[139]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[139]
Ergonovine	DM0VEC1	Postpartum haemorrhage	JA43	Approved	[115]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[140]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[141]
Mizolastine	DM1FDN8	Allergic rhinitis	CA08.0	Approved	[142]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[143]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[144]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[145]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[146]

Drug(s) Affected By Protein kinase C beta type (PRKCB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[20]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[148]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[149]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[150]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[128]

Drug(s) Affected By Insulin-like growth factor-binding protein 1 (IGFBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[46]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[152]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[153]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[154]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[155]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[156]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[156]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[149]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[157]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[158]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[159]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[160]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[161]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[162]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[163]
Selenium	DM25CGV	N. A.	N. A.	Approved	[164]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[146]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[165]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[122]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[166]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[167]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[168]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[169]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[170]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[169]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[171]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[172]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[173]

Drug(s) Affected By Amphiregulin (AREG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[174]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[131]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[175]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[176]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[155]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[125]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[177]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[178]

Drug(s) Affected By E-selectin (SELE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[179]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[180]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[181]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[184]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[185]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[186]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[187]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[188]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[159]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[131]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[189]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[190]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[191]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[152]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[153]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[192]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[134]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[37]

Drug(s) Affected By Cytochrome P450 7A1 (CYP7A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[86]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[97]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[193]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[133]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[194]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[81]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[195]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[196]

Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[115]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[197]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[198]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[162]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[163]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[199]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[200]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[152]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[133]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[201]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[202]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[203]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[204]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[205]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[206]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[207]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[208]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[209]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[197]

Drug(s) Affected By Gastrotropin (FABP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[192]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[210]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[211]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[212]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[213]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[214]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[215]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[216]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[217]

Drug(s) Affected By Microsomal triglyceride transfer protein large subunit (MTTP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[218]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[218]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[152]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[218]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[218]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[219]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[220]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[221]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[150]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[222]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[223]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[224]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[225]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[226]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[168]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[227]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[228]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[229]

Drug(s) Affected By Caspase-6 (CASP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[230]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[198]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[30]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[231]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[232]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[152]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[233]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[234]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[235]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[236]

Drug(s) Affected By Protein kinase C epsilon type (PRKCE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[22]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[233]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Indomethacin	DMSC4A7	Bursitis		Approved	[237]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[215]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[238]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[239]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[240]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[241]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[198]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[242]
Selenium	DM25CGV	N. A.	N. A.	Approved	[20]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[243]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[244]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[152]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[245]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[246]
Desloratadine	DM56YN7	Allergic rhinitis	CA08.0	Approved	[247]

Drug(s) Affected By Peroxisomal bifunctional enzyme (EHHADH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[98]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[152]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[219]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[128]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[249]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[250]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[219]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[251]

Drug(s) Affected By Nuclear receptor subfamily 0 group B member 2 (NR0B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[86]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[252]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[46]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[253]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[97]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[252]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[152]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[252]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[193]

Drug(s) Affected By Organic solute transporter subunit alpha (SLC51A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[30]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[97]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[152]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[192]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[255]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[5]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[256]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[149]

Drug(s) Affected By Organic solute transporter subunit beta (SLC51B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[160]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[30]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[152]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[22]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[255]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[257]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[5]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[258]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[149]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]

Drug(s) Affected By Metallothionein-1M (MT1M)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[159]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[152]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[259]
Phenoxybenzamine	DM8KSQH	Malignant essential hypertension	BA00	Approved	[260]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[149]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[260]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[261]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[262]

Drug(s) Affected By G-protein coupled bile acid receptor 1 (GPBAR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[5]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[263]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[261]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[5]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[264]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[265]
tauroursodeoxycholic acid	DMFKRQE	Discovery agent	N.A.	Investigative	[263]

Drug(s) Affected By Scavenger receptor class B member 1 (SCARB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[266]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[267]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[233]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[268]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[269]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[270]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[271]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[272]

Drug(s) Affected By Bile acid receptor (NR1H4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[253]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[273]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[152]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[274]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[194]
Nisoldipine	DM7ISKJ	Hypertension	BA00-BA04	Approved	[273]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[5]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[275]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[276]

Drug(s) Affected By ATP-binding cassette sub-family G member 5 (ABCG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[97]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[152]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[277]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[5]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[149]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[94]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[251]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[5]

Drug(s) Affected By Solute carrier organic anion transporter family member 1B3 (SLCO1B3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[278]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[279]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[280]
Trospium chloride	DM32XZT	Discovery agent	N.A.	Approved	[281]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[22]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[255]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[5]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[256]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[282]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]

Drug(s) Affected By Peroxisomal carnitine O-octanoyltransferase (CROT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[128]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[102]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[219]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[230]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[283]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[284]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[285]

Drug(s) Affected By 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase (CYP8B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[5]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[97]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[152]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[22]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[5]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[276]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[215]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[74]

Drug(s) Affected By TNF receptor-associated factor 2 (TRAF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[286]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[287]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[22]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[288]
Ceritinib	DMB920Z	Non-small-cell lung cancer	2C25.Y	Approved	[289]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[128]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[129]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[290]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[251]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[230]

Drug(s) Affected By 5'-AMP-activated protein kinase subunit beta-1 (PRKAB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[291]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[152]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[137]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[137]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[137]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[127]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[292]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[291]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[291]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[251]

Drug(s) Affected By Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (PIP5K1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[293]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[149]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[137]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[294]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[240]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[295]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[296]

Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[297]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[191]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[152]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[192]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[134]
Quinolones	DM5GVHU	Bacterial infection	1A00-1C4Z	Approved	[298]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[299]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[235]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[211]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[137]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[300]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[301]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[302]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[303]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[115]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[304]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[224]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[117]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[242]

Drug(s) Affected By D-dopachrome decarboxylase (DDT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[198]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[305]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[128]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[153]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[230]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[306]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[217]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[307]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[218]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[308]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[309]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[310]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[311]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[312]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[313]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[152]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[314]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 1 (NAIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[150]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[129]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[290]
Bortezomib	DMNO38U	Leukemia		Approved	[315]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[251]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[316]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[317]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[318]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[319]

Drug(s) Affected By Glutathione S-transferase P (GSTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[320]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[230]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[321]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[321]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[322]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[87]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[297]
Selenium	DM25CGV	N. A.	N. A.	Approved	[20]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[309]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[323]

Drug(s) Affected By Peroxiredoxin-2 (PRDX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[230]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[324]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[309]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[325]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[34]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[210]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[326]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[327]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]

Drug(s) Affected By Protein kinase C zeta type (PRKCZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[211]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[328]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[294]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[215]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[329]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[330]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[239]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[331]

Drug(s) Affected By Solute carrier organic anion transporter family member 1B1 (SLCO1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[332]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[333]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[94]
Repaglinide	DM5SXUV	Diabetic complication	5A2Y	Approved	[334]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[335]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[336]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[337]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[337]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[280]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[338]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[158]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[339]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[109]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[340]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[297]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[341]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[342]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[32]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[244]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[287]

Drug(s) Affected By Serine protease HTRA1 (HTRA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[343]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[150]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[345]
Tirbanibulin	DMJNV4O	Actinic keratosis	EK90.0	Approved	[343]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[346]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[294]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[251]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[343]

Drug(s) Affected By Serpin B5 (SERPINB5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[131]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[122]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[347]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[348]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[137]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[349]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[137]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[350]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[351]

Drug(s) Affected By Peroxiredoxin-4 (PRDX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[352]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[353]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[354]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[128]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[355]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[251]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[356]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[357]

Drug(s) Affected By L-dopachrome tautomerase (DCT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[358]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[305]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[306]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[322]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[322]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[359]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[360]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[359]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[361]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[362]

Molecular Interaction Atlas of This Drug

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Apical sodium-dependent bile acid transporter (SLC10A2)	DT7JELC	NTCP2_HUMAN	Substrate	[2]
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
5'-AMP-activated protein kinase subunit beta-1 (PRKAB1)	OT1OG4QZ	AAKB1_HUMAN	Drug Response	[4]
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase (CYP8B1)	OTRI4UR1	CP8B1_HUMAN	Gene/Protein Processing	[5]
Amphiregulin (AREG)	OTJFOR67	AREG_HUMAN	Protein Interaction/Cellular Processes	[6]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Drug Response	[4]
ATP-binding cassette sub-family C member 3 (ABCC3)	OTC3IJV4	MRP3_HUMAN	Gene/Protein Processing	[5]
ATP-binding cassette sub-family G member 5 (ABCG5)	OT1OMY93	ABCG5_HUMAN	Gene/Protein Processing	[5]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Gene/Protein Processing	[7]
Baculoviral IAP repeat-containing protein 1 (NAIP)	OTLA925F	BIRC1_HUMAN	Drug Response	[4]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)	OT4SO7J4	BNIP3_HUMAN	Drug Response	[4]
Bile acid receptor (NR1H4)	OTWZLPTB	NR1H4_HUMAN	Gene/Protein Processing	[5]

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