Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM82Y75)

• Drug Name: PIRINIXIC ACID Drug Info
• Synonyms: Pirinixic acid; 50892-23-4; WY-14643; [4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid; WY-14,643; WY14643; Wyeth 14,643; Wy 14643; Pirinixic acid [INN]; WY-14643 (Pirinixic Acid); (4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthio)acetic acid; UNII-86C4MRT55A; C14H14ClN3O2S; CCRIS 133; Acidum pirinixicum [INN-Latin]; Acide pirinixique [INN-French]; Acido pirinixico [INN-Spanish]; NSC310038; NSC-310038; NSC 310038; BRN 0759945; ((4-Chloro-6-((2,3-dimethylphenyl)amino)-2-pyrimidinyl)thio)acetic acid; Acetic acid, ((4-chloro-6-(

Indication

Disease Entry	ICD 11	Status	REF
Pulmonary fibrosis	CB03.4	Preclinical	[1]

• Cross-matching ID:
  PubChem CID: 5694
  ChEBI ID: CHEMBL295416
  CAS Number: CAS 50892-23-4
  TTD Drug ID: DM82Y75

Molecule-Related Drug Atlas

Drug(s) Targeting Peroxisome proliferator-activated receptor alpha (PPARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lobeglitazone	DMHY3IP	Type-2 diabetes	5A11	Approved	[12]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[13]
Bezafibrate	DMZDCS0	Hypercholesterolaemia	5C80.0	Approved	[14]
Ciprofibrate	DMGC5DB	Hyperlipoproteinemia	5C80	Approved	[13]
Pemafibrate	DMD1VZL	Hyperlipidemia	5C80.Z	Approved	[15]
MURAGLITAZAR	DMG3NFZ	N. A.	N. A.	Phase 3	[16]
Ragaglitazar	DMFSHEM	Type-1 diabetes	5A10	Phase 3	[17]
CS-038	DM67P0F	Type-2 diabetes	5A11	Phase 3	[18]
TESAGLITAZAR	DMGRBN5	Type-1 diabetes	5A10	Phase 3	[19]
GFT-505	DM7ZOAE	Non-alcoholic steatohepatitis	DB92.1	Phase 3	[20]

Drug(s) Affected By Aldo-keto reductase family 1 member B1 (AKR1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[23]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[29]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[26]

Drug(s) Affected By Bile salt export pump (ABCB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[7]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[30]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[30]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[31]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[7]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[30]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[32]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[7]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[33]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[7]

Drug(s) Affected By Aldo-keto reductase family 1 member B10 (AKR1B10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[35]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[36]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[37]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[38]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[39]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[26]

Drug(s) Affected By Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[42]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[10]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[43]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]

Drug(s) Affected By Synaptophysin (SYP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[49]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[48]
Abacavir	DMMN36E	Human immunodeficiency virus infection	1C62	Approved	[50]
Methamphetamine	DMPM4SK	Anxiety		Approved	[51]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[53]

Drug(s) Affected By Drebrin (DBN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[49]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[56]

Drug(s) Affected By POTE ankyrin domain family member B (POTEB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]

Drug(s) Affected By POTE ankyrin domain family member C (POTEC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[58]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[59]

Drug(s) Affected By Nephrin (NPHS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[62]
Bezafibrate	DMZDCS0	Hypercholesterolaemia	5C80.0	Approved	[63]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[64]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[65]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[58]
Puromycin	DMDKLB5	N. A.	N. A.	Preclinical	[66]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[67]

Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[68]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[70]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[71]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[72]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[73]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[42]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]

Drug(s) Affected By Choriogonadotropin subunit beta 3 (CGB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[78]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[80]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[81]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[80]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]
Bezafibrate	DMZDCS0	Hypercholesterolaemia	5C80.0	Approved	[82]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[83]

Drug(s) Affected By Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[84]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[85]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[86]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[84]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[88]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[23]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[89]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[84]

Drug(s) Affected By C-X-C motif chemokine 5 (CXCL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[90]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[92]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[95]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[96]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[29]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[97]

Drug(s) Affected By Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADVL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[98]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[99]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[43]
Haloperidol	DM96SE0	Delirium		Approved	[98]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[102]

Drug(s) Affected By Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[103]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[99]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[42]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[104]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[92]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[105]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[106]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[107]

Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, mitochondrial (HMGCS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[36]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[109]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[110]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[53]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[45]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[111]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[112]

Drug(s) Affected By GTP-binding protein RAD (RRAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[39]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[113]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[114]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[115]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[116]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[117]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[118]

Drug(s) Affected By Tumor protein D52 (TPD52)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[84]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[120]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[121]

Drug(s) Affected By Cytochrome P450 4A11 (CYP4A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[122]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[123]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[99]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[42]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[124]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[123]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[123]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[123]

Drug(s) Affected By Glycine N-methyltransferase (GNMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[36]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[125]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[36]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[121]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[118]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[126]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[127]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[104]
Artemether	DM48QOT	Malaria	1F40-1F45	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[75]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[130]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[131]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[132]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]

Drug(s) Affected By Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[42]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[102]
Ciprofibrate	DMGC5DB	Hyperlipoproteinemia	5C80	Approved	[133]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[134]
Sodium Acetate Anhydrous	DMH21E0	Hyponatraemia	5C72	Approved	[135]

Drug(s) Affected By kinase isozyme 4, mitochondrial (PDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[136]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[106]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[139]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[139]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]

Drug(s) Affected By Programmed cell death protein 4 (PDCD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[84]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[84]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[142]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[39]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[84]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[93]

Drug(s) Affected By POTE ankyrin domain family member D (POTED)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[118]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[58]
2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE	DMNQL17	Discovery agent	N.A.	Investigative	[144]

Drug(s) Affected By Cytochrome P450 4X1 (CYP4X1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[146]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[36]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[118]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[53]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[45]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[147]

Drug(s) Affected By Thyroid hormone-inducible hepatic protein (THRSP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[36]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[36]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[36]
Clopidogrel	DMOL54H	Acute coronary syndrome	BA41	Approved	[149]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[118]
Mitotane	DMU1GX0	Adrenocortical carcinoma	2D11.Z	Approved	[149]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[150]

Drug(s) Affected By Bcl-2-modifying factor (BMF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[151]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[152]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[153]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[154]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[155]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[36]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[156]

Drug(s) Affected By Nectin-4 (NECTIN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[157]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[120]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[115]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[125]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[158]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[159]

Drug(s) Affected By Perilipin-2 (PLIN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[160]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[139]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]

Drug(s) Affected By Ankyrin repeat domain-containing protein 30A (ANKRD30A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[163]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[58]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[163]

Drug(s) Affected By Leucine-rich melanocyte differentiation-associated protein (LRMDA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[125]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[118]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[164]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[158]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[53]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[165]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[166]

Drug(s) Affected By Ankyrin repeat domain-containing protein 26 (ANKRD26)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[28]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[118]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[159]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[168]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[165]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[147]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[58]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Peroxisome proliferator-activated receptor alpha (PPARA)	TTJ584C	PPARA_HUMAN	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Aldo-keto reductase family 1 member B1 (AKR1B1)	OTRX72TH	ALDR_HUMAN	Gene/Protein Processing	[3]
Aldo-keto reductase family 1 member B10 (AKR1B10)	OTOA4HTH	AK1BA_HUMAN	Gene/Protein Processing	[4]
Ankyrin repeat domain-containing protein 26 (ANKRD26)	OT2ENKKV	ANR26_HUMAN	Gene/Protein Processing	[5]
Ankyrin repeat domain-containing protein 30A (ANKRD30A)	OTJXYAE5	AN30A_HUMAN	Gene/Protein Processing	[5]
Bcl-2-modifying factor (BMF)	OT90NSLI	BMF_HUMAN	Gene/Protein Processing	[6]
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Gene/Protein Processing	[7]
C-X-C motif chemokine 5 (CXCL5)	OTZOUPCA	CXCL5_HUMAN	Gene/Protein Processing	[8]
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)	OTI862QH	CPT1A_HUMAN	Gene/Protein Processing	[9]
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2)	OTIN6G20	CPT2_HUMAN	Gene/Protein Processing	[10]
Choriogonadotropin subunit beta 3 (CGB3)	OTVM2SU3	CGB3_HUMAN	Gene/Protein Processing	[11]

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