Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9B6Y1)

• Drug Name: NORCANTHARIDIN Drug Info
• Synonyms: Norcantharidin; 5442/12/6; Endothall anhydride; Norcantharadine; 7-Oxabicyclo[221]heptane-2,3-dicarboxylic anhydride; 4,7-Epoxyisobenzofuran-1,3-dione, hexahydro-; 3,6-Endoxohexahydrophthalic anhydride; 29745-04-8; Hexahydro-4,7-epoxyisobenzofuran-1,3-dione; NSC 14003; 7-Oxabicyclo(221)heptane-2,3-dicarboxylic anhydride; FR-0742; 3,6-Endooxyphthalic anhydride, hexahydro-; Phthalic anhydride, hexahydro-3,6-endoxo-; C8H8O4; 4,10-dioxatricyclo[5210< 2,6> ]decane-3,5-dione; NSC 59023; BRN 0084287; DEMETHYL-CANTHARIDIN

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 93004
  CAS Number: CAS 5442-12-6
  TTD Drug ID: DM9B6Y1

Molecule-Related Drug Atlas

Drug(s) Targeting Serine/threonine PP1-alpha (PPP1CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[7]
PALASONIN	DMDTP1R	Discovery agent	N.A.	Investigative	[7]
TAUTOMYCIN	DMC92DQ	Discovery agent	N.A.	Investigative	[7]
CANTHARIDIC_ACID	DME32XU	Discovery agent	N.A.	Investigative	[7]
MICROCYSTIN-LR	DMTMLRN	Discovery agent	N.A.	Investigative	[7]

Drug(s) Affected By Serine/threonine-protein kinase Chk1 (CHEK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[8]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[9]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[10]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[11]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[12]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[13]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[15]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[16]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[17]

Drug(s) Affected By Angiopoietin-2 (ANGPT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[18]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[21]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[22]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[23]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[24]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[24]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[25]

Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[27]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[30]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[31]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[33]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[34]

Drug(s) Affected By Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[35]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[36]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[38]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[41]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[42]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[38]

Drug(s) Affected By Serine/threonine-protein kinase Chk2 (CHEK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[43]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[8]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[44]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[15]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[45]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[46]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[24]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[48]

Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[36]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[49]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[41]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[55]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[56]

Drug(s) Affected By Thrombospondin-1 (THBS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[57]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[58]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[59]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[60]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[63]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[62]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[64]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[65]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[66]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[68]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[69]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[70]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[71]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[70]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[72]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[73]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[74]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[75]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[76]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[77]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[78]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[79]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[66]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[80]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[81]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[82]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[83]

Drug(s) Affected By Proliferating cell nuclear antigen (PCNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[66]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[84]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[85]
Selenium	DM25CGV	N. A.	N. A.	Approved	[86]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[87]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[88]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[89]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[90]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[60]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[91]

Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[8]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[92]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[93]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[94]
Selenium	DM25CGV	N. A.	N. A.	Approved	[86]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[95]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[71]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[96]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[97]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[98]

Drug(s) Affected By Metalloproteinase inhibitor 2 (TIMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[94]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[99]
Selenium	DM25CGV	N. A.	N. A.	Approved	[100]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[103]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[64]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]
Tetracaine	DM9J6C2	Spinal anesthesia	MB40.3	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[107]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[110]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[111]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[112]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[113]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[114]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[115]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[36]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[117]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[118]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[97]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[41]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[42]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[119]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[120]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[121]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[122]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[9]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[69]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[123]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[125]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[126]
Fructose	DM43AN2	Vomiting	MD90	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[128]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[129]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[130]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[131]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[82]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[132]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[133]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[134]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[135]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[136]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[138]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[130]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[139]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[140]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[141]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[129]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[79]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[142]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[82]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[132]

Drug(s) Affected By M-phase inducer phosphatase 3 (CDC25C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[8]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[118]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[13]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[143]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[145]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[24]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[146]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[147]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[36]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[117]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[38]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[9]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[148]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[149]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[98]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[150]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[93]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[152]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[153]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[9]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[95]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[154]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[71]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[155]

Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[79]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[142]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[158]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[159]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[160]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[161]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[162]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[163]

Drug(s) Affected By Signal transducer and activator of transcription 5A (STAT5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[59]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[13]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[165]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[24]
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[166]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[167]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[168]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[169]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[170]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[171]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[172]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[173]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[174]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[175]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[176]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[178]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[179]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[180]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[181]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[182]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[183]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[11]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[55]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[184]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[183]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[185]

Drug(s) Affected By Mitogen-activated protein kinase 9 (MAPK9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[180]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[118]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[183]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[186]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[187]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[183]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[188]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[190]

Drug(s) Affected By Signal transducer and activator of transcription 5B (STAT5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[192]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[64]
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[166]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[168]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[194]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[195]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[196]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[197]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[198]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[66]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[81]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[199]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[69]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[201]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[202]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[203]

Drug(s) Affected By BH3-interacting domain death agonist (BID)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[142]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[69]
Selenium	DM25CGV	N. A.	N. A.	Approved	[204]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[11]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[205]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[206]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[207]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[208]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[190]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[75]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[178]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[66]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[80]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[122]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[199]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[153]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[118]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[89]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[71]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[209]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[210]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[69]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[211]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[90]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[212]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[213]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[11]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[214]

Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[82]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[122]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[215]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[216]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[217]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[125]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[218]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[219]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[220]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[221]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[222]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[142]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[223]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[224]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[69]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[202]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[59]

Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[225]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[118]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[226]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[227]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[228]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[229]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[230]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[231]

Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-2 (SIRT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[209]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[232]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[233]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[234]
Vitamin B3	DMQVRZH	Chronic renal failure	GB61.Z	Approved	[235]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[236]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[237]
Nicotinamide	DMUPE07	Acne vulgaris	ED80	Approved	[238]

Drug(s) Affected By NAD-dependent protein deacylase sirtuin-6 (SIRT6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[239]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[34]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[240]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[234]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[241]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[242]
SEN-196	DMLDBQ5	Huntington disease	8A01.10	Phase 2	[243]
TAK-715	DMZKPI8	Rheumatoid arthritis	FA20	Phase 2	[244]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[245]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[246]

Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[247]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[178]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[142]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[248]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[249]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[250]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[205]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[46]

Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-7 (SIRT7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[167]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[234]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[241]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[252]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[253]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[245]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[254]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[237]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
PP2A B subunit isoform R5-alpha (PPP2R5A)	TTLONKX	2A5A_HUMAN	Inhibitor	[2]
Serine/threonine PP1-alpha (PPP1CA)	TTFLH0E	PP1A_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Angiopoietin-2 (ANGPT2)	OTEQK65P	ANGP2_HUMAN	Gene/Protein Processing	[3]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[4]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[5]
Bcl-2 homologous antagonist/killer (BAK1)	OTDP6ILW	BAK_HUMAN	Gene/Protein Processing	[5]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Gene/Protein Processing	[4]
Bcl-2-like protein 11 (BCL2L11)	OTNQQWFJ	B2L11_HUMAN	Gene/Protein Processing	[5]
Bcl2-associated agonist of cell death (BAD)	OT63ERYM	BAD_HUMAN	Gene/Protein Processing	[4]
BH3-interacting domain death agonist (BID)	OTOSHSHU	BID_HUMAN	Gene/Protein Processing	[5]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Gene/Protein Processing	[6]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Gene/Protein Processing	[6]

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