Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMC3YUA)

Drug Name

Benzbromarone Drug Info

Synonyms

Acifugan; Azubromaron; Benzbromaron; Benzbromaronratiopharm; Benzbromaronum; Benzobromarona; Besuric; Desuric; Exurate; Harolan; Hipurik; Minuric; Narcaricin; Normurat; Uricovac; Urinorm; Uroleap; Aliud Brand of Benzbromarone; Benzbromaron AL; Benzbromaron ratiopharm; Benzbromarone Aliud Brand; Benzbromarone Heumann Brand; Benzbromarone Sanfer Brand; Benzbromarone ratiopharm Brand; Heumann Brand of Benzbromarone; Ratiopharm Brand of Benzbromarone; Sanfer Brand of Benzbromarone; Sanofi Winthrop Brand of Benzbromarone; L 2214; L2214; MJ 10061; NCI85433; AL, Benzbromaron; Benzbromaron-ratiopharm; Benzbromaronum [INN-Latin]; Benzobromarona [INN-Spanish]; L 2214-Labaz; L-2214; Uroleap (TN); Benzbromarone [USAN:INN:BAN]; Methanone, (3; Benzbromarone (JP15/USAN/INN); KETONE, 3,5-DIBROMO-4-HYDROXYPHENYL 2-ETHYL-3-BENZOFURANYL; Ketone, 3,5-dibromo-4-hydroxyphenyl 2-ethyl-3-benzofuranyl; (2-Ethyl-3-benzofuranyl)-(3,5-dibrom-4-hydroxyphenyl)keton; (3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-1-benzofuran-3-yl)methanone; (3,5-dibromo-4-hydroxyphenyl)-(2-ethyl-1-benzofuran-3-yl)methanone; 2-Ethyl-3-(3,5-dibrom-4-hydroxybenzoyl)benzofuran; 3, 5-Dibromo-4-hydroxyphenyl-2-ethyl-3-benzofuranyl ketone; 3,5-Dibromo-4-hydroxyphenyl-2-ethyl-3-benzofuranyl ketone; 3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethylbenzofuran; 3-[3,5-DIBROMO-4-HYDROXYBENZOYL]-2-ETHYLBENZOFURAN

Indication

Disease Entry	ICD 11	Status	REF
Gout	FA25	Approved	[1]

Cross-matching ID

PubChem CID: 2333
ChEBI ID: CHEMBL388590
CAS Number: CAS 3562-84-3
TTD Drug ID: DMC3YUA
VARIDT Drug ID: DR00327
INTEDE Drug ID: DR0193

Molecule-Related Drug Atlas

Molecule Type:

DTT

DTP

DME

DOT

Drug Status:

Approved Drug(s)

Investigative Drug(s)

Preclinical Drug(s)

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting Calcium-dependent chloride channel anoctamin (ANO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Crofelemer	DM4AMQZ	HIV-associated diarrhoea	1A2Z	Approved	[13]
NPPB	DMFIWAN	Discovery agent	N.A.	Investigative	[14]
DIDS	DMKSQUB	Discovery agent	N.A.	Investigative	[14]
9-anthroic acid	DMGCVT2	Discovery agent	N.A.	Investigative	[14]
SITS	DMCMIUG	Discovery agent	N.A.	Investigative	[14]
DCDPC	DMG9BFR	Discovery agent	N.A.	Investigative	[14]
tannic acid	DM52WGH	Discovery agent	N.A.	Investigative	[14]
Ins(3,4,5,6)P4	DMAQU71	Discovery agent	N.A.	Investigative	[14]
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Drug(s) Targeting Multidrug resistance-associated protein 1 (ABCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[15]
XR-9456	DMTUFI1	Discovery agent	N.A.	Investigative	[16]
XR-9504	DMIQP69	Discovery agent	N.A.	Investigative	[16]
XR-9544	DM1OZPN	Discovery agent	N.A.	Investigative	[16]
XR-9577	DMIZV6T	Discovery agent	N.A.	Investigative	[16]
Pyrrolopyrimidine	DMZLFVG	Discovery agent	N.A.	Investigative	[17]
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Drug(s) Transported By Multidrug resistance-associated protein 6 (ABCC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[18]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[18]
Epipodophyllotoxins	DMVNR20	N. A.	N. A.	Preclinical	[18]
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Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[19]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[20]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[21]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[22]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[23]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[22]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[24]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[25]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
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Drug(s) Affected By ATP-binding cassette sub-family C member 6 (ABCC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[7]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[31]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[32]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[29]
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Drug(s) Affected By Aldo-keto reductase family 1 member C4 (AKR1C4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[36]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Flufenamic Acid	DMC8VNH	Dysmenorrhea	GA34.3	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Nitrazepam	DMEGIQ6	Epilepsy	8A60-8A68	Approved	[37]
Flunitrazepam	DMGR5Z3	Insomnia	7A00-7A0Z	Approved	[37]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[38]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[39]
Indomethacin	DMSC4A7	Bursitis		Approved	[6]
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Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[40]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[41]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[37]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[42]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[42]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[41]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[41]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[43]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
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Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[41]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[37]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[46]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[47]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[48]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[41]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[49]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[50]
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Drug(s) Affected By Bile salt export pump (ABCB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[8]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[51]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[51]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[52]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[8]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[51]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[53]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[8]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[54]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[8]
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Drug(s) Affected By Eyes absent homolog 2 (EYA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[58]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[59]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[60]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[55]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[62]
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Drug(s) Affected By C-reactive protein (CRP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[63]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[64]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[65]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[66]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[67]
Acalabrutinib	DM7GCVW	leukaemia	2A60-2B33	Approved	[68]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[69]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[70]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[71]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[50]
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Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Selenium	DM25CGV	N. A.	N. A.	Approved	[73]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[74]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[75]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[78]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[67]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
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Drug(s) Affected By Phosphatidylcholine translocator ABCB4 (ABCB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[81]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[82]
Methysergide	DM1EF73	Migraine	8A80	Approved	[53]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[83]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[84]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[67]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[85]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[86]
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Drug(s) Affected By Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[87]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[67]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[85]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[90]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[91]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[92]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[93]
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Drug(s) Affected By Iodotyrosine deiodinase 1 (IYD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[29]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[96]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[12]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[97]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[98]
3-iodotyrosine	DMNZMH6	Discovery agent	N.A.	Investigative	[99]
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Drug(s) Affected By Solute carrier family 22 member 12 (SLC22A12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[100]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[101]
Oxypurinol	DMURH4X	Heart failure	BD10-BD13	Phase 2/3	[102]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[62]
Erythropoietin	DM3R8YL	Periventricular leukomalacia		Investigative	[103]
[3H]estrone-3-sulphate	DMGPF0N	Discovery agent	N.A.	Investigative	[104]
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Drug(s) Affected By Eyes absent homolog 3 (EYA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[107]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[101]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[108]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[40]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[109]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[110]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[111]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[106]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Calcium-dependent chloride channel anoctamin (ANO)	TTOJI4S	ANO1_HUMAN	Antagonist	[2]
Multidrug resistance-associated protein 1 (ABCC1)	TTOI92F	MRP1_HUMAN	Stimulator	[3]

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Multidrug resistance-associated protein 6 (ABCC6)	DT582KR	MRP6_HUMAN	Substrate	[4]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 2C9 (CYP2C9)^{Main DME}	DE5IED8	CP2C9_HUMAN	Substrate	[5]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Aldo-keto reductase family 1 member C2 (AKR1C2)	OTQ2XMO3	AK1C2_HUMAN	Gene/Protein Processing	[6]
Aldo-keto reductase family 1 member C3 (AKR1C3)	OTU2SXBA	AK1C3_HUMAN	Gene/Protein Processing	[6]
Aldo-keto reductase family 1 member C4 (AKR1C4)	OTW2MMOF	AK1C4_HUMAN	Gene/Protein Processing	[6]
ATP-binding cassette sub-family C member 6 (ABCC6)	OTZT0LKT	MRP6_HUMAN	Gene/Protein Processing	[7]
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Gene/Protein Processing	[8]
C-reactive protein (CRP)	OT0RFT8F	CRP_HUMAN	Gene/Protein Processing	[9]
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)	OTI862QH	CPT1A_HUMAN	Gene/Protein Processing	[10]
Eyes absent homolog 2 (EYA2)	OTPVLA73	EYA2_HUMAN	Gene/Protein Processing	[11]
Eyes absent homolog 3 (EYA3)	OTHLP1J3	EYA3_HUMAN	Gene/Protein Processing	[11]
Iodotyrosine deiodinase 1 (IYD)	OT8BQWTE	IYD1_HUMAN	Gene/Protein Processing	[12]

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References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	Anoctamin Channels in Human Myometrium: A Novel Target for Tocolysis.Reprod Sci. 2018 Nov;25(11):1589-1600.
3	Transport of diclofenac by breast cancer resistance protein (ABCG2) and stimulation of multidrug resistance protein 2 (ABCC2)-mediated drug transpo... Drug Metab Dispos. 2009 Jan;37(1):129-36.
4	The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 3.A.1.208.10)
5	Quantitative binding models for CYP2C9 based on benzbromarone analogues. Biochemistry. 2004 Jun 8;43(22):6948-58.
6	Selective and potent inhibitors of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) that metabolizes neurosteroids derived from progesterone. Chem Biol Interact. 2003 Feb 1;143-144:503-13.
7	Multidrug resistance protein-6 (MRP6) in human dermal fibroblasts. Comparison between cells from normal subjects and from Pseudoxanthoma elasticum patients. Matrix Biol. 2003 Nov;22(6):491-500. doi: 10.1016/j.matbio.2003.09.001.
8	Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicol Sci. 2010 Dec; 118(2):485-500.
9	Serum CRP in patients with gout and effects of benzbromarone. Int J Clin Pharmacol Ther. 2011 Mar;49(3):191-7. doi: 10.5414/cp201425.
10	Hepatocellular toxicity of benzbromarone: effects on mitochondrial function and structure. Toxicology. 2014 Oct 3;324:136-46. doi: 10.1016/j.tox.2014.08.002. Epub 2014 Aug 7.
11	The EYA tyrosine phosphatase activity is pro-angiogenic and is inhibited by benzbromarone. PLoS One. 2012;7(4):e34806. doi: 10.1371/journal.pone.0034806. Epub 2012 Apr 24.
12	Structure-activity relationships of 44 halogenated compounds for iodotyrosine deiodinase-inhibitory activity. Toxicology. 2013 Dec 6;314(1):22-9. doi: 10.1016/j.tox.2013.08.017. Epub 2013 Sep 3.
13	Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
14	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 708).
15	Species-dependent transport and modulation properties of human and mouse multidrug resistance protein 2 (MRP2/Mrp2, ABCC2/Abcc2). Drug Metab Dispos. 2008 Apr;36(4):631-40.
16	Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors. Bioorg Med Chem. 2008 Mar 1;16(5):2448-62.
17	Topological model for the prediction of MRP1 inhibitory activity of pyrrolopyrimidines and templates derived from pyrrolopyrimidine. Bioorg Med Chem Lett. 2005 Nov 15;15(22):4967-72.
18	Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6). Cancer Res. 2002 Nov 1;62(21):6172-7.
19	Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes. Arch Biochem Biophys. 1997 Oct 1;346(1):161-9.
20	Tamoxifen inhibits cytochrome P450 2C9 activity in breast cancer patients. J Chemother. 2006 Aug;18(4):421-4.
21	Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. Endocrinology. 2003 Aug;144(8):3382-98.
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