Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDZ6Q3)

Drug Name
Napabucasin Drug Info
Synonyms
83280-65-3; UNII-Z1HHM49K7O; 2-acetylnaphtho[2,3-b]furan-4,9-dione; Z1HHM49K7O; 2-Acetylnaphtho(2,3-b)furan-4,9-dione; 2-Acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione; Napabucasin [USAN:INN]; Napabucasin (BBI608); 2-Acetylfuranonaphthoquinone; CHEMBL64130; Napabucasin (JAN/USAN/INN); SCHEMBL1883845; Napabucasin - BBI 608/ FNQ; 2-Acetylfuro-1,4-naphthoquinone; DPHUWDIXHNQOSY-UHFFFAOYSA-N; MolPort-039-101-321; EX-A1314; ZINC13306865; s7977; AKOS027470201; DB12155; CS-1747; ACN-053294; HY-13919
Indication
Disease Entry ICD 11 Status REF
Colorectal cancer 2B91.Z Phase 3 [1]
Pancreatic cancer 2C10 Phase 3 [1]
Solid tumour/cancer 2A00-2F9Z Phase 3 [2]
Advanced malignancy 2A00-2F9Z Phase 1/2 [1]
Gastrointestinal cancer 2C11 Phase 1/2 [1]
Hepatocellular carcinoma 2C12.02 Phase 1/2 [1]
Recurrent glioblastoma 2A00.00 Phase 1/2 [3]
Recurring respiratory infection CA07-CA45 Phase 1/2 [1]
Haematological malignancy 2B33.Y Phase 1 [1]
Cross-matching ID
PubChem CID
10331844
ChEBI ID
CHEMBL64130
CAS Number
CAS 83280-65-3
TTD Drug ID
DMDZ6Q3

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Signal transducer and activator of transcription 3 (STAT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acitretin DM8BKU9 Psoriasis vulgaris EA90 Approved [6]
Golotimod DMKZN3A Immune System disease 4A01-4B41 Phase 2 [7]
NT219 DMOYS1N Solid tumour/cancer 2A00-2F9Z Phase 1/2 [8]
WP-1066 DMUGHWR Recurrent glioblastoma 2A00.00 Phase 1/2 [1]
Atiprimod DM84YEC Multiple myeloma 2A83 Phase 1/2 [9]
OPB-31121 DM6VGO3 Hepatocellular carcinoma 2C12.02 Phase 1/2 [10]
IMX-110 DMNHZS4 Solid tumour/cancer 2A00-2F9Z Phase 1/2 [1]
GLG-801 DMY1CP9 Chronic lymphocytic leukaemia 2A82.0 Phase 1/2 [1]
OPB-51602 DM760FA Solid tumour/cancer 2A00-2F9Z Phase 1 [11]
TAK-114 DMTXE19 Ulcerative colitis DD71 Phase 1 [12]
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Drug(s) Affected By Serine/threonine-protein kinase Chk1 (CHEK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [13]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [14]
Methotrexate DM2TEOL Anterior urethra cancer Approved [15]
Quercetin DM3NC4M Obesity 5B81 Approved [16]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [17]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [18]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [19]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [20]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [21]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [22]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [23]
Gefitinib DM15F0X Colon adenocarcinoma Approved [24]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [25]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [26]
Etretinate DM2CZFA Keratosis ED56 Approved [27]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [28]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [29]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [30]
Quercetin DM3NC4M Obesity 5B81 Approved [31]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [32]
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Drug(s) Affected By Tyrosine-protein kinase JAK2 (JAK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Momelotinib DMF98Q0 Myelofibrosis 2A20.2 Approved [33]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [34]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [35]
Quercetin DM3NC4M Obesity 5B81 Approved [36]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [37]
Paroxetine DM5PVQE Anxiety disorder 6B00-6B0Z Approved [38]
Estrone DM5T6US Acne vulgaris ED80 Approved [34]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [39]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [40]
Amlodipine DMBDAZV Angina pectoris BA40 Approved [41]
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Drug(s) Affected By Serine/threonine-protein kinase LATS1 (LATS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [42]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [43]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [44]
Leflunomide DMR8ONJ Arthritis FA20 Approved [45]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [46]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [47]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [48]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [49]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [50]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [51]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [52]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [53]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [54]
Gefitinib DM15F0X Colon adenocarcinoma Approved [55]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [56]
Selenium DM25CGV N. A. N. A. Approved [57]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [58]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [59]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [60]
Methotrexate DM2TEOL Anterior urethra cancer Approved [61]
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Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Trastuzumab DMZQOUX Breast cancer 2C60-2C65 Approved [62]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [63]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [64]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [54]
Gefitinib DM15F0X Colon adenocarcinoma Approved [65]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Selenium DM25CGV N. A. N. A. Approved [67]
Methotrexate DM2TEOL Anterior urethra cancer Approved [68]
Quercetin DM3NC4M Obesity 5B81 Approved [69]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [19]
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Drug(s) Affected By Large ribosomal subunit protein uL10 (RPLP0)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [37]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [71]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [72]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [48]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [73]
Arsenic DMTL2Y1 N. A. N. A. Approved [74]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [75]
Geldanamycin DMS7TC5 Kidney cancer 2C90.0 Discontinued in Phase 2 [76]
9-hydroxyoctadecadienoic acid DM0FWNJ Discovery agent N.A. Investigative [77]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [78]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [79]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [80]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [81]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [82]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [83]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [84]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [85]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [86]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [84]
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Drug(s) Affected By Electron transfer flavoprotein subunit alpha, mitochondrial (ETFA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [87]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [40]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [88]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [72]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [89]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [90]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [50]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [91]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [92]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [93]
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Drug(s) Affected By CD44 antigen (CD44)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [94]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [34]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Selenium DM25CGV N. A. N. A. Approved [96]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [97]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [98]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [99]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [100]
Panobinostat DM58WKG Chronic graft versus host disease Approved [101]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [43]
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Drug(s) Affected By Epithelial cell adhesion molecule (EPCAM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [37]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [100]
Panobinostat DM58WKG Chronic graft versus host disease Approved [101]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [102]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [103]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [88]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [104]
Paclitaxel DMLB81S Breast carcinoma Approved [105]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [48]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [106]
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Drug(s) Affected By Endoglin (ENG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [67]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [37]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [71]
Testosterone enanthate DMB6871 N. A. N. A. Approved [107]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [88]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [108]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [104]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [109]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [48]
Ximelegatran DMU8ANS Myocardial infarction BA41-BA43 Approved [110]
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Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [111]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [112]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [53]
Gefitinib DM15F0X Colon adenocarcinoma Approved [113]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [114]
Methotrexate DM2TEOL Anterior urethra cancer Approved [115]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [116]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [117]
Quercetin DM3NC4M Obesity 5B81 Approved [16]
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Drug(s) Affected By Kit ligand (KITLG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [13]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Methotrexate DM2TEOL Anterior urethra cancer Approved [61]
Quercetin DM3NC4M Obesity 5B81 Approved [16]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [19]
Panobinostat DM58WKG Chronic graft versus host disease Approved [101]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [118]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [119]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [120]
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Drug(s) Affected By Signal transducer CD24 (CD24)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [121]
Methotrexate DM2TEOL Anterior urethra cancer Approved [122]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [123]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [37]
Panobinostat DM58WKG Chronic graft versus host disease Approved [101]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [124]
Testosterone DM7HUNW Hot flushes GA30 Approved [125]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [125]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [104]
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Drug(s) Affected By Tyrosine-protein kinase receptor UFO (AXL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [67]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [126]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [127]
Quercetin DM3NC4M Obesity 5B81 Approved [36]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [126]
Plicamycin DM7C8YV Hypercalcaemia 5B91.0 Approved [128]
Leflunomide DMR8ONJ Arthritis FA20 Approved [45]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [129]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [129]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [129]
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Drug(s) Affected By Catenin beta-1 (CTNNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [130]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [131]
Quercetin DM3NC4M Obesity 5B81 Approved [132]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [133]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [134]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [135]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [136]
Testosterone DM7HUNW Hot flushes GA30 Approved [137]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [138]
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Drug(s) Affected By DNA-binding protein inhibitor ID-1 (ID1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [139]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [81]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Selenium DM25CGV N. A. N. A. Approved [67]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [140]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [141]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [142]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [44]
Leflunomide DMR8ONJ Arthritis FA20 Approved [45]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [40]
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Drug(s) Affected By Neurogenic locus notch homolog protein 1 (NOTCH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [143]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [19]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [144]
Propranolol DM79NTF Angina pectoris BA40 Approved [145]
Testosterone DM7HUNW Hot flushes GA30 Approved [146]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [88]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [147]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [148]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [104]
Mebendazole DMO14SG Ascariasis 1F62 Approved [149]
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Drug(s) Affected By Ataxin-1 (ATXN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [150]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [42]
Selenium DM25CGV N. A. N. A. Approved [67]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [151]
Methotrexate DM2TEOL Anterior urethra cancer Approved [122]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [19]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [152]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [129]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [129]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [129]
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Drug(s) Affected By Actin, cytoplasmic 1 (ACTB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Selenium DM25CGV N. A. N. A. Approved [67]
Etretinate DM2CZFA Keratosis ED56 Approved [153]
Quercetin DM3NC4M Obesity 5B81 Approved [36]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [37]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [154]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [71]
Leflunomide DMR8ONJ Arthritis FA20 Approved [45]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [36]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [88]
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Drug(s) Affected By Protein jagged-1 (JAG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Methotrexate DM2TEOL Anterior urethra cancer Approved [155]
Quercetin DM3NC4M Obesity 5B81 Approved [36]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [156]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [118]
Leflunomide DMR8ONJ Arthritis FA20 Approved [45]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [40]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [147]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [157]
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Drug(s) Affected By POU domain, class 5, transcription factor 1 (POU5F1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [97]
Quercetin DM3NC4M Obesity 5B81 Approved [158]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [159]
Panobinostat DM58WKG Chronic graft versus host disease Approved [101]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [43]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [160]
Testosterone DM7HUNW Hot flushes GA30 Approved [161]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [162]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [163]
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Drug(s) Affected By Neurogenic locus notch homolog protein 2 (NOTCH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [164]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [88]
Clozapine DMFC71L Schizophrenia 6A20 Approved [165]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [147]
Bortezomib DMNO38U Leukemia Approved [166]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [167]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [168]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [169]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [50]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [170]
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Drug(s) Affected By Epithelial discoidin domain-containing receptor 1 (DDR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [19]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [103]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [172]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [173]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [108]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [174]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [175]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [50]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [176]
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Drug(s) Affected By Serine-protein kinase ATM (ATM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [177]
Paromomycin DM1AGXN Amoebiasis 1A36 Approved [178]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [179]
Etretinate DM2CZFA Keratosis ED56 Approved [27]
Quercetin DM3NC4M Obesity 5B81 Approved [132]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [180]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [181]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [182]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [183]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [184]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CD166 antigen (ALCAM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [94]
Selenium DM25CGV N. A. N. A. Approved [67]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [19]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [185]
Panobinostat DM58WKG Chronic graft versus host disease Approved [101]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [186]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [46]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [172]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [72]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [104]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Flotillin-2 (FLOT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [42]
Selenium DM25CGV N. A. N. A. Approved [67]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [187]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [40]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [172]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [72]
Folic Acid DMEMBJC Colorectal carcinoma Approved [188]
Benzatropine DMF7EXL Parkinsonian disorder Approved [189]
Clozapine DMFC71L Schizophrenia 6A20 Approved [189]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [48]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tafazzin (TAFAZZIN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [190]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [191]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [192]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [51]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [93]
Drug(s) Affected By Krueppel-like factor 17 (KLF17)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic DMTL2Y1 N. A. N. A. Approved [193]
Fenfluramine DM0762O Dravet syndrome 8A61.11 Phase 3 [194]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [195]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [51]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [150]
Drug(s) Affected By Mastermind-like protein 1 (MAML1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [71]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [46]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [170]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [147]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [196]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [93]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [197]
Glyphosate DM0AFY7 Malaria 1F40-1F45 Investigative [198]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Protein smoothened (SMO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [199]
Quercetin DM3NC4M Obesity 5B81 Approved [200]
Vismodegib DM5IXKQ Basal cell carcinoma 2C32 Approved [201]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [202]
Leflunomide DMR8ONJ Arthritis FA20 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [88]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [104]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [109]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [48]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [203]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Homeobox protein NANOG (NANOG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [204]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [97]
Quercetin DM3NC4M Obesity 5B81 Approved [158]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [159]
Panobinostat DM58WKG Chronic graft versus host disease Approved [101]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [43]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [160]
Testosterone DM7HUNW Hot flushes GA30 Approved [161]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [172]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [205]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein lin-28 homolog A (LIN28A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [19]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [172]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [206]
Arsenic DMTL2Y1 N. A. N. A. Approved [207]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [162]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [208]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [51]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [150]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Dachshund homolog 1 (DACH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [180]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [40]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [172]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [104]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [209]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [210]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [211]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [101]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [51]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [212]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Signal transducer and activator of transcription 3 (STAT3) TTH8FZW STAT3_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Actin, cytoplasmic 1 (ACTB) OT1MCP2F ACTB_HUMAN Gene/Protein Processing [4]
Ataxin-1 (ATXN1) OTQF0HNR ATX1_HUMAN Gene/Protein Processing [4]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Gene/Protein Processing [5]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Gene/Protein Processing [4]
CD166 antigen (ALCAM) OTCO4LP7 CD166_HUMAN Gene/Protein Processing [4]
CD44 antigen (CD44) OT9TTJ41 CD44_HUMAN Gene/Protein Processing [4]
Dachshund homolog 1 (DACH1) OTMKNAGG DACH1_HUMAN Gene/Protein Processing [4]
DNA-binding protein inhibitor ID-1 (ID1) OTKGNZN5 ID1_HUMAN Gene/Protein Processing [4]
Electron transfer flavoprotein subunit alpha, mitochondrial (ETFA) OTXX61VZ ETFA_HUMAN Gene/Protein Processing [4]
Endoglin (ENG) OTL2LSMI EGLN_HUMAN Gene/Protein Processing [4]

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