Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGC287)

Drug Name
Heme Drug Info
Synonyms
heme; protoheme; Haem; ferroprotoporphyrin; UNII-42VZT0U6YR; Iron protoporphyrin ix; Protohaem; Ferroheme; Reduced hematin; Ferrous protoheme; Iron protoporphyrin; Ferrous protoheme IX; Ferroprotoporphyrin IX; 14875-96-8; 42VZT0U6YR; Iron(II) protoporphyrin IX; Protoheme IX (VAN); Ferroheme (VAN); Heme (VAN); 85758-EP2305825A1; 85758-EP2305243A1; 85758-EP2270505A1; 85758-EP2270016A1; 3-[18-(2-carboxyethyl)-7,12-bis(ethenyl)-3,8,13,17-tetramethylporphyrin-21,23-diid-2-yl]propanoic acid; iron(2+); NSC 16669; NSC 267100; AC1L9FPJ; Hemin
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
26945
CAS Number
CAS 14875-96-8
TTD Drug ID
DMGC287
VARIDT Drug ID
DR00298

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Arachidonate 5-lipoxygenase (5-LOX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zileuton DMVRIC2 Allergic asthma CA23.0 Approved [11]
Diethylcarbamazine DM1TJ8F Elephantiasis Approved [12]
Silymarin DMXBYQR N. A. N. A. Phase 4 [13]
3,4-Dihydroxycinnamic Acid DMVZL26 Thrombocytopenia 3B64 Phase 4 [14]
Avastin+/-Tarceva DMA86FL Non-small-cell lung cancer 2C25.Y Phase 3 [15]
ABT-761 DM3FIC2 Asthma CA23 Phase 3 [16]
Tenidap DMHQRYE Rheumatoid arthritis FA20 Phase 3 [17]
FPL-62064 DMGF8MZ Inflammation 1A00-CA43.1 Phase 3 [18]
Flobufen DMPSG4D Rheumatoid arthritis FA20 Phase 3 [19]
Darbufelone DMYVKM5 Asthma CA23 Phase 2/3 [20]
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Drug(s) Targeting Nitric-oxide synthase inducible (NOS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [21]
SD-6010 DM9DEYL Osteoarthritis FA00-FA05 Phase 3 [22]
MPL-S DMNDCFY Endotoxic shock 1G41 Phase 3 [23]
Pimagedine HCl DMPWH30 Diabetic kidney disease GB61.Z Phase 2/3 [24]
GW274150 DMZMCB1 Asthma CA23 Phase 2 [25]
BXT-51072 DMD8GNB Cardiovascular disease BA00-BE2Z Phase 2 [26]
HP-228 DMNZ35F Postoperative pain MG30-MG3Z Phase 2 [27]
CR-3294 DMHJEZS Diarrhea ME05.1 Phase 2 [28]
KD-7040 DME1WV2 Pain MG30-MG3Z Phase 2 [29]
LT-1951 DM5N04G Coronary artery disease BA80 Phase 1/2 [30]
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Drug(s) Targeting Nitric-oxide synthase endothelial (NOS3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tilarginine acetate DMZBGI8 Myocardial infarction BA41-BA43 Phase 3 [31]
L-NAME DM01SR6 Hypertension BA00-BA04 Phase 2 [32]
ACCLAIM DM0FGDO Angina pectoris BA40 Phase 2 [33]
VAS-203 DMKU93J Brain injury NA07.Z Phase 2 [34]
MTR105 DMT0K4F Hypotension BA20-BA21 Phase 2 [35]
Autologous cell based gene therapy DMQA1VT Pulmonary hypertension BB01 Phase 1 [36]
L-NIL DM6Y49D N. A. N. A. Terminated [37]
Acetate Ion DMD08RH Discovery agent N.A. Investigative [38]
2-Methyl-2,4-Pentanediol DMD45CU Discovery agent N.A. Investigative [38]
2-Propanol, Isopropanol DML5O0H Discovery agent N.A. Investigative [38]
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Drug(s) Targeting Nitric-oxide synthase brain (NOS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
NXN-188 DMMBAIH Migraine 8A80 Phase 2 [39]
NXN-462 DMWVBS2 Headache 8A80-8A84 Phase 2 [40]
L-NIL DM6Y49D N. A. N. A. Terminated [37]
Alpha-D-Mannose DMF5DLW Discovery agent N.A. Investigative [38]
Acetate Ion DMD08RH Discovery agent N.A. Investigative [38]
Flavin-Adenine Dinucleotide DM5S4GK Discovery agent N.A. Investigative [38]
Formic Acid DMNFZC6 Discovery agent N.A. Investigative [38]
2'-Monophosphoadenosine 5'-Diphosphoribose DME9S8M Discovery agent N.A. Investigative [38]
6-isobutyl-4-methylpyridin-2-amine DM2XB68 Discovery agent N.A. Investigative [41]
7-Methyl-[1,4]thiazepan-(5E)-ylideneamine DMUCJA6 Discovery agent N.A. Investigative [42]
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Drug(s) Targeting Bacterial Flavohemoglobin (Bact hmp)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nicotinamide-Adenine-Dinucleotide DM9LRKB N. A. N. A. Investigative [38]
Flavin-Adenine Dinucleotide DM5S4GK Discovery agent N.A. Investigative [38]
2-(N-Morpholino)-Ethanesulfonic Acid DMZVHSB Discovery agent N.A. Investigative [38]
Drug(s) Targeting Heme oxygenase 1 (HMOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Stannsoporfin DMEG4TC Neonatal hyperbilirubinemia KA87 Phase 2 [43]
Formic Acid DMNFZC6 Discovery agent N.A. Investigative [38]
2-Propanol, Isopropanol DML5O0H Discovery agent N.A. Investigative [38]
2-Phenylheme DMPIQTE Discovery agent N.A. Investigative [38]
Biliverdine Ix Alpha DMCA0WJ N. A. N. A. Investigative [38]
Verdoheme DM7NRK5 Discovery agent N.A. Investigative [44]
Tin protoporphyrin DMTXJ5S Discovery agent N.A. Investigative [45]
1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone DMOTJWZ Discovery agent N.A. Investigative [2]
12-Phenylheme DMLR2FB Discovery agent N.A. Investigative [38]
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Drug(s) Targeting Bacterial Fumarate reductase flavoprotein (Bact frdA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Thiabendazole DM7YCK3 Ascariasis 1F62 Approved [46]
Oxantel pamoate DMZ30JT Trichuris trichiura infection 1F6G Approved [46]
Morantel tartrate DM560Y3 Mature gastrointestinal nematode infection 1F6Y Approved [46]
Flavin-Adenine Dinucleotide DM5S4GK Discovery agent N.A. Investigative [38]
Fumarate DM9VLS2 Discovery agent N.A. Investigative [38]
2,3-DIMETHYL-1,4-NAPHTHOQUINONE DMGXVBA Discovery agent N.A. Investigative [2]
Citraconic acid DMCIM9A Discovery agent N.A. Investigative [44]
2-[1-(4-CHLORO-PHENYL)-ETHYL]-4,6-DINITRO-PHENOL DMUZDSC Discovery agent N.A. Investigative [2]
2-HEPTYL-4-HYDROXY QUINOLINE N-OXIDE DMJ3ATL Discovery agent N.A. Investigative [2]
Malate Like Intermediate DM4OQWZ Discovery agent N.A. Investigative [44]
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Drug(s) Targeting Albendazole monooxygenase (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [47]
PMX-53 DMZUAJ4 Atopic dermatitis EA80 Phase 2 [48]
BMS-536924 DMXJB4N Discovery agent N.A. Investigative [49]
ML-3163 DM3S5UC Discovery agent N.A. Investigative [50]
6-(3-Hydroxy-phenyl)-naphthalen-2-ol DMH8WA2 Discovery agent N.A. Investigative [51]
2-(2-(4-tert-Butylphenylthio)ethyl)-1H-imidazole DMZVBPG Discovery agent N.A. Investigative [52]
ML-3375 DMXJY6W Discovery agent N.A. Investigative [50]
ML-3403 DMTQWI8 Discovery agent N.A. Investigative [50]
4-[5-(3-Hydroxyphenyl)-3-thienyl]-2-methylphenol DM7ERYJ Discovery agent N.A. Investigative [53]
2-Fluoro-4-[5-(3-hydroxyphenyl)-2-thienyl]phenol DMUGAT8 Discovery agent N.A. Investigative [53]
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Drug(s) Targeting Hemoglobin (HB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Voxelotor DMCS6M5 Sickle-cell disorder 3A51 Approved [54]
Iron DMAP8MV Anemia of prematurity Approved [55]
Iron Dextran DM5OY70 Iron-deficiency anemia 3A00 Approved [55]
PolyHeme DMV8EXG Blood forming organ disorder JB64.1 Phase 3 [56]
Efaproxyn DMX7BM4 Lung cancer 2C25.0 Phase 3 [57]
Hemoglobin raffimer DMMTL7V Anemia 3A00-3A9Z Phase 2/3 [58]
GBT021601 DMD3C21 Sickle-cell disorder 3A51 Phase 2/3 [59]
FBS-0701 DMR3952 Iron overload disease 5C64.10 Phase 2 [60]
HQK-1001 DM7QUN0 Beta thalassemia 3A50.2 Phase 2 [61]
5-hydroxymethyl-2-furfural DMPFVJB Anemia 3A00-3A9Z Phase 2 [62]
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Drug(s) Targeting Mycobacterium Cytochrome p450 121 (MycB cyp121)
Drug Name Drug ID Indication ICD 11 Highest Status REF
4-Iodopyrazole DMF3CLX Discovery agent N.A. Investigative [38]
Drug(s) Targeting Prostaglandin G/H synthase 1 (COX-1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [63]
Naproxen DMZ5RGV Bursitis Approved [64]
Mesalazine DMOL5IU Diverticulitis Approved [65]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [66]
Bromfenac DMKB79O Pain MG30-MG3Z Approved [67]
Aminosalicylic Acid DMENSL5 Crohn disease DD70 Approved [68]
Flufenamic Acid DMC8VNH Dysmenorrhea GA34.3 Approved [69]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [68]
Suprofen DMKXJZ7 Miosis LA11.62 Approved [70]
Gamma-Homolinolenic acid DMSXKYG Malnutrition 5B50-5B71 Approved [71]
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Drug(s) Targeting Prostaglandin G/H synthase 2 (COX-2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [72]
Naproxen DMZ5RGV Bursitis Approved [64]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [73]
Indomethacin DMSC4A7 Bursitis Approved [68]
Celecoxib DM6LOQU Dysmenorrhea GA34.3 Approved [74]
Nabumetone DMAT2XH Osteoarthritis FA00-FA05 Approved [75]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [76]
Flurbiprofen DMGN4BY Osteoarthritis FA00-FA05 Approved [77]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [66]
Aminosalicylic Acid DMENSL5 Crohn disease DD70 Approved [68]
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Drug(s) Targeting Cystathionine beta-synthase (CBS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
OT-58 DMWCJ1F Homocystinuria 5C50.B Phase 1/2 [78]
aminooxyacetic acid DMHNDTW Discovery agent N.A. Investigative [79]
Drug(s) Affected By Protein AMBP (AMBP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [80]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [81]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [82]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [84]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
Benazepril DMH1M9B Hypertension BA00-BA04 Approved [86]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [87]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [88]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [89]
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Drug(s) Affected By Albumin (ALB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [90]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [91]
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [92]
Diazepam DM08E9O Alcohol withdrawal Approved [93]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [94]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [95]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [96]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [97]
Methotrexate DM2TEOL Anterior urethra cancer Approved [98]
Quercetin DM3NC4M Obesity 5B81 Approved [99]
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Drug(s) Affected By C-C motif chemokine 3 (CCL3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [100]
Methotrexate DM2TEOL Anterior urethra cancer Approved [101]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [102]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [103]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [104]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [105]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [106]
Betamethasone DMAHJEF Acute adrenal insufficiency Approved [107]
Emetine DMCT2YF Hepatitis virus infection 1E50-1E51 Approved [107]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [100]
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Drug(s) Affected By 5-aminolevulinate synthase, non-specific, mitochondrial (ALAS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [108]
Quercetin DM3NC4M Obesity 5B81 Approved [109]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [110]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [111]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [112]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [113]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [114]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [115]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [116]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [117]
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Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [118]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [119]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [120]
Gefitinib DM15F0X Colon adenocarcinoma Approved [121]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [122]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [123]
Methotrexate DM2TEOL Anterior urethra cancer Approved [124]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [125]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [126]
Quercetin DM3NC4M Obesity 5B81 Approved [127]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [128]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [129]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [130]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [131]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [132]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [133]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [134]
Gefitinib DM15F0X Colon adenocarcinoma Approved [135]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [136]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [137]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [138]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [129]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [139]
Paclitaxel DMLB81S Breast carcinoma Approved [140]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [141]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [128]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [91]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [142]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [131]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [132]
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Drug(s) Affected By Transcription factor p65 (RELA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [142]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [143]
Selenium DM25CGV N. A. N. A. Approved [108]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [144]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [126]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [145]
Quercetin DM3NC4M Obesity 5B81 Approved [109]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [146]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [110]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [147]
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Drug(s) Affected By Microprocessor complex subunit DGCR8 (DGCR8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [148]
Selenium DM25CGV N. A. N. A. Approved [108]
Quercetin DM3NC4M Obesity 5B81 Approved [109]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [149]
Leflunomide DMR8ONJ Arthritis FA20 Approved [150]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [151]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [152]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [153]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [154]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [155]
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Drug(s) Affected By Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial (CPOX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [115]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [156]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [157]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [87]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [88]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [158]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [159]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [109]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [160]
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Drug(s) Affected By Amyloid-beta precursor protein (APP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [122]
Selenium DM25CGV N. A. N. A. Approved [108]
Methotrexate DM2TEOL Anterior urethra cancer Approved [101]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [161]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [162]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [163]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [164]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [165]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [166]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [167]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Albendazole monooxygenase (CYP3A4) TTXV4FI CP3A4_HUMAN Inhibitor [2]
Arachidonate 5-lipoxygenase (5-LOX) TT2J34L LOX5_HUMAN Inhibitor [2]
Bacterial Flavohemoglobin (Bact hmp) TTNAW8S HMP_ECOLI Inhibitor [2]
Bacterial Fumarate reductase flavoprotein (Bact frdA) TTHDSE2 FRDA_HELPY Inhibitor [2]
Cystathionine beta-synthase (CBS) TTVZJ7G CBS_HUMAN Inhibitor [2]
Heme oxygenase 1 (HMOX1) TTI6V2A HMOX1_HUMAN Inhibitor [2]
Hemoglobin (HB) TTQO71U HBA_HUMAN Inhibitor [2]
Mycobacterium Cytochrome p450 121 (MycB cyp121) TTBK0PU CP121_MYCBO Inhibitor [2]
Nitric-oxide synthase brain (NOS1) TTZUFI5 NOS1_HUMAN Inhibitor [2]
Nitric-oxide synthase endothelial (NOS3) TTCM4B3 NOS3_HUMAN Inhibitor [2]
Nitric-oxide synthase inducible (NOS2) TTF10I9 NOS2_HUMAN Inhibitor [2]
Prostaglandin G/H synthase 1 (COX-1) TT8NGED PGH1_HUMAN Inhibitor [2]
Prostaglandin G/H synthase 2 (COX-2) TTVKILB PGH2_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
5-aminolevulinate synthase, non-specific, mitochondrial (ALAS1) OTQY6ZSF HEM1_HUMAN Gene/Protein Processing [3]
Albumin (ALB) OTVMM513 ALBU_HUMAN Protein Interaction/Cellular Processes [4]
Amyloid-beta precursor protein (APP) OTKFD7R4 A4_HUMAN Drug Response [5]
C-C motif chemokine 3 (CCL3) OTW2H3ND CCL3_HUMAN Protein Interaction/Cellular Processes [6]
Microprocessor complex subunit DGCR8 (DGCR8) OT62LXE4 DGCR8_HUMAN Drug Response [7]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Gene/Protein Processing [8]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Gene/Protein Processing [8]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Protein Interaction/Cellular Processes [6]
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial (CPOX) OTIAY121 HEM6_HUMAN Biotransformations [9]
Protein AMBP (AMBP) OTLU8GU8 AMBP_HUMAN Gene/Protein Processing [10]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4349).
2 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
3 Lon peptidase 1 (LONP1)-dependent breakdown of mitochondrial 5-aminolevulinic acid synthase protein by heme in human liver cells. J Biol Chem. 2011 Jul 29;286(30):26424-30. doi: 10.1074/jbc.M110.215772. Epub 2011 Jun 9.
4 Allosteric modulation of anti-HIV drug and ferric heme binding to human serum albumin. FEBS J. 2005 Dec;272(24):6287-96. doi: 10.1111/j.1742-4658.2005.05015.x.
5 Key roles for tyrosine 10 in a-heme complexes and its relevance to oxidative stress. Chem Res Toxicol. 2015 Mar 16;28(3):365-72. doi: 10.1021/tx5003035. Epub 2014 Sep 24.
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