Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMH1M6N)

• Drug Name: ORG2058 Drug Info
• Synonyms: IJLXLZGJDSJGIQ-BILPMHSYSA-N; Org-2058; Org 2058; CHEMBL2311103; 24320-06-7; (8R,9S,10R,13S,14S,16R,17S)-16-ethyl-17-(2-hydroxyacetyl)-13-methyl-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-one; O-2058; [3H]ORG2058; [3H]-ORG2058; A)-16-ethyl-21-hydroxy-19-norpregn-4-ene-3,20-dione; AC1Q6OBA; AC1L3O6Q; SCHEMBL3273165; GTPL3454; GTPL3453; 16alpha-Ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione; BDBM50422735; (16alpha)-16-Ethyl-21-hydroxy-19-norpregn-4-ene-3,20-dione; 19-Norpregn-4-ene-3,20-dione,; ORG-2058; ORG 2058

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 119086
  CAS Number: CAS 24320-06-7
  TTD Drug ID: DMH1M6N

Molecule-Related Drug Atlas

Drug(s) Targeting Progesterone receptor (PGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[4]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[5]
Ulipristal	DMBNI20	Contraception	QA21	Approved	[6]
Etonogestrel	DMKA8J4	Contraception	QA21	Approved	[7]
Megestrol	DMDH9KX	Breast cancer	2C60-2C65	Approved	[8]
Segesterone acetate; ethinyl estradiol	DMFEGB0	Contraception	QA21	Approved	[9]
Norgestimate	DMYP4XC	Acne vulgaris	ED80	Approved	[7]
Dydrogesterone	DMAKIDV	Menstrual disorder	GA20.3	Approved	[10]
Medroxyprogesterone	DMBGWPH	Solid tumour/cancer	2A00-2F9Z	Approved	[10]
Ethynodiol Diacetate	DMZM84R	Contraception	QA21	Approved	[11]

Drug(s) Affected By Annexin A1 (ANXA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[12]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[13]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[15]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[16]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[17]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[18]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[19]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[13]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]

Drug(s) Affected By Laminin subunit gamma-1 (LAMC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[22]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[23]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[27]
Indomethacin	DMSC4A7	Bursitis		Approved	[28]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[29]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[30]

Drug(s) Affected By Microtubule-associated protein 2 (MAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[32]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[15]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[35]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]

Drug(s) Affected By Nucleoprotein TPR (TPR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[41]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[44]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[44]

Drug(s) Affected By Desmoplakin (DSP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[45]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[47]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[36]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[49]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[50]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[51]

Drug(s) Affected By Glycerol-3-phosphate dehydrogenase , cytoplasmic (GPD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[52]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[54]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[55]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[20]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[56]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[57]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[57]

Drug(s) Affected By Neuropeptide Y receptor type 1 (NPY1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[15]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[58]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[60]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[61]
Methamphetamine	DMPM4SK	Anxiety		Approved	[62]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[63]

Drug(s) Affected By Transmembrane 4 L6 family member 1 (TM4SF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[67]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[68]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[69]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[58]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]

Drug(s) Affected By Cyclin-dependent kinases regulatory subunit 2 (CKS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[72]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[73]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[68]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[68]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[42]

Drug(s) Affected By Transcription factor RFX3 (RFX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[76]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[56]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[15]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[77]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[63]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[78]

Drug(s) Affected By Retinoic acid receptor responder protein 1 (RARRES1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[79]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[58]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[79]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[79]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[54]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[80]

Drug(s) Affected By Retinal guanylyl cyclase 1 (GUCY2D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[83]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[63]

Drug(s) Affected By DNA topoisomerase 2-beta (TOP2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[85]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[86]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[87]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[88]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[29]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[89]

Drug(s) Affected By A-kinase anchor protein 13 (AKAP13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[67]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[49]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[92]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[93]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[51]

Drug(s) Affected By Tripartite motif-containing protein 29 (TRIM29)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[95]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[47]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[98]

Drug(s) Affected By Non-POU domain-containing octamer-binding protein (NONO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[99]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[49]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[51]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[63]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[40]
biochanin A	DM0HPWY	Discovery agent	N.A.	Investigative	[101]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[102]

Drug(s) Affected By Fidgetin (FIGN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[103]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[49]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[108]

Drug(s) Affected By Transmembrane protein 164 (TMEM164)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[22]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[76]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[109]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[51]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[110]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[63]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[64]

Drug(s) Affected By Caprin-2 (CAPRIN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[58]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[49]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[55]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[56]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[39]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[111]

Drug(s) Affected By Pre-mRNA-processing-splicing factor 8 (PRPF8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[112]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[113]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[114]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[115]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[116]

Drug(s) Affected By Protein shisa-2 homolog (SHISA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[117]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[27]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[119]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[93]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[51]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[120]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[15]

Drug(s) Affected By Adropin (ENHO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[58]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[121]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[121]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[122]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[63]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[123]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[124]

Drug(s) Affected By Protein AHNAK2 (AHNAK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[125]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[27]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[119]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[76]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[126]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[127]

Drug(s) Affected By Mitochondrial cardiolipin hydrolase (PLD6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[113]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[55]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[129]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[56]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[130]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[63]

Drug(s) Affected By Phospholipid-transporting ATPase IG (ATP11C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[27]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[131]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[119]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[55]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[129]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[51]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[63]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[132]

Drug(s) Affected By Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (ATP2A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[47]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[44]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[44]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[87]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[112]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[108]

Drug(s) Affected By Sororin (CDCA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[133]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[68]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[68]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[134]

Drug(s) Affected By Nucleosome assembly protein 1-like 3 (NAP1L3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[51]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[77]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[116]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[135]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[78]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[136]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[124]

Drug(s) Affected By Kinetochore protein Spc25 (SPC25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[103]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[132]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[46]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[68]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[68]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]

Drug(s) Affected By ETS-related transcription factor Elf-5 (ELF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[15]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[58]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[137]
Promegestone	DMK4S8I	Gynecological disease	GA6Z	Approved	[3]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[138]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[139]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[63]
SB-431542	DM0YOXQ	Pulmonary fibrosis	CB03.4	Preclinical	[140]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[141]

Drug(s) Affected By Integrator complex subunit 6 (INTS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[142]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[67]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[58]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[49]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[108]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[55]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[143]

Drug(s) Affected By Centrosomal protein of 83 kDa (CEP83)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[49]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[20]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[64]
flavone	DMEQH6J	Discovery agent	N.A.	Investigative	[144]

Drug(s) Affected By Transcription factor MafB (MAFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[15]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[125]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[27]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[49]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[145]

Drug(s) Affected By Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (ARFGEF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[55]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[146]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[78]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[40]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[147]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[102]

Drug(s) Affected By Protein piccolo (PCLO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[58]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[27]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[108]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[51]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[120]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[56]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[122]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[78]

Drug(s) Affected By SET-binding protein (SETBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[39]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[96]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[125]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[54]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[148]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[107]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[51]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[149]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Progesterone receptor (PGR)	TTUV8G9	PRGR_HUMAN	Agonist	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
A-kinase anchor protein 13 (AKAP13)	OTOZAR14	AKP13_HUMAN	Gene/Protein Processing	[3]
Adropin (ENHO)	OT91QASK	ENHO_HUMAN	Gene/Protein Processing	[3]
Annexin A1 (ANXA1)	OT5OFDJC	ANXA1_HUMAN	Gene/Protein Processing	[3]
Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (ARFGEF1)	OTPAU0L4	BIG1_HUMAN	Gene/Protein Processing	[3]
Caprin-2 (CAPRIN2)	OTDYKD95	CAPR2_HUMAN	Gene/Protein Processing	[3]
Centrosomal protein of 83 kDa (CEP83)	OTNJGQ11	CEP83_HUMAN	Gene/Protein Processing	[3]
Cyclin-dependent kinases regulatory subunit 2 (CKS2)	OTPTMHIV	CKS2_HUMAN	Gene/Protein Processing	[3]
Desmoplakin (DSP)	OTB2MOP8	DESP_HUMAN	Gene/Protein Processing	[3]
DNA topoisomerase 2-beta (TOP2B)	OTDHKQZ8	TOP2B_HUMAN	Gene/Protein Processing	[3]
ETS-related transcription factor Elf-5 (ELF5)	OTLRU8YF	ELF5_HUMAN	Gene/Protein Processing	[3]

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