General Information of Drug (ID: DMTGBAX)

Drug Name
Pomalidomide Drug Info
Synonyms Actimid (TN); Pomalidomide (Immunomodulator)
Indication
Disease Entry ICD 11 Status REF
Plasma cell myeloma 2A83.1 Approved [1]
Systemic sclerosis 4A42 Approved [2]
Cross-matching ID
PubChem CID
134780
ChEBI ID
CHEMBL43452
CAS Number
CAS 19171-19-8
TTD Drug ID
DMTGBAX
VARIDT Drug ID
DR00151
INTEDE Drug ID
DR1313
ACDINA Drug ID
D00540

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Preclinical Drug(s)
Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [10]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [11]
Methotrexate DM2TEOL Anterior urethra cancer Approved [12]
Folic Acid DMEMBJC Colorectal carcinoma Approved [13]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [12]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [12]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [14]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [12]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [15]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [16]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [17]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [18]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [19]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [20]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [21]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [22]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [23]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [24]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [18]
Verapamil DMA7PEW Angina pectoris BA40 Approved [25]
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Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [26]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [27]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [28]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [29]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [31]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [23]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [32]
Verapamil DMA7PEW Angina pectoris BA40 Approved [33]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [34]
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Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [35]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [36]
Gefitinib DM15F0X Colon adenocarcinoma Approved [37]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [38]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [39]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [40]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [41]
Methotrexate DM2TEOL Anterior urethra cancer Approved [42]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [43]
Quercetin DM3NC4M Obesity 5B81 Approved [44]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [45]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [46]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [47]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [48]
Aclarubicin DMLFZHD Acute myeloid leukaemia 2A60 Approved [49]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [50]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [51]
phorbol 12-myristate 13-acetate DMJWD62 Acute myeloid leukaemia 2A60 Phase 2 [52]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [53]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [54]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [55]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [56]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [57]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [58]
Quercetin DM3NC4M Obesity 5B81 Approved [59]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [60]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [61]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [62]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [63]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [64]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [65]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [66]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [67]
Testosterone DM7HUNW Hot flushes GA30 Approved [68]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [48]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [69]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [70]
phorbol 12-myristate 13-acetate DMJWD62 Acute myeloid leukaemia 2A60 Phase 2 [71]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [72]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [54]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [73]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Panobinostat DM58WKG Chronic graft versus host disease Approved [76]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [46]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [47]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [69]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [54]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [79]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [80]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [57]
Selenium DM25CGV N. A. N. A. Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [82]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [83]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [84]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [85]
Leflunomide DMR8ONJ Arthritis FA20 Approved [86]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [87]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [88]
Quercetin DM3NC4M Obesity 5B81 Approved [59]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [89]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [90]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [91]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [92]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [85]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [87]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [92]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [93]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [94]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Panobinostat DM58WKG Chronic graft versus host disease Approved [76]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [97]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [98]
Testosterone DM7HUNW Hot flushes GA30 Approved [99]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [99]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [48]
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Drug(s) Affected By Krueppel-like factor 1 (KLF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [101]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [48]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [102]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [54]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [103]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [104]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [105]
Leflunomide DMR8ONJ Arthritis FA20 Approved [86]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [69]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [106]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [54]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [107]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [108]
Caffeic acid phenethyl ester DMRJKIV Discovery agent N.A. Investigative [109]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [45]
Leflunomide DMR8ONJ Arthritis FA20 Approved [86]
Aclarubicin DMLFZHD Acute myeloid leukaemia 2A60 Approved [49]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [69]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [110]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [110]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [111]
Urethane DM7NSI0 N. A. N. A. Phase 4 [112]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [113]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [114]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [54]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [115]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [116]
Cotinine DMCEZ1B Insecticide N.A. Approved [117]
Arsenic DMTL2Y1 N. A. N. A. Approved [118]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [119]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [120]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [121]
phorbol 12-myristate 13-acetate DMJWD62 Acute myeloid leukaemia 2A60 Phase 2 [115]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [122]
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Drug(s) Affected By Sal-like protein 4 (SALL4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Lenalidomide DM6Q7U4 Adult T-cell leukemia/lymphoma Approved [9]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [9]
Testosterone DM7HUNW Hot flushes GA30 Approved [68]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [124]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [125]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [119]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [126]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [127]
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Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [128]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [129]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [130]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [131]
Capsaicin DMGMF6V Back pain ME84.Z Approved [132]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [133]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [134]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [133]
Desipramine DMT2FDC Attention deficit hyperactivity disorder 6A05.Z Approved [129]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [135]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Angiogenesis/myeloma cell growth (AMCG) TTDIBYJ NOUNIPROTAC Modulator [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [5]
Cytochrome P450 1A2 (CYP1A2) Main DME DEJGDUW CP1A2_HUMAN Substrate [6]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Protein Interaction/Cellular Processes [7]
CCAAT/enhancer-binding protein alpha (CEBPA) OTOM9OE4 CEBPA_HUMAN Gene/Protein Processing [7]
CCAAT/enhancer-binding protein delta (CEBPD) OTNBIPMY CEBPD_HUMAN Gene/Protein Processing [7]
CCAAT/enhancer-binding protein epsilon (CEBPE) OTKZA25M CEBPE_HUMAN Gene/Protein Processing [7]
Cytochrome P450 2C19 (CYP2C19) OTFMJYYE CP2CJ_HUMAN Biotransformations [8]
DNA-binding protein inhibitor ID-1 (ID1) OTKGNZN5 ID1_HUMAN Gene/Protein Processing [7]
Endothelial transcription factor GATA-2 (GATA2) OTBP2QQ2 GATA2_HUMAN Gene/Protein Processing [7]
Erythroid transcription factor (GATA1) OTX1R7O1 GATA1_HUMAN Gene/Protein Processing [7]
Krueppel-like factor 1 (KLF1) OT1FK08U KLF1_HUMAN Gene/Protein Processing [7]
Sal-like protein 4 (SALL4) OTC08PR5 SALL4_HUMAN Protein Interaction/Cellular Processes [9]

References

1 Pomalidomide FDA Label
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3 Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651.
4 DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. (ID: DB08910)
5 Pomalidomide: evaluation of cytochrome P450 and transporter-mediated drug-drug interaction potential in vitro and in healthy subjects. J Clin Pharmacol. 2015 Feb;55(2):168-78.
6 Population pharmacokinetics of pomalidomide. J Clin Pharmacol. 2015 May;55(5):563-72.
7 Immunomodulatory derivative of thalidomide (IMiD CC-4047) induces a shift in lineage commitment by suppressing erythropoiesis and promoting myelopoiesis. Blood. 2005 May 15;105(10):3833-40. doi: 10.1182/blood-2004-03-0828. Epub 2004 Aug 3.
8 Human cytochrome P450 oxidation of 5-hydroxythalidomide and pomalidomide, an amino analogue of thalidomide. Chem Res Toxicol. 2014 Jan 21;27(1):147-56. doi: 10.1021/tx4004215. Epub 2013 Dec 24.
9 Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome. Elife. 2018 Aug 1;7:e38430. doi: 10.7554/eLife.38430.
10 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
11 MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents. Cancer Chemother Pharmacol. 2009 Jun;64(1):183-8.
12 Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
13 Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia. Pregnancy Hypertens. 2012 Apr;2(2):123-31.
14 Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8.
15 Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92.
16 Association of genetic polymorphisms in the influx transporter SLCO1B3 and the efflux transporter ABCB1 with imatinib pharmacokinetics in patients with chronic myeloid leukemia. Ther Drug Monit. 2011 Apr;33(2):244-50.
17 Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines. Cancer. 2007 Mar 1;109(5):957-65.
18 Contribution of human hepatic cytochrome P450 isoforms to regioselective hydroxylation of steroid hormones. Xenobiotica. 1998 Jun;28(6):539-47.
19 Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6. J Pharmacol Exp Ther. 2004 Sep;310(3):1062-75.
20 Isoform-specific regulation of cytochromes P450 expression by estradiol and progesterone. Drug Metab Dispos. 2013 Feb;41(2):263-9.
21 Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in-vitro inhibition studies. J Pharm Pharmacol. 2017 Dec;69(12):1762-1772.
22 Potent mechanism-based inhibition of CYP3A4 by imatinib explains its liability to interact with CYP3A4 substrates. Br J Pharmacol. 2012 Apr;165(8):2787-98.
23 Effects of morin on the pharmacokinetics of etoposide in rats. Biopharm Drug Dispos. 2007 Apr;28(3):151-6.
24 The metabolism of zidovudine by human liver microsomes in vitro: formation of 3'-amino-3'-deoxythymidine. Biochem Pharmacol. 1994 Jul 19;48(2):267-76.
25 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
26 Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes. Drug Metab Dispos. 2000 Dec;28(12):1457-63.
27 Effects of polyunsaturated fatty acids on prostaglandin synthesis and cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines in human adenocarcinoma colon cells. Mol Carcinog. 2004 Jul;40(3):180-8.
28 Endoxifen and other metabolites of tamoxifen inhibit human hydroxysteroid sulfotransferase 2A1 (hSULT2A1). Drug Metab Dispos. 2014 Nov;42(11):1843-50.
29 Cytochrome P450 1A2 (CYP1A2) activity and risk factors for breast cancer: a cross-sectional study. Breast Cancer Res. 2004;6(4):R352-65.
30 PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses. Pharmacogenet Genomics. 2015 Aug;25(8):416-26.
31 The effect of apigenin on pharmacokinetics of imatinib and its metabolite N-desmethyl imatinib in rats. Biomed Res Int. 2013;2013:789184.
32 The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers. Sci Total Environ. 2007 Aug 1;381(1-3):38-46.
33 Identification of P450 enzymes involved in metabolism of verapamil in humans. Naunyn Schmiedebergs Arch Pharmacol. 1993 Sep;348(3):332-7.
34 Metabolism and metabolic inhibition of xanthotoxol in human liver microsomes. Evid Based Complement Alternat Med. 2016;2016:5416509.
35 Some HIV antiretrovirals increase oxidative stress and alter chemokine, cytokine or adiponectin production in human adipocytes and macrophages. Antivir Ther. 2007;12(4):489-500.
36 Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
37 Crosstalk between alveolar macrophages and alveolar epithelial cells/fibroblasts contributes to the pulmonary toxicity of gefitinib. Toxicol Lett. 2021 Mar 1;338:1-9. doi: 10.1016/j.toxlet.2020.11.011. Epub 2020 Nov 25.
38 Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts. Biomed Res Int. 2015;2015:257090. doi: 10.1155/2015/257090. Epub 2015 Aug 3.
39 Cannabidiol selectively modulates interleukin (IL)-1 and IL-6 production in toll-like receptor activated human peripheral blood monocytes. Toxicology. 2021 Dec;464:153016. doi: 10.1016/j.tox.2021.153016. Epub 2021 Nov 2.
40 Monitoring of deiodinase deficiency based on transcriptomic responses in SH-SY5Y cells. Arch Toxicol. 2013 Jun;87(6):1103-13. doi: 10.1007/s00204-013-1018-4. Epub 2013 Feb 10.
41 Dimethyl Fumarate Inhibits the Nuclear Factor B Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein. J Biol Chem. 2016 Feb 12;291(7):3639-47. doi: 10.1074/jbc.M115.679704. Epub 2015 Dec 18.
42 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
43 Simvastatin reduces expression of cytokines interleukin-6, interleukin-8, and monocyte chemoattractant protein-1 in circulating monocytes from hypercholesterolemic patients. Arterioscler Thromb Vasc Biol. 2002 Jul 1;22(7):1194-9. doi: 10.1161/01.atv.0000022694.16328.cc.
44 Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NFB and AhR and EGFR-ERK pathway. Toxicol Appl Pharmacol. 2011 Sep 1;255(2):138-49.
45 3'-Azido-3'-deoxythymidine inhibits erythroid-specific transcription factors in human erythroid K562 leukemia cells. Eur J Haematol. 1996 Jan-Feb;56(1-2):62-7. doi: 10.1111/j.1600-0609.1996.tb00296.x.
46 In vitro dual effect of arsenic trioxide on hemopoiesis: inhibition of erythropoiesis and stimulation of megakaryocytic maturation. Blood Cells Mol Dis. 2006 Jan-Feb;36(1):59-76. doi: 10.1016/j.bcmd.2005.10.005. Epub 2005 Dec 15.
47 Phenolic metabolites of benzene inhibited the erythroid differentiation of K562 cells. Toxicol Lett. 2011 Jun 24;203(3):190-9. doi: 10.1016/j.toxlet.2011.03.012. Epub 2011 Mar 23.
48 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
49 Oxidative stress involvement in chemically induced differentiation of K562 cells. Free Radic Biol Med. 2000 Jan 1;28(1):18-27.
50 Accumulation of gamma-globin mRNA and induction of irreversible erythroid differentiation after treatment of CML cell line K562 with new doxorubicin derivatives. Biochem Pharmacol. 2007 Jan 15;73(2):175-84. doi: 10.1016/j.bcp.2006.09.028. Epub 2006 Oct 4.
51 Effects of arsenic disulfide on apoptosis, histone acetylation, toll like receptor 2 activation, and erythropoiesis in bone marrow mononuclear cells of myelodysplastic syndromes patients in vitro. Leuk Res. 2017 Nov;62:4-11. doi: 10.1016/j.leukres.2017.09.010. Epub 2017 Sep 19.
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