Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTN0OK)

• Drug Name: Octanal Drug Info
• Synonyms: ALDEHIDO C-8; Aldehyde C-8; Aldehyde C8; Antifoam-LF; Caprylaldehyd; Caprylaldehyde; Caprylic aldehyde; Kaprylaldehyd; OCTYLALDEHYDE; Octaldehyde; Octanal; Octanal (natural); Octanal, tech.; Octanaldehyde; Octanoic aldehyde; Octyl aldehyde; Octyl aldehydes; Octylaldehyd; Oktanal; Oktylaldehyd; n-Caprylaldehyde; n-Octaldehyde; n-Octanal; n-Octanaldehyde; n-Octyl aldehyde; n-Octylal; 1-Caprylaldehyde; 1-Octaldehyde; 1-Octylaldehyde; 1-octanal; 124-13-0; C-8 aldehyde; FEMA No. 2797; HSDB 5147; MFCD00007029; NSC 1508; UNII-XGE9999H19
• Cross-matching ID:
  PubChem CID: 454
  ChEBI ID: CHEBI:17935
  CAS Number: CAS 124-13-0
  TTD Drug ID: DMTN0OK
  INTEDE Drug ID: DR2008

Molecule-Related Drug Atlas

Drug(s) Metabolized By Alcohol dehydrogenase class-I gamma (ADH1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[6]
octanol	DMBGHPE	Discovery agent	N.A.	Investigative	[1]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[1]
Pyrene-1-aldehyde	DMEF6IP	N. A.	N. A.	Investigative	[1]
Hydroxymethylpyrene	DMPGAR2	N. A.	N. A.	Investigative	[1]
BRN-2330710	DM87VP6	N. A.	N. A.	Investigative	[1]
Pyrenemethanol	DMGJ0RM	N. A.	N. A.	Investigative	[1]

Drug(s) Metabolized By Alcohol dehydrogenase class-II (ADH4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1]
ANDROSTERONE	DMITJAK	N. A.	N. A.	Phase 3	[7]
octanol	DMBGHPE	Discovery agent	N.A.	Investigative	[1]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[1]
Pyrene-1-aldehyde	DMEF6IP	N. A.	N. A.	Investigative	[1]
Hydroxymethylpyrene	DMPGAR2	N. A.	N. A.	Investigative	[1]
BRN-2330710	DM87VP6	N. A.	N. A.	Investigative	[1]
Pyrenemethanol	DMGJ0RM	N. A.	N. A.	Investigative	[1]

Drug(s) Affected By Beta-1,3-galactosyltransferase 4 (B3GALT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[8]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[9]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[9]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[10]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[11]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[12]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[13]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[14]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[15]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[16]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[17]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[18]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[19]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[20]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[22]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[23]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[24]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[25]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[26]

Drug(s) Affected By Carbonic anhydrase 9 (CA9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[27]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[28]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[29]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[30]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Bortezomib	DMNO38U	Leukemia		Approved	[35]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[36]

Drug(s) Affected By Suprabasin (SBSN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[10]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[38]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[36]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[39]
Hexadecanoic acid	DMWUXDZ	Discovery agent	N.A.	Investigative	[40]

Drug(s) Affected By Zinc transporter ZIP5 (SLC39A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[10]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[44]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[45]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[46]

Drug(s) Affected By Cell migration-inducing and hyaluronan-binding protein (CEMIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[30]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[47]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[38]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[49]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[50]

Drug(s) Affected By Dehydrogenase/reductase SDR family member 9 (DHRS9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[10]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[54]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[52]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[55]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[11]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]

Drug(s) Affected By Adhesion G protein-coupled receptor E2 (ADGRE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[60]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[62]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[63]

Drug(s) Affected By Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[64]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[66]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[67]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[68]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[69]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[70]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]

Drug(s) Affected By Autoimmune regulator (AIRE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[10]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[73]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[13]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[74]

Drug(s) Affected By Serine protease inhibitor Kazal-type 4 (SPINK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[30]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[75]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[76]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[77]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[78]

Drug(s) Affected By Bone morphogenetic protein 10 (BMP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[13]

Drug(s) Affected By Immunoglobulin J chain (JCHAIN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[80]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[48]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[66]
Coprexa	DMA0WEK	Neurological disorder	6B60	Phase 3	[82]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[83]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[66]

Drug(s) Affected By Lithostathine-1-alpha (REG1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[10]
Coprexa	DMA0WEK	Neurological disorder	6B60	Phase 3	[82]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[13]

Drug(s) Affected By Zinc finger protein RFP (TRIM27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[84]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[85]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[86]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[70]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[84]

Drug(s) Affected By cAMP-dependent protein kinase catalytic subunit beta (PRKACB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[86]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[88]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[67]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[90]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[68]

Drug(s) Affected By 3',5'-cyclic-AMP phosphodiesterase 4A (PDE4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[10]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[92]
Roflumilast	DMPGHY8	Asthma	CA23	Approved	[93]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[36]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[60]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[95]

Drug(s) Affected By Peroxisome biogenesis factor 2 (PEX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[10]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[11]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[96]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[97]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[98]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[66]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[60]

Drug(s) Affected By Neuromedin-B receptor (NMBR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[100]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[13]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[101]
1,6-hexamethylene diisocyanate	DMLB3RT	Discovery agent	N.A.	Investigative	[102]

Drug(s) Affected By Alpha-synuclein (SNCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[104]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[86]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[106]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Bortezomib	DMNO38U	Leukemia		Approved	[107]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[108]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[109]

Drug(s) Affected By Aldehyde dehydrogenase family 3 member B1 (ALDH3B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[110]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[15]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[10]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[36]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[111]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[112]

Drug(s) Affected By Histone H2B type 1-C/E/F/G/I (H2BC10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[86]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[115]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[116]

Drug(s) Affected By Cyclin-A1 (CCNA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[118]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[30]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[119]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[10]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[92]
Atropine	DMEN6X7	Organophosphate poisoning	NE6Z	Approved	[121]

Drug(s) Affected By Myelin transcription factor 1 (MYT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[122]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[10]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[123]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[124]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[97]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[77]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[44]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[123]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[124]

Drug(s) Affected By Leucine-rich repeat-containing protein 74A (LRRC74A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[13]

Drug(s) Affected By Chromodomain-helicase-DNA-binding protein 3 (CHD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[84]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[10]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[86]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[36]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[125]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[126]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[83]

Drug(s) Affected By Cytochrome c oxidase copper chaperone (COX17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[86]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[67]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[127]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[96]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[12]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[12]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[12]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[12]

Drug(s) Affected By Kinesin-like protein KIF7 (KIF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[9]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[9]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[10]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[36]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[128]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[94]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[13]

Drug(s) Affected By Phospholipid phosphatase-related protein type 5 (PLPPR5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[129]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[130]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[60]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[13]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[15]

Drug(s) Affected By Centrosomal protein of 85 kDa (CEP85)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[10]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[131]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[13]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[71]

Drug(s) Affected By NF-X1-type zinc finger protein NFXL1 (NFXL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[32]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[132]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[130]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[14]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[101]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[133]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[134]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[135]

Drug(s) Affected By LHFPL tetraspan subfamily member 3 protein (LHFPL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[10]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[13]

Drug(s) Affected By Mitofusin-1 (MFN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[137]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[138]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[139]
Bortezomib	DMNO38U	Leukemia		Approved	[67]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]

Drug(s) Affected By Protein STPG4 (STPG4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[140]

Drug(s) Affected By Estradiol 17-beta-dehydrogenase 11 (HSD17B11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[8]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[9]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[9]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[86]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[113]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[70]

Drug(s) Affected By Olfactory receptor 10Z1 (OR10Z1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[13]

Drug(s) Affected By tRNA (THUMPD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[86]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[131]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[141]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[13]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[14]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[101]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[142]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[101]

Drug(s) Affected By Kinetochore protein Nuf2 (NUF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[143]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[144]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[9]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[9]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]

Drug(s) Affected By Phosphatase and actin regulator 1 (PHACTR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[130]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[145]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[146]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[14]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[15]

Drug(s) Affected By STE20-like serine/threonine-protein kinase (SLK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[86]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[94]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[147]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[148]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[149]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[101]

Drug(s) Affected By Potassium voltage-gated channel subfamily F member 1 (KCNF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[10]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[106]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[150]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[96]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[150]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[141]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[151]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[150]

Drug(s) Affected By E3 ubiquitin-protein ligase CCNB1IP1 (CCNB1IP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[85]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[10]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[109]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[56]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[147]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[152]

Drug(s) Affected By Scavenger receptor cysteine-rich type 1 protein M160 (CD163L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[10]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[153]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[97]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[13]

Drug(s) Affected By Protein kintoun (DNAAF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[10]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[70]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[154]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[131]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[33]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[14]

Drug(s) Affected By Large ribosomal subunit protein mL66 (MRPS18A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[53]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[155]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[127]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[100]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[156]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[13]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[157]

Drug(s) Affected By Tudor and KH domain-containing protein (TDRKH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[47]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[86]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[131]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[158]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[159]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[13]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[14]

Drug(s) Affected By Acyl-coenzyme A thioesterase 9, mitochondrial (ACOT9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[160]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[161]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[162]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[10]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[86]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[130]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[156]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[13]

Drug(s) Affected By Protocadherin alpha-9 (PCDHA9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[13]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[63]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[163]

Drug(s) Affected By Protocadherin alpha-10 (PCDHA10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[10]

Drug(s) Affected By Guanine nucleotide-binding protein G(olf) subunit alpha (GNAL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[164]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[10]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[128]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[125]
Azelaic Acid	DMHVL0J	Acne vulgaris	ED80	Approved	[165]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[165]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[156]

Drug(s) Affected By Guanine nucleotide-binding protein subunit alpha-15 (GNA15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[10]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[11]
Azelaic Acid	DMHVL0J	Acne vulgaris	ED80	Approved	[165]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[83]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[13]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[15]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[66]
Caprylic acid	DMLGS82	Discovery agent	N.A.	Investigative	[165]

Drug(s) Affected By Aldo-keto reductase family 1 member B1 (AKR1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[167]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[168]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[169]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[10]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[86]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[145]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[169]

Molecular Interaction Atlas of This Drug

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Alcohol dehydrogenase class-II (ADH4)	DEOCWU3	ADH4_HUMAN	Substrate	[1]
Alcohol dehydrogenase class-I gamma (ADH1C)	DEM1HNL	ADH1G_HUMAN	Substrate	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
3',5'-cyclic-AMP phosphodiesterase 4A (PDE4A)	OTMUUZLF	PDE4A_HUMAN	Post-Translational Modifications	[2]
Acyl-coenzyme A thioesterase 9, mitochondrial (ACOT9)	OTBOQE6N	ACOT9_HUMAN	Post-Translational Modifications	[2]
Adhesion G protein-coupled receptor E2 (ADGRE2)	OTUYJVYG	AGRE2_HUMAN	Gene/Protein Processing	[3]
Aldehyde dehydrogenase family 3 member B1 (ALDH3B1)	OT5NEUQE	AL3B1_HUMAN	Protein Interaction/Cellular Processes	[4]
Aldo-keto reductase family 1 member B1 (AKR1B1)	OTRX72TH	ALDR_HUMAN	Biotransformations	[5]
Alpha-synuclein (SNCA)	OTPWC1MR	SYUA_HUMAN	Post-Translational Modifications	[2]
Autoimmune regulator (AIRE)	OTA7G1Y1	AIRE_HUMAN	Post-Translational Modifications	[2]
Beta-1,3-galactosyltransferase 4 (B3GALT4)	OTLKSMQE	B3GT4_HUMAN	Gene/Protein Processing	[3]
Bone morphogenetic protein 10 (BMP10)	OTA3QKKG	BMP10_HUMAN	Post-Translational Modifications	[2]
cAMP-dependent protein kinase catalytic subunit beta (PRKACB)	OT6RMDCE	KAPCB_HUMAN	Post-Translational Modifications	[2]

References

• [1] Oxidation of alcohols and reduction of aldehydes derived from methyl- and dimethylpyrenes by cDNA-expressed human alcohol dehydrogenases. Toxicology. 2008 Mar 12;245(1-2):65-75.
• [2] DNA Methylome Analysis of Saturated Aliphatic Aldehydes in Pulmonary Toxicity. Sci Rep. 2018 Jul 12;8(1):10497. doi: 10.1038/s41598-018-28813-z.
• [3] Transcriptome profile analysis of saturated aliphatic aldehydes reveals carbon number-specific molecules involved in pulmonary toxicity. Chem Res Toxicol. 2014 Aug 18;27(8):1362-70.
• [4] Molecular characterization, expression analysis, and role of ALDH3B1 in the cellular protection against oxidative stress. Free Radic Biol Med. 2010 Nov 15;49(9):1432-43. doi: 10.1016/j.freeradbiomed.2010.08.004. Epub 2010 Aug 10.
• [5] Characterization of the glutathione binding site of aldose reductase. Chem Biol Interact. 2001 Jan 30;130-132(1-3):537-48. doi: 10.1016/s0009-2797(00)00297-0.
• [6] Natural alcohol exposure: is ethanol the main substrate for alcohol dehydrogenases in animals? Chem Biol Interact. 2011 May 30;191(1-3):14-25.
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