General Information of Drug (ID: DMTP1DC)

Drug Name
Irbesartan Drug Info
Synonyms
irbesartan; 138402-11-6; Aprovel; Avapro; Karvea; SR-47436; BMS-186295; BMS 186295; Irbesartan [USAN:INN]; SR 47436; UNII-J0E2756Z7N; CHEMBL1513; 8-butyl-7-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-7,9-diazaspiro[44]non-8-en-6-one; CHEBI:5959; C25H28N6O; YOSHYTLCDANDAN-UHFFFAOYSA-N; J0E2756Z7N; 2-butyl-3-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1,3-diazaspiro[44]non-1-en-4-one; 3-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-1,3-diazaspiro[44]non-1-en-4-one; NCGC00095122-01; AK-57149; DSSTox_CID_3169; Aprovel; Irbesarran; Irbetan; Lrbesartan; BMS Brand of Irbesartan; Bristol Myers Brand of Irbesartan; SanofiWinthrop Brand of Irbesartan; Aprovel (TN); Avalide (TN); Avapro (TN); Karvea (TN); Irbesartan (JAN/USAN/INN); BMS-186295, SR-47436,Aprovel, Karvea, Irbesartan; 2-Butyl-3-(p-(o-1H-tetrazol-5-ylphenyl)benzyl)-1,3-diazaspiro(44)non-1-en-4-one; 2-Butyl-3-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]1,3-diaza-spiro[44]non-1-en-4-one; 2-butyl-3-[ p-(o-1 H-tetrazol-5-ylphenyl)benzyl]-1,3-diazaspiro[4,4]non-1-en-4-one; 2-butyl-3-[p-(o-1H-tetrazol-5-ylphenyl)benzyl]-1,3-diazaspiro[44]non-1-en-4-one; 2-butyl-3-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-1,3-diazaspiro[44]non-1-en-4-one; 2-n-butyl-3-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-1,3-diazaspiro(4,4)non-1-en-4-one; [3H]irbesartan
Indication
Disease Entry ICD 11 Status REF
Diabetic kidney disease GB61.Z Approved [1]
Hypertension BA00-BA04 Approved [2]
Coronavirus Disease 2019 (COVID-19) 1D6Y Investigative [3]
High blood pressure BA00 Investigative [1]
Therapeutic Class
Antihypertensive Agents
Cross-matching ID
PubChem CID
3749
ChEBI ID
CHEBI:5959
CAS Number
CAS 138402-11-6
TTD Drug ID
DMTP1DC
VARIDT Drug ID
DR00482
INTEDE Drug ID
DR0879
ACDINA Drug ID
D00330

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Losartan DM72JXH Diabetic kidney disease GB61.Z Approved [4]
Olmesartan medoxomil DMWBHRY High blood pressure BA00 Approved [20]
Valsartan DMREUQ6 Chronic heart failure BD1Z Approved [4]
Candesartan DMRK8OT Chronic heart failure BD1Z Approved [21]
Telmisartan DMS3GX2 Hypertension BA00-BA04 Approved [22]
ANGIOTENSIN II DMLWQ27 Increase blood pressure BA04 Approved [23]
SARALASIN DMKS1DV Hypertension BA00-BA04 Approved [24]
Tasosartan DMM13DI Hypertension BA00-BA04 Approved [25]
Eprosartan DM07K2I Hypertension BA00-BA04 Approved [26]
Sparsentan DMMP51W IgA nephropathy MF8Y Approved [27]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Telmisartan DMS3GX2 Hypertension BA00-BA04 Approved [28]
Losartan DM72JXH Diabetic kidney disease GB61.Z Approved [28]
Drug(s) Transported By Peptide transporter 1 (SLC15A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [29]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [30]
Ampicillin DMHWE7P Acute epiglottitis Approved [31]
Losartan DM72JXH Diabetic kidney disease GB61.Z Approved [6]
Enalapril DMNFUZR Congestive heart failure BD10 Approved [32]
Cefazolin DMPDYFR Bacteremia 1A73 Approved [33]
Ceftriaxone DMCEW64 Acute gonococcal cervicitis Approved [34]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [30]
Cefadroxil DMMC345 Bacterial infection 1A00-1C4Z Approved [6]
Valsartan DMREUQ6 Chronic heart failure BD1Z Approved [6]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [35]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [36]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [37]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [38]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [39]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [40]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [41]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [42]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [36]
Verapamil DMA7PEW Angina pectoris BA40 Approved [10]
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Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [43]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [44]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [44]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [45]
Verapamil DMA7PEW Angina pectoris BA40 Approved [46]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [47]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [48]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [44]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [49]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [50]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [9]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [68]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [9]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [68]
Sulfinpyrazone DMEV954 Gout FA25 Approved [69]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [9]
Zafirlukast DMHNQOG Asthma CA23 Approved [9]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [9]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [70]
Dabrafenib DMX6OE3 Melanoma 2C30 Approved [71]
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Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [51]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [52]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [53]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [45]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [54]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [45]
Verapamil DMA7PEW Angina pectoris BA40 Approved [55]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [56]
Estrone DM5T6US Acne vulgaris ED80 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [151]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [152]
Dapsone DM4LT8A Acne vulgaris ED80 Approved [153]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [154]
Capsaicin DMGMF6V Back pain ME84.Z Approved [155]
Zafirlukast DMHNQOG Asthma CA23 Approved [156]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [153]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [157]
Fluconazole DMOWZ6B Cryptococcal meningitis Approved [154]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [153]
⏷ Show the Full List of 20 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [59]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [60]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [10]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [61]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [62]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [63]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [64]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [65]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [66]
Losartan DM72JXH Diabetic kidney disease GB61.Z Approved [10]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [10]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [67]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [10]
Diazepam DM08E9O Alcohol withdrawal Approved [10]
Dapsone DM4LT8A Acne vulgaris ED80 Approved [10]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [10]
Nateglinide DMLK2QH Diabetic complication 5A2Y Approved [10]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [10]
Ketobemidone DMM3L6Z Pain MG30-MG3Z Approved [10]
Terbinafine DMI6HUW Fungal infection 1F29-1F2F Approved [10]
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Drug(s) Affected By Bile salt export pump (ABCB11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [72]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [73]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [73]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [74]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [72]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [73]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [75]
Gefitinib DM15F0X Colon adenocarcinoma Approved [72]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [15]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [72]
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Drug(s) Affected By Renin (REN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [76]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [77]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [78]
Reboxetine DM26PRD Depression 6A70-6A7Z Approved [79]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [80]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [81]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [82]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [83]
Epinephrine DM3KJBC Acute asthma CA23 Approved [84]
Chlorthalidone DM4DMBT Edema MG29 Approved [85]
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Drug(s) Affected By Carbonic anhydrase 1 (CA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [86]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [87]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [88]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [89]
Candesartan DMRK8OT Chronic heart failure BD1Z Approved [16]
Indomethacin DMSC4A7 Bursitis Approved [90]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [91]
Phenylephrine DMZHUO5 Allergic rhinitis CA08.0 Approved [92]
GUAIACOL DMN4E7T N. A. N. A. Phase 3 [88]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [93]
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Drug(s) Affected By Angiotensinogen (AGT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [94]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [95]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [96]
Reboxetine DM26PRD Depression 6A70-6A7Z Approved [79]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [97]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [98]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [82]
Quercetin DM3NC4M Obesity 5B81 Approved [99]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [100]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [101]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Natriuretic peptides A (NPPA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [102]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [103]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [104]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [105]
Cilazapril DM4V6JA Congestive heart failure BD10 Approved [106]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [100]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [107]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [108]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [109]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [110]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [111]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [112]
Fructose DM43AN2 Vomiting MD90 Approved [113]
Ketoprofen DMRKXPT Bursitis Approved [113]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [114]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [115]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [116]
Gefitinib DM15F0X Colon adenocarcinoma Approved [117]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [118]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [119]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interferon gamma (IFNG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [120]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [121]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [122]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [123]
Methotrexate DM2TEOL Anterior urethra cancer Approved [124]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [125]
Quercetin DM3NC4M Obesity 5B81 Approved [126]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [127]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [128]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [129]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [130]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [131]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [130]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [132]
Estrone DM5T6US Acne vulgaris ED80 Approved [131]
Methazolamide DM7J2TA Glaucoma/ocular hypertension 9C61 Approved [130]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [133]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [134]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [108]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [135]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [136]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [137]
Quercetin DM3NC4M Obesity 5B81 Approved [99]
Fructose DM43AN2 Vomiting MD90 Approved [138]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [139]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [140]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [141]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [142]
Estriol DMOEM2I Hormone deficiency 5A61.1 Approved [143]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [144]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [145]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [132]
Panobinostat DM58WKG Chronic graft versus host disease Approved [146]
Haloperidol DM96SE0 Delirium Approved [145]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [141]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [147]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [148]
Clozapine DMFC71L Schizophrenia 6A20 Approved [145]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [150]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apolipoprotein B-100 (APOB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [158]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [96]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [158]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [159]
Quercetin DM3NC4M Obesity 5B81 Approved [99]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [160]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [158]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [161]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [158]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [162]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [163]
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [164]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [165]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [108]
Potassium Chloride DMMTAJC Hypokalemia 5C77 Approved [166]
Dutasteride DMQ4TJK Benign prostatic hyperplasia GA90 Approved [167]
Mitotane DMU1GX0 Adrenocortical carcinoma 2D11.Z Approved [168]
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [165]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [169]
Testosterone DM7HUNW Hot flushes GA30 Approved [163]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [113]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [139]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [170]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [108]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [171]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [172]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [173]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [174]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [175]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Captopril DM458UM Chronic heart failure BD1Z Approved [176]
Diazepam DM08E9O Alcohol withdrawal Approved [177]
Dantrolene DM1D8XY Hyperthermia MG26 Approved [177]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [177]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [177]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [177]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [177]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [177]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [177]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [177]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [178]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [113]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [179]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [180]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [181]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [182]
Prednisone DM2HG4X Acute asthma CA23 Approved [183]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [184]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [185]
Methotrexate DM2TEOL Anterior urethra cancer Approved [124]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Endothelin-1 (EDN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [186]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [187]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [188]
Methotrexate DM2TEOL Anterior urethra cancer Approved [189]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [190]
Quercetin DM3NC4M Obesity 5B81 Approved [191]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [192]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [193]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [194]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [195]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Angiotensin II receptor type-1 (AGTR1) TT8DBY3 AGTR1_HUMAN Antagonist [4]
HUMAN type-1 angiotensin II receptor (AGTR1) TTPKMXQ AGTR1_HUMAN Antagonist [5]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Peptide transporter 1 (SLC15A1) DT9G7XN S15A1_HUMAN Substrate [6]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [7]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [8]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Substrate [9]
Prostaglandin G/H synthase 1 (COX-1) DE073H6 PGH1_HUMAN Substrate [10]
UDP-glucuronosyltransferase 1A3 (UGT1A3) DEF2WXN UD13_HUMAN Substrate [10]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Angiotensin-converting enzyme 2 (ACE2) OTTRZGU7 ACE2_HUMAN Drug Response [11]
Angiotensinogen (AGT) OTBZLYR3 ANGT_HUMAN Gene/Protein Processing [12]
Apolipoprotein B-100 (APOB) OTH0UOCZ APOB_HUMAN Drug Response [13]
B2 bradykinin receptor (BDKRB2) OTOA9D3W BKRB2_HUMAN Drug Response [14]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Gene/Protein Processing [15]
Carbonic anhydrase 1 (CA1) OTNFBVVQ CAH1_HUMAN Gene/Protein Processing [16]
Cytochrome P450 11B2, mitochondrial (CYP11B2) OTIOLWYN C11B2_HUMAN Drug Response [17]
Cytochrome P450 2C8 (CYP2C8) OTHCWT42 CP2C8_HUMAN Gene/Protein Processing [9]
Cytochrome P450 2C9 (CYP2C9) OTGLBN29 CP2C9_HUMAN Drug Response [18]
Endoplasmic reticulum aminopeptidase 1 (ERAP1) OT72S99B ERAP1_HUMAN Drug Response [19]

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