Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXYJ9C)

Drug Name
Busulfan Drug Info
Synonyms
Busulfano; Busulfanum; Busulfex; Busulphan; Busulphane; Butanedioldimethanesulfonate; Buzulfan; Citosulfan; Glyzophrol; Leucosulfan; Mablin; Methanesulfonic; Mielevcin; Mielosan; Mielucin; Milecitan; Mileran; Misulban; Mitosan; Mitostan; Myeleukon; Myeloleukon; Myelosan; Myelosanum; Mylecytan; Myleran; Mylerlan; Sulfabutin; Sulphabutin; Busulfan GlaxoSmithKline Brand; Busulfan Orphan Brand; Busulfan Wellcome; Busulfan Wellcome Brand; Glaxo Wellcome Brand of Busulfan; GlaxoSmithKline Brand of Busulfan; Myleran tablets; Orphan Brand of Busulfan; Tetramethylene bis[methanesulfonate]; Tetramethylene dimethane sulfonate; Tetramethylenester kyseliny methansulfonove; Tetramethylenester kyseliny methansulfonove[Czech]; Wellcome Brand of Busulfan; AN 33501; CB 2041; GT 2041; GT 41; X 149; Acid, tetramethylene ester; Alkylating agent: crosslinks guanine residues; Busulfan [INN:JAN]; Busulfano [INN-Spanish]; Busulfanum [INN-Latin]; MYLERAN (TN); Methanesulfonic acid, tetram ethylene ester; Methanesulfonic acid, tetramethylene ester; Myleran (TN); Sulfabutin (VAN); Tetramethylene bis(methanesulfonate); Tetramethylene {bis[methanesulfonate]}; Wellcome, Busulfan; C.B. 2041; G.T. 41; Myleran, Busulfex, Busulfan; Busulfan (JP15/USP/INN); Butane-1,4-diyl dimethanesulfonate; BUSULFAN (1,4-BUTANEDIOL, DIMETHANESULFONATE); N-Butane-1,3-di(methylsulfonate); 1,4-BUTANEDIOL DIMETHANESULFONATE; 1,4-Bis(methanesulfonoxy)butane; 1,4-Bis(methanesulfonyloxy)butane; 1,4-Bis[methanesulfonoxy]butane; 1,4-Butanedi yl dimethanesulfonate; 1,4-Butanediol dimethanesulphonate; 1,4-Butanediol dimethylsulfonate; 1,4-Butanediol, dimethanesulfonate; 1,4-Butanediol, dimethanesulphonate; 1,4-Butanediyl dimethanesulfonate; 1,4-Di(methylsulfonoxy)butane; 1,4-Dimesyloxybutane; 1,4-Dimethane sulfonyl oxybutane; 1,4-Dimethanesulfonoxybutane; 1,4-Dimethanesulfonoxylbutane; 1,4-Dimethanesulfonyloxybutane; 1,4-Dimethanesulphonyloxybutane; 1,4-Dimethylsulfonoxybutane; 1,4-Dimethylsulfonyloxybutane; 1,{4-Bis[methanesulfonoxy]butane}; 4-((Methylsulfonyl)oxy)butyl methanesulfonate; 4-methylsulfonyloxybutyl methanesulfonate
Indication
Disease Entry ICD 11 Status REF
Chronic myelogenous leukaemia 2A20.0 Approved [1]
Hematologic disease 3C0Z Approved [1]
Immunodeficiency 4A00-4A85 Approved [1]
Leukemia Approved [1]
Myeloproliferative syndrome 2A22 Approved [2]
Systemic lupus erythematosus 4A40.0 Approved [1]
Systemic sclerosis 4A42 Approved [1]
Neuroblastoma 2D11.2 Investigative [1]
Retinoblastoma 2D02.2 Investigative [1]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
2478
ChEBI ID
CHEBI:28901
CAS Number
CAS 55-98-1
TTD Drug ID
DMXYJ9C
INTEDE Drug ID
DR0249
ACDINA Drug ID
D00085

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Human Deoxyribonucleic acid (hDNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [17]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [18]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [19]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [20]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [21]
Carboplatin DMG281S Adenocarcinoma 2D40 Approved [22]
Procarbazine DMIK367 Hodgkin lymphoma 2B30 Approved [23]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [24]
Dacarbazine DMNPZL4 Adenocarcinoma 2D40 Approved [25]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [26]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [27]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [28]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [29]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [30]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [31]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [32]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [33]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [34]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [28]
Verapamil DMA7PEW Angina pectoris BA40 Approved [35]
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Drug(s) Metabolized By Glutathione S-transferase alpha-1 (GSTA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [36]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [37]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [38]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [39]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [40]
Trabectedin DMG3Y89 Leiomyosarcoma 2B58 Approved [41]
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [42]
Ethacrynic acid DM60QMR Edema MG29 Approved [43]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [44]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [45]
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Drug(s) Metabolized By Glutathione S-transferase alpha-2 (GSTA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [46]
Drug(s) Metabolized By Glutathione S-transferase pi (GSTP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [47]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [48]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [49]
Carboplatin DMG281S Adenocarcinoma 2D40 Approved [49]
Chlorambucil DMRKE63 Chronic lymphocytic leukaemia 2A82.0 Approved [50]
Drug(s) Metabolized By Glutathione S-transferase mu-1 (GSTM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [47]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [49]
Carboplatin DMG281S Adenocarcinoma 2D40 Approved [49]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [46]
Drug(s) Affected By Glutathione S-transferase P (GSTP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [51]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [52]
Chlorambucil DMRKE63 Chronic lymphocytic leukaemia 2A82.0 Approved [52]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [53]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [54]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [55]
Selenium DM25CGV N. A. N. A. Approved [56]
Etretinate DM2CZFA Keratosis ED56 Approved [57]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [58]
Quercetin DM3NC4M Obesity 5B81 Approved [59]
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Drug(s) Affected By Glutathione S-transferase Mu 1 (GSTM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [60]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [61]
Ethanol DMDRQZU Chronic pain MG30 Approved [62]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [63]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [63]
Methyldopa DM5I621 Hypertension BA00-BA04 Approved [64]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [65]
Testosterone DM7HUNW Hot flushes GA30 Approved [66]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [66]
Testosterone enanthate DMB6871 N. A. N. A. Approved [67]
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Drug(s) Affected By Microsomal glutathione S-transferase 2 (MGST2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [70]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [71]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [72]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [73]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [74]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [75]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [76]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [51]
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Drug(s) Affected By Glutathione S-transferase A1 (GSTA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [42]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [77]
Thiotepa DMIZKOP Breast cancer 2C60-2C65 Approved [78]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [79]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [80]
Ethacrynic acid DM60QMR Edema MG29 Approved [81]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [82]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [83]
Methotrexate DM2TEOL Anterior urethra cancer Approved [84]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
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Drug(s) Affected By Serotransferrin (TF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [85]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [83]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [86]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [71]
Isoflurophate DMBSK7X Glaucoma/ocular hypertension 9C61 Approved [87]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [88]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [89]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [90]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [75]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [91]
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Drug(s) Affected By Inhibin beta A chain (INHBA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [92]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [65]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [93]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [94]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [95]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [96]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [97]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [98]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [99]
Arsenic DMTL2Y1 N. A. N. A. Approved [100]
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Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [101]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [102]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [103]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [104]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [105]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [106]
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [107]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [108]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [109]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [110]
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Drug(s) Affected By Antithrombin-III (SERPINC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Prednisone DM2HG4X Acute asthma CA23 Approved [112]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [71]
Testosterone enanthate DMB6871 N. A. N. A. Approved [113]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [96]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [73]
Aminocaproic Acid DMFGND4 Bleeding disorder GA20-GA21 Approved [112]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [114]
Warfarin DMJYCVW Atrial fibrillation BC81.3 Approved [115]
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Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [116]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [117]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [118]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [119]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [120]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [121]
Prednisone DM2HG4X Acute asthma CA23 Approved [122]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [123]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [124]
Methotrexate DM2TEOL Anterior urethra cancer Approved [125]
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Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [126]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [127]
Fructose DM43AN2 Vomiting MD90 Approved [117]
Ketoprofen DMRKXPT Bursitis Approved [117]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [128]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [129]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [130]
Gefitinib DM15F0X Colon adenocarcinoma Approved [131]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [132]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [133]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [134]
Methotrexate DM2TEOL Anterior urethra cancer Approved [125]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [135]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [136]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [137]
Paclitaxel DMLB81S Breast carcinoma Approved [138]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [139]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [140]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [141]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [142]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [143]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [14]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [144]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [145]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [146]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [147]
Ethacrynic acid DM60QMR Edema MG29 Approved [148]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [149]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [150]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [151]
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Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [152]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [153]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [154]
Methotrexate DM2TEOL Anterior urethra cancer Approved [155]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [156]
Quercetin DM3NC4M Obesity 5B81 Approved [157]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [158]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [159]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [160]
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Drug(s) Affected By Thrombospondin-1 (THBS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [108]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [153]
Methotrexate DM2TEOL Anterior urethra cancer Approved [125]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [161]
Quercetin DM3NC4M Obesity 5B81 Approved [162]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [63]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [163]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [63]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [164]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [165]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [166]
Gefitinib DM15F0X Colon adenocarcinoma Approved [167]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [168]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [169]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [170]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [171]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [170]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [172]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [173]
Methotrexate DM2TEOL Anterior urethra cancer Approved [174]
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Drug(s) Affected By Tissue factor pathway inhibitor (TFPI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [175]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [92]
Panobinostat DM58WKG Chronic graft versus host disease Approved [176]
Estrone DM5T6US Acne vulgaris ED80 Approved [175]
Testosterone DM7HUNW Hot flushes GA30 Approved [177]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [71]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [72]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [178]
Ethanol DMDRQZU Chronic pain MG30 Approved [179]
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Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [180]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [181]
Selenium DM25CGV N. A. N. A. Approved [56]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [182]
Etretinate DM2CZFA Keratosis ED56 Approved [183]
Methotrexate DM2TEOL Anterior urethra cancer Approved [184]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [185]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [186]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [187]
Quercetin DM3NC4M Obesity 5B81 Approved [188]
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Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [189]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [190]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [55]
Selenium DM25CGV N. A. N. A. Approved [56]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [191]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [192]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [193]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [70]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [194]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [195]
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Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [196]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [197]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [189]
Gefitinib DM15F0X Colon adenocarcinoma Approved [198]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [55]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [199]
Methotrexate DM2TEOL Anterior urethra cancer Approved [200]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [201]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [202]
Quercetin DM3NC4M Obesity 5B81 Approved [203]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [204]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [205]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [206]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [129]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [207]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [208]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [209]
Gefitinib DM15F0X Colon adenocarcinoma Approved [210]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [211]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [212]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [213]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [205]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [214]
Paclitaxel DMLB81S Breast carcinoma Approved [215]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [216]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [204]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [117]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [217]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [129]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [207]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aryl hydrocarbon receptor (AHR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [108]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [218]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [219]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [220]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [221]
Quercetin DM3NC4M Obesity 5B81 Approved [222]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [223]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [224]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [225]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [226]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [104]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Quercetin DM3NC4M Obesity 5B81 Approved [228]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [92]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [230]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [231]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [232]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [233]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [234]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [235]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [236]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [237]
Gefitinib DM15F0X Colon adenocarcinoma Approved [238]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [239]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [240]
Etretinate DM2CZFA Keratosis ED56 Approved [241]
Prednisone DM2HG4X Acute asthma CA23 Approved [242]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [171]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [243]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Signal transducer and activator of transcription 1-alpha/beta (STAT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [244]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [245]
Methotrexate DM2TEOL Anterior urethra cancer Approved [163]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [201]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [246]
Quercetin DM3NC4M Obesity 5B81 Approved [247]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [248]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [163]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [93]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [95]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [249]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [250]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [251]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [137]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [252]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [253]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [254]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [255]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [256]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [257]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Signal transducer and activator of transcription 2 (STAT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [95]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [96]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [73]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [74]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [10]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [51]
Arsenic DMTL2Y1 N. A. N. A. Approved [258]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [259]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [260]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [261]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [262]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [263]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [217]
Gefitinib DM15F0X Colon adenocarcinoma Approved [264]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [265]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [169]
Selenium DM25CGV N. A. N. A. Approved [56]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [266]
Methotrexate DM2TEOL Anterior urethra cancer Approved [125]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Metal regulatory transcription factor 1 (MTF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [267]
Gallium nitrate DMF9O6B Hypercalcaemia 5B91.0 Approved [268]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [10]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [269]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [260]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [270]
Urethane DM7NSI0 N. A. N. A. Phase 4 [271]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [272]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [273]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [274]
Verapamil DMA7PEW Angina pectoris BA40 Approved [275]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [189]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [276]
Selenium DM25CGV N. A. N. A. Approved [56]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [277]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [278]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [279]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [280]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [281]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [282]
Prednisone DM2HG4X Acute asthma CA23 Approved [283]
Triamterene DM2HU9I Congestive heart failure BD10 Approved [283]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [284]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [285]
Epinephrine DM3KJBC Acute asthma CA23 Approved [286]
Quercetin DM3NC4M Obesity 5B81 Approved [287]
Fluoxetine DM3PD2C Bipolar depression Approved [288]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [289]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pseudouridylate synthase 7 homolog (PUS7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [83]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [92]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [290]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [96]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [73]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [74]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [75]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [291]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [83]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [292]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA repair nuclease/redox regulator APEX1 (APEX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [293]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [72]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [73]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [294]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [295]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [75]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [291]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [296]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [297]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [298]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Rho GDP-dissociation inhibitor 1 (ARHGDIA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [55]
Selenium DM25CGV N. A. N. A. Approved [56]
Etretinate DM2CZFA Keratosis ED56 Approved [57]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [224]
Estrone DM5T6US Acne vulgaris ED80 Approved [299]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [300]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [301]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [72]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [73]
Ampicillin DMHWE7P Acute epiglottitis Approved [68]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Human Deoxyribonucleic acid (hDNA) TTUTN1I NOUNIPROTAC Modulator [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [4]
Glutathione S-transferase alpha-1 (GSTA1) DE4ZHS1 GSTA1_HUMAN Substrate [5]
Glutathione S-transferase pi (GSTP1) DEK6079 GSTP1_HUMAN Substrate [6]
Glutathione S-transferase mu-1 (GSTM1) DEYZEJA GSTM1_HUMAN Substrate [6]
Microsomal glutathione S-transferase 2 (MGST2) DE31KMQ MGST2_HUMAN Substrate [7]
Glutathione S-transferase alpha-2 (GSTA2) DEH49YS GSTA2_HUMAN Substrate [8]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Antithrombin-III (SERPINC1) OTDFATG0 ANT3_HUMAN Gene/Protein Processing [9]
Aryl hydrocarbon receptor (AHR) OTFE4EYE AHR_HUMAN Gene/Protein Processing [10]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [11]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Gene/Protein Processing [12]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [10]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) OTRFV19J ATF4_HUMAN Gene/Protein Processing [10]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [13]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Gene/Protein Processing [14]
DNA repair nuclease/redox regulator APEX1 (APEX1) OT53OI14 APEX1_HUMAN Drug Response [15]
Glutathione S-transferase A1 (GSTA1) OTA7K5XA GSTA1_HUMAN Drug Response [16]

References

1 Busulfan FDA Label
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8 Endothelial cells do not express GSTA1: potential relevance to busulfan-mediated endothelial damage during haematopoietic stem cell transplantation. Eur J Haematol. 2008 Apr;80(4):299-302.
9 Decreased incidence of hepatic veno-occlusive disease and fewer hemostatic derangements associated with intravenous busulfan vs oral busulfan in adults conditioned with busulfan + cyclophosphamide for allogeneic bone marrow transplantation. Ann Hematol. 2005 May;84(5):321-30. doi: 10.1007/s00277-004-0982-4. Epub 2004 Dec 4.
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31 Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in-vitro inhibition studies. J Pharm Pharmacol. 2017 Dec;69(12):1762-1772.
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53 Cell-type-specific responses to chemotherapeutics in breast cancer. Cancer Res. 2004 Jun 15;64(12):4218-26.
54 Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biol. 2020 Jan;28:101321. doi: 10.1016/j.redox.2019.101321. Epub 2019 Sep 5.
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59 Single and concerted effects of benzo[a]pyrene and flavonoids on the AhR and Nrf2-pathway in the human colon carcinoma cell line Caco-2. Toxicol In Vitro. 2011 Apr;25(3):671-83.
60 Glutathione-S-transferase genotypes and the adverse effects of azathioprine in young patients with inflammatory bowel disease. Inflamm Bowel Dis. 2007 Jan;13(1):57-64. doi: 10.1002/ibd.20004.
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68 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
69 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
70 Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury. Arch Toxicol. 2020 Apr;94(4):1151-1172. doi: 10.1007/s00204-020-02691-9. Epub 2020 Mar 10.
71 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
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