Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXYJ9C)

Drug Name
Busulfan Drug Info
Synonyms
Busulfano; Busulfanum; Busulfex; Busulphan; Busulphane; Butanedioldimethanesulfonate; Buzulfan; Citosulfan; Glyzophrol; Leucosulfan; Mablin; Methanesulfonic; Mielevcin; Mielosan; Mielucin; Milecitan; Mileran; Misulban; Mitosan; Mitostan; Myeleukon; Myeloleukon; Myelosan; Myelosanum; Mylecytan; Myleran; Mylerlan; Sulfabutin; Sulphabutin; Busulfan GlaxoSmithKline Brand; Busulfan Orphan Brand; Busulfan Wellcome; Busulfan Wellcome Brand; Glaxo Wellcome Brand of Busulfan; GlaxoSmithKline Brand of Busulfan; Myleran tablets; Orphan Brand of Busulfan; Tetramethylene bis[methanesulfonate]; Tetramethylene dimethane sulfonate; Tetramethylenester kyseliny methansulfonove; Tetramethylenester kyseliny methansulfonove[Czech]; Wellcome Brand of Busulfan; AN 33501; CB 2041; GT 2041; GT 41; X 149; Acid, tetramethylene ester; Alkylating agent: crosslinks guanine residues; Busulfan [INN:JAN]; Busulfano [INN-Spanish]; Busulfanum [INN-Latin]; MYLERAN (TN); Methanesulfonic acid, tetram ethylene ester; Methanesulfonic acid, tetramethylene ester; Myleran (TN); Sulfabutin (VAN); Tetramethylene bis(methanesulfonate); Tetramethylene {bis[methanesulfonate]}; Wellcome, Busulfan; C.B. 2041; G.T. 41; Myleran, Busulfex, Busulfan; Busulfan (JP15/USP/INN); Butane-1,4-diyl dimethanesulfonate; BUSULFAN (1,4-BUTANEDIOL, DIMETHANESULFONATE); N-Butane-1,3-di(methylsulfonate); 1,4-BUTANEDIOL DIMETHANESULFONATE; 1,4-Bis(methanesulfonoxy)butane; 1,4-Bis(methanesulfonyloxy)butane; 1,4-Bis[methanesulfonoxy]butane; 1,4-Butanedi yl dimethanesulfonate; 1,4-Butanediol dimethanesulphonate; 1,4-Butanediol dimethylsulfonate; 1,4-Butanediol, dimethanesulfonate; 1,4-Butanediol, dimethanesulphonate; 1,4-Butanediyl dimethanesulfonate; 1,4-Di(methylsulfonoxy)butane; 1,4-Dimesyloxybutane; 1,4-Dimethane sulfonyl oxybutane; 1,4-Dimethanesulfonoxybutane; 1,4-Dimethanesulfonoxylbutane; 1,4-Dimethanesulfonyloxybutane; 1,4-Dimethanesulphonyloxybutane; 1,4-Dimethylsulfonoxybutane; 1,4-Dimethylsulfonyloxybutane; 1,{4-Bis[methanesulfonoxy]butane}; 4-((Methylsulfonyl)oxy)butyl methanesulfonate; 4-methylsulfonyloxybutyl methanesulfonate
Indication
Disease Entry ICD 11 Status REF
Chronic myelogenous leukaemia 2A20.0 Approved [1]
Hematologic disease 3C0Z Approved [1]
Immunodeficiency 4A00-4A85 Approved [1]
Leukemia Approved [1]
Myeloproliferative syndrome 2A22 Approved [2]
Systemic lupus erythematosus 4A40.0 Approved [1]
Systemic sclerosis 4A42 Approved [1]
Neuroblastoma 2D11.2 Investigative [1]
Retinoblastoma 2D02.2 Investigative [1]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
2478
ChEBI ID
CHEMBL820
CAS Number
CAS 55-98-1
TTD Drug ID
DMXYJ9C
INTEDE Drug ID
DR0249
ACDINA Drug ID
D00085

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Human Deoxyribonucleic acid (hDNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [15]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [16]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [17]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [18]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [19]
Carboplatin DMG281S Adenocarcinoma 2D40 Approved [20]
Procarbazine DMIK367 Hodgkin lymphoma 2B30 Approved [21]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [22]
Dacarbazine DMNPZL4 Adenocarcinoma 2D40 Approved [23]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [24]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [25]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [26]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [27]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [28]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [29]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [30]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [31]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [32]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [26]
Verapamil DMA7PEW Angina pectoris BA40 Approved [33]
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Drug(s) Metabolized By Glutathione S-transferase alpha-1 (GSTA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [34]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [35]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [36]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [37]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [38]
Trabectedin DMG3Y89 Leiomyosarcoma 2B58 Approved [39]
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [40]
Ethacrynic acid DM60QMR Edema MG29 Approved [41]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [42]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [43]
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Drug(s) Metabolized By Glutathione S-transferase alpha-2 (GSTA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [44]
Drug(s) Metabolized By Glutathione S-transferase pi (GSTP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [45]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [46]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [47]
Carboplatin DMG281S Adenocarcinoma 2D40 Approved [47]
Chlorambucil DMRKE63 Chronic lymphocytic leukaemia 2A82.0 Approved [48]
Drug(s) Metabolized By Glutathione S-transferase mu-1 (GSTM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [45]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [47]
Carboplatin DMG281S Adenocarcinoma 2D40 Approved [47]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [44]
Drug(s) Affected By Serotransferrin (TF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [49]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [51]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [52]
Isoflurophate DMBSK7X Glaucoma/ocular hypertension 9C61 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [54]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [55]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [56]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [57]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [58]
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Drug(s) Affected By Antithrombin-III (SERPINC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [59]
Prednisone DM2HG4X Acute asthma CA23 Approved [60]
Quercetin DM3NC4M Obesity 5B81 Approved [61]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [52]
Testosterone enanthate DMB6871 N. A. N. A. Approved [62]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [64]
Aminocaproic Acid DMFGND4 Bleeding disorder GA20-GA21 Approved [60]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [65]
Warfarin DMJYCVW Atrial fibrillation BC81.3 Approved [66]
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Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [67]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [68]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [69]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [70]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [71]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [72]
Prednisone DM2HG4X Acute asthma CA23 Approved [73]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [74]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [75]
Methotrexate DM2TEOL Anterior urethra cancer Approved [76]
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Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [77]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [78]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [79]
Methotrexate DM2TEOL Anterior urethra cancer Approved [80]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [81]
Quercetin DM3NC4M Obesity 5B81 Approved [82]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [83]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [84]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [85]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [86]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [87]
Gefitinib DM15F0X Colon adenocarcinoma Approved [88]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [89]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [90]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [91]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [92]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [91]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [93]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [94]
Methotrexate DM2TEOL Anterior urethra cancer Approved [95]
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Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [96]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [97]
Selenium DM25CGV N. A. N. A. Approved [98]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [99]
Etretinate DM2CZFA Keratosis ED56 Approved [100]
Methotrexate DM2TEOL Anterior urethra cancer Approved [101]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [102]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [103]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [104]
Quercetin DM3NC4M Obesity 5B81 Approved [105]
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Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [106]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [107]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [108]
Selenium DM25CGV N. A. N. A. Approved [98]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [109]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [110]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [111]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [85]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [112]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [113]
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Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [114]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [115]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [106]
Gefitinib DM15F0X Colon adenocarcinoma Approved [116]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [108]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [117]
Methotrexate DM2TEOL Anterior urethra cancer Approved [118]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [119]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [120]
Quercetin DM3NC4M Obesity 5B81 Approved [121]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [122]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [123]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [124]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [125]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [126]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [127]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [128]
Gefitinib DM15F0X Colon adenocarcinoma Approved [129]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [130]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [131]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [132]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [123]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [133]
Paclitaxel DMLB81S Breast carcinoma Approved [134]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [135]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [122]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [68]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [136]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [125]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [126]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [137]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [138]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [139]
Gefitinib DM15F0X Colon adenocarcinoma Approved [140]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [141]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [142]
Etretinate DM2CZFA Keratosis ED56 Approved [143]
Prednisone DM2HG4X Acute asthma CA23 Approved [144]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [92]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [145]
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Drug(s) Affected By Signal transducer and activator of transcription 2 (STAT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [146]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [147]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [64]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [148]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [10]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [149]
Arsenic DMTL2Y1 N. A. N. A. Approved [150]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [151]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [152]
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Drug(s) Affected By Pseudouridylate synthase 7 homolog (PUS7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [153]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [154]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [64]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [148]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [57]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [155]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [50]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [156]
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Drug(s) Affected By DNA repair nuclease/redox regulator APEX1 (APEX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [157]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [158]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [64]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [159]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [160]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [57]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [155]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [161]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [162]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [163]
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Drug(s) Affected By Rho GDP-dissociation inhibitor 1 (ARHGDIA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [108]
Selenium DM25CGV N. A. N. A. Approved [98]
Etretinate DM2CZFA Keratosis ED56 Approved [164]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [165]
Estrone DM5T6US Acne vulgaris ED80 Approved [166]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [167]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [168]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [158]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [64]
Ampicillin DMHWE7P Acute epiglottitis Approved [61]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Human Deoxyribonucleic acid (hDNA) TTUTN1I NOUNIPROTAC Modulator [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [4]
Glutathione S-transferase alpha-1 (GSTA1) DE4ZHS1 GSTA1_HUMAN Substrate [5]
Glutathione S-transferase pi (GSTP1) DEK6079 GSTP1_HUMAN Substrate [6]
Glutathione S-transferase mu-1 (GSTM1) DEYZEJA GSTM1_HUMAN Substrate [6]
Microsomal glutathione S-transferase 2 (MGST2) DE31KMQ MGST2_HUMAN Substrate [7]
Glutathione S-transferase alpha-2 (GSTA2) DEH49YS GSTA2_HUMAN Substrate [8]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Antithrombin-III (SERPINC1) OTDFATG0 ANT3_HUMAN Gene/Protein Processing [9]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) OTRFV19J ATF4_HUMAN Gene/Protein Processing [10]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [11]
DNA repair nuclease/redox regulator APEX1 (APEX1) OT53OI14 APEX1_HUMAN Drug Response [12]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Post-Translational Modifications [13]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Gene/Protein Processing [11]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Gene/Protein Processing [11]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Gene/Protein Processing [10]
Plasminogen activator inhibitor 1 (SERPINE1) OTT0MPQ3 PAI1_HUMAN Gene/Protein Processing [14]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Protein Interaction/Cellular Processes [13]

References

1 Busulfan FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7136).
3 DNA intrastrand cross-link at the 5'-GA-3' sequence formed by busulfan and its role in the cytotoxic effect. Cancer Sci. 2004 May;95(5):454-8.
4 Update: clinically significant cytochrome P-450 drug interactions. Pharmacotherapy. 1998 Jan-Feb;18(1):84-112.
5 Glutathione S-transferase M1 polymorphism: a risk factor for hepatic venoocclusive disease in bone marrow transplantation. Blood. 2004 Sep 1;104(5):1574-7.
6 Busulfan conjugation by glutathione S-transferases alpha, mu, and pi. Drug Metab Dispos. 1996 Sep;24(9):1015-9.
7 Overexpression of glutathione-S-transferase, MGSTII, confers resistance to busulfan and melphalan. Cancer Invest. 2005;23(1):19-25.
8 Endothelial cells do not express GSTA1: potential relevance to busulfan-mediated endothelial damage during haematopoietic stem cell transplantation. Eur J Haematol. 2008 Apr;80(4):299-302.
9 Decreased incidence of hepatic veno-occlusive disease and fewer hemostatic derangements associated with intravenous busulfan vs oral busulfan in adults conditioned with busulfan + cyclophosphamide for allogeneic bone marrow transplantation. Ann Hematol. 2005 May;84(5):321-30. doi: 10.1007/s00277-004-0982-4. Epub 2004 Dec 4.
10 Direct transcriptomic comparison of xenobiotic metabolism and toxicity pathway induction of airway epithelium models at an air-liquid interface generated from induced pluripotent stem cells and primary bronchial epithelial cells. Cell Biol Toxicol. 2023 Feb;39(1):1-18. doi: 10.1007/s10565-022-09726-0. Epub 2022 May 31.
11 Busulfan selectively induces cellular senescence but not apoptosis in WI38 fibroblasts via a p53-independent but extracellular signal-regulated kinase-p38 mitogen-activated protein kinase-dependent mechanism. J Pharmacol Exp Ther. 2006 Nov;319(2):551-60. doi: 10.1124/jpet.106.107771. Epub 2006 Aug 1.
12 Impairment of APE1 function enhances cellular sensitivity to clinically relevant alkylators and antimetabolites. Mol Cancer Res. 2009 Jun;7(6):897-906. doi: 10.1158/1541-7786.MCR-08-0519. Epub 2009 May 26.
13 Altered gene expression in busulfan-resistant human myeloid leukemia. Leuk Res. 2008 Nov;32(11):1684-97. doi: 10.1016/j.leukres.2008.01.016. Epub 2008 Mar 12.
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