Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZ3OU6)

• Drug Name: Lithium Drug Info
• Synonyms: 7439-93-2; Li; litio; UNII-9FN79X2M3F; 9FN79X2M3F; CHEBI:30145; MFCD00134051; Litium; Lithium, metallic; Lithium, elemental; Lithium, 99+%, granular, dry; Lithium compounds; 3Li; HSDB 647; EINECS 231-102-5; UN1415; monolithium; Lithium standard solution, for AAS, 1 mg-ml Li in 2% HCl; Hydrure de lithium [French]; Lithium ribbon; Lithium rod; HSDB 549; Lithium granules; EINECS 231-484-3; UN1414; UN2805; Normothymin-E (TN); Epitope ID:114079; EC 231-102-5; Lithium, 99%, low sodium; Lithium, 99%, high sodium; CHEMBL2146126; DTXSID5036761; HSDB 6900; 7321AH; AKOS015833388; AKOS015902481; HSD6900000; Lithium wire, 3.2mm (0.125in) dia; Lithium [UN1415] [Dangerous when wet]; Lithium granules, 1-6mm (0.04-0.2in); Lithium, granular, 99% trace metals basis; FT-0627905; C15473; D08133; EC 231-484-3; Lithium hydride [UN1414] [Dangerous when wet]; Lithium, shot, 99%, 4-16 mesh, in mineral oil; Lithium, wire, diam. 3.2 mm, in mineral oil, >=98%; Lithium, ~25 wt % dispersion in mineral oil, high sodium; Lithium, AAS standard solution, Specpure?, Li 1000?g/ml; Lithium, ingot, diam. 5.7 cm, 99.9% trace metals basis; Lithium, rod, diam. 12.7 mm, 99.9% trace metals basis; Lithium foil, 0.75mm (0.03in) thick x 19mm (0.75in) wide; Lithium hydride, fused solid [UN2805] [Dangerous when wet]; Lithium ingot, 5.7cm (2.2in) dia x 8.6cm (3.4in) long; Lithium, Oil based standard solution, Specpure, Li 5000g/g; Lithium, plasma standard solution, Specpure?, Li 10,000?g/ml; Lithium, plasma standard solution, Specpure?, Li 1000?g/ml; Lithium, rod, 12.7 mm diameter, length 165 mm, purity 99%; Lithium, rod, 12.7 mm diameter, length 200 mm, purity 99%; Lithium, foil, 25x100mm, thickness 0.6mm, as rolled, 99.9%; Lithium, Oil based standard solution, Specpure(R), Li 1000?g/g; Lithium, foil, thickness 0.6 mm, size 25 x 300 mm, purity 99.9%; Lithium, Ion chromatography standard solution, Specpure, Li+ 1000?g/ml; Lithium, wire (in mineral oil), diam. 3.2 mm, 99.9% trace metals basis; Lithium, foil, not light tested, 38x200mm, thickness 0.20mm, as rolled, 99.9%; Lithium, foil, not light tested, 38x500mm, thickness 0.20mm, as rolled, 99.9%; Lithium, foil, not light tested, 45x200mm, thickness 0.12mm, as rolled, 99.9%; Lithium, granular, 4-10 mesh particle size, high sodium, 99% (metals basis); Lithium, ribbon, thickness x W 0.38 mm x 23 mm, 99.9% trace metals basis; Lithium, ribbon, thickness x W 0.75 mm x 19 mm, 99.9% trace metals basis; Lithium, ribbon, thickness x W 0.75 mm x 45 mm, 99.9% trace metals basis; Lithium, ribbon, thickness x W 1.5 mm x 100 mm, 99.9% trace metals basis

Indication

Disease Entry	ICD 11	Status	REF
Bipolar disorder	6A60	Approved	[1]
Canavan disease	5C50.E1	Approved	[1]
Dysmenorrhea	GA34.3	Approved	[1]
Fever	MG26	Approved	[1]
Headache	8A80-8A84	Approved	[1]
Major depressive disorder	6A70.3	Approved	[1]
Osteoarthritis	FA00-FA05	Approved	[1]
Pain	MG30-MG3Z	Approved	[1]
Fragile X syndrome	LD55	Phase 2	[2]

• Cross-matching ID:
  PubChem CID: 3028194
  ChEBI ID: CHEMBL30145
  CAS Number: CAS 7439-93-2
  TTD Drug ID: DMZ3OU6

Molecule-Related Drug Atlas

Drug(s) Targeting Glycogen synthase kinase-3 beta (GSK-3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AMO-02	DMJRU3A	Myotonic dystrophy	8C71.0	Phase 2/3	[8]
LY2090314	DMTBFE4	Acute myeloid leukaemia	2A60	Phase 2	[9]
Tideglusib	DME4LA1	Alzheimer disease	8A20	Phase 2	[10]
9-ING-41	DM57TY3	Myelofibrosis	2A20.2	Phase 2	[11]
Neu-120	DMXKOUC	Parkinson disease	8A00.0	Phase 1/2	[12]
KENPAULLONE	DMAGVXW	Discovery agent	N.A.	Patented	[13]
CHIR-99021	DMB8MNU	Allergic inflammation	4A80-4A85	Patented	[14]
TDZD-8	DMG6Q45	Malignant glioma	2A00.0	Patented	[15]
AR-A014418	DMUPN01	Ovarian cancer	2C73	Patented	[16]
PMID26161698-Compound-18	DM6JVR5	N. A.	N. A.	Patented	[17]

Drug(s) Targeting Glycogen synthase kinase-3 alpha (GSK-3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
LY2090314	DMTBFE4	Acute myeloid leukaemia	2A60	Phase 2	[9]
KENPAULLONE	DMAGVXW	Discovery agent	N.A.	Patented	[9]
CHIR-99021	DMB8MNU	Allergic inflammation	4A80-4A85	Patented	[9]
TDZD-8	DMG6Q45	Malignant glioma	2A00.0	Patented	[9]
AR-A014418	DMUPN01	Ovarian cancer	2C73	Patented	[9]
PMID27828716-Compound-21	DMO1NAR	N. A.	N. A.	Patented	[9]
Thiadiazolidindione derivative 2	DM5AUL0	N. A.	N. A.	Patented	[9]
PMID27828716-Compound-18	DMNR6KL	N. A.	N. A.	Patented	[9]
PMID27828716-Compound-BIO-acetoxime	DMUM5L6	Malignant glioma	2A00.0	Patented	[9]

Drug(s) Affected By Peroxisomal ATPase PEX1 (PEX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Selenium	DM25CGV	N. A.	N. A.	Approved	[20]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[24]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[20]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[25]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[25]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[26]

Drug(s) Affected By Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[27]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Haloperidol	DM96SE0	Delirium		Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[31]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[29]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[27]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[32]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[28]

Drug(s) Affected By Serine-protein kinase ATM (ATM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[33]
Paromomycin	DM1AGXN	Amoebiasis	1A36	Approved	[34]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[35]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[36]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[39]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[40]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]

Drug(s) Affected By Activity-dependent neuroprotector homeobox protein 2 (ADNP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[28]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[46]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[47]

Drug(s) Affected By 26S proteasome non-ATPase regulatory subunit 1 (PSMD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[48]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[31]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[51]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[52]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[53]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[25]

Drug(s) Affected By Homer protein homolog 3 (HOMER3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[56]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[52]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[57]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[32]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[58]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[59]

Drug(s) Affected By Protein mono-ADP-ribosyltransferase PARP4 (PARP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[31]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[62]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[63]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[32]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[64]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[48]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[65]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[66]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[67]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[66]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[68]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[70]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[73]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[74]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[75]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[76]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[77]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[78]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[79]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[80]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[81]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[79]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[82]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[83]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[84]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[85]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[86]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[87]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[88]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[89]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[90]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[92]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[83]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[93]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[94]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[82]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[96]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[97]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[85]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[86]

Drug(s) Affected By Regulator of G-protein signaling 2 (RGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[98]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[99]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[101]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[102]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]

Drug(s) Affected By Nuclear receptor subfamily 4 group A member 2 (NR4A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[105]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[106]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[107]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[108]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[109]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[112]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[113]

Drug(s) Affected By Cysteine-rich protein 1 (CRIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[31]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[115]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[19]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[116]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[117]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[111]

Drug(s) Affected By Protein FosB (FOSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[118]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[119]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[120]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[109]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[102]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[123]

Drug(s) Affected By Anthrax toxin receptor 2 (ANTXR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[112]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[50]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[124]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[115]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[52]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[97]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[125]
Selenium	DM25CGV	N. A.	N. A.	Approved	[20]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[126]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[127]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[130]

Drug(s) Affected By Krueppel-like factor 6 (KLF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[131]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[132]
Selenium	DM25CGV	N. A.	N. A.	Approved	[20]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[133]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[99]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[134]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[135]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]

Drug(s) Affected By Regulator of cell cycle RGCC (RGCC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[136]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[137]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[100]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[138]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[139]

Drug(s) Affected By Hypoxia-inducible lipid droplet-associated protein (HILPDA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[140]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[140]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[119]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[141]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]

Drug(s) Affected By Nuclear receptor subfamily 1 group D member 1 (NR1D1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[131]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[56]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[142]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[143]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[144]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[32]

Drug(s) Affected By D(1A) dopamine receptor (DRD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[96]
Haloperidol	DM96SE0	Delirium		Approved	[145]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[146]
Pergolide mesylate	DM5GKOV	N. A.	N. A.	Approved	[147]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[145]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[149]
Methamphetamine	DMPM4SK	Anxiety		Approved	[150]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[151]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glycogen synthase kinase-3 alpha (GSK-3A)	TTRZQE3	GSK3A_HUMAN	Inhibitor	[3]
Glycogen synthase kinase-3 beta (GSK-3B)	TTRSMW9	GSK3B_HUMAN	Inhibitor	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
26S proteasome non-ATPase regulatory subunit 1 (PSMD1)	OTW258OV	PSMD1_HUMAN	Gene/Protein Processing	[4]
Activity-dependent neuroprotector homeobox protein 2 (ADNP2)	OT7NQWJK	ADNP2_HUMAN	Gene/Protein Processing	[4]
Anthrax toxin receptor 2 (ANTXR2)	OTOGFGOJ	ANTR2_HUMAN	Gene/Protein Processing	[5]
Cysteine-rich protein 1 (CRIP1)	OT0EICG3	CRIP1_HUMAN	Gene/Protein Processing	[5]
D(1A) dopamine receptor (DRD1)	OTLZPBT7	DRD1_HUMAN	Drug Response	[6]
Homer protein homolog 3 (HOMER3)	OTQ6D9X1	HOME3_HUMAN	Gene/Protein Processing	[4]
Hypoxia-inducible lipid droplet-associated protein (HILPDA)	OTEID3ZM	HLPDA_HUMAN	Gene/Protein Processing	[5]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Gene/Protein Processing	[7]
Krueppel-like factor 6 (KLF6)	OTQY9S7F	KLF6_HUMAN	Gene/Protein Processing	[5]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Gene/Protein Processing	[7]

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