Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZKYIV)

Drug Name
Amsacrine Drug Info
Synonyms
Acridinylanisidide; Amecrin; Amekrin; Amsacrina; Amsacrinum; Amsidine; Amsidyl; Amsine; Lamasine; MAMSA; NAMSA; Acridinyl Anisidide; SN 21429; SN11841; AMSA P-D; Acridinyl anisidide (TN); Amsacrina [INN-Spanish]; Amsacrinum [INN-Latin]; Amsidyl (TN); Cain's Acridine; M-AMSA; Meta-AMSA; Meta-Amsacrine; SN-11841; Amsacrine (USAN/INN); Amsacrine [USAN:BAN:INN]; M-AMSA (TN); N-[4-(9-Acridinylamino)-3-methoxyphenyl]methanesulfonamide; N-(4-(9-Acridinylamino)-3-methoxyphenyl)methanesulfonamide; N-[4-(9-Acridinylamino)-3-methoxy-phenyl]methanesulfonamide; N-[4-(acridin-9-ylamino)-3-methoxyphenyl]methanesulfonamide; N-[4-(acridin-9-ylmethyl)-3-methoxyphenyl]methanesulfonamide; N-(4-(Acridin-9-ylamino)-3-methoxyphenyl)methanesulfonamide; N-[4-(Acridin-9-ylamino)-3-(methyloxy)phenyl]methanesulfonamide; N-[4-(acridin-9-ylamino)-3-(methyloxy)phenyl]methanesulfonamide; 4'-(9-Acridinylamino)-3'-methoxymethanesulfonanilide; 4'-(9-Acridinylamino)methanesulfon-m-anisidide; 4'-(9-Acridinylamino)methanesulfon-meta-anisidide; 4'-(9-Acridinylamino)methanesulphon-m-anisidide
Indication
Disease Entry ICD 11 Status REF
Acute lymphoblastic leukaemia 2A85 Approved [1]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
2179
ChEBI ID
CHEBI:2687
CAS Number
CAS 51264-14-3
TTD Drug ID
DMZKYIV
VARIDT Drug ID
DR00917
INTEDE Drug ID
DR0109

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting DNA topoisomerase II (TOP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [13]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [14]
Teniposide DMLW57T Acute lymphoblastic leukaemia 2A85 Approved [13]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [15]
Idarubicin DMM0XGL Acute myelogenous leukaemia 2A41 Approved [13]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [13]
Lomefloxacin DMVRH9C Bacterial infection 1A00-1C4Z Approved [16]
Dexrazoxane DMD7X1O Breast cancer 2C60-2C65 Approved [13]
Podofilox DMT2EJP Condyloma 1A95 Approved [17]
Enoxacin DMYTE6L Acute gonococcal cervicitis Approved [18]
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Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [19]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [20]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [21]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [22]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [23]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [24]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [25]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [26]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [27]
Propranolol DM79NTF Angina pectoris BA40 Approved [28]
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Drug(s) Affected By Protein regulator of cytokinesis 1 (PRC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [29]
Methotrexate DM2TEOL Anterior urethra cancer Approved [30]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [31]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [33]
Testosterone DM7HUNW Hot flushes GA30 Approved [34]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [34]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [35]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [35]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [36]
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Drug(s) Affected By Ubiquitin-like modifier-activating enzyme ATG7 (ATG7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [37]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [38]
Quercetin DM3NC4M Obesity 5B81 Approved [39]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [40]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [41]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [42]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [43]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [40]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [44]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [45]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [46]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [47]
Gefitinib DM15F0X Colon adenocarcinoma Approved [48]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [49]
Selenium DM25CGV N. A. N. A. Approved [50]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [51]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [52]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [53]
Methotrexate DM2TEOL Anterior urethra cancer Approved [54]
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Drug(s) Affected By Albumin (ALB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [55]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [12]
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [56]
Diazepam DM08E9O Alcohol withdrawal Approved [57]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [58]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [59]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [60]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [61]
Methotrexate DM2TEOL Anterior urethra cancer Approved [62]
Quercetin DM3NC4M Obesity 5B81 Approved [63]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [64]
Methotrexate DM2TEOL Anterior urethra cancer Approved [54]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [65]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [66]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [67]
Paclitaxel DMLB81S Breast carcinoma Approved [68]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [69]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [70]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [71]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [72]
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Drug(s) Affected By Retinoic acid receptor beta (RARB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [73]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [75]
Panobinostat DM58WKG Chronic graft versus host disease Approved [76]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Ethanol DMDRQZU Chronic pain MG30 Approved [79]
Folic Acid DMEMBJC Colorectal carcinoma Approved [80]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [81]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [73]
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Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [82]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [83]
Selenium DM25CGV N. A. N. A. Approved [84]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [85]
Etretinate DM2CZFA Keratosis ED56 Approved [86]
Methotrexate DM2TEOL Anterior urethra cancer Approved [87]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [88]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [89]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [90]
Quercetin DM3NC4M Obesity 5B81 Approved [91]
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Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [92]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [93]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [94]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [95]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [96]
Quercetin DM3NC4M Obesity 5B81 Approved [97]
Fluoxetine DM3PD2C Bipolar depression Approved [98]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [99]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [100]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [101]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [102]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [103]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [104]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [105]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [106]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [107]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [108]
Gefitinib DM15F0X Colon adenocarcinoma Approved [109]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [110]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [112]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [103]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [113]
Paclitaxel DMLB81S Breast carcinoma Approved [114]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [115]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [102]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [12]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [116]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [105]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [106]
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Drug(s) Affected By Caspase-2 (CASP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [117]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [118]
Methotrexate DM2TEOL Anterior urethra cancer Approved [119]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [120]
Quercetin DM3NC4M Obesity 5B81 Approved [121]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [122]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [123]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [124]
Leflunomide DMR8ONJ Arthritis FA20 Approved [125]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [126]
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Drug(s) Affected By Mitogen-activated protein kinase 12 (MAPK12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [127]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [128]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [129]
Sorbitol DMAN0DE Constipation DD91.1 Approved [130]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [132]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [133]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [76]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [134]
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Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [70]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [135]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [136]
Selenium DM25CGV N. A. N. A. Approved [84]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [137]
Methotrexate DM2TEOL Anterior urethra cancer Approved [138]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [139]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [140]
Quercetin DM3NC4M Obesity 5B81 Approved [141]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [142]
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Drug(s) Affected By Beclin-1 (BECN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcipotriol DM03CP7 Psoriasis EA90 Approved [143]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [92]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [144]
Methotrexate DM2TEOL Anterior urethra cancer Approved [138]
Quercetin DM3NC4M Obesity 5B81 Approved [39]
Fluoxetine DM3PD2C Bipolar depression Approved [145]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [146]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [147]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [148]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [149]
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Drug(s) Affected By ELAV-like protein 1 (ELAVL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [150]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [42]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [151]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [152]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [153]
Flurbiprofen DMGN4BY Osteoarthritis FA00-FA05 Approved [151]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [154]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [155]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [156]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [157]
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Drug(s) Affected By Quinone oxidoreductase PIG3 (TP53I3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [136]
Methotrexate DM2TEOL Anterior urethra cancer Approved [138]
Quercetin DM3NC4M Obesity 5B81 Approved [158]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [159]
Amifostine DM5FL14 Mucositis CA00 Approved [160]
Testosterone DM7HUNW Hot flushes GA30 Approved [161]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [162]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [35]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [35]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [35]
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Drug(s) Affected By SID1 transmembrane family member 2 (SIDT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [163]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [42]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [36]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [164]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [154]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [165]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [166]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [167]
Arsenic DMTL2Y1 N. A. N. A. Approved [168]
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Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [169]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [144]
Methotrexate DM2TEOL Anterior urethra cancer Approved [138]
Quercetin DM3NC4M Obesity 5B81 Approved [97]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [40]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [171]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [41]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [172]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [173]
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Drug(s) Affected By NADPH oxidase 4 (NOX4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [174]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [175]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [42]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [176]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Capsaicin DMGMF6V Back pain ME84.Z Approved [177]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [178]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [179]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [180]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [181]
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Drug(s) Affected By DNA topoisomerase 1 (TOP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Teniposide DMLW57T Acute lymphoblastic leukaemia 2A85 Approved [12]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [182]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [167]
Selenium DM25CGV N. A. N. A. Approved [84]
Methotrexate DM2TEOL Anterior urethra cancer Approved [119]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [90]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [35]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [184]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [152]
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Drug(s) Affected By DNA topoisomerase 2-alpha (TOP2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [185]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [186]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [187]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [188]
Methotrexate DM2TEOL Anterior urethra cancer Approved [189]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [90]
Quercetin DM3NC4M Obesity 5B81 Approved [97]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [31]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [190]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [191]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [192]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [193]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [194]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [12]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [92]
Verapamil DMA7PEW Angina pectoris BA40 Approved [195]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [117]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [105]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [196]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [191]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [197]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [92]
Verapamil DMA7PEW Angina pectoris BA40 Approved [195]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [73]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [198]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [199]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [200]
Meloxicam DM2AR7L Arthritis FA20 Approved [201]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [95]
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Drug(s) Affected By Nucleolin (NCL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [202]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [182]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [167]
Methotrexate DM2TEOL Anterior urethra cancer Approved [119]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [203]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [153]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [204]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [205]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [206]
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Drug(s) Affected By DNA topoisomerase 2-beta (TOP2B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [186]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [182]
Quercetin DM3NC4M Obesity 5B81 Approved [97]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [153]
Menthol DMG2KW7 Back pain ME84.Z Approved [207]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [208]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [167]
Arsenic DMTL2Y1 N. A. N. A. Approved [209]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA repair protein RAD51 homolog 1 (RAD51)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [210]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [211]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [212]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [213]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [31]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [214]
Testosterone DM7HUNW Hot flushes GA30 Approved [34]
Quizartinib DM8Y4JS Acute myeloid leukaemia 2A60 Approved [215]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [34]
Leflunomide DMR8ONJ Arthritis FA20 Approved [125]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [116]
Flucytosine DM13VTW Cryptococcal meningitis Approved [139]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [139]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [216]
Methotrexate DM2TEOL Anterior urethra cancer Approved [138]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [217]
Quercetin DM3NC4M Obesity 5B81 Approved [97]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [65]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [218]
Amifostine DM5FL14 Mucositis CA00 Approved [160]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
DNA topoisomerase II (TOP2) TT0IHXV TOP2A_HUMAN; TOP2B_HUMAN Inhibitor [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 2D6 (CYP2D6) Main DME DECB0K3 CP2D6_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Albumin (ALB) OTVMM513 ALBU_HUMAN Protein Interaction/Cellular Processes [4]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Drug Response [5]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Drug Response [6]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [7]
Beclin-1 (BECN1) OT4X293M BECN1_HUMAN Gene/Protein Processing [7]
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN OT81JS6K WRN_HUMAN Drug Response [8]
Caspase-2 (CASP2) OTUDYSPP CASP2_HUMAN Gene/Protein Processing [9]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [10]
DNA repair protein RAD51 homolog 1 (RAD51) OTNVWGC1 RAD51_HUMAN Drug Response [11]
DNA topoisomerase 1 (TOP1) OT51O0CF TOP1_HUMAN Drug Response [12]

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115 Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids. J Biol Chem. 2005 Sep 9;280(36):31498-507. doi: 10.1074/jbc.M505537200. Epub 2005 Jul 13.
116 Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
117 Inhibition of caspase-dependent mitochondrial permeability transition protects airway epithelial cells against mustard-induced apoptosis. Apoptosis. 2006 Sep;11(9):1545-59. doi: 10.1007/s10495-006-8764-1.
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119 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
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