Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZKYIV)

Drug Name
Amsacrine Drug Info
Synonyms
Acridinylanisidide; Amecrin; Amekrin; Amsacrina; Amsacrinum; Amsidine; Amsidyl; Amsine; Lamasine; MAMSA; NAMSA; Acridinyl Anisidide; SN 21429; SN11841; AMSA P-D; Acridinyl anisidide (TN); Amsacrina [INN-Spanish]; Amsacrinum [INN-Latin]; Amsidyl (TN); Cain's Acridine; M-AMSA; Meta-AMSA; Meta-Amsacrine; SN-11841; Amsacrine (USAN/INN); Amsacrine [USAN:BAN:INN]; M-AMSA (TN); N-[4-(9-Acridinylamino)-3-methoxyphenyl]methanesulfonamide; N-(4-(9-Acridinylamino)-3-methoxyphenyl)methanesulfonamide; N-[4-(9-Acridinylamino)-3-methoxy-phenyl]methanesulfonamide; N-[4-(acridin-9-ylamino)-3-methoxyphenyl]methanesulfonamide; N-[4-(acridin-9-ylmethyl)-3-methoxyphenyl]methanesulfonamide; N-(4-(Acridin-9-ylamino)-3-methoxyphenyl)methanesulfonamide; N-[4-(Acridin-9-ylamino)-3-(methyloxy)phenyl]methanesulfonamide; N-[4-(acridin-9-ylamino)-3-(methyloxy)phenyl]methanesulfonamide; 4'-(9-Acridinylamino)-3'-methoxymethanesulfonanilide; 4'-(9-Acridinylamino)methanesulfon-m-anisidide; 4'-(9-Acridinylamino)methanesulfon-meta-anisidide; 4'-(9-Acridinylamino)methanesulphon-m-anisidide
Indication
Disease Entry ICD 11 Status REF
Acute lymphoblastic leukaemia 2A85 Approved [1]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
2179
ChEBI ID
CHEMBL43
CAS Number
CAS 51264-14-3
TTD Drug ID
DMZKYIV
VARIDT Drug ID
DR00917
INTEDE Drug ID
DR0109

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting DNA topoisomerase II (TOP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [10]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [11]
Teniposide DMLW57T Acute lymphoblastic leukaemia 2A85 Approved [10]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [12]
Idarubicin DMM0XGL Acute myelogenous leukaemia 2A41 Approved [10]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [10]
Lomefloxacin DMVRH9C Bacterial infection 1A00-1C4Z Approved [13]
Dexrazoxane DMD7X1O Breast cancer 2C60-2C65 Approved [10]
Podofilox DMT2EJP Condyloma 1A95 Approved [14]
Enoxacin DMYTE6L Acute gonococcal cervicitis Approved [15]
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Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [16]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [17]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [18]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [19]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [20]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [21]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [22]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [23]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [24]
Propranolol DM79NTF Angina pectoris BA40 Approved [25]
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Drug(s) Affected By Protein regulator of cytokinesis 1 (PRC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [26]
Methotrexate DM2TEOL Anterior urethra cancer Approved [9]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [27]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [28]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [29]
Testosterone DM7HUNW Hot flushes GA30 Approved [30]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [30]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [31]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [31]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [32]
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Drug(s) Affected By Ubiquitin-like modifier-activating enzyme ATG7 (ATG7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [33]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [34]
Quercetin DM3NC4M Obesity 5B81 Approved [35]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [28]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [36]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [37]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [38]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [39]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [36]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [40]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [41]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [42]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [43]
Gefitinib DM15F0X Colon adenocarcinoma Approved [44]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [45]
Selenium DM25CGV N. A. N. A. Approved [46]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [47]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [48]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [49]
Methotrexate DM2TEOL Anterior urethra cancer Approved [50]
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Drug(s) Affected By Albumin (ALB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [51]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [52]
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [53]
Diazepam DM08E9O Alcohol withdrawal Approved [54]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [55]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [56]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [57]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [58]
Methotrexate DM2TEOL Anterior urethra cancer Approved [59]
Quercetin DM3NC4M Obesity 5B81 Approved [60]
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Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [61]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [62]
Selenium DM25CGV N. A. N. A. Approved [63]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [64]
Etretinate DM2CZFA Keratosis ED56 Approved [65]
Methotrexate DM2TEOL Anterior urethra cancer Approved [66]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [67]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [68]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [69]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [71]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [72]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [73]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [74]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [75]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [76]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [77]
Gefitinib DM15F0X Colon adenocarcinoma Approved [78]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [79]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [80]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [81]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [72]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [82]
Paclitaxel DMLB81S Breast carcinoma Approved [83]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [84]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [71]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [52]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [85]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [74]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [75]
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Drug(s) Affected By Mitogen-activated protein kinase 12 (MAPK12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [86]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [87]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [88]
Sorbitol DMAN0DE Constipation DD91.1 Approved [89]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [91]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [7]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [92]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [93]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [94]
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Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [95]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [96]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [97]
Selenium DM25CGV N. A. N. A. Approved [63]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [98]
Methotrexate DM2TEOL Anterior urethra cancer Approved [99]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [100]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [101]
Quercetin DM3NC4M Obesity 5B81 Approved [102]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [103]
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Drug(s) Affected By Quinone oxidoreductase PIG3 (TP53I3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [97]
Methotrexate DM2TEOL Anterior urethra cancer Approved [99]
Quercetin DM3NC4M Obesity 5B81 Approved [104]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [105]
Amifostine DM5FL14 Mucositis CA00 Approved [106]
Testosterone DM7HUNW Hot flushes GA30 Approved [107]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [108]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [31]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [31]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [31]
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Drug(s) Affected By SID1 transmembrane family member 2 (SIDT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [109]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [38]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [32]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [91]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [110]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [111]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [112]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [113]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [114]
Arsenic DMTL2Y1 N. A. N. A. Approved [115]
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Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [116]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [117]
Methotrexate DM2TEOL Anterior urethra cancer Approved [99]
Quercetin DM3NC4M Obesity 5B81 Approved [118]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [119]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [36]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [120]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [37]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [121]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [122]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
DNA topoisomerase II (TOP2) TT0IHXV TOP2A_HUMAN; TOP2B_HUMAN Inhibitor [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 2D6 (CYP2D6) Main DME DECB0K3 CP2D6_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Albumin (ALB) OTVMM513 ALBU_HUMAN Protein Interaction/Cellular Processes [4]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [5]
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN OT81JS6K WRN_HUMAN Drug Response [6]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Post-Translational Modifications [5]
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) OTUYHB84 MLP3B_HUMAN Gene/Protein Processing [5]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [5]
Mitogen-activated protein kinase 12 (MAPK12) OTTCKE27 MK12_HUMAN Gene/Protein Processing [7]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [5]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Gene/Protein Processing [8]
Protein regulator of cytokinesis 1 (PRC1) OTHD0XS0 PRC1_HUMAN Gene/Protein Processing [9]

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