Details of Disease

General Information of Disease (ID: DISFSOM3)

• Disease Name: Pneumocystis pneumonia
• Synonyms: pneumocystosis pneumonia; Pneumocystis carinii pneumonia; PCP; Pneumocystis; pneumocystosis; Pneumocystis pneumonia; pulmonary pneumocystosis; Pneumocystis Pneumonia; Pneumocystis jirovecii pneumonia; PJP
• Disease Class: CA40: Pneumonia
• Definition: Human pneumocystosis is caused by an infectious agent, which (after recent nomenclature and taxonomy revisions) is now classed as the fungus Pneumocystis jiroveci. The prevalence is unknown. Pneumocystis jiroveci is an opportunistic infectious agent, developing in immunosuppressed patients. It is an air-borne infection, localized to the lungs. However, extrapulmonary involvement is seen in AIDS patients. The disease manifests progressively with coughing, respiratory problems (dyspnea) and fever, followed by acute respiratory insufficiency and death within a few weeks in untreated cases. The most reliable diagnostic method is bronchoalveolar lavage. The treatment of choice is cotrimoxazole.
• Disease Hierarchy:
  DIS8EF3M: Pneumonia
  DISH0JV6: Fungal lung infectious disease
  DIS67GEL: Opportunistic mycosis
  DISOX2NY: Pneumocystis infectious disease
  DISFSOM3: Pneumocystis pneumonia
• ICD Code:
  ICD-11: ICD-11: CA40.20
  ICD-10: ICD-10: B59
• Disease Identifiers:
  MONDO ID: MONDO_0019121
  MESH ID: D011020
  UMLS CUI: C1535939
  MedGen ID: 777048
  HPO ID: HP:0020102
  Orphanet ID: 723
  SNOMED CT ID: 415125002

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 7 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Dapsone	DM4LT8A	Approved	Small molecular drug	[1]
Levoleucovorin	DMH5LME	Approved	Small molecular drug	[2]
Methylprednisolone	DM4BDON	Approved	Small molecular drug	[3]
Pentamidine	DMHZJCG	Approved	Small molecular drug	[4]
Prednisolone	DMQ8FR2	Approved	Small molecular drug	[5]
Sulfamethoxazole	DMB08GE	Approved	Small molecular drug	[6]
Trimethoprim	DMM7CHK	Approved	Small molecular drug	[7]

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Aerucin	DMCK28R	Phase 2	Antibody	[8]

This Disease is Treated as An Indication in 2 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
CGP-40215A	DM69YWS	Terminated	Small molecular drug	[9]
FR-901379	DM0VR6H	Terminated	NA	[10]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 11 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CEL	TTTRNQW	Limited	Genetic Variation	[12]
CLEC6A	TTQ02HK	Limited	Biomarker	[13]
DAAM2	TTN0Z6H	Limited	Biomarker	[14]
NEK2	TT3VZ24	Limited	Biomarker	[15]
PKN1	TTSL41O	Limited	Posttranslational Modification	[16]
RORC	TTGV6LY	Limited	Genetic Variation	[17]
AGRP	TT4DE1O	Strong	Biomarker	[18]
C3	TTJGY7A	Strong	Biomarker	[19]
DHFR	TTYZVDJ	Strong	Genetic Variation	[20]
DHPS	TTBO2A9	Strong	Genetic Variation	[21]
ROR2	TTUDPCI	Strong	Biomarker	[22]

This Disease Is Related to 2 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC27A5	DT0TQS3	Limited	Genetic Variation	[12]
SLC9A6	DTN0JXW	Strong	Biomarker	[18]

This Disease Is Related to 2 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
MAT1A	DEQ6NC9	Limited	Genetic Variation	[23]
UAP1	DETYWG5	Limited	Altered Expression	[24]

This Disease Is Related to 39 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ALKBH3	OTS1CD9Z	Limited	Biomarker	[25]
APOBEC3F	OT750IJM	Limited	Genetic Variation	[26]
ATMIN	OTEADE76	Limited	Biomarker	[27]
BTBD8	OT3A3RD7	Limited	Genetic Variation	[28]
CCRL2	OT5PX0RX	Limited	Biomarker	[29]
CLEC4E	OT7P8ICY	Limited	Biomarker	[30]
DAAM1	OT0VHIYZ	Limited	Biomarker	[14]
GSC	OT4DH7PR	Limited	Biomarker	[31]
LRRFIP1	OTN7XAUD	Limited	Biomarker	[32]
LURAP1	OTJ1EZDJ	Limited	Biomarker	[33]
MPP1	OTA2ENZQ	Limited	Biomarker	[34]
NR6A1	OTFZOOQ9	Limited	Genetic Variation	[35]
OFD1	OTAZW5TK	Limited	Biomarker	[36]
PARP9	OT7K4494	Limited	Genetic Variation	[12]
PKHD1	OTAH8SMF	Limited	Altered Expression	[27]
PLEKHA4	OTNOCQTF	Limited	Biomarker	[37]
POLG2	OTDBMZJB	Limited	Biomarker	[34]
PRICKLE1	OT9HHEM9	Limited	Biomarker	[38]
PSMD12	OTWICA51	Limited	Biomarker	[34]
RECQL4	OT59LSW7	Limited	Genetic Variation	[39]
SEC24B	OT6W8CWP	Limited	Genetic Variation	[40]
SMURF1	OT5UIZR8	Limited	Biomarker	[41]
STATH	OTQHBHM9	Limited	Biomarker	[42]
TES	OTL8PP6V	Limited	Biomarker	[38]
CYTB	OTAHB98A	Disputed	Biomarker	[43]
ARTN	OTWIWGL6	Strong	Biomarker	[18]
AZIN1	OTX5W77I	Strong	Biomarker	[44]
CELSR1	OT7PS8O1	Strong	Genetic Variation	[45]
CLEC7A	OTRTBH27	Strong	Biomarker	[46]
EMP1	OTSZHUHQ	Strong	Biomarker	[47]
FZD6	OTBCPII8	Strong	Altered Expression	[48]
HLA-DQB1	OTVVI3UI	Strong	Biomarker	[49]
MAX	OTKZ0YKM	Strong	Biomarker	[50]
MUC5B	OTPW6K5C	Strong	Biomarker	[51]
SFTPA2	OT6SFOMU	Strong	Altered Expression	[52]
SFTPB	OTOHS07E	Strong	Altered Expression	[52]
CELSR2	OTON6JSZ	Definitive	Genetic Variation	[53]
DVL3	OTPRROHJ	Definitive	Genetic Variation	[53]
SCRIB	OTW4N3FV	Definitive	Genetic Variation	[54]

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