Details of Disease

Disease Name

Pituitary tumor

tumour of the pituitary gland; neoplasm of pituitary; neoplasm of pituitary gland; tumour of pituitary; tumor of pituitary gland; pituitary neoplasm; tumor of the pituitary gland; pituitary tumor; tumor of the pituitary; pituitary gland tumor; pituitary gland neoplasm; neoplasm of the pituitary gland; tumour of the pituitary; neoplasm of the pituitary; pituitary gland tumour; tumour of pituitary gland; tumor of pituitary

Definition

A benign or malignant neoplasm affecting the pituitary gland. The vast majority are adenomas arising from the anterior lobe of the pituitary gland.

Disease Hierarchy

DISIFI14: Sella turcica neoplasm

DIS7XB48: Pituitary gland disorder

DISTBY9Z: Tumour

DISGQU9D: Endocrine gland neoplasm

:

DISN67JD: Pituitary tumor

Disease Identifiers

MONDO ID

MONDO_0017611

MESH ID

D010911

UMLS CUI

C0032019

MedGen ID

19326

HPO ID

HP:0040277

Orphanet ID

304055

SNOMED CT ID

127024001

General Information of Disease (ID: DISN67JD)

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 13 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
AGTR1	TT8DBY3	Limited	Biomarker	[1]
CDKN1B	TTLGFVW	Limited	Genetic Variation	[2]
DIO1	TTU3X26	Limited	Altered Expression	[3]
HDAC11	TT8K17W	Limited	Altered Expression	[4]
SCGB1D2	TT5D314	Limited	Altered Expression	[5]
SSTR1	TTIND6G	Limited	Biomarker	[6]
SSTR5	TT2BC4G	Limited	Altered Expression	[7]
TBXAS1	TTKNWZ4	Limited	Biomarker	[8]
GHR	TTHJWYD	moderate	Genetic Variation	[9]
IGF1	TTT6LOU	moderate	Biomarker	[10]
DRD2	TTEX248	Strong	Altered Expression	[11]
GH1	TTT3YKH	Strong	Biomarker	[12]
PRL	TTJ2TSA	Strong	Altered Expression	[13]
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⏷ Show the Full List of 13 DTT(s)

This Disease Is Related to 27 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ASAP2	OTGEXULW	Limited	Biomarker	[14]
CCNB2	OTIEXTDK	Limited	Altered Expression	[15]
CCNG1	OT17IA9L	Limited	Biomarker	[16]
CSH1	OT33HTRR	Limited	Altered Expression	[17]
CSH2	OTW8JVAN	Limited	Altered Expression	[17]
DIO2	OTGPNSLH	Limited	Altered Expression	[3]
ESPL1	OTMGEVOK	Limited	Altered Expression	[18]
GADD45G	OT8V1J4M	Limited	Altered Expression	[19]
KLF10	OT4F4UGS	Limited	Altered Expression	[20]
LRIG3	OT6TKZTU	Limited	Altered Expression	[21]
MPP2	OTPH8CZY	Limited	Biomarker	[14]
GH2	OT32TR4C	moderate	Altered Expression	[17]
AIP	OTDJ3OSV	Strong	Genetic Variation	[22]
AKAP4	OTL4Z99V	Strong	Biomarker	[23]
CCDC54	OTW5WCX9	Strong	Biomarker	[23]
ECT2	OTQDUCT6	Strong	Biomarker	[24]
FZD6	OTBCPII8	Strong	Altered Expression	[25]
HNRNPK	OTNPRM8U	Strong	Biomarker	[26]
IL6ST	OT1N9C70	Strong	Biomarker	[27]
MEN1	OTN6U6V0	Strong	Genetic Variation	[28]
POU1F1	OTXT8A5C	Strong	Altered Expression	[29]
PTTG1	OTIMYS4W	Strong	Biomarker	[30]
PTTG1IP	OTX21QTE	Strong	Genetic Variation	[31]
RAB18	OTNMAQLS	Strong	Altered Expression	[32]
RB1	OT9VMY7B	Strong	Posttranslational Modification	[33]
SCGN	OTGD7SKH	Strong	Biomarker	[34]
SPA17	OT8J7T7U	Strong	Biomarker	[23]
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⏷ Show the Full List of 27 DOT(s)

References

1	Immunohistochemical detection of angiotensin receptors AT1 and AT2 in normal rat pituitary gland, estrogen-induced rat pituitary tumor and human pituitary adenomas.Folia Histochem Cytobiol. 2006;44(3):173-7.
2	p27 variant and corticotropinoma susceptibility: a genetic and in vitro study.Endocr Relat Cancer. 2014 Apr 28;21(3):395-404. doi: 10.1530/ERC-13-0486. Print 2014 Jun.
3	Expression of 5'-deiodinase enzymes in normal pituitaries and in various human pituitary adenomas.Eur J Endocrinol. 2002 Aug;147(2):263-8. doi: 10.1530/eje.0.1470263.
4	Histone deacetylase 11 suppresses p53 expression in pituitary tumor cells.Cell Biol Int. 2017 Dec;41(12):1290-1295. doi: 10.1002/cbin.10834. Epub 2017 Aug 29.
5	Secretoglobins in the human pituitary: high expression of lipophilin B and its down-regulation in pituitary adenomas.Acta Neuropathol. 2005 Apr;109(4):381-6. doi: 10.1007/s00401-004-0972-6. Epub 2005 Jan 25.
6	Somatostatin receptor subtype 1 selective activation in human growth hormone (GH)- and prolactin (PRL)-secreting pituitary adenomas: effects on cell viability, GH, and PRL secretion.J Clin Endocrinol Metab. 2003 Jun;88(6):2797-802. doi: 10.1210/jc.2002-021825.
7	Dopamine receptor subtype 2 and somatostatin receptor subtype 5 expression influences somatostatin analogs effects on human somatotroph pituitary adenomas in vitro.J Mol Endocrinol. 2005 Oct;35(2):333-41. doi: 10.1677/jme.1.01876.
8	Analysis of Cox-2 and thromboxane synthase expression in pituitary adenomas and carcinomas.Endocr Pathol. 2004 Spring;15(1):17-27. doi: 10.1385/ep:15:1:17.
9	Short stature and decreased insulin-like growth factor I (IGF-I)/growth hormone (GH)-ratio in an adult GH-deficient patient pointing to additional partial GH insensitivity due to a R179C mutation of the growth hormone receptor.Growth Horm IGF Res. 2007 Aug;17(4):307-14. doi: 10.1016/j.ghir.2007.03.001. Epub 2007 Apr 25.
10	Decrease of Serum IGF-I following Transsphenoidal Pituitary Surgery for Acromegaly.Clin Chem. 2017 Feb;63(2):486-494. doi: 10.1373/clinchem.2016.262592. Epub 2016 Dec 14.
11	Effect of 9-cis retinoic acid on dopamine D2 receptor expression in pituitary adenoma cells.Exp Biol Med (Maywood). 2008 Apr;233(4):439-46. doi: 10.3181/0704-RM-94.
12	E-cadherin expression is associated with somatostatin analogue response in acromegaly.J Cell Mol Med. 2019 May;23(5):3088-3096. doi: 10.1111/jcmm.13851. Epub 2019 Mar 6.
13	Human pituitary tumor-transforming gene (PTTG1) motif suppresses prolactin expression.Mol Endocrinol. 2003 Apr;17(4):600-9. doi: 10.1210/me.2001-0006. Epub 2003 Jan 16.
14	Identification of differentially coexpressed genes in gonadotrope tumors and normal pituitary using bioinformatics methods.Pathol Oncol Res. 2014 Apr;20(2):375-80. doi: 10.1007/s12253-013-9706-1. Epub 2013 Nov 7.
15	HMGA proteins up-regulate CCNB2 gene in mouse and human pituitary adenomas.Cancer Res. 2009 Mar 1;69(5):1844-50. doi: 10.1158/0008-5472.CAN-08-4133. Epub 2009 Feb 17.
16	Antitumor function of microRNA-122 against hepatocellular carcinoma.J Gastroenterol. 2014 Apr;49(4):589-93. doi: 10.1007/s00535-014-0932-4. Epub 2014 Feb 17.
17	Differential binding of rat pituitary-specific nuclear factors to the 5'-flanking region of pituitary and placental members of the human growth hormone gene family.Mol Cell Biochem. 1991 Aug 14;106(2):181-7. doi: 10.1007/BF00230184.
18	PTTG is a secretory protein in human pituitary adenomas and in mouse pituitary tumor cell lines.Endocr Pathol. 2007 Spring;18(1):8-15. doi: 10.1007/s12022-007-0005-9.
19	Loss of expression of GADD45 gamma, a growth inhibitory gene, in human pituitary adenomas: implications for tumorigenesis.J Clin Endocrinol Metab. 2002 Mar;87(3):1262-7. doi: 10.1210/jcem.87.3.8315.
20	TGF-inducible early gene-1 (TIEG1) mutations in hypertrophic cardiomyopathy.J Cell Biochem. 2012 Jun;113(6):1896-903. doi: 10.1002/jcb.24058.
21	Down-regulation of leucine-rich repeats and immunoglobulin-like domain proteins (LRIG1-3) in HP75 pituitary adenoma cell line.J Huazhong Univ Sci Technolog Med Sci. 2007 Feb;27(1):91-4. doi: 10.1007/s11596-007-0126-x.
22	AIP limits neurotransmitter release by inhibiting calcium bursts from the ryanodine receptor.Nat Commun. 2017 Nov 9;8(1):1380. doi: 10.1038/s41467-017-01704-z.
23	Novel antigens in non-small cell lung cancer: SP17, AKAP4, and PTTG1 are potential immunotherapeutic targets.Oncotarget. 2015 Feb 20;6(5):2812-26. doi: 10.18632/oncotarget.2802.
24	ECT2/PSMD14/PTTG1 axis promotes the proliferation of glioma through stabilizing E2F1.Neuro Oncol. 2019 Mar 18;21(4):462-473. doi: 10.1093/neuonc/noy207.
25	Expression of Wnt4 in human pituitary adenomas regulates activation of the beta-catenin-independent pathway.Endocr Pathol. 2008 Winter;19(4):261-73. doi: 10.1007/s12022-008-9048-9.
26	Age-associated changes in hypothalamic and pituitary neuroendocrine gene expression in the rat.J Neuroendocrinol. 2003 Jun;15(6):592-601. doi: 10.1046/j.1365-2826.2003.01039.x.
27	Involvement of the gp130 cytokine transducer in MtT/S pituitary somatotroph tumour development in an autocrine-paracrine model.Eur J Endocrinol. 2004 Nov;151(5):595-604. doi: 10.1530/eje.0.1510595.
28	Loss of heterozygosity of the MEN1 gene in a large series of TSH-secreting pituitary adenomas.J Endocrinol Invest. 2001 Nov;24(10):796-801. doi: 10.1007/BF03343929.
29	Pituitary-specific repression of placental members of the human growth hormone gene family. A possible mechanism for locus regulation.J Biol Chem. 1993 Apr 25;268(12):8473-9.
30	In silico repurposing the Rac1 inhibitor NSC23766 for treating PTTG1-high expressing clear cell renal carcinoma.Pathol Res Pract. 2019 Jun;215(6):152373. doi: 10.1016/j.prp.2019.03.002. Epub 2019 Mar 4.
31	Functional consequences of the first reported mutations of the proto-oncogene PTTG1IP/PBF.Endocr Relat Cancer. 2017 Sep;24(9):459-474. doi: 10.1530/ERC-16-0340. Epub 2017 Jul 4.
32	Rab18 is reduced in pituitary tumors causing acromegaly and its overexpression reverts growth hormone hypersecretion.J Clin Endocrinol Metab. 2008 Jun;93(6):2269-76. doi: 10.1210/jc.2007-1893. Epub 2008 Mar 18.
33	Promoter hypermethylation profile of cell cycle regulator genes in pituitary adenomas.J Neurooncol. 2007 Jun;83(2):153-62. doi: 10.1007/s11060-006-9316-9. Epub 2007 Jan 11.
34	Proteomics and transcriptomics analyses of secretagogin down-regulation in human non-functional pituitary adenomas.Pituitary. 2003;6(4):189-202. doi: 10.1023/b:pitu.0000023426.99808.40.