Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE1Z0MO)

DME Name	Carbonic anhydrase II (CA2)
Synonyms	Carbonate dehydratase II; Carbonic anhydrase 2; Carbonic anhydrase C; CA-II; CA2; CAC
Gene Name	CA2
UniProt ID	CAH2_HUMAN
INTEDE ID	DME0409
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Gene ID	760
EC Number	EC: 4.2.1.1 Lyases Carbon-oxygen lyase Hydro-lyase EC: 4.2.1.1
Lineage	Species: Homo sapiens Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Sequence	MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM VDNWRPAQPLKNRQIKASFK
Function	This enzyme can hydrate cyanamide to urea.
KEGG Pathway	Bile secretion (hsa04976 ) Collecting duct acid secretion (hsa04966 ) Gastric acid secretion (hsa04971 ) Metabolic pathways (hsa01100 ) Nitrogen metabolism (hsa00910 ) Pancreatic secretion (hsa04972 ) Proximal tubule bicarbonate reclamation (hsa04964 )
Reactome Pathway	Erythrocytes take up oxygen and release carbon dioxide (R-HSA-1247673 ) Reversible hydration of carbon dioxide (R-HSA-1475029 ) Erythrocytes take up carbon dioxide and release oxygen (R-HSA-1237044 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitrophenyl acetate	DMHSD8A	N. A.	N. A.	Investigative	[77]
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Molecular Expression Atlas (MEA) of This DME

Molecular Expression Atlas (MEA)

MEA Detail

Jump to Detail Molecular Expression Atlas of This DME

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Acute myelocytic leukaemia	2B33.1	Bone marrow	1.22E-19	-1.34E+00	-1.24E+00
Alopecia	ED70	Skin from scalp	6.95E-02	-1.89E-01	-4.08E-01
Alzheimer's disease	8A20	Entorhinal cortex	1.02E-03	3.82E-01	4.81E-01
Ankylosing spondylitis	FA92.0	Pheripheral blood	4.73E-02	3.38E-01	1.36E+00
Aortic stenosis	BB70	Calcified aortic valve	6.11E-01	2.89E-01	2.01E-01
Apnea	7A40	Hyperplastic tonsil	1.89E-02	-1.22E+00	-1.44E+00
Arthropathy	FA00-FA5Z	Peripheral blood	2.88E-01	1.83E-01	2.66E-01
Asthma	CA23	Nasal and bronchial airway	5.20E-08	8.53E-01	6.98E-01
Atopic dermatitis	EA80	Skin	4.95E-02	2.70E-01	4.05E-01
Autism	6A02	Whole blood	1.92E-03	1.06E+00	8.74E-01
Autoimmune uveitis	9A96	Peripheral monocyte	2.69E-01	-2.64E-01	-6.37E-01
Autosomal dominant monocytopenia	4B04	Whole blood	3.54E-01	-1.32E+00	-1.00E+00
Bacterial infection of gingival	1C1H	Gingival tissue	6.64E-01	9.25E-02	1.66E-01
Batten disease	5C56.1	Whole blood	9.08E-01	-2.78E-01	-5.96E-01
Behcet's disease	4A62	Peripheral blood	2.35E-01	1.82E-01	2.55E-01
Bipolar disorder	6A60-6A6Z	Prefrontal cortex	5.98E-01	-3.48E-02	-6.74E-02
Bladder cancer	2C94	Bladder tissue	2.06E-04	1.04E+00	2.38E+00
Breast cancer	2C60-2C6Z	Breast tissue	7.95E-08	5.22E-01	3.33E-01
Cardioembolic stroke	8B11.20	Whole blood	6.73E-01	2.98E-02	4.23E-02
Cervical cancer	2C77	Cervical tissue	9.53E-01	3.03E-01	1.71E-01
Childhood onset rheumatic disease	FA20.Z	Peripheral blood	3.64E-01	3.47E-01	2.15E-01
Chronic hepatitis C	1E51.1	Whole blood	9.25E-01	1.17E-02	1.45E-02
Chronic obstructive pulmonary disease	CA22	Lung tissue	2.15E-01	-1.94E-01	-3.56E-01
Chronic obstructive pulmonary disease	CA22	Small airway epithelium	5.36E-02	3.98E-01	4.47E-01
Chronic rhinosinusitis	CA0A	Sinus mucosa tissue	3.13E-01	1.51E+00	1.04E+00
Colon cancer	2B90	Colon tissue	1.21E-240	-4.98E+00	-6.95E+00
Coronary artery disease	BA80-BA8Z	Peripheral blood	2.46E-01	1.40E-01	2.49E-01
Diffuse large B-cell lymphoma	2A81	Tonsil tissue	1.37E-01	1.88E-01	3.43E-01
Endometriosis	GA10	Endometrium tissue	2.79E-01	-1.86E-01	-2.49E-01
Familial hypercholesterolemia	5C80.00	Peripheral blood	9.50E-01	9.77E-02	1.27E-01
Familial hypercholesterolemia	5C80.00	Whole blood	9.04E-05	2.01E+00	1.72E+00
Gastric cancer	2B72	Gastric tissue	4.37E-01	-1.89E+00	-8.22E-01
Glioblastopma	2A00.00	Nervous tissue	1.24E-17	-6.60E-01	-5.31E-01
Glioma	2A00.0Y-2A00.0Z	Brain stem tissue	2.23E-10	-1.31E+00	-1.70E+01
Glioma	2A00.0Y-2A00.0Z	White matter tissue	7.70E-03	-6.94E-01	-1.27E+00
Head and neck cancer	2D42	Head and neck tissue	4.47E-36	3.92E+00	2.36E+00
HIV-associated neurocognitive impairment	8A2Y-8A2Z	White matter tissue	7.75E-01	-2.75E-02	-2.81E-02
Huntington's disease	8A01.10	Whole blood	4.44E-01	5.12E-01	6.99E-01
Idiopathic pulmonary fibrosis	CB03.4	Lung tissue	6.23E-02	-6.03E-01	-1.22E+00
Immunodeficiency	4A00-4A20	Peripheral blood	5.10E-01	8.13E-02	5.87E-01
Influenza	1E30	Whole blood	5.44E-04	-2.14E+00	-5.32E+00
Interstitial cystitis	GC00.3	Bladder tissue	5.15E-02	5.15E-01	1.41E+00
Intracranial aneurysm	8B01.0	Intracranial artery	2.38E-02	1.69E+00	1.30E+00
Irritable bowel syndrome	DD91.0	Rectal colon tissue	8.80E-03	-8.51E-02	-3.87E-01
Ischemic stroke	8B11	Peripheral blood	6.17E-02	6.63E-01	8.94E-01
Juvenile idiopathic arthritis	FA24	Peripheral blood	9.77E-07	3.39E-01	5.26E-01
Lateral sclerosis	8B60.4	Skin	6.23E-02	1.27E-01	1.22E+00
Lateral sclerosis	8B60.4	Cervical spinal cord	7.63E-02	-3.71E-02	-5.09E-02
Liver cancer	2C12.0	Liver tissue	7.61E-31	-2.18E+00	-3.17E+00
Liver failure	DB99.7-DB99.8	Liver tissue	1.42E-06	-2.17E+00	-3.75E+00
Lung cancer	2C25	Lung tissue	5.08E-92	-1.97E+00	-2.64E+00
Lupus erythematosus	4A40	Whole blood	9.06E-02	-5.38E-01	-3.76E-01
Major depressive disorder	6A70-6A7Z	Hippocampus	8.64E-01	-5.69E-02	-1.11E-01
Major depressive disorder	6A70-6A7Z	Whole blood	9.64E-02	3.32E-01	6.96E-01
Melanoma	2C30	Skin	6.70E-01	-4.82E-01	-2.30E-01
Multiple myeloma	2A83.1	Peripheral blood	8.15E-01	-2.35E-01	-4.83E-01
Multiple myeloma	2A83.1	Bone marrow	2.46E-03	6.36E-01	1.16E+00
Multiple sclerosis	8A40	Plasmacytoid dendritic cells	7.40E-01	-8.58E-02	-1.86E-01
Myelodysplastic syndrome	2A36-2A3Z	Bone marrow	7.14E-01	-5.80E-02	-4.26E-02
Myelofibrosis	2A20.2	Whole blood	3.53E-02	2.60E+00	4.21E+00
Myocardial infarction	BA41-BA50	Peripheral blood	4.30E-01	6.72E-01	3.00E-01
Myopathy	8C70.6	Muscle tissue	5.50E-02	-9.36E-02	-2.20E-01
Neonatal sepsis	KA60	Whole blood	8.03E-12	1.02E+00	1.17E+00
Neuroectodermal tumour	2A00.11	Brain stem tissue	1.21E-04	-1.31E+00	-1.79E+00
Non-alcoholic fatty liver disease	DB92	Liver tissue	3.16E-01	1.25E-02	2.73E-02
Obesity related type 2 diabetes	5A11	Omental adipose tissue	3.96E-01	6.13E-02	1.49E-01
Olive pollen allergy	CA08.00	Peripheral blood	3.32E-01	1.08E+00	5.71E-01
Oral cancer	2B6E	Oral tissue	1.54E-08	2.31E+00	1.80E+00
Osteoarthritis	FA00-FA0Z	Synovial tissue	2.45E-01	-2.67E+00	-1.06E+00
Osteoporosis	FB83.1	Bone marrow	7.36E-01	-9.60E-01	-4.14E-01
Ovarian cancer	2C73	Ovarian tissue	7.64E-09	2.72E+00	5.74E+00
Pancreatic cancer	2C10	Pancreas	1.92E-03	9.75E-01	8.55E-01
Parkinson's disease	8A00.0	Substantia nigra tissue	2.16E-01	8.67E-01	9.60E-01
Pediatric respiratory syncytial virus infection	CA40.11	Peripheral blood	1.03E-02	6.72E-01	6.14E-01
Pituitary cancer	2D12	Pituitary tissue	9.32E-01	-5.41E-01	-5.45E-01
Pituitary gonadotrope tumour	2D12	Pituitary tissue	1.76E-02	-1.07E+00	-1.00E+00
Polycystic ovary syndrome	5A80.1	Vastus lateralis muscle	4.39E-01	-6.00E-02	-2.42E-01
Polycythemia vera	2A20.4	Whole blood	9.08E-03	3.15E-01	5.53E-01
Pompe disease	5C51.3	Biceps muscle	1.81E-05	-7.20E-01	-1.75E+00
Preterm birth	KA21.4Z	Myometrium	2.45E-01	1.36E-01	3.73E-01
Prostate cancer	2C82	Prostate	6.99E-02	8.12E-01	6.90E-01
Psoriasis	EA90	Skin	8.37E-05	-2.46E-01	-4.66E-01
Rectal cancer	2B92	Rectal colon tissue	3.97E-36	-3.87E+00	-2.15E+01
Renal cancer	2C90-2C91	Kidney	3.17E-04	-1.04E+00	-1.25E+00
Retinoblastoma	2D02.2	Uvea	1.48E-07	-6.28E+00	-1.51E+01
Rheumatoid arthritis	FA20	Synovial tissue	4.38E-01	6.21E-01	2.76E-01
Rhinovirus infection	CA42.1	Nasal epithelium tissue	6.77E-02	3.70E-01	6.11E-01
Schizophrenia	6A20	Prefrontal cortex	3.17E-02	-2.70E-01	-3.45E-01
Schizophrenia	6A20	Superior temporal cortex	8.59E-02	-3.89E-01	-7.26E-01
Scleroderma	4A42.Z	Whole blood	9.04E-02	-2.02E-01	-4.00E-01
Seizure	8A60-8A6Z	Whole blood	2.38E-03	-7.78E-01	-9.34E-01
Sensitive skin	EK0Z	Skin	8.49E-01	-4.22E-02	-7.10E-02
Sepsis with septic shock	1G41	Whole blood	8.10E-13	5.77E-01	7.96E-01
Shwachman-Diamond syndrome	3A70.0	Bone marrow	9.33E-02	6.87E-01	1.48E+00
Sickle cell disease	3A51.0-3A51.3	Peripheral blood	1.39E-01	-3.00E-01	-3.68E-01
Simpson golabi behmel syndrome	LD2C	Adipose tissue	8.95E-02	1.23E-01	2.52E+00
Sjogren's syndrome	4A43.2	Salivary gland tissue	3.36E-01	-9.46E-01	-1.24E+00
Skin cancer	2C30-2C3Z	Skin	7.23E-53	-1.91E+00	-2.51E+00
Thrombocythemia	3B63	Whole blood	7.92E-01	-1.77E-02	-2.92E-02
Thrombocytopenia	3B64	Whole blood	6.14E-01	9.99E-02	9.48E-02
Thyroid cancer	2D10	Thyroid	3.95E-34	1.42E+00	1.68E+00
Tibial muscular dystrophy	8C75	Muscle tissue	1.42E-10	-2.25E+00	-6.45E+00
Tuberous sclerosis complex	LD2D.2	Perituberal tissue	3.74E-01	2.94E-01	1.02E+00
Type 2 diabetes	5A11	Liver tissue	9.54E-01	-6.27E-02	-1.53E-01
Ureter cancer	2C92	Urothelium	8.70E-01	-9.73E-02	-2.71E-01
Uterine cancer	2C78	Endometrium tissue	4.51E-06	1.09E+00	6.02E-01
Vitiligo	ED63.0	Skin	5.60E-01	-1.80E-01	-3.98E-01
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⏷ Show the Full List of DME Expression Under 107 Diseases

The Drug Therapeutic Target (DTT) Role of This DME

DME DTT Name

Carbonic anhydrase II (CA-II) DTT Info

DME DTT Type

Successful

9 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzthiazide	DMQWZ0H	High blood pressure	BA00	Approved	[1]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[2]
Cyclothiazide	DMJ4AWC	Congestive heart failure	BD10	Approved	[3]
Dichlorphenamide	DMH7IDQ	Chronic glaucoma	9C61.0Z	Approved	[4]
Dorzolamide	DMA17D0	Ocular hypertension	9C61.01	Approved	[5]
Ethinamate	DMK57GB	Insomnia	7A00-7A0Z	Approved	[6]
Ethoxzolamide	DMVO4ED	Glaucoma/ocular hypertension	9C61	Approved	[4]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[7]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[8]
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⏷ Show the Full List of 9 Approved Drug(s)

10 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CG-100649	DMIKMA9	Arthritis	FA20	Phase 3	[9]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[10]
GUAIACOL	DMN4E7T	N. A.	N. A.	Phase 3	[11]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[12]
SULTHIAME	DM07653	N. A.	N. A.	Phase 3	[4]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[10]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[13]
STX-140	DMJK5CT	Osteoporosis	FB83.0	Phase 2	[14]
BUTYLATEDHYDROXYTOLUENE	DMJ56MS	N. A.	N. A.	Phase 1	[11]
SULFAMIDE	DMMAS3K	N. A.	N. A.	Phase 1	[15]
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⏷ Show the Full List of 10 Clinical Trial Drug(s)

1 Patented Agent(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[12]
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259 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(2,2-dimethyl-1,3-dioxolan-4-yl)methyl sulfamate	DM2ATRC	Discovery agent	N.A.	Investigative	[16]
(2-bromophenyl)difluoromethanesulfonamide	DMFX9H8	Discovery agent	N.A.	Investigative	[17]
(4-bromophenyl)difluoromethanesulfonamide	DMOCYZJ	Discovery agent	N.A.	Investigative	[17]
1,2,4-Triazole	DM73F5A	Discovery agent	N.A.	Investigative	[18]
1,4-Dihydro-1-methyl-4-oxo-3-pyridinesulfonamide	DMNHGVD	Discovery agent	N.A.	Investigative	[19]
1,4-phenylene disulfamate	DMEDBO2	Discovery agent	N.A.	Investigative	[20]
1-(3,4-dichlorophenyl)-3-hydroxyurea	DMVOJ7K	Discovery agent	N.A.	Investigative	[21]
1-acetamido-5-sulfonamidoindane	DM92ZCU	Discovery agent	N.A.	Investigative	[22]
1-Benzyl-1,4-dihydro-4-oxo-3-pyridinesulfonamide	DMUXSH5	Discovery agent	N.A.	Investigative	[19]
1-cyclohexylamido-5-sulfonamidoindane	DMFPQME	Discovery agent	N.A.	Investigative	[22]
1-pentafluorophenylamido-5-sulfonamidoindane	DM9PNTQ	Discovery agent	N.A.	Investigative	[22]
1-pentenyl-4-(aminosulfonyl)benzoate	DMNUAB9	Discovery agent	N.A.	Investigative	[23]
1-valproylamido-5-sulfonamidoindane	DM9ZRU2	Discovery agent	N.A.	Investigative	[22]
2,2,2-Trifluoro-N-(4-sulfamoyl-phenyl)-acetamide	DMG4ITB	Discovery agent	N.A.	Investigative	[24]
2,2-Dimethyl-N-(4-sulfamoyl-phenyl)-propionamide	DMATB8H	Discovery agent	N.A.	Investigative	[24]
2,3-dihydro-1H-indene-5-sulfonamide	DM46MKY	Discovery agent	N.A.	Investigative	[4]
2,4-dichloro-5-sulfamoylbenzoic acid	DM4EY5S	Discovery agent	N.A.	Investigative	[25]
2,4-Disulfamyltrifluoromethylaniline	DM2AW0Z	Discovery agent	N.A.	Investigative	[26]
2,6-di-t-butylphenol	DMY8LDT	Discovery agent	N.A.	Investigative	[11]
2,6-di-tert-butyl-4-methoxyphenol	DMFO1H2	Discovery agent	N.A.	Investigative	[11]
2,6-Difluorobenzenesulfonamide	DMGEYAK	Discovery agent	N.A.	Investigative	[27]
2-(4-chlorobenzyloxyamino)-N-hydroxyacetamide	DM1JKWL	Discovery agent	N.A.	Investigative	[28]
2-(4-chlorobenzyloxyamino)-N-hydroxyhexanamide	DMFGQ7K	Discovery agent	N.A.	Investigative	[28]
2-(4-chlorobenzyloxyamino)-N-hydroxypropanamide	DMRADWB	Discovery agent	N.A.	Investigative	[28]
2-(4-hydroxybenzylideneamino)ethanesulfonamide	DMCPN7V	Discovery agent	N.A.	Investigative	[29]
2-(4-tert-butylbenzylideneamino)ethanesulfonamide	DMIOW3D	Discovery agent	N.A.	Investigative	[29]
2-(benzylideneamino)ethanesulfonamide	DM3VJLZ	Discovery agent	N.A.	Investigative	[29]
2-(benzyloxyamino)-N-hydroxyhexanamide	DMOUKTH	Discovery agent	N.A.	Investigative	[28]
2-(N''-Acetyl-hydrazino)-benzenesulfonamide	DMHYKR8	Discovery agent	N.A.	Investigative	[30]
2-acetamido-5-sulfonamidoindane	DMPKBVR	Discovery agent	N.A.	Investigative	[22]
2-Acetylamino-indan-5-sulfonic acid hydrate	DMEQKIU	Discovery agent	N.A.	Investigative	[31]
2-Amino-benzenesulfonamide	DMEMANH	Discovery agent	N.A.	Investigative	[26]
2-Amino-indan-5-sulfonic acid	DMCUSH1	Discovery agent	N.A.	Investigative	[31]
2-butylamido-5-sulfonamidoindane	DML9MCU	Discovery agent	N.A.	Investigative	[22]
2-cyclohexylamido-5-sulfonamidoindane	DMFBD3K	Discovery agent	N.A.	Investigative	[22]
2-ethylamido-5-sulfonamidoindane	DMDY3JQ	Discovery agent	N.A.	Investigative	[22]
2-Hydrazinocarbonyl-benzenesulfonamide	DMG78U2	Discovery agent	N.A.	Investigative	[30]
2-hydrazinylbenzenesulfonamide	DMCNXZM	Discovery agent	N.A.	Investigative	[5]
2-Hydroxycinnamic acid	DM86HTZ	Discovery agent	N.A.	Investigative	[10]
2-Mercapto-N-(4-sulfamoyl-phenyl)-benzamide	DMXEUDM	Discovery agent	N.A.	Investigative	[4]
2-methoxyestradiol-17-O-sulfamate	DMIBKNZ	Discovery agent	N.A.	Investigative	[14]
2-methoxyestrrone-3-O-sulfamate	DMD6L7C	Discovery agent	N.A.	Investigative	[14]
2-Morpholin-4-yl-N-(4-sulfamoyl-phenyl)-acetamide	DMDTRZ2	Discovery agent	N.A.	Investigative	[32]
2-nonylamido-5-sulfonamidoindane	DMOGWIK	Discovery agent	N.A.	Investigative	[22]
2-oxo-2H-thiochromene-3-carboxylic acid	DMZTCOM	Discovery agent	N.A.	Investigative	[33]
2-pentafluorophenylamido-5-sulfonamidoindane	DMZ9NCA	Discovery agent	N.A.	Investigative	[22]
2-propylamido-5-sulfonamidoindane	DMG0I25	Discovery agent	N.A.	Investigative	[22]
2-Sulfamoyl-benzoic acid methyl ester	DMAO7DS	Discovery agent	N.A.	Investigative	[30]
2-Sulfhydryl-Ethanol	DMJBO3D	Discovery agent	N.A.	Investigative	[18]
2-valproylamido-5-sulfonamidoindane	DM8XSE3	Discovery agent	N.A.	Investigative	[22]
3,5-Difluorobenzenesulfonamide	DMET46F	Discovery agent	N.A.	Investigative	[18]
3-((4-aminophenyl)diazenyl)benzenesulfonamide	DM37X04	Discovery agent	N.A.	Investigative	[34]
3-((4-hydroxyphenyl)diazenyl)benzenesulfonamide	DMAPZQW	Discovery agent	N.A.	Investigative	[34]
3-(3-Phenyl-ureido)-benzenesulfonamide	DM314ZE	Discovery agent	N.A.	Investigative	[24]
3-(4'-Hydroxyphenyl)diazenylbenzenesulfonamide	DM18MOH	Discovery agent	N.A.	Investigative	[34]
3-(4-sulfamoylphenyl)propanoic acid	DMBDW8P	Discovery agent	N.A.	Investigative	[4]
3-Amino-benzenesulfonamide	DME0TNA	Discovery agent	N.A.	Investigative	[35]
3-bromophenyl-difluoromethanesulfonamide	DMXZW3R	Discovery agent	N.A.	Investigative	[17]
3-Chloro-4-hydrazino-benzenesulfonamide	DMSB5IQ	Discovery agent	N.A.	Investigative	[30]
3-Fluoro-4-hydrazino-benzenesulfonamide	DMLG69R	Discovery agent	N.A.	Investigative	[30]
3-hydroxy-2-methoxybenzaldehyde	DMI785L	Discovery agent	N.A.	Investigative	[11]
3-mercapto-N-(4-sulfamoyl-phenyl)-propionamide	DMQ09J8	Discovery agent	N.A.	Investigative	[36]
3-Mercuri-4-Aminobenzenesulfonamide	DMX3ANZ	Discovery agent	N.A.	Investigative	[18]
3-Nitro-benzenesulfonamide	DMAY4OZ	Discovery agent	N.A.	Investigative	[37]
3-phenyl-5-sulfamoyl-1H-indole-2-carboxamide	DM43CIK	Discovery agent	N.A.	Investigative	[38]
3-phenylprop-1-enylboronic acid	DMIJN9E	Discovery agent	N.A.	Investigative	[39]
4,4'-thiodipyridine-3-sulfonamide	DM0K5JM	Discovery agent	N.A.	Investigative	[40]
4,6-Dinitro salicylic acid	DMIJ4VZ	Discovery agent	N.A.	Investigative	[41]
4-((4-hydroxyphenyl)diazenyl)benzenesulfonamide	DM5EP3V	Discovery agent	N.A.	Investigative	[34]
4-((benzylideneamino)methyl)benzenesulfonamide	DM6R43J	Discovery agent	N.A.	Investigative	[29]
4-(2-AMINOETHYL)BENZENESULFONAMIDE	DMEK6WX	Discovery agent	N.A.	Investigative	[4]
4-(2-aminopyrimidin-4-ylamino)benzenesulfonamide	DMWG706	Discovery agent	N.A.	Investigative	[26]
4-(2-Hydroxy-ethyl)-benzenesulfonamide	DM1C5U6	Discovery agent	N.A.	Investigative	[42]
4-(2-Methyl-8-quinolinoxy)-3-pyridinesulfonamide	DME6DHX	Discovery agent	N.A.	Investigative	[40]
4-(2-Phenylacetamido)-3-bromobenzenesulfonamide	DMZ62L3	Discovery agent	N.A.	Investigative	[43]
4-(2-Phenylacetamido)-3-chlorobenzenesulfonamide	DM9GOTA	Discovery agent	N.A.	Investigative	[43]
4-(2-Phenylacetamido)-3-fluorobenzenesulfonamide	DMCOD4N	Discovery agent	N.A.	Investigative	[43]
4-(2-Phenylacetamido)benzenesulfonamide	DMFYR6H	Discovery agent	N.A.	Investigative	[43]
4-(2-Phenylacetamidoethyl)benzenesulfonamide	DM1JL03	Discovery agent	N.A.	Investigative	[43]
4-(2-Phenylacetamidomethyl)benzenesulfonamide	DMDYHXE	Discovery agent	N.A.	Investigative	[43]
4-(2-Propynylthio)pyridine-3-sulfonamide	DMT9RAC	Discovery agent	N.A.	Investigative	[40]
4-(2-Pyridin-2-ylacetamido)benzenesulfonamide	DM9LKMP	Discovery agent	N.A.	Investigative	[43]
4-(2-Pyridin-4-ylacetamido)benzenesulfonamide	DMD6AYQ	Discovery agent	N.A.	Investigative	[43]
4-(4-Cyanophenoxy)-3-pyridinesulfonamide	DMNEAJH	Discovery agent	N.A.	Investigative	[40]
4-(4-Fluorophenoxy)-3-pyridinesulfonamide	DMRJLAP	Discovery agent	N.A.	Investigative	[40]
4-(4-hydroxy-benzylideneamino)-benzenesulfonamide	DMNY0I5	Discovery agent	N.A.	Investigative	[29]
4-(4-hydroxybenzylideneamino)benzoic acid	DML357W	Discovery agent	N.A.	Investigative	[29]
4-(4-tert-butylbenzylideneamino)benzoic acid	DMFLH2G	Discovery agent	N.A.	Investigative	[29]
4-(5-Methyl-2-pirazolino)-3-pyridinesulfonamide	DMKT20Q	Discovery agent	N.A.	Investigative	[40]
4-(Allylamino)-3-pyridinesulfonamide	DM6MQCI	Discovery agent	N.A.	Investigative	[40]
4-(benzylideneamino)benzenesulfonamide	DM03BQD	Discovery agent	N.A.	Investigative	[29]
4-(benzylideneamino)benzoic acid	DMJM2H1	Discovery agent	N.A.	Investigative	[29]
4-(Carbamolymethylthio)pyridine-3-sulfonamide	DM12R4M	Discovery agent	N.A.	Investigative	[40]
4-(Cyanomethylthio)pyridine-3-sulfonamide	DMZP20H	Discovery agent	N.A.	Investigative	[40]
4-(Hydroxymercury)Benzoic Acid	DMWJN73	Discovery agent	N.A.	Investigative	[18]
4-(hydroxymethyl)benzenesulfonamide	DMR6VWL	Discovery agent	N.A.	Investigative	[26]
4-(Methylhydrazino)-3-pyridinesulfonamide	DM4BPL1	Discovery agent	N.A.	Investigative	[40]
4-(N-Methyl-hydrazino)-benzenesulfonamide	DMADWTI	Discovery agent	N.A.	Investigative	[44]
4-(N-Oxide-2-pyridylthio)pyridine-3-sulfonamide	DMYCV8E	Discovery agent	N.A.	Investigative	[40]
4-(Quinolinoxy)-3-pyridinesulfonamide	DMPNXFA	Discovery agent	N.A.	Investigative	[40]
4-Amino-3-bromo-benzenesulfonamide	DMVUCZK	Discovery agent	N.A.	Investigative	[26]
4-Amino-3-chloro-benzenesulfonamide	DMERTQ4	Discovery agent	N.A.	Investigative	[26]
4-Amino-3-fluoro-benzenesulfonamide	DMIQ3VR	Discovery agent	N.A.	Investigative	[42]
4-Amino-3-iodo-benzenesulfonamide	DMCOYHR	Discovery agent	N.A.	Investigative	[26]
4-amino-6-chlorobenzene-1,3-disulfonamide	DMIWGZS	Discovery agent	N.A.	Investigative	[42]
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide	DMJZNX6	Discovery agent	N.A.	Investigative	[26]
4-azidobenzenesulfonamide	DM7EQ06	Discovery agent	N.A.	Investigative	[45]
4-Benzenesulfonylamino-benzenesulfonamide	DMC7HKA	Discovery agent	N.A.	Investigative	[24]
4-Benzythiopyridine-3-sulfonamide	DMI1EFY	Discovery agent	N.A.	Investigative	[40]
4-bromophenylboronic acid	DM2YN37	Discovery agent	N.A.	Investigative	[39]
4-butylphenylboronic acid	DMD9FZW	Discovery agent	N.A.	Investigative	[39]
4-Chloro-N-(5-sulfamoyl-indan-2-yl)-benzamide	DM2UYCS	Discovery agent	N.A.	Investigative	[31]
4-CYANOPHENOL	DMN12EX	Discovery agent	N.A.	Investigative	[7]
4-Ethoxy-3-pyridinesulfonamide	DM8WAOR	Discovery agent	N.A.	Investigative	[40]
4-ethynyl benzene sulfonamide	DMIF1D6	Discovery agent	N.A.	Investigative	[46]
4-Flourobenzenesulfonamide	DMNDS19	Discovery agent	N.A.	Investigative	[18]
4-fluoro-N-(4-sulfamoylbenzyl)benzenesulfonamide	DMGBKN7	Discovery agent	N.A.	Investigative	[20]
4-Hydrazino-3-pyridinesulfonamide	DMSZMQU	Discovery agent	N.A.	Investigative	[40]
4-Hydrazino-benzenesulfonamide	DM49B18	Discovery agent	N.A.	Investigative	[47]
4-Hydrazinocarbonyl-benzenesulfonamide	DM8PBEJ	Discovery agent	N.A.	Investigative	[30]
4-isothiocyanatobenzenesulfonamide	DMBK67H	Discovery agent	N.A.	Investigative	[48]
4-Methanesulfonylamino-benzenesulfonamide	DMPH4C8	Discovery agent	N.A.	Investigative	[24]
4-Methoxy-3-pyridinesulfonamide	DMJIX7H	Discovery agent	N.A.	Investigative	[40]
4-methoxyphenylboronic acid	DMP5YFQ	Discovery agent	N.A.	Investigative	[39]
4-methoxyphenylsulfamide	DMVW8KN	Discovery agent	N.A.	Investigative	[16]
4-Methylamino-benzenesulfonamide	DM5XMI9	Discovery agent	N.A.	Investigative	[44]
4-Methylimidazole	DM45N6U	Discovery agent	N.A.	Investigative	[27]
4-methylphenyl-difluoromethanesulfonamide	DMR5NLM	Discovery agent	N.A.	Investigative	[17]
4-Methylthiopyridine-3-sulfonamide	DMEB5XP	Discovery agent	N.A.	Investigative	[40]
4-Nitro-benzenesulfonamide	DMZY8UW	Discovery agent	N.A.	Investigative	[37]
4-nitrophenyl phosphate	DMBX4UJ	Discovery agent	N.A.	Investigative	[49]
4-nitrophenyl-difluoromethanesulfonamide	DM9ETMD	Discovery agent	N.A.	Investigative	[17]
4-nitrophenylsulfamide	DM47IFL	Discovery agent	N.A.	Investigative	[16]
4-phenoxyphenylboronic acid	DMMWYI9	Discovery agent	N.A.	Investigative	[39]
4-Sulfonamide-[1-(4-Aminobutane)]Benzamide	DM61CJK	Discovery agent	N.A.	Investigative	[18]
4-Thiocyanato-benzenesulfonamide	DMUGMVI	Discovery agent	N.A.	Investigative	[37]
4-[2-(2-Thienyl)acetamidoethyl]benzenesulfonamide	DMH3UPO	Discovery agent	N.A.	Investigative	[43]
4-[2-(2-Thienyl)acetamido]benzenesulfonamide	DMYESXB	Discovery agent	N.A.	Investigative	[43]
4-[2-(3-Phenyl-ureido)-ethyl]-benzenesulfonamide	DMGXM9C	Discovery agent	N.A.	Investigative	[24]
5-Amino-[1,3,4]thiadiazole-2-thiol	DMGA47N	Discovery agent	N.A.	Investigative	[50]
5-Chlorosalicylic Acid	DMH397E	Discovery agent	N.A.	Investigative	[41]
5-hydroxy-1-tosyl-1H-pyrrol-2(5H)-one	DM5RI4H	Discovery agent	N.A.	Investigative	[51]
6-(aminomethyl)-2H-chromen-2-one	DMJU9TG	Discovery agent	N.A.	Investigative	[33]
6-(hydroxymethyl)-2H-chromen-2-one	DM5TOX2	Discovery agent	N.A.	Investigative	[33]
6-Amino-benzothiazole-2-sulfonic acid amide	DMWPELS	Discovery agent	N.A.	Investigative	[52]
6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE	DMPSOIF	Discovery agent	N.A.	Investigative	[4]
6-Hydroxy-benzothiazole-2-sulfonic acid amide	DM2B4S5	Discovery agent	N.A.	Investigative	[47]
6-hydroxybenzo[d][1,3]oxathiol-2-one	DMDRSNH	Discovery agent	N.A.	Investigative	[53]
6-methoxy-2-oxo-2H-chromene-3-carboxylic acid	DM7WH82	Discovery agent	N.A.	Investigative	[33]
6-methyl-2-oxo-2H-chromene-3-carboxylic acid	DMZ6HQL	Discovery agent	N.A.	Investigative	[33]
6-Nitro-benzothiazole-2-sulfonic acid amide	DMYP7UG	Discovery agent	N.A.	Investigative	[37]
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[18]
ACETYLSULFANILAMIDE	DMG8P24	Discovery agent	N.A.	Investigative	[24]
AL4623	DMHG54F	Discovery agent	N.A.	Investigative	[18]
AL5300	DM1QJIV	Discovery agent	N.A.	Investigative	[18]
AL5424	DMSD2U1	Discovery agent	N.A.	Investigative	[18]
AL5927	DM624WO	Discovery agent	N.A.	Investigative	[18]
AL6528	DM1JIVR	Discovery agent	N.A.	Investigative	[18]
Al7089a	DMTXPJI	Discovery agent	N.A.	Investigative	[18]
AL7099A	DMRI08C	Discovery agent	N.A.	Investigative	[27]
AL7182	DMG2D4S	Discovery agent	N.A.	Investigative	[18]
Allyl 4-(aminosulfonyl)benzoate	DMYNKLR	Discovery agent	N.A.	Investigative	[23]
Aminobenzolamide derivative	DMWYS0Z	Discovery agent	N.A.	Investigative	[54]
Azide	DM5XZYB	Discovery agent	N.A.	Investigative	[15]
BENZOLAMIDE	DME5QPX	Discovery agent	N.A.	Investigative	[26]
Benzothiazole-2-sulfonic acid amide	DMROP5Q	Discovery agent	N.A.	Investigative	[55]
Beta-naphthylboronic acid	DMZ8Y67	Discovery agent	N.A.	Investigative	[39]
Biphenyl-4-ylboronic acid	DMIHMP5	Discovery agent	N.A.	Investigative	[39]
Carzenide	DMVD481	Discovery agent	N.A.	Investigative	[23]
CATECHIN	DMY38SB	Discovery agent	N.A.	Investigative	[10]
CATECHOL	DML0YEK	Discovery agent	N.A.	Investigative	[12]
CL-5343	DM9AFZ3	Solid tumour/cancer	2A00-2F9Z	Investigative	[56]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[57]
Dansylamide	DMQ4L1I	Discovery agent	N.A.	Investigative	[18]
Decane-1,10-diyl disulfamate	DM1ESVR	Discovery agent	N.A.	Investigative	[58]
Decyl sulfamate	DMIERWO	Discovery agent	N.A.	Investigative	[58]
Di(2,6-di-t-butylphenol)	DMO6Z02	Discovery agent	N.A.	Investigative	[11]
Di(2,6-diisopropylphenol)	DMG21PZ	Discovery agent	N.A.	Investigative	[11]
Di(2,6-dimethylphenol)	DMZ3EML	Discovery agent	N.A.	Investigative	[11]
ELLAGIC ACID	DMX8BS5	Discovery agent	N.A.	Investigative	[12]
EMATE	DMFQX1U	Discovery agent	N.A.	Investigative	[59]
ETHYL 3-[4-(AMINOSULFONYL)PHENYL]PROPANOATE	DMKJGLO	Discovery agent	N.A.	Investigative	[4]
Formic Acid	DMNFZC6	Discovery agent	N.A.	Investigative	[18]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[12]
HYDROSULFIDE	DMO32HN	Discovery agent	N.A.	Investigative	[15]
IODIDE	DM3FZ6P	Discovery agent	N.A.	Investigative	[15]
Mercuribenzoic Acid	DMT56ER	Discovery agent	N.A.	Investigative	[18]
Methyl 4-(4-hydroxybenzylideneamino)benzoate	DMUROGX	Discovery agent	N.A.	Investigative	[29]
Methyl 4-(4-tert-butylbenzylideneamino)benzoate	DMSBCL6	Discovery agent	N.A.	Investigative	[29]
Methyl Mercury Ion	DM6YEW4	Discovery agent	N.A.	Investigative	[18]
MMI270	DM38N2K	Discovery agent	N.A.	Investigative	[28]
N-(1-benzofuran-3-ylmethyl)sulfamide	DM3WBZP	Discovery agent	N.A.	Investigative	[60]
N-(2,3-DIFLUORO-BENZYL)-4-SULFAMOYL-BENZAMIDE	DMUZL3J	Discovery agent	N.A.	Investigative	[4]
N-(2,6-Diflouro-Benzyl)-4-Sulfamoyl-Benzamide	DM9ATQ6	Discovery agent	N.A.	Investigative	[18]
N-(2-Flouro-Benzyl)-4-Sulfamoyl-Benzamide	DM3CZVW	Discovery agent	N.A.	Investigative	[18]
N-(2-Thienylmethyl)-2,5-Thiophenedisulfonamide	DME9HNO	Discovery agent	N.A.	Investigative	[18]
N-(4-cyanophenyl)sulfamide	DMW8S2D	Discovery agent	N.A.	Investigative	[61]
N-(4-Sulfamoyl-phenyl)-benzamide	DMZDACT	Discovery agent	N.A.	Investigative	[24]
N-(4-Sulfamoyl-phenyl)-butyramide	DM3FW9Q	Discovery agent	N.A.	Investigative	[24]
N-(4-Sulfamoyl-phenyl)-isobutyramide	DMJCXYQ	Discovery agent	N.A.	Investigative	[24]
N-(4-Sulfamoyl-phenyl)-propionamide	DM7MHQD	Discovery agent	N.A.	Investigative	[24]
N-(4-sulfamoylphenylethyl)-4-sulfamoylbenzamide	DM7QX03	Discovery agent	N.A.	Investigative	[62]
N-(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamide	DMNQDLC	Discovery agent	N.A.	Investigative	[63]
N-(5-Mercapto-[1,3,4]thiadiazol-2-yl)-acetamide	DMSQEXP	Discovery agent	N.A.	Investigative	[50]
N-(5-phenyl-1,3,4-thiadiazol-2-yl)sulfamide	DMA21WB	Discovery agent	N.A.	Investigative	[63]
N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)sulfamide	DM5E7OC	Discovery agent	N.A.	Investigative	[63]
N-(pentafluorophenyl)sulfamide	DME45J8	Discovery agent	N.A.	Investigative	[61]
N-(phosphonacetyl)-L-aspartate	DMGHQJ8	Discovery agent	N.A.	Investigative	[64]
N-1,3,4-thiadiazol-2-ylsulfamide	DMJ10WH	Discovery agent	N.A.	Investigative	[63]
N-Benzyl-4-Sulfamoyl-Benzamide	DMCIJU0	Discovery agent	N.A.	Investigative	[18]
N-hydroxysulfamide	DMTDBMU	Discovery agent	N.A.	Investigative	[65]
N-hydroxysulfonamides	DMJBC03	Discovery agent	N.A.	Investigative	[66]
N-propynyl amidebenzenesulphonide	DMWTPJH	Discovery agent	N.A.	Investigative	[67]
N-[(4-bromo-1-benzothien-3-yl)methyl]sulfamide	DMLTYPS	Discovery agent	N.A.	Investigative	[60]
N-[(5-chloro-1-benzothien-3-yl)methyl]sulfamide	DMYJHRV	Discovery agent	N.A.	Investigative	[60]
N-[2-(1h-Indol-5-Yl)-Butyl]-4-Sulfamoyl-Benzamide	DMM7T13	Discovery agent	N.A.	Investigative	[18]
N-[4-(trifluoromethyl)phenyl]sulfamide	DMMX65T	Discovery agent	N.A.	Investigative	[61]
N-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]sulfamide	DMSI4PE	Discovery agent	N.A.	Investigative	[63]
N-[5-(methylthio)-1,3,4-thiadiazol-2-yl]sulfamide	DMXLJGR	Discovery agent	N.A.	Investigative	[63]
N-{2-[4-(AMINOSULFONYL)PHENYL]ETHYL}ACETAMIDE	DMX4QKU	Discovery agent	N.A.	Investigative	[4]
NITRATE	DMVFB93	Discovery agent	N.A.	Investigative	[15]
NSC-654077	DMW3QAK	Discovery agent	N.A.	Investigative	[68]
Octane-1,8-diyl disulfamate	DMBQMGH	Discovery agent	N.A.	Investigative	[58]
Octyl sulfamate	DM40ZCA	Discovery agent	N.A.	Investigative	[58]
P-Coumaric Acid	DMGJSVD	Discovery agent	N.A.	Investigative	[12]
P-toluenesulfonamide	DMPEKTO	Discovery agent	N.A.	Investigative	[26]
P-tolylboronic acid	DM8MZF4	Discovery agent	N.A.	Investigative	[39]
PARAOXON	DMN4ZKC	Discovery agent	N.A.	Investigative	[49]
Pentane-1,5-diamine	DMVPZG9	Discovery agent	N.A.	Investigative	[69]
Pentanoic acid (4-sulfamoyl-phenyl)-amide	DMAZ07T	Discovery agent	N.A.	Investigative	[24]
Phenethylboronic acid	DMPDVG2	Discovery agent	N.A.	Investigative	[39]
Phenoxyarsonous acid	DMZJO5V	Discovery agent	N.A.	Investigative	[15]
Phenyl Boronic acid	DMFZH49	Discovery agent	N.A.	Investigative	[15]
Phenyl-phosphonic acid	DMYMNBL	Discovery agent	N.A.	Investigative	[64]
PHENYLDIFLUOROMETHANESULFONAMIDE	DME75VC	Discovery agent	N.A.	Investigative	[17]
PHENYLMETHANESULFONAMIDE	DMGLDFI	Discovery agent	N.A.	Investigative	[17]
PHENYLSULFAMATE	DMRLFJV	Discovery agent	N.A.	Investigative	[16]
PHENYLSULFAMIDE	DMRTHW1	Discovery agent	N.A.	Investigative	[16]
PRONTOCIL	DMIUV25	Discovery agent	N.A.	Investigative	[34]
Prop-2-ynyl 4-sulfamoylbenzoate	DM8O41M	Discovery agent	N.A.	Investigative	[67]
Quinoline-8-sulfonamide	DMTPFLU	Discovery agent	N.A.	Investigative	[20]
RESORCINOL	DMM37C0	Discovery agent	N.A.	Investigative	[7]
SACCHARIN	DMRA736	Discovery agent	N.A.	Investigative	[42]
Sodium 2,3,5,6-tetrafluorobenzoate	DMSRM49	Discovery agent	N.A.	Investigative	[70]
SODIUM PERFLUOROHEXANESULFONAMIDE	DMESHV2	Discovery agent	N.A.	Investigative	[71]
Sodium trithiocarbonate	DM6WYGC	Discovery agent	N.A.	Investigative	[72]
SULFAMATE	DMF1589	Discovery agent	N.A.	Investigative	[15]
Sulfamic acid 12-sulfamoyloxy-dodecyl ester	DM9XNSK	Discovery agent	N.A.	Investigative	[73]
Sulfamic acid 16-sulfamoyloxy-hexadecyl ester	DM7VBSY	Discovery agent	N.A.	Investigative	[73]
Sulfamic acid 3-sulfamoyloxy-phenyl ester	DMA0MEV	Discovery agent	N.A.	Investigative	[73]
Sulfamic acid 4-sulfamoyloxy-butyl ester	DMQZGNJ	Discovery agent	N.A.	Investigative	[73]
Sulfamic acid 4-sulfamoyloxymethyl-benzyl ester	DMFJR0S	Discovery agent	N.A.	Investigative	[73]
Sulfamic acid 6-sulfamoyloxy-hexyl ester	DMT3U2D	Discovery agent	N.A.	Investigative	[73]
Sulfamic acid 7-sulfamoyloxy-heptyl ester	DMVWEN3	Discovery agent	N.A.	Investigative	[73]
Sulfamic acid benzo[1,3]dioxol-2-ylmethyl ester	DMFVQYI	Discovery agent	N.A.	Investigative	[74]
Sulfamic acid chroman-2-ylmethyl ester	DMN0Q71	Discovery agent	N.A.	Investigative	[74]
Syringic Acid	DM802V7	Discovery agent	N.A.	Investigative	[12]
Thioureido sulfonamide	DM8WYEM	Discovery agent	N.A.	Investigative	[75]
Trecadrine	DMDX0VI	Discovery agent	N.A.	Investigative	[76]
------------------------------------------------------------------------------------


⏷ Show the Full List of 259 Investigative Drug(s)

References

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2	Localization of diuretic effects along the loop of Henle: an in vivo microperfusion study in rats. Clin Sci (Lond). 2000 Apr;98(4):481-8.
3	Selective effect of thiazides on the human osteoblast-like cell line MG-63. Kidney Int. 1996 Nov;50(5):1476-82.
4	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
5	Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides. Bioorg Med Chem. 2009 Jul 15;17(14):5054-8.
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7	Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg Med Chem. 2008 Aug 1;16(15):7424-8.
8	Sulfonamide linked neoglycoconjugates--a new class of inhibitors for cancer-associated carbonic anhydrases. J Med Chem. 2010 Apr 8;53(7):2913-26.
9	Understanding the Dual Inhibition of COX-2 and Carbonic Anhydrase-II by Celecoxib and CG100649 Using Density Functional Theory Calculations and other Molecular Modelling Approaches. Protein Pept Lett. 2015;22(10):903-12.
10	Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3.
11	Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols. Bioorg Med Chem. 2009 Apr 15;17(8):3207-11.
12	Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164.
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