Details of the Drug Combination

General Information of Drug Combination (ID: DCR5LXX)

Drug Combination Name
Carvedilol Metoprolol
Indication
Disease Entry Status REF
Pulmonary Disease, Chronic Obstructive Phase 4 [1]
Component Drugs Carvedilol   DMHTEAO Metoprolol   DMOJ0V6
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Carvedilol
Disease Entry ICD 11 Status REF
Chronic heart failure BD1Z Approved [2]
Congestive heart failure BD10 Approved [3]
Pulmonary hypertension BB01 Approved [2]
Coronavirus Disease 2019 (COVID-19) 1D6Y Investigative [4]
Carvedilol Interacts with 3 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
HUAMN alpha-1 adrenergic receptor (ADRA1) TTDBOI7 ADA1A_HUMAN; ADA1B_HUMAN; ADA1D_HUMAN Inhibitor [8]
Adrenergic receptor Alpha-1 (ADRA1) TTG28O6 NOUNIPROTAC Antagonist [9]
HUMAN beta adrenergic receptor (BAR) TTJB8UY ADRB1_HUMAN; ADRB2_HUMAN; ADRB3_HUMAN Antagonist [4]
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Carvedilol Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [10]
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Carvedilol Interacts with 7 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [11]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Metabolism [12]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Metabolism [13]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Metabolism [14]
Cytochrome P450 2E1 (CYP2E1) DEVDYN7 CP2E1_HUMAN Metabolism [15]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [16]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DEB3CV1 UD2B7_HUMAN Metabolism [13]
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⏷ Show the Full List of 7 DME(s)
Carvedilol Interacts with 28 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 2D6 (CYP2D6) OTZJC802 CP2D6_HUMAN Affects Glucuronidation [17]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Increases Transport [18]
Beta-1 adrenergic receptor (ADRB1) OTQBWN4U ADRB1_HUMAN Increases Activity [19]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Increases Phosphorylation [20]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Increases Phosphorylation [21]
Potassium channel subfamily K member 3 (KCNK3) OTWMAV6G KCNK3_HUMAN Decreases Activity [22]
Renin (REN) OT52GZR2 RENI_HUMAN Decreases Expression [23]
Angiotensinogen (AGT) OTBZLYR3 ANGT_HUMAN Decreases Expression [24]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Decreases Expression [25]
Natriuretic peptides A (NPPA) OTMQNTNX ANF_HUMAN Decreases Expression [26]
Vasopressin-neurophysin 2-copeptin (AVP) OTAVZ76K NEU2_HUMAN Decreases Expression [27]
Insulin (INS) OTZ85PDU INS_HUMAN Decreases Expression [28]
C-reactive protein (CRP) OT0RFT8F CRP_HUMAN Decreases Expression [29]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Decreases Activity [30]
Endothelin-1 (EDN1) OTZCACEG EDN1_HUMAN Decreases Expression [31]
Beta-2 adrenergic receptor (ADRB2) OTSDOX4Q ADRB2_HUMAN Increases Phosphorylation [20]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Increases Expression [25]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Affects Activity [32]
Natriuretic peptides B (NPPB) OTSN2IPY ANFB_HUMAN Decreases Expression [33]
Gap junction alpha-1 protein (GJA1) OTT94MKL CXA1_HUMAN Increases Expression [34]
Interleukin-10 (IL10) OTIRFRXC IL10_HUMAN Increases Expression [35]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Increases Phosphorylation [20]
Potassium voltage-gated channel subfamily H member 2 (KCNH2) OTZX881H KCNH2_HUMAN Decreases Activity [36]
Adiponectin (ADIPOQ) OTNX23LE ADIPO_HUMAN Decreases Expression [33]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Decreases Activity [30]
Ryanodine receptor 2 (RYR2) OT0PF19E RYR2_HUMAN Increases Activity [37]
Vascular endothelial growth factor receptor 2 (KDR) OT15797V VGFR2_HUMAN Increases ADR [38]
Proto-oncogene tyrosine-protein kinase Src (SRC) OTETYX40 SRC_HUMAN Increases ADR [38]
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⏷ Show the Full List of 28 DOT(s)
Indication(s) of Metoprolol
Disease Entry ICD 11 Status REF
Acute coronary syndrome BA41 Approved [5]
Angina pectoris BA40 Approved [5]
Cardiac arrest MC82 Approved [5]
Chronic heart failure BD1Z Approved [5]
Hypertension BA00-BA04 Approved [6]
Malignant essential hypertension BA00 Approved [5]
Myocardial infarction BA41-BA43 Approved [5]
Obesity 5B81 Approved [5]
Ventricular fibrillation BC71.1 Approved [5]
Metoprolol Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Adrenergic receptor beta-1 (ADRB1) TTR6W5O ADRB1_HUMAN Antagonist [40]
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Metoprolol Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Peptide transporter 1 (SLC15A1) DT9G7XN S15A1_HUMAN Substrate [41]
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Metoprolol Interacts with 3 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [42]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Metabolism [43]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Metabolism [44]
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Metoprolol Interacts with 15 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Increases Hydroxylation [45]
Interleukin-1 alpha (IL1A) OTPSGILV IL1A_HUMAN Increases Expression [46]
72 kDa type IV collagenase (MMP2) OT5NIWA2 MMP2_HUMAN Decreases Expression [39]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Decreases Expression [39]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Decreases Expression [39]
Renin (REN) OT52GZR2 RENI_HUMAN Decreases Expression [23]
Collagen alpha-1(III) chain (COL3A1) OTT1EMLM CO3A1_HUMAN Increases Expression [47]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Cleavage [48]
Endothelin-converting enzyme 1 (ECE1) OTPFHC6F ECE1_HUMAN Decreases Expression [49]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Increases Cleavage [48]
Potassium voltage-gated channel subfamily H member 2 (KCNH2) OTZX881H KCNH2_HUMAN Decreases Activity [50]
Ryanodine receptor 2 (RYR2) OT0PF19E RYR2_HUMAN Increases Activity [37]
Angiotensin-converting enzyme (ACE) OTDF1964 ACE_HUMAN Affects Response To Substance [51]
Beta-2 adrenergic receptor (ADRB2) OTSDOX4Q ADRB2_HUMAN Affects Response To Substance [52]
G protein-coupled receptor kinase 4 (GRK4) OTUU8V2S GRK4_HUMAN Affects Response To Substance [53]
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⏷ Show the Full List of 15 DOT(s)

References

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2 Carvedilol FDA Label
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