Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1DEYU)

Drug Name

JWH-133 Drug Info

Synonyms

JWH-133; 259869-55-1; JWH 133; JWH133; CHEMBL371214; (6AR,10AR)-3-(1,1-DIMETHYLBUTYL)-6A,7,10,10A-TETRAHYDRO-6,6,9-TRIMETHYL-6H-DIBENZO[B,D]PYRAN; JW-133/JW133; (6aR,10aR)-6,6,9-trimethyl-3-(2-methylpentan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromene; (6aR,10aR)-6,6,9-trimethyl-3-(2-methylpentan-2-yl)-6a,7,10,10a-tetrahydro-6H-benzo[c]chromene; (6aR,10aR)-6,6,9-Trimethyl-3-(2-methyl-2-pentanyl)-6a,7,10,10a-tetrahydro-6H-benzo[c]chromene; YSBFLLZNALVODA-RBUKOAKNSA-N; JW 133; AC1OCFIJ

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 6918505
ChEBI ID: CHEBI:146243
CAS Number: CAS 259869-55-1
TTD Drug ID: DM1DEYU

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Cannabinoid receptor 2 (CB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Guanfacine extended release	DMB1CZ8	Attention deficit hyperactivity disorder	6A05.Z	Approved	[6]
NABILONE	DMVRYT2	Insomnia	7A00-7A0Z	Approved	[7]
GW-42004	DMY3KSU	Lipid metabolism disorder	5C52.Z	Phase 2	[8]
KHK-6188	DMF6CTI	Neuropathic pain	8E43.0	Phase 2	[9]
LY-2828360	DMO8IEZ	Pain	MG30-MG3Z	Phase 2	[9]
APD371	DM3XT5V	Crohn disease	DD70	Phase 2	[10]
S-777469	DMZGNOJ	Atopic dermatitis	EA80	Phase 2	[11]
842166X	DMOV0AP	Pain	MG30-MG3Z	Phase 2	[12]
Beta-caryophyllene	DM7583A	Pain	MG30-MG3Z	Phase 2	[13]
Vicasinabin	DMF16CU	Diabetic retinopathy	9B71.0	Phase 2	[14]
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Drug(s) Targeting Cannabinoid receptor 1 (CB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[15]
NABILONE	DMVRYT2	Insomnia	7A00-7A0Z	Approved	[7]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[16]
SR141716A	DMCO5JZ	Obesity	5B81	Approved	[17]
Tebipenem	DMVSX6O	Urinary tract infection	GC08	Phase 3	[18]
Conatumumab	DM2UOSN	Colorectal cancer	2B91.Z	Phase 2	[19]
GW-42004	DMY3KSU	Lipid metabolism disorder	5C52.Z	Phase 2	[8]
SR-147778	DMNAECP	Obesity	5B81	Phase 2	[20]
Nimacimab	DM21Z68	Diabetic nephropathy	GB61.Z	Phase 2	[21]
AEF0117	DMQ1GH4	Marijuana use disorder	6C41	Phase 2	[22]
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Drug(s) Affected By Claudin-5 (CLDN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[23]
Guanfacine extended release	DMB1CZ8	Attention deficit hyperactivity disorder	6A05.Z	Approved	[24]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[25]
Glycine	DMIOZ29	Allergic rhinitis	CA08.0	Approved	[26]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[27]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[28]
CS-600G	DM1PV4Y	N. A.	N. A.	Phase 3	[29]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
LY294002	DMY1AFS	Neuroblastoma	2D11.2	Phase 1	[31]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[26]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[32]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[33]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[34]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[35]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[36]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[37]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[38]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[39]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[40]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[42]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[33]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[43]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[44]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[45]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[32]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[46]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[35]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[36]
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Drug(s) Affected By Occludin (OCLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[52]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[53]
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[54]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[57]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cannabinoid receptor 1 (CB1)	TT6OEDT	CNR1_HUMAN	Inhibitor	[2]
Cannabinoid receptor 2 (CB2)	TTMSFAW	CNR2_HUMAN	Inhibitor	[3]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Claudin-5 (CLDN5)	OTUX60YO	CLD5_HUMAN	Gene/Protein Processing	[4]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Post-Translational Modifications	[5]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Post-Translational Modifications	[5]
Occludin (OCLN)	OTSUTVWL	OCLN_HUMAN	Gene/Protein Processing	[4]

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References

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