Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1LGKP)

Drug Name
Mevastatin Drug Info
Synonyms
Mevastatin; compactin; 73573-88-3; ML-236B; Mevastatinum; Mevastatine; Mevastatina; Mevastatinum [INN-Latin]; Antibiotic ML 236B; Mevastatin [INN]; CS 500; Compactin (penicillium); Mevastatine [INN-French]; UNII-1UQM1K0W9X; ML 236 B; Mevastatina [INN-Spanish]; CCRIS 4505; 1UQM1K0W9X; CHEMBL54440; CHEBI:34848; [(1S,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate; Mevastatin (Compactin); ML236B
Cross-matching ID
PubChem CID
64715
ChEBI ID
CHEBI:34848
CAS Number
CAS 73573-88-3
TTD Drug ID
DM1LGKP
INTEDE Drug ID
DR2217

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Metabolized By Cytochrome P450 105D7 (cyp105)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Diclofenac DMPIHLS Osteoarthritis FA00-FA05 Approved [2]
Naringenin DMHAZLM N. A. N. A. Phase 1 [2]
Q-27137207 DML5KMT Discovery agent N.A. Investigative [2] , [3]
Drug(s) Targeting HMG-CoA reductase (HMGCR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pravastatin DM6A0X7 Hypercholesterolaemia 5C80.0 Approved [4]
Atorvastatin DMF28YC Cardiovascular disease BA00-BE2Z Approved [5]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [6]
Pitavastatin calcium DM1UJO0 Dyslipidemia 5C80-5C81 Approved [7]
Rosuvastatin DMMIQ7G Hypercholesterolaemia 5C80.0 Approved [8]
Fluvastatin DM4MDJY Hypercholesterolaemia 5C80.0 Approved [5]
Aspirin DM672AH Myocardial infarction BA41-BA43 Approved [9]
Simvastatin DM30SGU Hypercholesterolaemia 5C80.0 Approved [5]
Lovastatin DM9OZWQ Hypercholesterolaemia 5C80.0 Approved [10]
Teriflunomide DMQ2FKJ Hyperlipidaemia 5C80 Approved [9]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
HMG-CoA reductase (HMGCR) TTPADOQ HMDH_HUMAN Antagonist [1]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 105D7 (cyp105) Main DME DECV2ME CYP28_STRAW Substrate [2] , [3]

References

1 Regulation of CYP2B6 and CYP3A expression by hydroxymethylglutaryl coenzyme A inhibitors in primary cultured human hepatocytes. Drug Metab Dispos. 2002 Dec;30(12):1400-5.
2 The metagenome of Caracolus marginella gut microbiome using culture independent approaches and shotgun sequencing. Data Brief. 2017 Nov 22;16:501-505.
3 Hydroxylation of Compactin (ML-236B) by CYP105D7 (SAV_7469) from Streptomyces avermitilis. J Microbiol Biotechnol. 2017 May 28;27(5):956-964.
4 A randomized, double-blind trial comparing the efficacy and safety of pitavastatin versus pravastatin in patients with primary hypercholesterolemia. Atherosclerosis. 2002 Jun;162(2):373-9.
5 Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Biopharm Drug Dispos. 2000 Dec;21(9):353-64.
6 Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127.
7 Cholesterol-lowering effect of NK-104, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, in guinea pig model of hyperlipidemia. Arzneimittelforschung. 2001;51(3):197-203.
8 New dimension of statin action on ApoB atherogenicity. Clin Cardiol. 2003 Jan;26(1 Suppl 1):I7-10.
9 Emerging drugs in peripheral arterial disease. Expert Opin Emerg Drugs. 2006 Mar;11(1):75-90.
10 Microarray and biochemical analysis of lovastatin-induced apoptosis of squamous cell carcinomas. Neoplasia. 2002 Jul-Aug;4(4):337-46.