Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1N62C)

Drug Name

Quetiapine Drug Info

Synonyms

quetiapine; 111974-69-7; Quetiapine [INN:BAN]; UNII-BGL0JSY5SI; BGL0JSY5SI; CHEMBL716; 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol; CHEBI:8707; C21H25N3O2S; URKOMYMAXPYINW-UHFFFAOYSA-N; 2-(2-(4-Dibenzo(b,f)(1,4)thiazepin-11-yl-1-piperazinyl)ethoxy)ethanol; Ethanol, 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]-; NCGC00095911-03; Co-Quetiapine; Norsic; Quetiapina; Quetiapinum; Quetiapine hemifumarate; Ketipinor (TN); Norsic (TN); Quetiapine (INN); Seroquel (Fumarate); Seroquel (TN); 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-ylpiperazin-1-yl)ethoxy]ethanol; 2-{[2-(4-dibenzo[b,f][1,4]thiazepin-11-ylpiperazin-1-yl)ethyl]oxy}ethanol; PD-172760

Indication

Disease Entry	ICD 11	Status	REF
Schizophrenia	6A20	Approved	[1] , [2] , [3]
Alcohol dependence	6C40.2	Phase 3	[4]

Therapeutic Class

Antipsychotic Agents

Cross-matching ID

PubChem CID: 5002
ChEBI ID: CHEBI:8707
CAS Number: CAS 111974-69-7
TTD Drug ID: DM1N62C
VARIDT Drug ID: DR00855
INTEDE Drug ID: DR1376
ACDINA Drug ID: D00575

Molecule-Related Drug Atlas

Molecule Type:

DTT

DTP

DME

Drug Status:

Approved Drug(s)

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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Solid tumour/cancer	2A00-2F9Z	Approved	[12]
Progesterone	DMUY35B	Premature labour	JB00	Approved	[13]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[14]
Estradiol	DMUNTE3	Breast cancer	2C60-2C65	Approved	[15]
Acetaminophen	DMUIE76	Pain	MG30-MG3Z	Approved	[16]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[17]
Etoposide	DMNH3PG	Solid tumour/cancer	2A00-2F9Z	Approved	[18]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[19]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[13]
Verapamil	DMA7PEW	Hypertension	BA00-BA04	Approved	[20]
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Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Solid tumour/cancer	2A00-2F9Z	Approved	[21]
Progesterone	DMUY35B	Premature labour	JB00	Approved	[22]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[23]
Acetaminophen	DMUIE76	Pain	MG30-MG3Z	Approved	[16]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[20]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[24]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[25]
Dopamine	DMPGUCF	Parkinson disease	8A00.0	Approved	[26]
Nicotine	DMWX5CO	Nicotine dependence	6C4A.2	Approved	[27]
Propranolol	DM79NTF	Migraine	8A80	Approved	[28]
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Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Solid tumour/cancer	2A00-2F9Z	Approved	[29]
Progesterone	DMUY35B	Premature labour	JB00	Approved	[30]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[31]
Estradiol	DMUNTE3	Breast cancer	2C60-2C65	Approved	[32]
Acetaminophen	DMUIE76	Pain	MG30-MG3Z	Approved	[33]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[34]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[35]
Etoposide	DMNH3PG	Solid tumour/cancer	2A00-2F9Z	Approved	[36]
Verapamil	DMA7PEW	Hypertension	BA00-BA04	Approved	[37]
Sorafenib	DMS8IFC	Hepatocellular carcinoma	2C12.02	Approved	[32]
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Drug(s) Metabolized By Cytochrome P450 3A7 (CYP3A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Premature labour	JB00	Approved	[38]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[32]
Estradiol	DMUNTE3	Breast cancer	2C60-2C65	Approved	[32]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[39]
Verapamil	DMA7PEW	Hypertension	BA00-BA04	Approved	[40]
Sorafenib	DMS8IFC	Hepatocellular carcinoma	2C12.02	Approved	[32]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[32]
Irinotecan	DMP6SC2	Colorectal cancer	2B91.Z	Approved	[32]
Metronidazole	DMTIVEN	Amoebiasis	1A36	Approved	[41]
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Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Bacterial infection	1A00-1C4Z	Approved	[42]
Progesterone	DMUY35B	Premature labour	JB00	Approved	[43]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[44]
Estradiol	DMUNTE3	Breast cancer	2C60-2C65	Approved	[45]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[39]
Verapamil	DMA7PEW	Hypertension	BA00-BA04	Approved	[46]
Diclofenac	DMPIHLS	Osteoarthritis	FA00-FA05	Approved	[47]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[49]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[50]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Bacterial infection	1A00-1C4Z	Approved	[51]
Doxorubicin	DMVP5YE	Solid tumour/cancer	2A00-2F9Z	Approved	[52]
Methotrexate	DM2TEOL	leukaemia	2A60-2B33	Approved	[53]
Folic acid	DMEMBJC	Folate-deficiency anemia	3A02.Y	Approved	[54]
Fluorouracil	DMUM7HZ	Solid tumour/cancer	2A00-2F9Z	Approved	[53]
Cisplatin	DMRHGI9	Solid tumour/cancer	2A00-2F9Z	Approved	[53]
Progesterone	DMUY35B	Premature labour	JB00	Approved	[55]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[53]
Estradiol	DMUNTE3	Breast cancer	2C60-2C65	Approved	[56]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[57]
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Drug(s) Targeting Dopamine D2 receptor (D2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dopamine	DMPGUCF	Parkinson disease	8A00.0	Approved	[58]
Haloperidol	DM96SE0	Schizophrenia	6A20	Approved	[59]
Perphenazine	DMA4MRX	Schizophrenia	6A20	Approved	[60]
Perazine	DM2AOTZ	Psychotic disorder	6A20-6A25	Approved	[61]
Domperidone	DMBDPY0	Gastrointestinal disease	DE2Z	Approved	[62]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[63]
Pimozide	DMW83TP	Schizophrenia	6A20	Approved	[64]
Chlorpromazine	DMBGZI3	Schizophrenia	6A20	Approved	[65]
Iloperidone	DM6AUFY	Schizophrenia	6A20	Approved	[66]
Risperidone	DMN6DXL	Schizophrenia	6A20	Approved	[67]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine D2 receptor (D2R)	TTEX248	DRD2_HUMAN	Agonist	[5] , [6] , [1]

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Solute carrier family 22 member 23 (SLC22A23)	DTMJK12	S22AN_HUMAN	Substrate	[7]
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[8]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[9]
Cytochrome P450 2D6 (CYP2D6)^{Main DME}	DECB0K3	CP2D6_HUMAN	Substrate	[10]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Substrate	[10]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Substrate	[11]
Cytochrome P450 3A7 (CYP3A7)	DERD86B	CP3A7_HUMAN	Substrate	[10]

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