Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1RMF5)

• Drug Name: Acadesine Drug Info
• Synonyms: AICAR; Acadra; ADV-P1; ATH-001; Acadesine (intravenous formulation, leukemia); Acadesine (intravenous formulation, leukemia), Advanced In Vitro Cell Technologies

Indication

Disease Entry	ICD 11	Status	REF
Diabetic complication	5A2Y	Phase 3	[1] , [2]

• Cross-matching ID:
  PubChem CID: 17513
  ChEBI ID: CHEBI:28498
  CAS Number: CAS 2627-69-2
  TTD Drug ID: DM1RMF5

Molecule-Related Drug Atlas

Drug(s) Targeting AMP-activated protein kinase (AMPK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MB-11055	DM3RBJW	Fatty liver disease	DB92.Z	Phase 2	[3]
Imeglimin	DMMQFG2	Diabetic complication	5A2Y	Phase 2	[4]
PXL-770	DMNSRY7	Non-alcoholic fatty liver disease	DB92	Phase 2	[5]
ENERGI-F701	DMMIHSO	Alopecia	ED70	Phase 2	[6]
O-304	DMXM34I	Type 2 diabetes	5A11	Phase 2	[7]
IM156	DM4MY9C	Solid tumour/cancer	2A00-2F9Z	Phase 1	[8]
Phenformin	DMQ52JG	Diabetic complication	5A2Y	Withdrawn from market	[9]
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole	DMN9YOB	Discovery agent	N.A.	Investigative	[10]
PMID23639540C13a	DMLXOAQ	Discovery agent	N.A.	Investigative	[11]
SU 6656	DMF1P6W	Discovery agent	N.A.	Investigative	[12]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
AMP-activated protein kinase (AMPK)	TTLAFZV	AAPK1_HUMAN; AAKB1_HUMAN; AAKG1_HUMAN	Modulator	[2]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5133).
• [2] Acadesine, an adenosine-regulating agent with the potential for widespread indications. Expert Opin Pharmacother. 2008 Aug;9(12):2137-44.
• [3] Antidiabetes and antiobesity effect of cryptotanshinone via activation of AMP-activated protein kinase.Mol Pharmacol.2007 Jul;72(1):62-72.
• [4] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800032542)
• [5] Clinical pipeline report, company report or official report of Poxel SA.
• [6] Clinical pipeline report, company report or official report of Energenesis Biomedical.
• [7] Clinical pipeline report, company report or official report of Betagenon.
• [8] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [9] Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators. Biochem J. 2008 Jan 15;409(2):449-59.
• [10] Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole. J Med Chem. 2004 Dec 2;47(25):6239-47.
• [11] Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52.
• [12] The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315.