Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCP2KH)

Drug Name
HE2100 Drug Info
Synonyms
Androstenediol; Hermaphrodiol; 5-Androstenediol; Androst-5-enediol; 521-17-5; Androst-5-ene-3beta,17beta-diol; Neumune; 3beta,17beta-Dihydroxyandrost-5-ene; delta(sup 5)-Androstenediol; Androstenediol [JAN]; UNII-95PS51EMXY; Androst-5-enediol (VAN); (3beta,17beta)-androst-5-ene-3,17-diol; 5-AED; 3beta,17beta-Dihydroxy-5-androstene; androst-5-en-3beta,17beta-diol; EINECS 208-306-8; NSC 12163; 95PS51EMXY; ANDROST-5-ENE-3-beta,17-beta-DIOL; CHEMBL440283; CHEBI:2710; (3-beta,17-beta)-Androst-5-ene-3,17-diol; delta(sup; ANDROSTENEDIOL
Indication
Disease Entry ICD 11 Status REF
Thrombocytopenia 3B64 Discontinued in Phase 1 [1]
Cross-matching ID
PubChem CID
10634
ChEBI ID
CHEBI:2710
CAS Number
CAS 521-17-5
TTD Drug ID
DMCP2KH
INTEDE Drug ID
DR0115

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Estrogen receptor beta (ESR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Conjugated Estrogens DMLT0E1 Dyspareunia GA12 Approved [6]
Trilostane DMQZ9GF Cushing disease 5A70 Approved [7]
ARZOXIFENE DMOKCVI Breast cancer 2C60-2C65 Approved [8]
Estrogen DMGY0UT Menopause symptom GA30.0 Approved [9]
MF-101 DM8Z0I3 Hepatitis virus infection 1E50-1E51 Phase 3 [10]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [11]
AUS-131 DMUXO3Z Hot flushes GA30 Phase 2 [12]
ERB-041 DMCEPUA Inflammatory bowel disease DD72 Phase 2 [13]
Erteberel DMU1XZD Prostate hyperplasia GA90 Phase 2 [14]
VG-101 DMAN21O Menopause symptom GA30.0 Phase 1/2 [15]
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Drug(s) Targeting Estrogen receptor (ESR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [16]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [17]
Estrone DM5T6US Acne vulgaris ED80 Approved [17]
Estradiol Valerate DM8MC6O Hormone replacement therapy 8E01 Approved [7]
Estradiol Acetate DM07U2A Hormone replacement therapy 8E01 Approved [7]
Estradiol Cypionate DM27Z5T Hormone replacement therapy 8E01 Approved [7]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [18]
Raloxifene DMDKF3M Osteoporosis FB83.0 Approved [19]
Ospemifene DMC4GEI Dyspareunia GA12 Approved [20]
Toremifene DMQYUWG Breast cancer 2C60-2C65 Approved [21]
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Drug(s) Metabolized By Dihydrotestosterone oxidoreductase (HSD3B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [22]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [23]
Pregnenolone DM6VFO1 Schizophrenia 6A20 Phase 4 [24]
17alpha-hydroxypregnenolone DMT2EPG Discovery agent N.A. Investigative [24]
Drug(s) Affected By Steryl-sulfatase (STS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [25]
Tazarotene DM8SMD1 Acne vulgaris ED80 Approved [27]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [30]
Danazol DML8KTN Menorrhagia GA20.50 Approved [5]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [27]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [25]
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Drug(s) Affected By 17-beta-hydroxysteroid dehydrogenase type 2 (HSD17B2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estrone DM5T6US Acne vulgaris ED80 Approved [3]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [3]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [31]
Quercetin DM3NC4M Obesity 5B81 Approved [32]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [33]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [34]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [35]
Plicamycin DM7C8YV Hypercalcaemia 5B91.0 Approved [36]
Testosterone DM7HUNW Hot flushes GA30 Approved [37]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [38]
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Drug(s) Affected By 17-beta-hydroxysteroid dehydrogenase type 1 (HSD17B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [3]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [39]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Metyrapone DMI7FVQ Cushing disease 5A70 Approved [40]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [41]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [42]
Dutasteride DMQ4TJK Benign prostatic hyperplasia GA90 Approved [43]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [44]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [42]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [45]
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Drug(s) Affected By Peroxisomal multifunctional enzyme type 2 (HSD17B4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estrone DM5T6US Acne vulgaris ED80 Approved [3]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [3]
Methotrexate DM2TEOL Anterior urethra cancer Approved [46]
Quercetin DM3NC4M Obesity 5B81 Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [47]
Haloperidol DM96SE0 Delirium Approved [48]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [49]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [50]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [51]
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Drug(s) Affected By Dehydrogenase/reductase SDR family member 11 (DHRS11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [4]
Quercetin DM3NC4M Obesity 5B81 Approved [4]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Flufenamic Acid DMC8VNH Dysmenorrhea GA34.3 Approved [4]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [30]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [54]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [55]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Estrogen receptor (ESR) TTZAYWL ESR1_HUMAN Inhibitor [2]
Estrogen receptor beta (ESR2) TTOM3J0 ESR2_HUMAN Inhibitor [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Dihydrotestosterone oxidoreductase (HSD3B1) Main DME DERDQWN 3BHS1_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
17-beta-hydroxysteroid dehydrogenase type 1 (HSD17B1) OT6EBDHM DHB1_HUMAN Biotransformations [3]
17-beta-hydroxysteroid dehydrogenase type 2 (HSD17B2) OT3K7HY5 DHB2_HUMAN Biotransformations [3]
Dehydrogenase/reductase SDR family member 11 (DHRS11) OTU3J0ZL DHR11_HUMAN Biotransformations [4]
Peroxisomal multifunctional enzyme type 2 (HSD17B4) OT8733D7 DHB4_HUMAN Biotransformations [3]
Steryl-sulfatase (STS) OTXTJQPC STS_HUMAN Gene/Protein Processing [5]

References

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