Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMEUWB8)

Drug Name
MDA-19 Drug Info
Synonyms Cannabinoid CB2 agonist (neuropathic pain), MD Anderson Cancer Center
Indication
Disease Entry ICD 11 Status REF
Neuropathic pain 8E43.0 Investigative [1]
Cross-matching ID
PubChem CID
135743701
CAS Number
CAS 1048973-47-2
TTD Drug ID
DMEUWB8

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Cannabinoid receptor 2 (CB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Guanfacine extended release DMB1CZ8 Attention deficit hyperactivity disorder 6A05.Z Approved [4]
NABILONE DMVRYT2 Insomnia 7A00-7A0Z Approved [5]
GW-42004 DMY3KSU Lipid metabolism disorder 5C52.Z Phase 2 [6]
KHK-6188 DMF6CTI Neuropathic pain 8E43.0 Phase 2 [7]
LY-2828360 DMO8IEZ Pain MG30-MG3Z Phase 2 [7]
APD371 DM3XT5V Crohn disease DD70 Phase 2 [8]
S-777469 DMZGNOJ Atopic dermatitis EA80 Phase 2 [9]
842166X DMOV0AP Pain MG30-MG3Z Phase 2 [10]
Beta-caryophyllene DM7583A Pain MG30-MG3Z Phase 2 [11]
Vicasinabin DMF16CU Diabetic retinopathy 9B71.0 Phase 2 [12]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [13]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [14]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [15]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [16]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [17]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [18]
Verapamil DMA7PEW Angina pectoris BA40 Approved [19]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [20]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [21]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [22]
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Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [23]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [24]
Selenium DM25CGV N. A. N. A. Approved [25]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [26]
Methotrexate DM2TEOL Anterior urethra cancer Approved [27]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [28]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [29]
Quercetin DM3NC4M Obesity 5B81 Approved [30]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [31]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
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Drug(s) Affected By Cannabinoid receptor 1 (CNR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [33]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [34]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [35]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [36]
Menthol DMG2KW7 Back pain ME84.Z Approved [37]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [38]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [39]
Norepinephrine DMOUC09 Alopecia ED70 Approved [40]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [41]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [42]
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Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [43]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [44]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [22]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [45]
Gefitinib DM15F0X Colon adenocarcinoma Approved [46]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [47]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [48]
Selenium DM25CGV N. A. N. A. Approved [49]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [50]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [51]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [52]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [53]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [54]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [22]
Gefitinib DM15F0X Colon adenocarcinoma Approved [55]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [56]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [57]
Selenium DM25CGV N. A. N. A. Approved [49]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [58]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [50]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [59]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [60]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [61]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [62]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [63]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [64]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [65]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [66]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [67]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [68]
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Drug(s) Affected By Cyclin-dependent kinase 6 (CDK6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [24]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [69]
Gefitinib DM15F0X Colon adenocarcinoma Approved [70]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [71]
Methotrexate DM2TEOL Anterior urethra cancer Approved [72]
Quercetin DM3NC4M Obesity 5B81 Approved [73]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [74]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [31]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [35]
Panobinostat DM58WKG Chronic graft versus host disease Approved [75]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [13]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [68]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [18]
Verapamil DMA7PEW Angina pectoris BA40 Approved [19]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [76]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [77]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [47]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [78]
Meloxicam DM2AR7L Arthritis FA20 Approved [79]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [80]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cannabinoid receptor 2 (CB2) TTMSFAW CNR2_HUMAN Agonist [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [2]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [2]
Cannabinoid receptor 1 (CNR1) OTEALO6G CNR1_HUMAN Gene/Protein Processing [3]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [2]
Cyclin-dependent kinase 4 (CDK4) OT7EP05T CDK4_HUMAN Gene/Protein Processing [2]
Cyclin-dependent kinase 6 (CDK6) OTR95N0X CDK6_HUMAN Gene/Protein Processing [2]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Gene/Protein Processing [2]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Post-Translational Modifications [2]

References

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2 MDA19, a novel CB2 agonist, inhibits hepatocellular carcinoma partly through inactivation of AKT signaling pathway. Biol Direct. 2019 May 3;14(1):9. doi: 10.1186/s13062-019-0241-1.
3 Pharmacological characterization of a novel cannabinoid ligand, MDA19, for treatment of neuropathic pain. Anesth Analg. 2010 Jul;111(1):99-109. doi: 10.1213/ANE.0b013e3181e0cdaf. Epub 2010 Jun 3.
4 Posttraining activation of CB1 cannabinoid receptors in the CA1 region of the dorsal hippocampus impairs object recognition long-term memory. Neurobiol Learn Mem. 2008 Sep;90(2):374-81.
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6 Company report (Gwpharm)
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38 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
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69 Fulvestrant induces resistance by modulating GPER and CDK6 expression: implication of methyltransferases, deacetylases and the hSWI/SNF chromatin remodelling complex. Br J Cancer. 2013 Nov 12;109(10):2751-62. doi: 10.1038/bjc.2013.583. Epub 2013 Oct 29.
70 Effects and mechanisms of betulinic acid on improving EGFR TKI-resistance of lung cancer cells. Environ Toxicol. 2018 Nov;33(11):1153-1159.
71 Sulindac induces specific degradation of the HPV oncoprotein E7 and causes growth arrest and apoptosis in cervical carcinoma cells. Cancer Lett. 2007 Jan 8;245(1-2):103-11. doi: 10.1016/j.canlet.2005.12.034. Epub 2006 Feb 20.
72 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
73 Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells. Biol Pharm Bull. 2013;36(6):944-51. doi: 10.1248/bpb.b12-01004.
74 Involvement of the p38 MAPK signaling pathway in S-phase cell-cycle arrest induced by Furazolidone in human hepatoma G2 cells. J Appl Toxicol. 2013 Dec;33(12):1500-5. doi: 10.1002/jat.2829. Epub 2012 Oct 30.
75 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
76 Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
77 Effects of gonadotrophin-releasing hormone agonists on apoptosis of granulosa cells. Ann N Y Acad Sci. 2005 May;1042:531-7. doi: 10.1196/annals.1338.065.
78 Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
79 Combining kallistatin gene therapy and meloxicam to treat hepatocellular carcinoma in mice. Cancer Sci. 2009 Nov;100(11):2226-33. doi: 10.1111/j.1349-7006.2009.01306.x. Epub 2009 Aug 4.
80 Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line. Clin Cancer Res. 2000 Mar;6(3):891-900.