Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGP8AX)

Drug Name
Thiopental Drug Info
Synonyms
Intraval; Penthiobarbital; Pentothiobarbital; Thiomebumal; Thionembutal; Thiopentobarbital; Thiopentobarbitone; Thiopentone; Thiothal; Tiopentale; Trapanal; Thiopental [BAN]; Thiopental solution; Thiopentobarbituric acid; Tiopentale [Italian]; Sodium Pentothal (TN); Thiopental (TN); Thiopentone sodium (TN); Trapanal (TN); (+-)-Thiopental; (+/-)-THIOPENTAL; (+/-)-Thiopental solution; 2-Thio-5-ethyl-5-sec-pentylbarbituric acid; 4,6,(1H,5H)-Pyrimidinedione, 5-ethyldihydro-5-(1-methylbutyl)-2-thioxo-(9CI); 5-Ethyl-5-(1-methyl-butyl)-2-thioxo-dihydro-pyrimidine-4,6-dione; 5-Ethyl-5-(1-methylbutyl)-2-thiobarbituric acid; 5-ethyl-2-mercapto-5-(1-methylbutyl)pyrimidine-4,6(1H,5H)-dione; 5-ethyl-5-(1-methylbutyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione; 5-ethyl-5-pentan-2-yl-2-sulfanylidene-1,3-diazinane-4,6-dione
Indication
Disease Entry ICD 11 Status REF
Anaesthesia 9A78.6 Approved [1]
Epilepsy 8A60-8A68 Approved [2]
Pseudotumor cerebri Approved [2]
Therapeutic Class
Hypnotics and Sedatives
Cross-matching ID
PubChem CID
3000715
ChEBI ID
CHEBI:102166
CAS Number
CAS 76-75-5
TTD Drug ID
DMGP8AX
INTEDE Drug ID
DR1580

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Fatty acid amide hydrolase (FAAH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [10]
JNJ-42165279 DM72GZO Anxiety disorder 6B00-6B0Z Phase 2 [11]
SSR411298 DMGTB2Q Major depressive disorder 6A70.3 Phase 2 [12]
IW-6118 DMP42W1 Inflammation 1A00-CA43.1 Phase 2 [13]
PF-04457845 DMPRYU1 Liver disease DB90-BD99 Phase 2 [14]
IPI-940 DMEIM5G Pain MG30-MG3Z Phase 1 [15]
PMID29053063-Compound-11d DMDRK68 N. A. N. A. Patented [16]
Piperazine carbamic compound 1 DMZSYU4 N. A. N. A. Patented [16]
Piperazine carbamic compound 2 DMMQ0ZO N. A. N. A. Patented [16]
Pyrazole derivative 82 DMETCI3 N. A. N. A. Patented [16]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [17]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [18]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [19]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [20]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [21]
Verapamil DMA7PEW Angina pectoris BA40 Approved [22]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [23]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [24]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [25]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [26]
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Drug(s) Affected By Angiotensinogen (AGT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [27]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [28]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [29]
Reboxetine DM26PRD Depression 6A70-6A7Z Approved [30]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [31]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [32]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [33]
Quercetin DM3NC4M Obesity 5B81 Approved [34]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [35]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [36]
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Drug(s) Affected By Interleukin-2 receptor subunit alpha (IL2RA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [37]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [38]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [39]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [40]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [41]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [42]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [8]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [43]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [44]
Folic Acid DMEMBJC Colorectal carcinoma Approved [45]
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Drug(s) Affected By Heat shock protein beta-1 (HSPB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [46]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Selenium DM25CGV N. A. N. A. Approved [48]
Methotrexate DM2TEOL Anterior urethra cancer Approved [49]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [50]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [51]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [52]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [53]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [54]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [55]
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Drug(s) Affected By Heat shock protein HSP 90-alpha (HSP90AA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [57]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [58]
Gefitinib DM15F0X Colon adenocarcinoma Approved [59]
Selenium DM25CGV N. A. N. A. Approved [48]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [60]
Quercetin DM3NC4M Obesity 5B81 Approved [61]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [62]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [63]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [44]
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Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fructose DM43AN2 Vomiting MD90 Approved [64]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [65]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [57]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [66]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [67]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [68]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [69]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [70]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [71]
Quercetin DM3NC4M Obesity 5B81 Approved [34]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [72]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [73]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [74]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [75]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [76]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [77]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [78]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [79]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [80]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [65]
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Drug(s) Affected By Heat shock factor protein 1 (HSF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [81]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [82]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [82]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [83]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [60]
Ceftazidime DM41GRA Bacteremia 1A73 Approved [82]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Chlorpheniramine DM5URA2 Allergic rhinitis CA08.0 Approved [82]
Ethacrynic acid DM60QMR Edema MG29 Approved [82]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [82]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Fatty acid amide hydrolase (FAAH) TTDP1UC NOUNIPROTAC Inhibitor [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Mephenytoin 4-hydroxylase (CYP2C19) Main DME DEGTFWK CP2CJ_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Angiotensinogen (AGT) OTBZLYR3 ANGT_HUMAN Gene/Protein Processing [5]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [6]
Heat shock factor protein 1 (HSF1) OTYNJ4KP HSF1_HUMAN Gene/Protein Processing [7]
Heat shock protein beta-1 (HSPB1) OTHFZ8ED HSPB1_HUMAN Gene/Protein Processing [7]
Heat shock protein HSP 90-alpha (HSP90AA1) OTLG1WPK HS90A_HUMAN Gene/Protein Processing [7]
Interleukin-2 receptor subunit alpha (IL2RA) OT0MWCHG IL2RA_HUMAN Protein Interaction/Cellular Processes [8]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Protein Interaction/Cellular Processes [9]

References

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2 Thiopental FDA Label
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80 mRNA expression analysis of a variety of apoptosis-related genes, including the novel gene of the BCL2-family, BCL2L12, in HL-60 leukemia cells after treatment with carboplatin and doxorubicin. Biol Chem. 2004 Nov;385(11):1099-103. doi: 10.1515/BC.2004.143.
81 NRF2 transcriptionally activates the heat shock factor 1 promoter under oxidative stress and affects survival and migration potential of MCF7 cells. J Biol Chem. 2018 Dec 14;293(50):19303-19316. doi: 10.1074/jbc.RA118.003376. Epub 2018 Oct 11.
82 A Gene Expression Biomarker Predicts Heat Shock Factor 1 Activation in a Gene Expression Compendium. Chem Res Toxicol. 2021 Jul 19;34(7):1721-1737. doi: 10.1021/acs.chemrestox.0c00510. Epub 2021 Jun 25.
83 Non-steroidal anti-inflammatory drugs inhibit the expression of cytokines and induce HSP70 in human monocytes. Cytokine. 1999 May;11(5):347-58. doi: 10.1006/cyto.1998.0437.
84 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.