Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMO1URE)

Drug Name

SC-236 Drug Info

Synonyms

SC-791; SC-872; COX-2 inhibitors (anticancer), Pfizer; COX-2 inhibitors (anticancer), Pharmacia

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Terminated	[1]

Cross-matching ID

PubChem CID: 9865808
CAS Number: CAS 170569-86-5
TTD Drug ID: DMO1URE

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Prostaglandin G/H synthase 2 (COX-2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[8]
Naproxen	DMZ5RGV	Bursitis		Approved	[9]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[10]
Indomethacin	DMSC4A7	Bursitis		Approved	[11]
Celecoxib	DM6LOQU	Dysmenorrhea	GA34.3	Approved	[12]
Nabumetone	DMAT2XH	Osteoarthritis	FA00-FA05	Approved	[13]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[14]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[15]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[16]
Aminosalicylic Acid	DMENSL5	Crohn disease	DD70	Approved	[11]
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Drug(s) Affected By High affinity copper uptake protein 1 (SLC31A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[17]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[18]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[19]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[20]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
TRIENTINE	DMD2WPG	Inborn error of metabolism	5C50-5C59	Approved	[18]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[24]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[25]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[26]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[27]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[28]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[29]
Selenium	DM25CGV	N. A.	N. A.	Approved	[30]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[25]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[31]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[32]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[31]
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Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[33]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[34]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[35]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[36]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[37]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[38]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[39]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[40]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[41]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[42]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[43]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[44]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[45]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[46]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[47]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[19]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[51]
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Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[28]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[52]
Selenium	DM25CGV	N. A.	N. A.	Approved	[53]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[54]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[55]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[60]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Prostaglandin G/H synthase 2 (COX-2)	TTVKILB	PGH2_HUMAN	Inhibitor	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
14-3-3 protein epsilon	OT3WQXNA	1433E_HUMAN	Gene/Protein Processing	[3]
Baculoviral IAP repeat-containing protein 3 (BIRC3)	OT3E95KB	BIRC3_HUMAN	Gene/Protein Processing	[4]
High affinity copper uptake protein 1 (SLC31A1)	OTXLRTUB	COPT1_HUMAN	Gene/Protein Processing	[5]
Prostaglandin G/H synthase 2 (PTGS2)	OT75U9M4	PGH2_HUMAN	Gene/Protein Processing	[6]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10)	OT4PXBTA	TNF10_HUMAN	Drug Response	[7]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)	OTA1CPBV	TR10B_HUMAN	Gene/Protein Processing	[7]

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