Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMPWB8G)

Drug Name
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Drug Info
Synonyms
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MPTP; 28289-54-5; CCRIS 2186; 1,2,3,6-Tetrahydro-1-methyl-4-phenylpyridine; HSDB 6942; PYRIDINE, 1,2,3,6-TETRAHYDRO-1-METHYL-4-PHENYL-; 1-METHYL-4-PHENYL-PIPERIDINE-3-EN; UNII-9P21XSP91P; N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; NSC 139654; EINECS 248-939-7; 1-Methyl-4-phenyl-1,2,3,6-tetrahydroxpyridine; BRN 0133712; CHEMBL24172; 9P21XSP91P; 1-methyl-4-phenyl-3,6-dihydro-2H-pyridine; CHEBI:17963; 1-Methyl-4-phenyl-1,2,5,6-tetrahydropyridine; PLRACCBDVIHHLZ-UHFFFAOYSA-N
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
1388
ChEBI ID
CHEBI:17963
CAS Number
CAS 28289-54-5
TTD Drug ID
DMPWB8G

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Monoamine oxidase type B (MAO-B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selegiline Hydrochloride DM3VR1L Parkinson disease 8A00.0 Approved [7]
Phenelzine DMHIDUE Depression 6A70-6A7Z Approved [8]
Tranylcypromine DMGB5RE Major depressive disorder 6A70.3 Approved [9]
Selegiline DM6034S Major depressive disorder 6A70.3 Approved [10]
Safinamide mesylate DM0J2ZT Parkinson disease 8A00.0 Approved [11]
Rasagiline DM3WKQ4 Parkinson disease 8A00.0 Approved [12]
Sulphadoxine DMZI2UF Malaria 1F40-1F45 Approved [13]
Pargyline DMM0HR1 Hypertension BA00-BA04 Approved [14]
Indeloxazine DMWO3N6 Dementia 6D80-6D86 Approved [15]
Budipine DMODHQI Migraine 8A80 Approved [16]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [17]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [18]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [19]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [20]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [21]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [22]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [23]
Gefitinib DM15F0X Colon adenocarcinoma Approved [24]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [25]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [26]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [27]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [18]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [28]
Paclitaxel DMLB81S Breast carcinoma Approved [29]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [30]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [17]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [31]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [32]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [20]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [21]
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Drug(s) Affected By Alpha-synuclein (SNCA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [33]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [34]
Testosterone enanthate DMB6871 N. A. N. A. Approved [35]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [36]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [37]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [38]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [39]
Bortezomib DMNO38U Leukemia Approved [40]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [41]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [42]
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Drug(s) Affected By Amine oxidase B (MAOB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [43]
Methotrexate DM2TEOL Anterior urethra cancer Approved [44]
Quercetin DM3NC4M Obesity 5B81 Approved [45]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [46]
Selegiline DM6034S Major depressive disorder 6A70.3 Approved [47]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [48]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
BENZYL BENZOATE DMDPYI5 Infestations of lice and scabies 1G00.Z Approved [51]
Linezolid DMGFPU2 Bacteremia 1A73 Approved [52]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [53]
Paliperidone DM7NPJS Psychotic disorder 6A20-6A25 Approved [54]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [55]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [56]
Oxatomide DM1F42Z Hay fever CA08.00 Approved [57]
Cinacalcet DMCX0K3 Hyperparathyroidism 5A51 Approved [58]
Capsaicin DMGMF6V Back pain ME84.Z Approved [59]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [60]
Quinidine DMLPICK N. A. N. A. Approved [61]
Buprenorphine DMPRI8G Opioid dependence 6C43.2Z Approved [62]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Monoamine oxidase type B (MAO-B) TTGP7BY AOFB_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Alpha-synuclein (SNCA) OTPWC1MR SYUA_HUMAN Gene/Protein Processing [2]
Amine oxidase B (MAOB) OTTDFM1O AOFB_HUMAN Biotransformations [3]
Cytochrome P450 2D6 (CYP2D6) OTZJC802 CP2D6_HUMAN Regulation of Drug Effects [4]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [2]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [2]
Thioredoxin OT6XU6VW THIO_HUMAN Gene/Protein Processing [5]
X-box-binding protein 1 OTJYCREE XBP1_HUMAN Drug Response [6]

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