Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTOK1D)

• Drug Name: AMP-PNP Drug Info
• Synonyms: Phosphoaminophosphonic acid-adenylate ester; gamma-Imino-ATP; ADENYLYL IMIDODIPHOSPHATE; AMPPNP; Adenyl imidodiphosphate; phosphoaminophosphonic acid-adenylate ester; 25612-73-1; adenyl-5'-yl imidodiphosphate; CHEBI:47785; App(NH)p; O(5')-(1,2-dihydroxy-2-phosphonoaminodiphosphoryl)adenosine; 5'-O-(hydroxy{[hydroxy(phosphonoamino)phosphoryl]oxy}phosphoryl)adenosine; [[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]amino]phosphonic acid; p(NH)Ppf; beta,gamma-Imido-ATP; beta,gamma-Imidoadenosine; Phosphoaminophosphonic Acid-Adenylate Ester

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1] , [2]

• Cross-matching ID:
  PubChem CID: 33113
  ChEBI ID: CHEBI:47785
  CAS Number: CAS 25612-73-1
  TTD Drug ID: DMTOK1D

Molecule-Related Drug Atlas

Drug(s) Targeting Stress-activated protein kinase JNK3 (JNK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID25991433-Compound-A1	DM89LF0	N. A.	N. A.	Patented	[4]
PMID25991433-Compound-F2	DM37VIQ	N. A.	N. A.	Patented	[4]
7-azaindole derivative 1	DMQL5B7	N. A.	N. A.	Patented	[4]
7-azaindole derivative 5	DMV3H98	N. A.	N. A.	Patented	[4]
PMID25991433-Compound-P6	DMNDVC9	N. A.	N. A.	Patented	[4]
PMID25991433-Compound-J3	DM17P3F	N. A.	N. A.	Patented	[4]
PMID25991433-Compound-P1	DMD8AX6	N. A.	N. A.	Patented	[4]
PMID25991433-Compound-O3	DMVOWS5	N. A.	N. A.	Patented	[4]
PMID25991433-Compound-J2	DMZSOCK	N. A.	N. A.	Patented	[4]
7-azaindole derivative 3	DMQ7BV4	N. A.	N. A.	Patented	[4]

Drug(s) Targeting LCK tyrosine protein kinase (LCK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dasatinib	DMJV2EK	Chronic myelogenous leukaemia	2A20.0	Approved	[5]
VX-680	DM93YKJ	Solid tumour/cancer	2A00-2F9Z	Phase 2	[5]
JNJ-26483327	DMSQ3AZ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[6]
ISIS-CRP	DMQDUG4	Cardiovascular disease	BA00-BE2Z	Phase 1	[7]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[8]
Bisindolylmaleimide-I	DMOQJZC	Discovery agent	N.A.	Investigative	[8]
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole	DMN9YOB	Discovery agent	N.A.	Investigative	[9]
CI-1040	DMF3DZX	Discovery agent	N.A.	Investigative	[8]
BMS-536924	DMXJB4N	Discovery agent	N.A.	Investigative	[10]
KN-62	DMLZ89P	Discovery agent	N.A.	Investigative	[8]

Drug(s) Targeting Insulin-like growth factor I receptor (IGF1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Teprotumumab	DM4L59B	Graves disease	5A02.0	Approved	[11]
Mecasermin	DM1O3BY	Growth failure	LD2F.1Y	Approved	[12]
Somatomedin-1	DMZ9FAO	Hormone deficiency	5A61.1	Approved	[13]
OSI-906	DMHKZLF	Solid tumour/cancer	2A00-2F9Z	Phase 3	[14]
Rinfabate	DML9FD4	Solid tumour/cancer	2A00-2F9Z	Phase 2/3	[15]
MM-141	DM2RJ4D	Pancreatic cancer	2C10	Phase 2	[16]
TT-100	DMZE6Y9	Non-small-cell lung cancer	2C25.Y	Phase 2	[17]
AMG 479	DM0DRAZ	Breast cancer	2C60-2C65	Phase 2	[18]
VPI-2690B	DMUQZT4	Diabetic nephropathy	GB61.Z	Phase 2	[19]
AXL-1717	DMTQ1Y3	Solid tumour/cancer	2A00-2F9Z	Phase 2	[20]

Drug(s) Targeting Ephrin type-A receptor 2 (EPHA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CAR-T cells targeting EphA2	DMN3C2I	Malignant glioma	2A00.0	Phase 1/2	[21]
BT5528	DMYBKMV	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[22]
DS-8895	DM31VNC	Solid tumour/cancer	2A00-2F9Z	Phase 1	[23]
MEDI-547	DM3WP70	Solid tumour/cancer	2A00-2F9Z	Phase 1	[24]
MEDI-543	DM7Q1PF	Solid tumour/cancer	2A00-2F9Z	Preclinical	[25]
PMID23489211C20	DMDYC4J	Discovery agent	N.A.	Investigative	[26]
PMID19788238C66	DMCVJK9	Discovery agent	N.A.	Investigative	[27]
PMID21561767C8h	DMABZH6	Discovery agent	N.A.	Investigative	[28]

Drug(s) Targeting DNA repair protein RAD51 homolog 1 (RAD51)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CYT-0851	DME6NMJ	B-cell lymphoma	2A86	Phase 1/2	[29]

Drug(s) Targeting Glycogen synthase kinase-3 beta (GSK-3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AMO-02	DMJRU3A	Myotonic dystrophy	8C71.0	Phase 2/3	[30]
LY2090314	DMTBFE4	Acute myeloid leukaemia	2A60	Phase 2	[31]
Lithium	DMZ3OU6	Fragile X syndrome	LD55	Phase 2	[32]
Tideglusib	DME4LA1	Osteosarcoma	2B51	Phase 2	[33]
9-ING-41	DM57TY3	Myelofibrosis	2A20.2	Phase 2	[34]
Neu-120	DMXKOUC	Parkinson disease	8A00.0	Phase 1/2	[35]
KENPAULLONE	DMAGVXW	Discovery agent	N.A.	Patented	[36]
CHIR-99021	DMB8MNU	Allergic inflammation	4A80-4A85	Patented	[37]
TDZD-8	DMG6Q45	Malignant glioma	2A00.0	Patented	[38]
AR-A014418	DMUPN01	Ovarian cancer	2C73	Patented	[39]

Drug(s) Targeting Ephrin type-B receptor 2 (EPHB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BVD-523	DMNB4XK	Melanoma	2C30	Phase 2	[40]
SEphB4-HSA	DMD8RU0	Kaposi sarcoma	2B57	Phase 2	[41]
KO-947	DMZMSBI	Solid tumour/cancer	2A00-2F9Z	Phase 1	[40]
MK-8353	DMLCTI5	Solid tumour/cancer	2A00-2F9Z	Phase 1	[40]
PMID23489211C20	DMDYC4J	Discovery agent	N.A.	Investigative	[26]
PMID19788238C66	DMCVJK9	Discovery agent	N.A.	Investigative	[27]
SNEWIQPRLPQH	DMYUH62	Discovery agent	N.A.	Investigative	[42]

Drug(s) Targeting MAP kinase p38 (MAPK12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SM-101	DMFX9O6	Idiopathic thrombocytopenic purpura	3B64.10	Approved (orphan drug)	[43]
VX-745	DMJAEG6	Alzheimer disease	8A20	Phase 2	[44]
ARRY-797	DMJ48AB	Dilated cardiomyopathy	BC43.0	Phase 2	[45]
KC706	DMBX6C7	Cardiovascular disease	BA00-BE2Z	Discontinued in Phase 2	[46]
SB 235699	DMNH8XU	Psoriasis vulgaris	EA90	Discontinued in Phase 1	[47]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[8]
Bisindolylmaleimide-I	DMOQJZC	Discovery agent	N.A.	Investigative	[8]
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole	DMN9YOB	Discovery agent	N.A.	Investigative	[9]
CI-1040	DMF3DZX	Discovery agent	N.A.	Investigative	[8]
KN-62	DMLZ89P	Discovery agent	N.A.	Investigative	[8]

Drug(s) Targeting DNA topoisomerase II beta (TOP2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexrazoxane	DMD7X1O	Breast cancer	2C60-2C65	Approved	[48]
XK-469	DMVYO41	Solid tumour/cancer	2A00-2F9Z	Phase 1	[49]
XB-947	DM1UIOA	Solid tumour/cancer	2A00-2F9Z	Phase 1	[50]
A-62176	DM4WT7Z	N. A.	N. A.	Terminated	[51]
3'-THIO-THYMIDINE-5'-PHOSPHATE	DM5SM8X	Discovery agent	N.A.	Investigative	[2]

Drug(s) Targeting Bacterial Pantothenate kinase (Bact coaA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Coenzyme A	DM1I8LU	Discovery agent	N.A.	Investigative	[48]

Drug(s) Targeting Long transient receptor potential channel 4 (TRPM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PIP2	DMOZV7N	Discovery agent	N.A.	Investigative	[52]
adenosine diphosphate	DMFUHKP	N. A.	N. A.	Investigative	[3]
decavanadate	DMLT1N3	Discovery agent	N.A.	Investigative	[53]
BTP2	DMNM63G	Discovery agent	N.A.	Investigative	[54]
9-phenanthrol	DMJFBQ1	Discovery agent	N.A.	Investigative	[55]

Drug(s) Targeting Mycobacterium Thymidine monophosphate kinase (MycB tmk)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[48]
2'-deoxythymidine triphosphate	DM9OEJT	Discovery agent	N.A.	Investigative	[48]
Deoxythymidine	DMR90HY	Discovery agent	N.A.	Investigative	[48]
Diphosphate	DMHY30B	Discovery agent	N.A.	Investigative	[48]
Thymidine-5'-Phosphate	DMKM6NQ	Discovery agent	N.A.	Investigative	[48]
P1-(5'-Adenosyl)P5-(5'-Thymidyl)Pentaphosphate	DMM4VWD	Discovery agent	N.A.	Investigative	[56]
3'-Azido-3'-Deoxythymidine-5'-Monophosphate	DMU08MN	Discovery agent	N.A.	Investigative	[48]
5-Hydroxymethyluridine-2'-Deoxy-5'-Monophosphate	DMWVCJ1	Discovery agent	N.A.	Investigative	[48]
CHLORODEOXYURIDINE	DMQT3WJ	Discovery agent	N.A.	Investigative	[57]
BROMODEOXYURIDINE	DM0D7LA	Discovery agent	N.A.	Investigative	[57]

Drug(s) Targeting DNA topoisomerase II (TOP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Solid tumour/cancer	2A00-2F9Z	Approved	[58]
Etoposide	DMNH3PG	Solid tumour/cancer	2A00-2F9Z	Approved	[59]
Teniposide	DMLW57T	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Mitoxantrone	DMM39BF	Solid tumour/cancer	2A00-2F9Z	Approved	[60]
Idarubicin	DMM0XGL	Acute myeloid leukaemia	2A60	Approved	[58]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[58]
Lomefloxacin	DMVRH9C	Bacterial infection	1A00-1C4Z	Approved	[61]
Dexrazoxane	DMD7X1O	Breast cancer	2C60-2C65	Approved	[58]
Podofilox	DMT2EJP	Condyloma	1A95	Approved	[62]
Enoxacin	DMYTE6L	Urinary tract infection	GC08	Approved	[63]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Pantothenate kinase (Bact coaA)	TTSEOPJ	COAA_ECOLI	Inhibitor	[2]
DNA repair protein RAD51 homolog 1 (RAD51)	TTC0G1L	RAD51_HUMAN	Inhibitor	[2]
DNA topoisomerase II (TOP2)	TT0IHXV	TOP2A_HUMAN; TOP2B_HUMAN	Inhibitor	[2]
DNA topoisomerase II beta (TOP2B)	TT4NVEM	TOP2B_HUMAN	Inhibitor	[2]
Ephrin type-A receptor 2 (EPHA2)	TTRJB2G	EPHA2_HUMAN	Inhibitor	[2]
Ephrin type-B receptor 2 (EPHB2)	TTKPV6O	EPHB2_HUMAN	Inhibitor	[2]
Glycogen synthase kinase-3 beta (GSK-3B)	TTRSMW9	GSK3B_HUMAN	Inhibitor	[2]
Insulin-like growth factor I receptor (IGF1R)	TTHRID2	IGF1R_HUMAN	Inhibitor	[2]
LCK tyrosine protein kinase (LCK)	TT860QF	LCK_HUMAN	Inhibitor	[2]
Long transient receptor potential channel 4 (TRPM4)	TTJ2HKA	TRPM4_HUMAN	Inhibitor (gating inhibitor)	[3]
MAP kinase p38 (MAPK12)	TTYT93M	MK12_HUMAN	Inhibitor	[2]
Mycobacterium Thymidine monophosphate kinase (MycB tmk)	TT5B8AX	KTHY_MYCTU	Inhibitor	[2]
Stress-activated protein kinase JNK3 (JNK3)	TT056SO	MK10_HUMAN	Inhibitor	[2]

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